| Patent Number |
Title Of Patent |
Date Issued |
| 7453010 |
Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof |
November 18, 2008 |
| The invention relates to compounds of general formula (I): ##STR00001## where R.sub.1 represents H or a (C.sub.1-C.sub.4)alkyl, --CO(C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkylphenyl or --CO-phenyl group, said phenyl optionally being substituted; R.sub.2 represents H, a halogen ato |
| 7452897 |
Use of substituted 2-(diaza-bicyclo-alkyl)-pyrimidone derivatives for the treatment of neurodege |
November 18, 2008 |
| The invention relates to therapeutic uses of a 2-(diaza-bicyclo-alkyl)-pyrimidone derivative represented by formula (I): ##STR00001## Wherein R1, R2, R3, R4 and n are as defined herein. Specifically, the compounds of formula (I) are used for preventive and/or therapeutic treatment o |
| 7442708 |
1,2,3-substituted indolizine derivatives, inhibitors of fgfs, method for making same and pharmac |
October 28, 2008 |
| Compounds of formula I or salts thereof: ##STR00001## in which R.sub.1 represents --OH, (C.sub.1-C.sub.5)alkoxy, carboxyl, (C.sub.2-C.sub.6)alkoxycarbonyl, --NR.sub.5R.sub.6, --NH--SO.sub.2-Alk, --NH--SO.sub.2-Ph, --NH--CO-Ph, --N(Alk)-CO-Ph, --NH--CO--NH-Ph, --NH--CO-Alk, --NH--CO. |
| 7439257 |
Aryloxyalkylcarbamate-type derivatives, preparation method thereof and use of same in therapeuti |
October 21, 2008 |
| The invention relates to a compound of formula (I): ##STR00001## Wherein m, n, X, Y, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined herein. The invention also relates to the use of same in therapeutics. |
| 7429668 |
Method and intermediates for the preparation of derivatives of N-(1-benzhydrylazetidin-3-yl)-N-p |
September 30, 2008 |
| The invention relates to a novel method for the synthesis of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)meth- ylsulfonamide. |
| 7429663 |
7-(Pyrimidin-4-yl)-Imidazo[1,2-a]Pyrimidin-5(1H)-ones as GSK3.beta. inhibitors |
September 30, 2008 |
| The invention relates to a imidazo[1,2-a]pyrimidone derivative represented by formula (I) or a salt thereof: R.sup.1 wherein X represents a bond, an ethenylene group, an ethenylene group, a methylene group optionally substituted; a carbonyl group, an oxygen atom, a sulfur atom, a sulfony |
| 7429256 |
Safety system for a syringe |
September 30, 2008 |
| The safety support device for a syringe comprises a support sheath (16) for the body (10) of the syringe and an inner sheath (18) suitable for sliding relative to the support sheath between a waiting, retracted position and an extended position for protecting the needle (14) of the s |
| 7425566 |
1,3-dihydro-2H-indol-2-one derivatives, process for preparing them and pharmaceutical compositio |
September 16, 2008 |
| The invention relates to compounds of formula: ##STR00001## and to solvates and/or hydrates thereof, with affinity for and selectivity towards the V.sub.1b receptors or both the V.sub.1b and V.sub.1a receptors of arginine-vasopressin.The invention also relates to a process for prepa |
| 7423039 |
(4-phenylpiperazin-1-yl)acylpiperidine derivatives, preparation thereof and application of same |
September 9, 2008 |
| The invention relates to substituted (4-phenylpiperazin-1-yl)acylpiperidine derivatives of formula (I) ##STR00001## in the form of a base or an addition salt with an acid, and also in the form of a hydrate or solvate, and their preparation process and therapeutic application. |
| 7423030 |
1-amino-phthalazine derivatives, the preparation and the therapeutic use thereof |
September 9, 2008 |
| A 1-amino-phthalazine derivative of general formula (I) ##STR00001## wherein the substituents are as defined herein. Also disclosed are a method for preparing such compounds, intermediates for use in such method and medical treatments using the compounds of formula (I). |
| 7419977 |
Imidazoquinoline derivatives as adenosine A3 receptor ligands |
September 2, 2008 |
| This invention is directed to a compound of formula (I), ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, X, Z, m, n, o, p and r are as defined herein, its preparation, pharmaceutical composition and use as an adenosine A |
| 7419974 |
Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing s |
September 2, 2008 |
| The present invention relates to the compounds of formula (I): ##STR00001## in which A is a group of formula (a) or (b) ##STR00002## in which R represents a hydrogen or halogen atom, an --S(O).sub.z(C.sub.1-C.sub.4)alkyl group, an --NHSO.sub.2(C.sub.1-C.sub.4)alkyl group, an --S |
| 7419056 |
Rigid plastic protective case for a blister pack |
September 2, 2008 |
| A protective case for a blister pack containing medicines, includes a semi-rigid horizontal upper panel having cells delimiting housings open at the bottom and which are obturated by covers with each housing containing medicine. The case includes: perforated horizontal bottom upon |
| 7407950 |
N-(heteroaryl)-1H-indole-2-carboxamide derivatives and their use as vanilloid TRPV1 receptor lig |
August 5, 2008 |
| The invention concerns compounds of general formula (I), wherein n, X.sub.1, X.sub.2, X.sub.3, X.sub.4, Z.sub.1, Z.sub.2, Z.sub.3, Z.sub.4, Z.sub.5 and W are as defined herein. ##STR00001## Said compounds are ligands of the TRPV.sub.1 vanilloid receptor, and are therefore, useful fo |
| 7405306 |
3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their prepara |
July 29, 2008 |
| The invention discloses and claims therapeutic uses of compounds of general formula (I) ##STR00001## Wherein X, R.sub.1, R.sub.2 and R.sub.3 are as described herein. The invention further discloses processes for preparing them, and novel intermediates therefor. |
| 7402682 |
3-heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-B]indole-1-carboxamide derivatives, their prepa |
July 22, 2008 |
| A subject-matter of the invention is the compounds of general formula (I) ##STR00001## in which X represents a hydrogen or halogen atom; R.sub.1 represents a hydrogen atom or a (C.sub.1-C.sub.4)alkyl group; R.sub.2 and R.sub.3 each represent, independently of one another, a hydrogen ato |
| 7396958 |
Sulphonamide derivatives, their preparation and their therapeutic application |
July 8, 2008 |
| Disclosed are compounds having the general formula (I) ##STR00001## as defined herein, the preparation thereof, and the use thereof for the prophylaxis or treatment of any disease involving a dysfunction associated with the orexin 2 receptor such as obesity, appetite or taste disord |
| 7393853 |
Use of substituted 8-Perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivative |
July 1, 2008 |
| The invention relates to use of a substituted-pyrimidone derivative represented by formula (I) or a salt thereof: ##STR00001## wherein X, Y, R1, R2, R3, R4, R5, n, p and q are as described herein for treating a variety of disease states. More specifically, the invention relates to a |
| 7390924 |
Terphenyl derivatives, preparation thereof, compositions containing same |
June 24, 2008 |
| The invention relates to terphenyl derivatives of formula: ##STR00001## and to their preparation and to the pharmaceutical compositions comprising them.These compounds exhibit an antagonist activity with respect to CB.sub.1 cannabinoid receptors. |
| 7390823 |
Use of saredutant and of its pharmaceutically acceptable salts for the preparation of medicinal |
June 24, 2008 |
| The present invention relates to the use of saredutant and of its pharmaceutically acceptable salts for the preparation of medicinal products that are useful in the treatment or prevention of all mood disorders, adaptation disorders or mixed anxiety-depression disorders. |
| 7390818 |
Pyridoindolone derivatives substituted in the 3-position by a phenyl, their preparation and thei |
June 24, 2008 |
| The present invention relates to pyridoindolone derivatives substituted in the 3-position by a phenyl of general formula (I): ##STR00001## to processes for preparing the same and to their use in therapeutics. |
| 7388031 |
Cyclohexyl(alkyl)-propanolamines, preparation method and pharmaceutical compositions containing |
June 17, 2008 |
| The present invention relates to the compounds of formula (I): ##STR00001## in which A is a group of formula (a) or (b) ##STR00002## in which R represents a hydrogen or halogen atom, an --S(O).sub.z(C.sub.1 C.sub.4)alkyl group, an --NHSO.sub.2(C.sub.1 C.sub.4)alkyl group, an --SO.su |
| 7388005 |
Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3 |
June 17, 2008 |
| The invention relates to a pyrimidone derivative represented by formula (I) or a salt thereof wherein: X represents two hydrogen atoms, a sulphur atom, an oxygen atom or a C.sub.1-2 alkyl group and a hydrogen atom; y represents a bond, an ethenylene group, an ethynylene group, an oxygen |
| 7384969 |
N-(1H-indolyl)-1H-indole-2-carboxamide derivatives, their preparation and their therapeutic use |
June 10, 2008 |
| The invention relates to compounds of general formula (I): ##STR00001## in which X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5, Z.sub.1, Z.sub.2, Z.sub.3, Z.sub.4 and Z.sub.5, R, Y and n are as defined herein. Also disclosed and claimed are the preparative methods and application of said |
| 7384960 |
Pyrazolecarboxylic acid tricyclic derivatives, preparation and pharmaceutical compositions conta |
June 10, 2008 |
| The subject of the invention is tricyclic derivatives of pyrazolecarboxylic acid of formula: ##STR00001## in which R.sub.1 represents a C.sub.3-C.sub.15 carboxyl radical or an NR.sub.2R.sub.3 group. The invention also relates to the method for preparing the compounds of formula (I), |
| 7381835 |
Resolution process for (R)-(-)-2-hydroxy-2-(2-chlorophenyl) acetic acid |
June 3, 2008 |
| The subject of the present invention is the preparation of the (R)-(-)-2-hydroxy-2-(2-chlorophenyl)acetic acid of the formula (I) by the resolution of the corresponding racemic compound by using the compounds of the general formula (II). |
| 7381727 |
Pyrrole derivatives, their preparation and their therapeutic use |
June 3, 2008 |
| The invention concerns compounds of formula (I): ##STR00001## Wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are as defined herein. The invention also concerns the method for preparing said compounds and their therapeutic use. |
| 7378521 |
Preparation of 2-(2-arylmorpholin-2-yl) ethanol derivatives and intermediates |
May 27, 2008 |
| The invention relates to a process for the preparation of substituted 2-vinyl-2-arylmorpholine derivatives as described herein. This invention also relates to 2-vinyl-2-arylmorpholine derivatives as well as intermediates therefor. |
| 7378413 |
2-amino-3-(alkyl)-pyrimidone derivatives |
May 27, 2008 |
| A pyrimidone derivative represented by formula (I) or a salt thereof: ##STR00001## Wherein: R1 represents a hydrogen atom or a C.sub.1-6 alkyl group which may be substituted by a C.sub.6,10 aryl group; R2 represents a C.sub.1-10 alkyl group which may be substituted, a C.sub.2-6 alkenyl |
| 7371770 |
Acylaminothiazole derivatives and use thereof as .beta.-amyloid inhibitors |
May 13, 2008 |
| Compounds of formula (I) as defined herein: ##STR00001## inhibit the formation of the .beta.-amyloid peptide (.beta.-A4) and are, therefore, useful in the treatment of pathologies in which a .beta.-amyloid peptide (.beta.-A4) formation inhibitor provides a therapeutic benefit. Parti |
| 7365089 |
Triazolo-quinolin derivatives useful as adenosine receptor ligands |
April 29, 2008 |
| The present invention relates to adenosine A3? receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I), |
| 7358371 |
Process for the preparation of 1,5--carboxylic acid derivatives |
April 15, 2008 |
| The present invention comprises a process for the preparation of compounds that possess an affinity for the cannabinoid receptor in the human brain. These compounds are useful as immunomodulators and psychotropic agents in the treatment of thymic disorders, vomiting, myo-relaxation, vari |
| 7348327 |
Compounds |
March 25, 2008 |
| The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms. |
| 7345059 |
Diphenylpyridine derivatives, preparation and therapeutic application thereof |
March 18, 2008 |
| The invention relates to 5,6-diphenylpyridine-3-carboxamide derivatives of general formula (I): ##STR00001## where: R.sub.1 represents hydrogen or a (C.sub.1-C.sub.4)alkyl; R.sub.2 represents: a monoazo saturated heterocycle of 5 to 7 atoms, the nitrogen atom being substituted with a |
| 7335670 |
Derivatives of N-[heteroaryl(piperidine-2-yl) methyl]benzamide, preparation method thereof and a |
February 26, 2008 |
| Compounds of formula (I) as defined herein: ##STR00001## are useful for treating behavioral disorders associated with dementia, psychoses, in particular schizophrenia (deficient form and productive form) and acute or chronic extrapyramidal symptoms induced by neuroleptics; for the t |
| 7326723 |
Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same |
February 5, 2008 |
| The present invention relates to compounds of formula (I): ##STR00001## in which X represents N or CH; R.sub.1 represents a hydrogen or halogen atom or a CF.sub.3 group; n is an integer from 1 to 5; A represents a partially saturated carbonaceous bi- or tricycle; it also relates to |
| 7326722 |
N-[Phenyl(piperidin-2-yl)methyl]benzamide derivatives, their preparation and their application i |
February 5, 2008 |
| The present invention discloses and claims a compound of general formula (I) ##STR00001## wherein A, X and R.sub.2 are as described herein. Also disclosed and claimed is application of this compound in a variety of therapeutic applications. |
| 7326720 |
Phenyl- and pyridylpiperidines with TNF activity |
February 5, 2008 |
| The present invention relates to compounds of formula (I): ##STR00001## in which X represents N or CH; R.sub.1 represents a hydrogen or halogen atom or a CF.sub.3 group; R.sub.2 and R.sub.3 independently represent a hydrogen atom or a methyl group; n is 0 or 1; A represents a condensed |
| 7323493 |
Solid pharmaceutical composition containing benzofuran derivatives |
January 29, 2008 |
| The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and a pharmaceutically |
| 7323467 |
3-heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their prepara |
January 29, 2008 |
| The invention discloses and claims therapeutic uses of compounds of general formula (I) ##STR00001## Wherein X, R.sub.1, R.sub.2 and R.sub.3 are as described herein. The invention further discloses processes for preparing them, and novel intermediates therefor. |
| 7320982 |
Use of 4-substituted tetrahydropyridines for the manufacture of medicaments acting upon TGF-.bet |
January 22, 2008 |
| The invention relates to the use of a compound of formula (I): ##STR00001## for the preparation of pharmaceutical compositions for increasing the circulating, cellular and extracellular levels of TGF-.beta.1. |
| 7320978 |
Oxazole derivatives, preparation and therapeutic use thereof |
January 22, 2008 |
| This invention relates to compounds of formula (I): ##STR00001## Wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are as described herein. The invention further relates to a method for prevention and therapeutic use thereof. |
| 7310848 |
Toothbrush provided with an articulated arm bearing a protective cap |
December 25, 2007 |
| A toothbrush having a head placed at a front longitudinal end of a handle made overall as a single piece. The head has flexible brushing elements on its upper surface. The toothbrush is equipped with an arm articulated at one end, and provided at the opposite free end with a protective c |
| 7297799 |
Preparation of benzoylalkyl-1,2,3,6-tetrahydropyridines and use thereof |
November 20, 2007 |
| The invention relates to the use of compounds of formula ##STR00001## for the preparation of medicines designed for the treatment of neuronal and cerebral disorders.The invention also relates to the compounds of formula: ##STR00002## a process for their preparation and the pharmace |
| 7297710 |
Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl]sulfonamide, their preparation and their |
November 20, 2007 |
| The present invention relates to compounds corresponding to the formula (I): ##STR00001## In which R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as described herein. The invention also relates to the method of preparation of said compounds and their application in therapeutics. |
| 7297692 |
1,3-dihydro-2H-indol-2-one derivatives, process for preparing them and pharmaceutical compositio |
November 20, 2007 |
| The invention relates to compounds of formula: ##STR00001## as well as the possible salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, which have affinity for and selectivity towards the V.sub.1b receptors or towards both the V.sub.1b and V.sub.1a |
| 7294645 |
Derivatives of N'-(1,5-diphenyl-1H-pyrazol-3-yl) sulfonamide with CB1 receptor affinity |
November 13, 2007 |
| The invention relates to compounds of formula (I): ##STR00001## Wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 are as defined herein. The invention also relates to the preparation method thereof and to the use of same in therapeutics. |
| 7294632 |
Substituted 8'-pyridinyl-dihydrospiro-[cycloalkyl]-pyrimido[1,2-a]pyrimidin-6-one and 8'-pyr |
November 13, 2007 |
| The invention relates to a dihydrospiro-[cycloalkyl]-pyrimidone derivative represented by formula (I) or a salt thereof: ##STR00001## wherein X, Y, R1, R2, R3, m, n, p and q are as described herein. The invention relates also to a medicament comprising the said derivative or a salt ther |
| 7294631 |
Substituted 8'-pyri(MI)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a]pyrimidin-- 6-one |
November 13, 2007 |
| The invention relates to a dihydrospiro-[cycloalkylamine]-pyrimidone derivative represented by formula (I) or a salt thereof: ##STR00001## wherein X, Y, R1, R2, R3, R4, o, m, n, p and q are as defined herein. The invention relates also to a medicament comprising the said derivative or |
| 7294628 |
Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof |
November 13, 2007 |
| The invention relates to substituted 1-piperazinylacylpiperidine derivatives of general formula (I) ##STR00001## in which: n is 1 or 2; R.sub.1 represents a halogen atom; a trifluoromethyl radical; a (C.sub.1-C.sub.4) alkyl; a (C.sub.1-C.sub.4)alkoxy; a trifluoromethoxy radical; R |
