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Sankyo Company, Limited Patents
Assignee:
Sankyo Company, Limited
Address:
Tokyo, JP
No. of patents:
563
Patents:


1 2 3 4 5 6 7 8 9 10 11 12










Patent Number Title Of Patent Date Issued
RE39420 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses December 5, 2006
Compounds of formula (I) and (II): ##STR00001## [wherein R is hydrogen, halogen or alkyl; R.sup.1 is alkyl, amino or substituted amino; R.sup.2 is optionally substituted phenyl; R.sup.3 is hydrogen, halogen or optionally substituted alkyl; R.sup.4 is hydrogen, optionally substituted
RE34960 Carbapenem compounds, and compositions containing them May 30, 1995
Compounds of formula (I): ##STR1## .[.[.]. wherein: R.sup.1 .[.represents a hydrogen atom, an alkyl group, an alkoxy group or various substituted alkyl groups.]. .Iadd.is hydroxyethyl; .Iaddend.R.sup.2 represents a group of formula ##STR2## in which ##STR3## .[.repr
8263349 Antibody specific for a mammalian sphingosine kinase type 2 isoform protein and methods of use t September 11, 2012
Polyclonal or monoclonal antibodies which are specific for a mammalian sphingosine kinase type 2 isoform protein and methods for detecting the presence of sphingosine kinase type 2 isoform using the antibodies.
8106079 Intermediate of 6-substituted-1-methyl-1-H-benzimidazole derivative and method for producing sam January 31, 2012
A compound having the following formula (III) ##STR00001## wherein R.sup.2 is hydrogen, alkyl, cycloalkyl, phenyl or a 5- or 6-membered heterocyclic, and X is oxygen, sulfur or nitrogen, and a method for preparing said compound.
8067396 Amino alcohol compounds or phosphonic acid derivatives thereof November 29, 2011
A compound having a formula II(a): ##STR00001## wherein R.sup.1 and R.sup.2 are hydrogen lower alkyl, lower aliphatic acyl, or lower alkoxycarbonyl; R.sup.4 is C.sub.1-C.sub.4 alkyl; n is 2 or 3; X is a formula .dbd.N-D, wherein D is hydrogen, C.sub.1-C.sub.6 alkyl or phenyl; Y is
7994152 Method of treating a cancer by administering A 2',5'-oligoadenylate analog August 9, 2011
A method of treating a tumor or a viral disease by administering to a human the following 2',5'-oligoadenylate analog: ##STR00001## Wherein m is 0; n is 0 or 1; R.sup.1 is alkoxy substituted by hydroxyl, mercapto, alkylthio substituted by hydroxyl or X.sub.1--X.sub.2--X.sub.3--S--;
7910617 Method for suppressing the number of peripheral blood lymphocytes using an amino alcohol compoun March 22, 2011
A method for suppressing the number of peripheral blood lymphocytes involving administering to a human in need thereof a pharmaceutically effective amount of a compound which is (2R) -2-amino-2-methyl-4-{1-methyl-5-[4-(4-methylphenyl)butanoyl]pyrrol-2-yl}b- utan-1-ol or a pharmacologi
7906639 Oligonucleotides having a 2'-O,4'-C-ethylene nucleotide in the third position of the 3'-end March 15, 2011
The present invention relates to a method for detecting gene polymorphism by PCR, using, as a primer, an oligonucleotide, wherein the third nucleotide from the 3'-end thereof is a 2'-O,4'-C-ethylene nucleotide (ENA) unit, the other oligonucleotides are natural oligonucleotides, the 3
7863243 Anti-tumor agent January 4, 2011
The present invention provides a new anti-tumor agent containing adiponectin as an active ingredient, particularly, an anti-tumor agent capable of inhibiting carcinogenesis in the liver, use of adiponectin as an anti-tumor agent, and a prophylactic or therapeutic method against a tum
7816552 Intermediate of 6-substituted 1-methyl-1-H-benzimidazole derivative and method for producing sam October 19, 2010
A method for preparing a compound having the following formula (I) ##STR00001## by reducing a nitro group of the following formula (III) ##STR00002## followed by carrying out an intramolecular dehydration condensation, wherein R.sup.2 is hydrogen, alkyl, cycloalkyl, phenyl or a 5-
7811556 Polymeric modifiers and pharmaceutical compositions October 12, 2010
A copolymer or a pharmacologically acceptable salt thereof is provided, which contains, as constitutional units, (a) one or more structural units of formula (I): wherein m is an integer of from 3 to 100, Alk represents alkyline, and R.sup.1 and R.sup.2 are the same or different and each
7803595 Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof September 28, 2010
Nucleic acids encoding mouse and human sphingosine kinase type 2 isoforms, methods for detecting agents or drugs which inhibit or promote sphingosine activity and therapeutic agents containing peptides or antibodies to peptides encoded by such nucleic acids.
7651999 2', 5'-oligoadenylate analogs January 26, 2010
A 2-5A analog represented by the formula (1): ##STR00001## wherein m is 0 or 1; n is 0 to 2; R.sup.1 represents an alkoxy group having from 1 to 6 carbon atoms which may be substituted, an unprotected mercapto group, a mercapto group protected by a nucleic acid synthesis protecting grou
7638551 Amino alcohol compounds or phosphonic acid derivatives thereof December 29, 2009
A method for the prevention or treatment of an immunology-related disease, which is not rheumatoid arthritis or psoriasis, in a mammal in need thereof which involves administering to the mammal a pharmaceutically effective amount of a compound, a pharmacologically acceptable salt of
7592140 2', 5'-oligoadenylate phosphodiesterase September 22, 2009
Polypeptides having 2',5'-oligoadenylate phosphodiesterase activity, antibodies against the polypeptides, polynucleotides coding for the polypeptides, recombinant plasmid DNAs into which the polynucleotides have been inserted, host cells transformed by the recombinant plasmid DNAs, p
7560549 Sulfonyloxy derivatives July 14, 2009
A compound having the formula (I) ##STR00001## wherein R.sup.1 is a substituted phenyl, R.sup.2 is a phenyl substituted with halogen atoms, R.sup.3 is a substituted phenyl, D is an oxygen or a methylene, and n is 0 or 1. The compound is a synthetic intermediate for a neurokinin rece
7547790 Optically active 4,4-di-substituted oxazolidine derivative and method for producing same June 16, 2009
An optically active 4,4-di-substituted oxazolidine compound having the formula (I) ##STR00001## wherein R.sup.1 represents a substituted C.sub.1-C.sub.3 alkyl group, a substituted C.sub.2-C.sub.3 alkenyl group, a formyl group, a hydroxymethyl group, a group of the formula COOR, a
7534782 Crystal of 1-methylcarbapenem solvate May 19, 2009
A 1-methylcarbapenem compound ethanolate of the formula (I-1) in the crystalline form that shows main peaks at interplanar spacings d=7.60, 6.69, 6.33, 6.14, 5.15, 4.58 and 4.48 in the X-ray powder diffraction pattern obtained with Cu K.sub..alpha. irradiation ##STR00001## and a 1-me
7419814 Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof September 2, 2008
Methods for detecting agents or drugs which inhibit or promote an activity of sphingosine kinase type 2 isoform involving providing a recombinant DNA construct into a cell such that sphingosine kinase type 2 isoform is produced in the cell, adding at least one drug or agent to the cell,
7417052 Phenylene derivative having tetrazole ring or thiazolidinedione ring August 26, 2008
The present invention provides a compound represented by the following formula (I) ##STR00001## wherein A is a cyclic group etc., B is a 1H-tetrazol-5-yl group or a 2,4-dioxothiazolidin-5-yl group, and Y is a single bond or a C6-10 arylene group, or a pharmacologically acceptable sa
7411095 Process for production of high-purity enamines August 12, 2008
A method for producing highly pure enamines, which comprises reacting an aldehyde or ketone with an amine and treating the resulting reaction mixture with an acidic aqueous solution at a temperature between 0.degree. C. and 30.degree. C.
7396930 Process for producing cyclic thioether and synthetic intermediate thereof July 8, 2008
A process for producing cyclic thioether compounds and their synthetic intermediates. The process produces a compound represented by formula (5): ##STR00001## wherein G.sup.1 is an alkylene group, R.sup.1 is a thiol protecting group, R.sup.2 is hydrogen or an amino protecting group,
7375189 Liver regeneration promoting agent May 20, 2008
Although it is known that adiponectin, which is adipose-specific protein, has effects of suppressing the proliferation and migration of vascular smooth muscle, an effect against arteriosclerosis, an effect of inhibiting the activation of monocytes and macrophages and an anti-inflamma
7371760 Medicinal compositions containing aspirin May 13, 2008
A combination of 2-acetoxy-5-(.alpha.-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahyd- rothieno[3,2-c]pyridine or a pharmaceutically acceptable salt thereof, and aspirin, which possess excellent inhibitory activity against platelet aggregation and thrombogenesis, and is useful fo
7365067 Indanol derivative April 29, 2008
The present invention provides a compound having the following general formula (I) which is useful as a neurokinin receptor antagonist: ##STR00001## (wherein, R.sup.1, R.sup.2: optionally substituted (hetero)aryl, R.sup.3: --CO--R.sup.4, --CO--O--R.sup.4, etc., R.sup.4: alkyl, cyc
7361744 Oligosaccharide derivative April 22, 2008
Compounds having the formula (I): ##STR00001## wherein A represents a group such as a cyclic group, R.sup.1 and R.sup.2 represent groups such as alkyl groups or hydroxymethyl groups, and n represents 1 or 2, or pharmacologically acceptable salts thereof or pharmacologically acceptab
7307096 Combined agents for treatment of glaucoma December 11, 2007
A pharmaceutical composition for the prophylaxis or treatment of glaucoma which comprises an angiotensin II antagonist and at least one compound selected from an adrenaline receptor blocker, a prostaglandin and a carbonic anhydrase inhibitor; and a method for the prophylaxis or treat
7230023 Water-soluble triazole fungicide June 12, 2007
A triazole compound of the formula (I) or a pharmacologically salt thereof: ##STR00001## wherein X represents a group of formula X--OH which has antifungal activity, L represents an -(adjacently substituted C.sub.6-C.sub.10 aryl)-CH.sub.2 group and R represents a --P(.dbd.O)(OH).sub
7217805 Bicyclonucleoside analogues May 15, 2007
Bicyclonucleoside analogues which exhibit anti-AIDS activity and intermediates to produce oligonucleotide analogues which have anti-sense or anti-gene activity as well as in vivo stability. Compounds of the following formula (1) or their pharmaceutically acceptable salts. ##STR00001#
7199150 Amino alcohol compounds April 3, 2007
Amino alcohol compounds and phosphonic acid compounds having excellent immunosuppressive activity, pharmacologically acceptable salts thereof and pharmacologically acceptable esters thereof, and pharmaceutical compositions comprising such compounds, the compounds having the following
7199139 Medicinal compositions containing diuretic and insulin resistance-improving agent April 3, 2007
The present invention relates to a pharmaceutical composition comprising an insulin sensitizer and a diuretic which can prevent or treat side effects such as edema, cardiac enlargement, body fluid retension or hydrothorax caused by administration of an insulin sensitizer.
7176323 Process for the production of .gamma.-keto acetals February 13, 2007
A process for the production of a .gamma.-ketoacetal compound wherein the desired product is obtained by a simple procedure in a high yield as a high purity product. The reaction scheme for the process is as follows: ##STR00001## wherein Ar is an aryl group; X is a halogen atom; R.sup.a
7157442 Antibacterial compound January 2, 2007
The present invention relates to a compound of formula (I) (wherein R.sup.1 and R.sup.2 represent an aryl group, a heterocyclic group, an alkyl group, an alkenyl group and the like which are optionally substituted, R.sup.3 represents a hydrogen atom or a hydroxyl group, and X.sup.1 a
7122666 Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses October 17, 2006
Compounds having activity against production of an inflammatory cytokine of formula (I)': ##STR00001## A' is pyrrole; R.sup.1' is phenyl or naphthyl; R.sup.2' is pyridyl or pyrimidinyl; R.sup.3' is (IIa)', (IIb)' or (IIc)': ##STR00002## m' is 1; E' is nitrogen; D' is >C(R.sup.5'
7091363 Compounds for the preparation of carbapenem-type antibacterial agents August 15, 2006
A compound of a formula (1) or a salt thereof ##STR00001## wherein R.sup.1 represents a methyl group. The compound is useful for the preparation of carbapenem-type antibacterial agents.
7091352 Compounds substituted with bicyclic amino groups August 15, 2006
Compounds of the formula (I) below, or pharmacologically acceptable salts, esters or other derivatives thereof: ##STR00001## wherein A is furan, thiophene, pyrazole, imidazole, isoxazole or isothiazole; R.sup.1 is a substituted or unsubstituted aryl or a substituted or unsubstituted
7074756 Liver generation promoter July 11, 2006
Although it is known that adiponectin, which is adipose-specific protein, has effects of suppressing the proliferation and migration of vascular smooth muscle, an effect against arteriosclerosis, an effect of inhibiting the activation of monocytes and macrophages and an anti-inflamma
7056710 Methods for producing ML-236B, a pravastatin precursor, using a host cell transformed with mlcR, June 6, 2006
Polynucleotides, such as DNA, are provided which accelerate the biosynthesis of a HMG-CoA reductase inhibitor, ML-236B, in an ML-236B producing micro-organism when introduced in the ML-236B producing micro-organism. Pravastatin, which is an HM-CoA reductase inhibitor, can be obtained
7041660 Crystalline 1-methylcarbapenem derivatives May 9, 2006
This invention provides crystalline forms of a 1-methylcarbapenem derivative of formula (I-1), (I-2) or (I-3) ##STR00001## The crystalline forms of the 1-methylcarbapenem derivative exhibit excellent antibiotic activity against various bacterial strains and sufficient stability for
7037934 Blood lipid ameliorant composition May 2, 2006
A blood lipid ameliorating composition containing atorvastatin in combination with an agent selected from the group consisting of a riboflavin derivative, a tocopherol compound, an ascorbic acid derivative, pantethine and taurine.
7034150 Processes for the preparation of carbapenem-type antibacterial agents April 25, 2006
A process for the preparation of a carbapenem antibacterial compound of the following formula (4) having a 1-alkylpyrrolidine structure or a salt thereof, a useful synthetic intermediate of the following formula (1) or a salt thereof, and a process for the preparation thereof: ##STR0000
7030138 Benzamidine derivatives April 18, 2006
A compound of a formula (1) and pharmacologically acceptable salts thereof: ##STR00001## wherein R.sup.1 represents hydrogen, halogen, alkyl or hydroxyl; R.sup.2 represents hydrogen or halogen; R.sup.3 represents hydrogen, alkyl, hydroxyl, carboxyalkyl, alkoxycarbonylalkyl, alkylsu
7012147 Indoline derivative and process for producing the same March 14, 2006
The present invention provides novel synthetic intermediates for the production of indoline derivatives, which exhibit excellent ACAT inhibitory activity, and processes for the preparation thereof.
7012067 Blood lipid ameliorant composition March 14, 2006
A blood lipid ameliorating composition containing simvastatin and one or more ingredients selected from a riboflavin compound, a d-.alpha.-tocopherol compound, an ascorbic acid compound, pantethine, and taurine.
7001897 1-methylcarbapenem derivatives February 21, 2006
A 1-methylcarbapenem compound represented by the formula (I): ##STR00001## having antibacterial activity, pharmacologically acceptable esters or salts thereof and pharmaceutical compositions (particularly antibacterial agents) containing them as an active ingredient are described. I
6998422 Lipid peroxide-lowering compositions February 14, 2006
Compositions having excellent blood lipid peroxide lowering activity are provided. In particular, compositions for lowering lipid peroxides in the blood which contain pravastatin together with at least one substance selected from the group consisting of taurine, pantethine and inositol
6972323 Anti-Fas antibodies December 6, 2005
Anti-Fas antibodies which are cross-reactive with mouse and human Fas and are useful in the treatment of conditions attributable to abnormalities in the Fas/Fas ligand system.
6964976 Amino alcohol derivatives November 15, 2005
Compounds of formula (I) which exhibit excellent immune suppression activity, pharmacologically acceptable salts thereof, esters thereof or other derivatives: ##STR1##wherein R.sup.1 and R.sup.2 are a hydrogen atom, an amino protecting group; R.sup.3 is a hydrogen atom, a hydroxy pro
6924279 Crystalline 1-methylcarbapenem derivatives August 2, 2005
This invention provides crystalline forms of a 1-methylcarbapenem derivative of formula (I) or of pharmaceutically acceptable salts thereof. ##STR1##The crystalline forms of the 1-methylcarbapenem derivative exhibit excellent antibiotic activity against various bacterial strains and
6916849 Compositions for improving lipid content in the blood July 12, 2005
The present invention relates to compositions for lowering the total amount of cholesterol in the blood and methods of using the compositions. The compositions are a mixture of pravastatin and one or more vitamins selected from riboflavins, d-.alpha.-tocopherols, ascorbic acids and i
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