| Patent Number |
Title Of Patent |
Date Issued |
| RE39420 |
1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses |
December 5, 2006 |
| Compounds of formula (I) and (II): ##STR00001## [wherein R is hydrogen, halogen or alkyl; R.sup.1 is alkyl, amino or substituted amino; R.sup.2 is optionally substituted phenyl; R.sup.3 is hydrogen, halogen or optionally substituted alkyl; R.sup.4 is hydrogen, optionally substituted |
| RE34960 |
Carbapenem compounds, and compositions containing them |
May 30, 1995 |
| Compounds of formula (I): ##STR1## .[.[.]. wherein: R.sup.1 .[.represents a hydrogen atom, an alkyl group, an alkoxy group or various substituted alkyl groups.]. .Iadd.is hydroxyethyl; .Iaddend.R.sup.2 represents a group of formula ##STR2## in which ##STR3## .[.repr |
| 7419814 |
Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof |
September 2, 2008 |
| Methods for detecting agents or drugs which inhibit or promote an activity of sphingosine kinase type 2 isoform involving providing a recombinant DNA construct into a cell such that sphingosine kinase type 2 isoform is produced in the cell, adding at least one drug or agent to the cell, |
| 7417052 |
Phenylene derivative having tetrazole ring or thiazolidinedione ring |
August 26, 2008 |
| The present invention provides a compound represented by the following formula (I) ##STR00001## wherein A is a cyclic group etc., B is a 1H-tetrazol-5-yl group or a 2,4-dioxothiazolidin-5-yl group, and Y is a single bond or a C6-10 arylene group, or a pharmacologically acceptable sa |
| 7411095 |
Process for production of high-purity enamines |
August 12, 2008 |
| A method for producing highly pure enamines, which comprises reacting an aldehyde or ketone with an amine and treating the resulting reaction mixture with an acidic aqueous solution at a temperature between 0.degree. C. and 30.degree. C. |
| 7396930 |
Process for producing cyclic thioether and synthetic intermediate thereof |
July 8, 2008 |
| A process for producing cyclic thioether compounds and their synthetic intermediates. The process produces a compound represented by formula (5): ##STR00001## wherein G.sup.1 is an alkylene group, R.sup.1 is a thiol protecting group, R.sup.2 is hydrogen or an amino protecting group, |
| 7375189 |
Liver regeneration promoting agent |
May 20, 2008 |
| Although it is known that adiponectin, which is adipose-specific protein, has effects of suppressing the proliferation and migration of vascular smooth muscle, an effect against arteriosclerosis, an effect of inhibiting the activation of monocytes and macrophages and an anti-inflamma |
| 7371760 |
Medicinal compositions containing aspirin |
May 13, 2008 |
| A combination of 2-acetoxy-5-(.alpha.-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahyd- rothieno[3,2-c]pyridine or a pharmaceutically acceptable salt thereof, and aspirin, which possess excellent inhibitory activity against platelet aggregation and thrombogenesis, and is useful fo |
| 7365067 |
Indanol derivative |
April 29, 2008 |
| The present invention provides a compound having the following general formula (I) which is useful as a neurokinin receptor antagonist: ##STR00001## (wherein, R.sup.1, R.sup.2: optionally substituted (hetero)aryl, R.sup.3: --CO--R.sup.4, --CO--O--R.sup.4, etc., R.sup.4: alkyl, cyc |
| 7361744 |
Oligosaccharide derivative |
April 22, 2008 |
| Compounds having the formula (I): ##STR00001## wherein A represents a group such as a cyclic group, R.sup.1 and R.sup.2 represent groups such as alkyl groups or hydroxymethyl groups, and n represents 1 or 2, or pharmacologically acceptable salts thereof or pharmacologically acceptab |
| 7307096 |
Combined agents for treatment of glaucoma |
December 11, 2007 |
| A pharmaceutical composition for the prophylaxis or treatment of glaucoma which comprises an angiotensin II antagonist and at least one compound selected from an adrenaline receptor blocker, a prostaglandin and a carbonic anhydrase inhibitor; and a method for the prophylaxis or treat |
| 7230023 |
Water-soluble triazole fungicide |
June 12, 2007 |
| A triazole compound of the formula (I) or a pharmacologically salt thereof: ##STR00001## wherein X represents a group of formula X--OH which has antifungal activity, L represents an -(adjacently substituted C.sub.6-C.sub.10 aryl)-CH.sub.2 group and R represents a --P(.dbd.O)(OH).sub |
| 7217805 |
Bicyclonucleoside analogues |
May 15, 2007 |
| Bicyclonucleoside analogues which exhibit anti-AIDS activity and intermediates to produce oligonucleotide analogues which have anti-sense or anti-gene activity as well as in vivo stability. Compounds of the following formula (1) or their pharmaceutically acceptable salts. ##STR00001# |
| 7199150 |
Amino alcohol compounds |
April 3, 2007 |
| Amino alcohol compounds and phosphonic acid compounds having excellent immunosuppressive activity, pharmacologically acceptable salts thereof and pharmacologically acceptable esters thereof, and pharmaceutical compositions comprising such compounds, the compounds having the following |
| 7199139 |
Medicinal compositions containing diuretic and insulin resistance-improving agent |
April 3, 2007 |
| The present invention relates to a pharmaceutical composition comprising an insulin sensitizer and a diuretic which can prevent or treat side effects such as edema, cardiac enlargement, body fluid retension or hydrothorax caused by administration of an insulin sensitizer. |
| 7176323 |
Process for the production of .gamma.-keto acetals |
February 13, 2007 |
| A process for the production of a .gamma.-ketoacetal compound wherein the desired product is obtained by a simple procedure in a high yield as a high purity product. The reaction scheme for the process is as follows: ##STR00001## wherein Ar is an aryl group; X is a halogen atom; R.sup.a |
| 7157442 |
Antibacterial compound |
January 2, 2007 |
| The present invention relates to a compound of formula (I) (wherein R.sup.1 and R.sup.2 represent an aryl group, a heterocyclic group, an alkyl group, an alkenyl group and the like which are optionally substituted, R.sup.3 represents a hydrogen atom or a hydroxyl group, and X.sup.1 a |
| 7122666 |
Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses |
October 17, 2006 |
| Compounds having activity against production of an inflammatory cytokine of formula (I)': ##STR00001## A' is pyrrole; R.sup.1' is phenyl or naphthyl; R.sup.2' is pyridyl or pyrimidinyl; R.sup.3' is (IIa)', (IIb)' or (IIc)': ##STR00002## m' is 1; E' is nitrogen; D' is >C(R.sup.5' |
| 7091363 |
Compounds for the preparation of carbapenem-type antibacterial agents |
August 15, 2006 |
| A compound of a formula (1) or a salt thereof ##STR00001## wherein R.sup.1 represents a methyl group. The compound is useful for the preparation of carbapenem-type antibacterial agents. |
| 7091352 |
Compounds substituted with bicyclic amino groups |
August 15, 2006 |
| Compounds of the formula (I) below, or pharmacologically acceptable salts, esters or other derivatives thereof: ##STR00001## wherein A is furan, thiophene, pyrazole, imidazole, isoxazole or isothiazole; R.sup.1 is a substituted or unsubstituted aryl or a substituted or unsubstituted |
| 7074756 |
Liver generation promoter |
July 11, 2006 |
| Although it is known that adiponectin, which is adipose-specific protein, has effects of suppressing the proliferation and migration of vascular smooth muscle, an effect against arteriosclerosis, an effect of inhibiting the activation of monocytes and macrophages and an anti-inflamma |
| 7056710 |
Methods for producing ML-236B, a pravastatin precursor, using a host cell transformed with mlcR, |
June 6, 2006 |
| Polynucleotides, such as DNA, are provided which accelerate the biosynthesis of a HMG-CoA reductase inhibitor, ML-236B, in an ML-236B producing micro-organism when introduced in the ML-236B producing micro-organism. Pravastatin, which is an HM-CoA reductase inhibitor, can be obtained |
| 7041660 |
Crystalline 1-methylcarbapenem derivatives |
May 9, 2006 |
| This invention provides crystalline forms of a 1-methylcarbapenem derivative of formula (I-1), (I-2) or (I-3) ##STR00001## The crystalline forms of the 1-methylcarbapenem derivative exhibit excellent antibiotic activity against various bacterial strains and sufficient stability for |
| 7037934 |
Blood lipid ameliorant composition |
May 2, 2006 |
| A blood lipid ameliorating composition containing atorvastatin in combination with an agent selected from the group consisting of a riboflavin derivative, a tocopherol compound, an ascorbic acid derivative, pantethine and taurine. |
| 7034150 |
Processes for the preparation of carbapenem-type antibacterial agents |
April 25, 2006 |
| A process for the preparation of a carbapenem antibacterial compound of the following formula (4) having a 1-alkylpyrrolidine structure or a salt thereof, a useful synthetic intermediate of the following formula (1) or a salt thereof, and a process for the preparation thereof: ##STR0000 |
| 7030138 |
Benzamidine derivatives |
April 18, 2006 |
| A compound of a formula (1) and pharmacologically acceptable salts thereof: ##STR00001## wherein R.sup.1 represents hydrogen, halogen, alkyl or hydroxyl; R.sup.2 represents hydrogen or halogen; R.sup.3 represents hydrogen, alkyl, hydroxyl, carboxyalkyl, alkoxycarbonylalkyl, alkylsu |
| 7012147 |
Indoline derivative and process for producing the same |
March 14, 2006 |
| The present invention provides novel synthetic intermediates for the production of indoline derivatives, which exhibit excellent ACAT inhibitory activity, and processes for the preparation thereof. |
| 7012067 |
Blood lipid ameliorant composition |
March 14, 2006 |
| A blood lipid ameliorating composition containing simvastatin and one or more ingredients selected from a riboflavin compound, a d-.alpha.-tocopherol compound, an ascorbic acid compound, pantethine, and taurine. |
| 7001897 |
1-methylcarbapenem derivatives |
February 21, 2006 |
| A 1-methylcarbapenem compound represented by the formula (I): ##STR00001## having antibacterial activity, pharmacologically acceptable esters or salts thereof and pharmaceutical compositions (particularly antibacterial agents) containing them as an active ingredient are described. I |
| 6998422 |
Lipid peroxide-lowering compositions |
February 14, 2006 |
| Compositions having excellent blood lipid peroxide lowering activity are provided. In particular, compositions for lowering lipid peroxides in the blood which contain pravastatin together with at least one substance selected from the group consisting of taurine, pantethine and inositol |
| 6972323 |
Anti-Fas antibodies |
December 6, 2005 |
| Anti-Fas antibodies which are cross-reactive with mouse and human Fas and are useful in the treatment of conditions attributable to abnormalities in the Fas/Fas ligand system. |
| 6964976 |
Amino alcohol derivatives |
November 15, 2005 |
| Compounds of formula (I) which exhibit excellent immune suppression activity, pharmacologically acceptable salts thereof, esters thereof or other derivatives: ##STR1##wherein R.sup.1 and R.sup.2 are a hydrogen atom, an amino protecting group; R.sup.3 is a hydrogen atom, a hydroxy pro |
| 6924279 |
Crystalline 1-methylcarbapenem derivatives |
August 2, 2005 |
| This invention provides crystalline forms of a 1-methylcarbapenem derivative of formula (I) or of pharmaceutically acceptable salts thereof. ##STR1##The crystalline forms of the 1-methylcarbapenem derivative exhibit excellent antibiotic activity against various bacterial strains and |
| 6916849 |
Compositions for improving lipid content in the blood |
July 12, 2005 |
| The present invention relates to compositions for lowering the total amount of cholesterol in the blood and methods of using the compositions. The compositions are a mixture of pravastatin and one or more vitamins selected from riboflavins, d-.alpha.-tocopherols, ascorbic acids and i |
| 6908906 |
Crystalline forms of pyrimidine nucleoside derivative |
June 21, 2005 |
| The present invention provides crystalline forms and compositions thereof, of a pyrimidine nucleoside derivative of formula (I) having anti-tumour activity, wherein formula (I) is: ##STR1## |
| 6887893 |
Methods and compositions for treatment and prevention of tumors, tumor-related disorders and cac |
May 3, 2005 |
| Certain cyclooxygenase-2 inhibitors are useful for the treatment and prevention of tumors and tumor-related disorders and cachexia. |
| 6878703 |
Pharmaceutical composition |
April 12, 2005 |
| A pharmaceutical composition comprises an angiotensin II receptor antagonist selected from among compounds having the following formula (I), a pharmacologically acceptable salt thereof, a pharmacologically acceptable ester thereof and a pharmacologically acceptable salt of such ester |
| 6844363 |
Hydrates of a neuraminic acid compound and crystalline forms thereof |
January 18, 2005 |
| Hydrates of the compound of formula (I) and crystalline forms thereof have excellent storage stability and are useful medicaments. ##STR1## |
| 6844173 |
Strain of Streptomyces griseus |
January 18, 2005 |
| A microorganism strain which is Streptomyces griseus FERM BP-5420 and processes for preparing compounds by cultivating such microorganism strain. |
| 6818614 |
Compounds having antifungal activity |
November 16, 2004 |
| A compound of the following chemical structure (I) which exhibits antifungal activity and is useful in treating and preventing fungal infectious diseases: ##STR1## |
| 6777436 |
Intraocular tension lowering compositions for topical administration |
August 17, 2004 |
| An intraocular tension lowering composition for topical administration is disclosed which comprises an effective amount of an (i) angiotensin II antagonist, (ii) a boric aid and (iii) an ethylenediamine tetraacetic acid. Said composition has excellent intraocular tension lowering act |
| 6753347 |
Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation t |
June 22, 2004 |
| This invention provides a process for the preparation of a benzimidazole derivative (I) or a pharmaceutically acceptable salt thereof, ##STR1##wherein R.sup.1 is C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxyl, etc., R.sup.2 is C.sub.1 -C.sub.6 alkyl, and R.sup.3 is hydrogen or a protec |
| 6746673 |
Pharmaceutical compositions containing anti-Fas antibody |
June 8, 2004 |
| A pharmaceutical composition containing an anti-human Fas antibody having apoptosis inducing activity and a compound having a folate antagonist activity or a dihydrofolate reductase inhibiting activity, as active ingredients for the prophylaxis and/or treatment of an autoimmune disease |
| 6743611 |
Expression systems utilizing autolyzing fusion proteins and a novel reducing polypeptide |
June 1, 2004 |
| The present invention provides expression systems for exogenous polypeptides wherein the polypeptide is expressed as a fusion protein together with clover yellow virus Nuclear Inclusion a (NIa), the NIa component serving to autolyze the fusion protein after expression. This system ca |
| 6734181 |
Pyrrolopyridazine compounds |
May 11, 2004 |
| A pyrrolopyridazine compound having the formula (I) or a pharmaceutically acceptable salt thereof: ##STR1##wherein, R.sup.1 is a C.sub.2 -C.sub.6 alkenyl group, a halogeno C.sub.2 -C.sub.6 alkenyl group, a C.sub.3 -C.sub.7 cycloalkyl group which may be optionally substituted or a C.s |
| 6723745 |
Amino alcohol derivatives |
April 20, 2004 |
| Compounds of formula (I) which exhibit excellent immune suppression activity, pharmacologically acceptable salts thereof esters thereof or other derivatives: ##STR1##wherein R.sup.1 and R.sup.2 are a hydrogen atom, an amino protecting group; R.sup.3 is a hydrogen atom, a hydroxy prot |
| 6706746 |
Thiazolidine-2,4-dione hydrochloride salt, pharmaceutical compositions thereof and treatment met |
March 16, 2004 |
| The present invention concerns the hydrochloride of the compound (5-[4-(6-methoxy-1-methyl-1H-benzimidazol-2-ylmethoxy)benzyl]thiazolidin-2 ,4-dione) of the following structure (I) which exhibits an excellent hypoglycemic activity and the like. ##STR1##Said hydrochloride is useful whe |
| 6693115 |
Acid addition salts of hydropyridine derivatives |
February 17, 2004 |
| Acid addition salts of 2-acetoxy-5-(.alpha.-cyclopropyl-carbonyl-2-fluorobenzyl)-4,5,6,7-tetrahyd rothieno[3,2-c]-pyridine. The acid addition salts of tetrahydrothienopyridine derivatives of the present invention exhibit excellent oral absorption, metabolization into the active compou |
| 6673804 |
Sulfonamide derivatives |
January 6, 2004 |
| A compound of the formula (I) or a pharmacologically acceptable salt, ester or other derivative thereof: ##STR1## R.sup.1 is H or NHOH. R.sup.2 is H, optionally substituted alkyl, cycloalkyl or a group --AR.sup.6. A is an alkylene which may be optionally interrupted by O, --S(O)m-- |
| 6673317 |
Automatic testing apparatus |
January 6, 2004 |
| In order to provide an automatic testing apparatus with improved reliability of test results, capable of conducting automatically such operations as sterile testing, microorganism limit testing, insoluble particulate measurement testing, divided portion testing for chemical analysis |
