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Sandoz, Inc. Patents |
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Assignee: Sandoz, Inc.
Address: East Hanover, NJ
No. of patents: 332
Patents:
| Patent Number |
Title Of Patent |
Date Issued |
| RE31061 |
5-Amino or substituted amino-7-phenyl or substituted phenyl-2,3-dihydro-1H-1,4-diazepines |
October 19, 1982 |
| Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms or amino, R.sub.2 is hydrogen or alkyl of 1 to 6 carbon atoms, with the provisos that (1) at least one of R.sub.1 and R.sub.2 is not a tertiary alkyl group and (2) R.sub.2 is hydrogen when |
| D275298 |
Beta blocker demonstration housing or the like |
August 28, 1984 |
|
| D250129 |
Specimen collection unit |
October 31, 1978 |
|
| D250085 |
Blood flow controller and the like |
October 31, 1978 |
|
| 7297789 |
Process of preparation of olanzapine form I |
November 20, 2007 |
| A process for the preparation of polymorph Form I of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine, or olanzapine. |
| 4670610 |
Preparation of 2,5-dichlorophenol |
June 2, 1987 |
| 2,5-Dichlorophenol is readily and facilely prepared from 2,5-dichloro-4-hydroxybenzenesulfonic acid or salt thereof, said sulfonic acid/sulfonate itself being characteristically produced by hydrolysis of a precursor trichlorobenzenesulfonic acid, by cleaving the sulfo/sulfonate moiet |
| 4593031 |
Method of treating depression |
June 3, 1986 |
| This invention relates to a composition and method for potentiating the antidepressant effect of dibenzocycloheptadiene-type antidepressant agents, for example, nortriptyline, in the treatment of depression, especially geriatric depression, by administering them in combination with a |
| 4592919 |
Souffle compositions |
June 3, 1986 |
| Dry souffle compositions having malto/Dextrin and Zanthan gum and wherein the resulting soufflees have an improved foam structure. |
| 4588715 |
Heptenoic acid derivatives |
May 13, 1986 |
| Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are alkyl or aryl groups, A, B, C and D are non-reactive substituents or two are joined to form an additional ring, and Z is either of the formula Z': ##STR2## wherein R.sup.4 is H, lower alkyl or a cation |
| 4582848 |
2-substituted-3-indolamines and use thereof as anti-diabetics |
April 15, 1986 |
| This disclosure relates to substituted indolamines, which exhibit anti-diabetic activity, having the formula: ##STR1## where m is an integer from 1 to 4,x represents hydrogen or --OHR represents Ar or ##STR2## and Ar represents ##STR3## R.sub.1 represents hydrogen, fluor |
| 4571428 |
6-Substituted-4-hydroxy-tetrahydropyran-2-ones |
February 18, 1986 |
| 6-Substituted-4-hydroxy-tetrahydropyran-2-ones, useful as anti-atherosclerotic agents, are obtainable by the process of the invention. The 6-substituents have a phenyl, naphthyl, tetrahydronaphthyl or indolyl nucleus bound through an ethenyl unit. The invention includes novel interme |
| 4551288 |
Processes for the preparation of liposome drug delivery systems |
November 5, 1985 |
| Process and apparatus for the production of medicament containing liposomes, comprising an aliphatic lipid-sterol-water lamellae, wherein a clear, mixed micellar medicament-detergent-aliphatic lipid-sterol sample is applied to a gel filtration column. The column effluent is continuously |
| 4544663 |
Indolamine derivatives as anti-fertility agents |
October 1, 1985 |
| This disclosure relates to the aspermatogenesis activity of(a) compounds of the formula: ##STR1## where m is an integer from 1 to 4X represents hydrogen or --OHR represents Ar, ##STR2## Ar represents ##STR3## R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl or lower a |
| 4536499 |
Isoxazolyl indolamines having anti-diabetic activity |
August 20, 1985 |
| This disclosure describes novel compounds of the formula ##STR1## where m is 2, 3 or 4X is hydrogen or hydroxyR.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 and R.sub.3 each independently represen |
| 4528191 |
Disilacyclohexane derivatives in anti-fertility agents |
July 9, 1985 |
| This disclosure relates to the aspermatogenesis activity of compounds of the following formula: ##STR1## where R.sub.1 and R.sub.2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl having 1 to 4 carbon atoms, lower alkoxy having 1 |
| 4499279 |
Isoxazolyl indolamines |
February 12, 1985 |
| This disclosure describes compounds of the formula ##STR1## where R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 represents hydroxy, andR.sub.3 and R.sub.4 each independently represent lower alkyl |
| 4479911 |
Process for preparation of microspheres and modification of release rate of core material |
October 30, 1984 |
| This invention provides for the production of microspheres in an oil-in-water emulsion process using an emulsifier, whereby solvent removal from the oil phase allows for isolation of discrete microspheres, wherein the release rate of a core material is modified by the use of an alkaline |
| 4474971 |
(Tetrahydropyran-2-yl)-aldehydes |
October 2, 1984 |
| Single enanitiomers of 6-(2-hydrocarbyl-substituted ethenyl)-bearing, 4-hydroxy tetrahydro-2H-pyran-2-ones, e.g., 6.alpha.-[2-(2-methyl-1-naphthyl)ethenyl]-3,4,5,6-tetrahydro-4.beta.-hydro xy-2H-pyran-2-one (4R,6S) are obtained by a multi-step process which includes protecting and dep |
| 4472313 |
Cyclopropanation of olefins |
September 18, 1984 |
| The invention provides a method of converting ethylenically unsaturated units of an olefinic substrate to corresponding cyclopropanyl units, comprising treating the olefinic substrate, in an ether medium, with zinc and diiodomethane and a catalytic amount of a metallo-hydride reducing |
| 4467096 |
Isoxazolyl indolamines |
August 21, 1984 |
| This disclosure describes compounds of the formula ##STR1## where R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 and R.sub.3 each independently represent lower alkyl as defined above, orR.sub. |
| 4460789 |
Process for preparing alkoxylates containing primary amine functions |
July 17, 1984 |
| The invention relates to a new process for preparing alkoxylates containing primary amine functions comprising reacting a monoalkanolamine or a polyamine compound with a carbonyl compound to form an amide- or carbamate-type condensation product, reacting said condensation product wit |
| 4456619 |
Amides of 2-alkynoic acids and use for inhibiting accumulation of cholesterol ester in arterial |
June 26, 1984 |
| The compounds are secondary amides of the formulawhereinA is alkyl, a mono- or poly-ethylenically unsaturated acyclic hydrocarbon chain, or a hydrocarbon chain having from 1 to 4 cyclopropanyl units thereon; andB is a radical which may be of the phenyl, benzyl, phenylalkyl, benzocycloalk |
| 4453001 |
Isoxazolyl indolamines as intermediates |
June 5, 1984 |
| This disclosure describes compounds of the formula ##STR1## wherein R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms, or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 represents lower alkyl or ##STR2## where R.sub.5 represents hydrogen, f |
| 4452787 |
1-Substituted tricyclic quinazolinones having biological activity as tranquilizers |
June 5, 1984 |
| Tranquilizers are of the formula I: ##STR1## wherein R.degree. is hydrogen, halo of atomic weight of from 18 to 80, i.e. fluoro, chloro or bromo, or alkyl of 1 to 3 carbon atoms,R is hydrogen, halo of atomic weight of from 18 to 80, alkyl of 1 to 4 carbon atoms, nitro or trifluoromet |
| 4451464 |
Trifluoromethyl substituted tricyclic quinazolinones useful as tranquilizers |
May 29, 1984 |
| Tranquilizers are of the formula: ##STR1## wherein R.degree. is alkyl of 1 to 8 carbon atoms, andn is 1 or 2. |
| 4451448 |
1-Substituted tricyclic quinazolinones useful as tranquilizers |
May 29, 1984 |
| Minor tranquilizers preparable by known processes are represented by the following structural formula I: ##STR1## wherein R.sup.o is hydrogen, halo of atomic weight of from 18 to 80, i.e. fluoro, chloro or bromo or alkyl of 1 to 3 carbon atoms,R is halo of atomic weight of from 18 to |
| 4448785 |
N-Unsaturated fatty acid amides of tryptophan ester homologues and anti-cholesteric use thereof |
May 15, 1984 |
| Ethylenically unsaturated fatty acid amides of tryptophan derivatives e.g. .alpha.-[1-oxo-9-octadecenylamino)]-1H-indole-3-propanoic acid, ethyl ester, are useful as pharmaceutical agents and are obtainable by reacting a mixed anhydride of a long chain unsaturated carboxylic acid with an |
| 4442017 |
Additive blends for polymeric materials |
April 10, 1984 |
| Additives, such as stabilizers, antioxidants, antistatic agents etc., are intimately blended with an irradiation-responsive substance, such as an optical brightener, and incorporated in a thermoplastic polymeric material which is then subjected to irradiation to determine the degree of |
| 4434161 |
Sulfur and silicon-containing fatty acid amides |
February 28, 1984 |
| Sulfur and silicon-containing amides, e.g. N-5-sila-3-thia-5,5-dimethyl-pentadecanoyl-1-phenyl-2-(4-methylphenyl)-eth ylamine, are useful as anti-atherosclerotic agents. The amides are obtainable by acylation of a primary amine (the substituents on the amine being of the aralkyl pheny |
| 4432989 |
.alpha.Aryl-1H-imidazole-1-ethanols |
February 21, 1984 |
| Fungicides of the formula: ##STR1## wherein R.degree. is alkyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, cycloalkylalkyl in which the cycloalkyl is of 3 to 6 carbon atoms and the alkyl portion of 1 to 3 carbon atoms, said cycloalkyl and cycloalkylalkyl being opti |
| 4421752 |
Isoxazolyl indolamines as hypoglycemics |
December 20, 1983 |
| This disclosure describes compounds of the formula ##STR1## where R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 and R.sub.3 each independently represent lower alkyl as defined above, orR.sub. |
| 4420475 |
Silicon-bearing amides |
December 13, 1983 |
| Compounds of the formula I: ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.3 is, independently, (a) alkyl having from 1 to 22 carbon atoms; or(b) of the formula ##STR2## in which m is 0, 1 or 2, and each R' and R" is independently a hydrogen atom, alkyl having from 1 to |
| 4419353 |
Isoxazolyl indolamines |
December 6, 1983 |
| This disclosure describes compounds of the formula ##STR1## where R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 represents hydroxy, andR.sub.3 and R.sub.4 each independently represent lower alkyl |
| 4416876 |
Para-amino benzoic and phenylacetic acid derivatives |
November 22, 1983 |
| Compounds of the formula ##STR1## in which R.sup.1 is a mono-silicon-containing hydrocarbyl radical having up to 35 carbon atoms;each of R.sup.2 and R.sup.3 is, independently, a hydrogen atom or lower alkyl having from 1 to 3 carbon atoms;n is 0 or 1; andM is a hydrogen atom, an equi |
| 4415568 |
Isoxazolyl indolamines for treating diabetes |
November 15, 1983 |
| This disclosure describes compounds of the formula ##STR1## wherein R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms, or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 represents lower alkyl or ##STR2## where R.sub.5 represents hydrogen, fl |
| 4415560 |
1-Oxa-2,6-disilacyclohexane-4-carboxamides |
November 15, 1983 |
| Silicon-containing amides, e.g., N-[1'-phenyl-2'-(4"-methylphenyl)ethyl]-2,2,6,6-tetramethyl-1-oxa-2,6-disi lacyclohexane-4-carboxamide, are useful as anti-atherosclerotic agents. The amides are obtainable by acylation of a primary amine (the substituents on the amine being of the ara |
| 4412952 |
Process for 3-hydroxy benzodiazepinones |
November 1, 1983 |
| Conversion of 3-acyloxy-benzodiazepin-2-ones into corresponding 3-hydroxy benzodiazepin-2-ones is carried out efficiently with potassium hydroxide or potassium alkoxide as catalyst in lower alkanol solvent at a pH of 11-11.5. The final products, which include temazepam, are useful as sle |
| 4397850 |
Isoxazolyl indolamines |
August 9, 1983 |
| This disclosure describes compounds of the formula ##STR1## where R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 represents hydroxy, andR.sub.3 and R.sub.4 each independently represent lower alkyl |
| 4384975 |
Process for preparation of microspheres |
May 24, 1983 |
| Microspheres, prepared by solvent removal from an oil-in-water emulsion using carboxylic acid salt surfactant, e.g., sodium oleate as the emulsifier. |
| 4384124 |
Cyclopropanyl-bearing amides of tryptophane |
May 17, 1983 |
| Cyclopropanyl-group-bearing-amides, eg N-[1-(benzyl)-2-(phenyl)ethyl]-cis-2-octyl-cyclopropanoctanamide and N-(.alpha.-methyl-benzyl)-(cis)-2-octyl-cyclopropanoctanamide, are useful as pharmaceutical agents and are obtainable, eg by reacting a mixed anhydride of a cyclopropanyl-group |
| 4378369 |
Esters of 2,5-anhydro-D-mannitol |
March 29, 1983 |
| Agents for lowering glucose levels in blood having the formula: ##STR1## wherein each R, independently, is hydrogen, C.sub.1-6 alkylcarbonyl or a group of the formula ##STR2## where R.sub.1 is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 -alkoxy, halo or trifluoromethyl, andR.sub.2 i |
| 4374130 |
4,4'-(Alkanediyl)-bis(2,2,6,6-tetraalkyl -1-oxa-4-aza-2,6-disilacyclohexanes) |
February 15, 1983 |
| This disclosure describes compounds of the formula ##STR1## wherein n is 3, 5 or 7, andeach R is lower alkyl having 1 to 4 carbon atoms, or pharmaceutically acceptable acid addition salts thereof, which are useful as anti-diabetic agents in particular glucagon inhibiting agents. |
| 4366154 |
Tropyl derivatives |
December 28, 1982 |
| Tropyl derivatives of the formula: ##STR1## in which R.sup.1 is (a) phenyl linked through a direct bond, --O--, ##STR2## (in which m=2 or 3); (b) diphenylmethyl; or (c) 10H-phenothiazin-10-yl; (each of which type may be substituted, or unsubstituted); R.sup.2 is --H, --OH, or |
| 4366145 |
Soft gelatin capsule with a liquid ergot alkaloid center fill solution and method of preparation |
December 28, 1982 |
| A stable ergot alkaloid soft gelatin capsule consisting essentially of a soft gelatin capsule shell and encapsulated therein a liquid center fill solution consisting essentially of a therapeutically effective amount of an ergot alkaloid of the formula ##STR1## wherein R.sub.1 is |
| 4361435 |
Copper and amine based aquatic herbicides |
November 30, 1982 |
| Herbicidal and algaestatic and algaecidal compositions and use thereof comprising copper salts; both soluble acid salts as copper sulfate, chloride, nitrate, acetate, sulfamate, gluconate, citrate, etc. and basic copper salts such as basic copper sulfate, cupric hydroxide, basic copper |
| 4359474 |
1-Phenyl-pyrazole derivatives as glucagon inhibitors |
November 16, 1982 |
| The invention discloses certain 1-phenyl-pyrazole derivatives having pharmacological activity in animals and useful as glucagon inhibiting agents. Nearly all of the compounds of this invention are prepared by cyclization of a phenyl hydrazine compound with a 1,1,3,3-tetra-C.sub.1-4 - |
| 4356167 |
Liposome drug delivery systems |
October 26, 1982 |
| A liposome medicament delivery system wherein the medicament is encapsulated in a liposome comprising an aliphatic liquid-sterol-water lamellae. The lipid may be a sodium or potassium salt of a C.sub.4 to C.sub.18 fatty acid, and the sterol may be cholesterol. |
| 4344966 |
Anti-inflammatory 1-alkyl-1-phenyl-butanes |
August 17, 1982 |
| The compounds are 1-aryl-1-lower alkyl-substituted-1-buten-3-ols, butan-3-ols, and acylation products thereof, e.g., (p-biphenylyl)-2-penten-4-ol and are useful as pharmaceuticals. |
| 4340385 |
Stable, concentrated, aqueous compositions containing para-sulfophenyl-azo-substituted 1,4-p |
July 20, 1982 |
| Compounds of the formula ##STR1## wherein R.sub.1 is C.sub.1-4 alkyl,R.sub.2 is hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy,R.sub.3 is hydrogen or C.sub.1-4 alkyl, andM is hydrogen or a monovalent non-chromophoric cation,and mixtures of such compounds, stable, concentrated, aqueous composi |
| 4336391 |
Isoxazolyl indolamines |
June 22, 1982 |
| This disclosure describes compounds of the formula ##STR1## where R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 and R.sub.3 each independently represent lower alkyl as defined above, orR.sub. |
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