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Sandoz, Inc. Patents
Assignee:
Sandoz, Inc.
Address:
East Hanover, NJ
No. of patents:
333
Patents:


1 2 3 4 5 6 7










Patent Number Title Of Patent Date Issued
RE31061 5-Amino or substituted amino-7-phenyl or substituted phenyl-2,3-dihydro-1H-1,4-diazepines October 19, 1982
Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms or amino, R.sub.2 is hydrogen or alkyl of 1 to 6 carbon atoms, with the provisos that (1) at least one of R.sub.1 and R.sub.2 is not a tertiary alkyl group and (2) R.sub.2 is hydrogen when
D275298 Beta blocker demonstration housing or the like August 28, 1984
D250129 Specimen collection unit October 31, 1978
D250085 Blood flow controller and the like October 31, 1978
7943585 Extended release antibiotic composition May 17, 2011
An extended-release antibiotic composition comprising at least one antibiotic, and greater than 50 weight percent, based on the total weight of the composition, of a polymer component, wherein said polymer component comprises at least one pharmaceutically acceptable hydrophilic polym
7297789 Process of preparation of olanzapine form I November 20, 2007
A process for the preparation of polymorph Form I of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine, or olanzapine.
4670610 Preparation of 2,5-dichlorophenol June 2, 1987
2,5-Dichlorophenol is readily and facilely prepared from 2,5-dichloro-4-hydroxybenzenesulfonic acid or salt thereof, said sulfonic acid/sulfonate itself being characteristically produced by hydrolysis of a precursor trichlorobenzenesulfonic acid, by cleaving the sulfo/sulfonate moiet
4593031 Method of treating depression June 3, 1986
This invention relates to a composition and method for potentiating the antidepressant effect of dibenzocycloheptadiene-type antidepressant agents, for example, nortriptyline, in the treatment of depression, especially geriatric depression, by administering them in combination with a
4592919 Souffle compositions June 3, 1986
Dry souffle compositions having malto/Dextrin and Zanthan gum and wherein the resulting soufflees have an improved foam structure.
4588715 Heptenoic acid derivatives May 13, 1986
Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are alkyl or aryl groups, A, B, C and D are non-reactive substituents or two are joined to form an additional ring, and Z is either of the formula Z': ##STR2## wherein R.sup.4 is H, lower alkyl or a cation
4582848 2-substituted-3-indolamines and use thereof as anti-diabetics April 15, 1986
This disclosure relates to substituted indolamines, which exhibit anti-diabetic activity, having the formula: ##STR1## where m is an integer from 1 to 4,x represents hydrogen or --OHR represents Ar or ##STR2## and Ar represents ##STR3## R.sub.1 represents hydrogen, fluor
4571428 6-Substituted-4-hydroxy-tetrahydropyran-2-ones February 18, 1986
6-Substituted-4-hydroxy-tetrahydropyran-2-ones, useful as anti-atherosclerotic agents, are obtainable by the process of the invention. The 6-substituents have a phenyl, naphthyl, tetrahydronaphthyl or indolyl nucleus bound through an ethenyl unit. The invention includes novel interme
4551288 Processes for the preparation of liposome drug delivery systems November 5, 1985
Process and apparatus for the production of medicament containing liposomes, comprising an aliphatic lipid-sterol-water lamellae, wherein a clear, mixed micellar medicament-detergent-aliphatic lipid-sterol sample is applied to a gel filtration column. The column effluent is continuously
4544663 Indolamine derivatives as anti-fertility agents October 1, 1985
This disclosure relates to the aspermatogenesis activity of(a) compounds of the formula: ##STR1## where m is an integer from 1 to 4X represents hydrogen or --OHR represents Ar, ##STR2## Ar represents ##STR3## R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl or lower a
4536499 Isoxazolyl indolamines having anti-diabetic activity August 20, 1985
This disclosure describes novel compounds of the formula ##STR1## where m is 2, 3 or 4X is hydrogen or hydroxyR.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 and R.sub.3 each independently represen
4528191 Disilacyclohexane derivatives in anti-fertility agents July 9, 1985
This disclosure relates to the aspermatogenesis activity of compounds of the following formula: ##STR1## where R.sub.1 and R.sub.2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl having 1 to 4 carbon atoms, lower alkoxy having 1
4499279 Isoxazolyl indolamines February 12, 1985
This disclosure describes compounds of the formula ##STR1## where R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 represents hydroxy, andR.sub.3 and R.sub.4 each independently represent lower alkyl
4479911 Process for preparation of microspheres and modification of release rate of core material October 30, 1984
This invention provides for the production of microspheres in an oil-in-water emulsion process using an emulsifier, whereby solvent removal from the oil phase allows for isolation of discrete microspheres, wherein the release rate of a core material is modified by the use of an alkaline
4474971 (Tetrahydropyran-2-yl)-aldehydes October 2, 1984
Single enanitiomers of 6-(2-hydrocarbyl-substituted ethenyl)-bearing, 4-hydroxy tetrahydro-2H-pyran-2-ones, e.g., 6.alpha.-[2-(2-methyl-1-naphthyl)ethenyl]-3,4,5,6-tetrahydro-4.beta.-hydro xy-2H-pyran-2-one (4R,6S) are obtained by a multi-step process which includes protecting and dep
4472313 Cyclopropanation of olefins September 18, 1984
The invention provides a method of converting ethylenically unsaturated units of an olefinic substrate to corresponding cyclopropanyl units, comprising treating the olefinic substrate, in an ether medium, with zinc and diiodomethane and a catalytic amount of a metallo-hydride reducing
4467096 Isoxazolyl indolamines August 21, 1984
This disclosure describes compounds of the formula ##STR1## where R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 and R.sub.3 each independently represent lower alkyl as defined above, orR.sub.
4460789 Process for preparing alkoxylates containing primary amine functions July 17, 1984
The invention relates to a new process for preparing alkoxylates containing primary amine functions comprising reacting a monoalkanolamine or a polyamine compound with a carbonyl compound to form an amide- or carbamate-type condensation product, reacting said condensation product wit
4456619 Amides of 2-alkynoic acids and use for inhibiting accumulation of cholesterol ester in arterial June 26, 1984
The compounds are secondary amides of the formulawhereinA is alkyl, a mono- or poly-ethylenically unsaturated acyclic hydrocarbon chain, or a hydrocarbon chain having from 1 to 4 cyclopropanyl units thereon; andB is a radical which may be of the phenyl, benzyl, phenylalkyl, benzocycloalk
4453001 Isoxazolyl indolamines as intermediates June 5, 1984
This disclosure describes compounds of the formula ##STR1## wherein R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms, or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 represents lower alkyl or ##STR2## where R.sub.5 represents hydrogen, f
4452787 1-Substituted tricyclic quinazolinones having biological activity as tranquilizers June 5, 1984
Tranquilizers are of the formula I: ##STR1## wherein R.degree. is hydrogen, halo of atomic weight of from 18 to 80, i.e. fluoro, chloro or bromo, or alkyl of 1 to 3 carbon atoms,R is hydrogen, halo of atomic weight of from 18 to 80, alkyl of 1 to 4 carbon atoms, nitro or trifluoromet
4451464 Trifluoromethyl substituted tricyclic quinazolinones useful as tranquilizers May 29, 1984
Tranquilizers are of the formula: ##STR1## wherein R.degree. is alkyl of 1 to 8 carbon atoms, andn is 1 or 2.
4451448 1-Substituted tricyclic quinazolinones useful as tranquilizers May 29, 1984
Minor tranquilizers preparable by known processes are represented by the following structural formula I: ##STR1## wherein R.sup.o is hydrogen, halo of atomic weight of from 18 to 80, i.e. fluoro, chloro or bromo or alkyl of 1 to 3 carbon atoms,R is halo of atomic weight of from 18 to
4448785 N-Unsaturated fatty acid amides of tryptophan ester homologues and anti-cholesteric use thereof May 15, 1984
Ethylenically unsaturated fatty acid amides of tryptophan derivatives e.g. .alpha.-[1-oxo-9-octadecenylamino)]-1H-indole-3-propanoic acid, ethyl ester, are useful as pharmaceutical agents and are obtainable by reacting a mixed anhydride of a long chain unsaturated carboxylic acid with an
4442017 Additive blends for polymeric materials April 10, 1984
Additives, such as stabilizers, antioxidants, antistatic agents etc., are intimately blended with an irradiation-responsive substance, such as an optical brightener, and incorporated in a thermoplastic polymeric material which is then subjected to irradiation to determine the degree of
4434161 Sulfur and silicon-containing fatty acid amides February 28, 1984
Sulfur and silicon-containing amides, e.g. N-5-sila-3-thia-5,5-dimethyl-pentadecanoyl-1-phenyl-2-(4-methylphenyl)-eth ylamine, are useful as anti-atherosclerotic agents. The amides are obtainable by acylation of a primary amine (the substituents on the amine being of the aralkyl pheny
4432989 .alpha.Aryl-1H-imidazole-1-ethanols February 21, 1984
Fungicides of the formula: ##STR1## wherein R.degree. is alkyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, cycloalkylalkyl in which the cycloalkyl is of 3 to 6 carbon atoms and the alkyl portion of 1 to 3 carbon atoms, said cycloalkyl and cycloalkylalkyl being opti
4421752 Isoxazolyl indolamines as hypoglycemics December 20, 1983
This disclosure describes compounds of the formula ##STR1## where R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 and R.sub.3 each independently represent lower alkyl as defined above, orR.sub.
4420475 Silicon-bearing amides December 13, 1983
Compounds of the formula I: ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.3 is, independently, (a) alkyl having from 1 to 22 carbon atoms; or(b) of the formula ##STR2## in which m is 0, 1 or 2, and each R' and R" is independently a hydrogen atom, alkyl having from 1 to
4419353 Isoxazolyl indolamines December 6, 1983
This disclosure describes compounds of the formula ##STR1## where R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 represents hydroxy, andR.sub.3 and R.sub.4 each independently represent lower alkyl
4416876 Para-amino benzoic and phenylacetic acid derivatives November 22, 1983
Compounds of the formula ##STR1## in which R.sup.1 is a mono-silicon-containing hydrocarbyl radical having up to 35 carbon atoms;each of R.sup.2 and R.sup.3 is, independently, a hydrogen atom or lower alkyl having from 1 to 3 carbon atoms;n is 0 or 1; andM is a hydrogen atom, an equi
4415568 Isoxazolyl indolamines for treating diabetes November 15, 1983
This disclosure describes compounds of the formula ##STR1## wherein R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms, or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 represents lower alkyl or ##STR2## where R.sub.5 represents hydrogen, fl
4415560 1-Oxa-2,6-disilacyclohexane-4-carboxamides November 15, 1983
Silicon-containing amides, e.g., N-[1'-phenyl-2'-(4"-methylphenyl)ethyl]-2,2,6,6-tetramethyl-1-oxa-2,6-disi lacyclohexane-4-carboxamide, are useful as anti-atherosclerotic agents. The amides are obtainable by acylation of a primary amine (the substituents on the amine being of the ara
4412952 Process for 3-hydroxy benzodiazepinones November 1, 1983
Conversion of 3-acyloxy-benzodiazepin-2-ones into corresponding 3-hydroxy benzodiazepin-2-ones is carried out efficiently with potassium hydroxide or potassium alkoxide as catalyst in lower alkanol solvent at a pH of 11-11.5. The final products, which include temazepam, are useful as sle
4397850 Isoxazolyl indolamines August 9, 1983
This disclosure describes compounds of the formula ##STR1## where R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 represents hydroxy, andR.sub.3 and R.sub.4 each independently represent lower alkyl
4384975 Process for preparation of microspheres May 24, 1983
Microspheres, prepared by solvent removal from an oil-in-water emulsion using carboxylic acid salt surfactant, e.g., sodium oleate as the emulsifier.
4384124 Cyclopropanyl-bearing amides of tryptophane May 17, 1983
Cyclopropanyl-group-bearing-amides, eg N-[1-(benzyl)-2-(phenyl)ethyl]-cis-2-octyl-cyclopropanoctanamide and N-(.alpha.-methyl-benzyl)-(cis)-2-octyl-cyclopropanoctanamide, are useful as pharmaceutical agents and are obtainable, eg by reacting a mixed anhydride of a cyclopropanyl-group
4378369 Esters of 2,5-anhydro-D-mannitol March 29, 1983
Agents for lowering glucose levels in blood having the formula: ##STR1## wherein each R, independently, is hydrogen, C.sub.1-6 alkylcarbonyl or a group of the formula ##STR2## where R.sub.1 is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 -alkoxy, halo or trifluoromethyl, andR.sub.2 i
4374130 4,4'-(Alkanediyl)-bis(2,2,6,6-tetraalkyl -1-oxa-4-aza-2,6-disilacyclohexanes) February 15, 1983
This disclosure describes compounds of the formula ##STR1## wherein n is 3, 5 or 7, andeach R is lower alkyl having 1 to 4 carbon atoms, or pharmaceutically acceptable acid addition salts thereof, which are useful as anti-diabetic agents in particular glucagon inhibiting agents.
4366154 Tropyl derivatives December 28, 1982
Tropyl derivatives of the formula: ##STR1## in which R.sup.1 is (a) phenyl linked through a direct bond, --O--, ##STR2## (in which m=2 or 3); (b) diphenylmethyl; or (c) 10H-phenothiazin-10-yl; (each of which type may be substituted, or unsubstituted); R.sup.2 is --H, --OH, or
4366145 Soft gelatin capsule with a liquid ergot alkaloid center fill solution and method of preparation December 28, 1982
A stable ergot alkaloid soft gelatin capsule consisting essentially of a soft gelatin capsule shell and encapsulated therein a liquid center fill solution consisting essentially of a therapeutically effective amount of an ergot alkaloid of the formula ##STR1## wherein R.sub.1 is
4361435 Copper and amine based aquatic herbicides November 30, 1982
Herbicidal and algaestatic and algaecidal compositions and use thereof comprising copper salts; both soluble acid salts as copper sulfate, chloride, nitrate, acetate, sulfamate, gluconate, citrate, etc. and basic copper salts such as basic copper sulfate, cupric hydroxide, basic copper
4359474 1-Phenyl-pyrazole derivatives as glucagon inhibitors November 16, 1982
The invention discloses certain 1-phenyl-pyrazole derivatives having pharmacological activity in animals and useful as glucagon inhibiting agents. Nearly all of the compounds of this invention are prepared by cyclization of a phenyl hydrazine compound with a 1,1,3,3-tetra-C.sub.1-4 -
4356167 Liposome drug delivery systems October 26, 1982
A liposome medicament delivery system wherein the medicament is encapsulated in a liposome comprising an aliphatic liquid-sterol-water lamellae. The lipid may be a sodium or potassium salt of a C.sub.4 to C.sub.18 fatty acid, and the sterol may be cholesterol.
4344966 Anti-inflammatory 1-alkyl-1-phenyl-butanes August 17, 1982
The compounds are 1-aryl-1-lower alkyl-substituted-1-buten-3-ols, butan-3-ols, and acylation products thereof, e.g., (p-biphenylyl)-2-penten-4-ol and are useful as pharmaceuticals.
4340385 Stable, concentrated, aqueous compositions containing para-sulfophenyl-azo-substituted 1,4-p July 20, 1982
Compounds of the formula ##STR1## wherein R.sub.1 is C.sub.1-4 alkyl,R.sub.2 is hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy,R.sub.3 is hydrogen or C.sub.1-4 alkyl, andM is hydrogen or a monovalent non-chromophoric cation,and mixtures of such compounds, stable, concentrated, aqueous composi
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