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Roche Vitamins Inc. Patents
Assignee:
Roche Vitamins Inc.
Address:
Parsippany, NJ
No. of patents:
174
Patents:


1 2 3 4










Patent Number Title Of Patent Date Issued
6846660 Method of making an aldehyde dehydrogenase with gluconobacter January 25, 2005
A new aldehyde dehydrogenase having the physico-chemical properties: molecular weight:150,000.+-.6,000 or 230,000.+-.9,000; substrate specificity active on aldehyde compounds; cofactors:pyrroloquinoline quinone and heme c; optimum pH: 7.0-8.5; and inhibitors: Co.sup.2+, Cu.sup.2+, Fe
6844470 Process for the purification of 1,3-diketones January 18, 2005
A process for the purification of 1,3-diketones comprising reacting a 1,3-diketone with an earth metal or alkaline earth metal complexing agent in an organic solvent, isolating, washing and decomposing the resulting complex, and isolating the purified 1,3-diketone.
6784207 Phytanic acid derivative compositions August 31, 2004
The present invention is a method for the treatment or prevention of preferably non-insulin dependent (NIDDM or so-called Type II) diabetes mellitus, or other conditions associated with impaired glucose tolerance such as obesity, and in particular to the use of phytanic acid derivatives
6777212 Microbial process for producing L-ascorbic acid, D-erythorbic acid, and salts thereof August 17, 2004
A process for producing L-ascorbic acid or D-erythorbic acid, or in each case its sodium, potassium or calcium salt, from 2-keto-L-gulonic acid or 2-keto-D-gluconic acid, or in each case its sodium, potassium or calcium salt, that involves incubating 2-keto-L-gulonic acid or 2-keto-D-glu
6743615 Process for the manufacture of a vitamin E intermediate June 1, 2004
The present invention is a process for converting trimethylhydroquinone diacetate (TMHQ-DA) into trimethylhydroquinone-1-monoacetate (TMHQ-1-MA) by contacting TMHQ-DA with a lipase to effect an enzymatic monosaponification of the TMHQ-DA. Also provided are methods of making (all-rac)
6737256 Overcoming DAPA aminotransferase bottlenecks in biotin vitamers biosynthesis May 18, 2004
A method is disclosed for the increased production of biotin and the biotin precursor dethiobiotin using a bacterium that produces a lysine-utilizing DAPA aminotransferase. This method involves the use of a bacterium that is either grown in the presence of lysine or deregulated for lysin
6734004 Modified phytases May 11, 2004
A process for the production of a modified phytase with a desired property improved over the property of the corresponding unmodified phytase is disclosed, as well as modified phytases, polynucleotides encoding modified phytases, and animal feed including modified phytases.
6730503 Alcohol/aldehyde dehydrogenase May 4, 2004
The present invention is directed to a recombinant enzymes having alcohol and aldehyde dehydrogenase activity which comprises one or mom recombinant polypeptides selected from the group consisting of polypeptides which are identified by SEQ ID NO 5, SEQ ID NO 6, SEQ ID NO 7, SEQ ID NO 8
6723544 Biotin biosynthetic genes April 20, 2004
The present invention relates to the production process of biotin by fermentation using a genetically engineered microorganism, and DNA sequences and vectors to be used in such process.
6723346 Process for preparing spray granules containing riboflavin April 20, 2004
The invention is concerned with a novel process for the manufacture of flowable, non-dusty, binder-free riboflavin granulates by subjecting an aqueous suspension of riboflavin crystals of crystal modification B/C to a fluidized bed spray drying process, a single fluid nozzle spray drying
6722780 Preparation of liquid dispersions April 20, 2004
A process for mixing or dispersing liquids is provided that includes introducing liquids to be mixed or dispersed into a mixing device having a cylindrical support. The cylindrical support includes an inlet nozzle having a bore which is in fluid communication through a turbulence chamber
6720174 Phytases April 13, 2004
This invention relates to improved phytases, preferably phytases of an increased thermostability, and a process of producing them. In particular, stabilizing amino acid mutations are introduced into a homologous protein, or the active site of a phytase is replaced in part or in toto. The
6700002 Process for making vitamin E using hydrogen-tris(oxalato) phosphate March 2, 2004
A process for the manufacture of (all-rac)-.alpha.-tocopherol by the catalyzed reaction of trimethylhydroquinone with isophytol or phytol is characterized by carrying out the reaction in the presence of hydrogen tris(oxalato)phosphate, or an adduct thereof with a solvent, as the cata
6699704 Heat tolerant phytases March 2, 2004
The present invention relates to heat tolerant phytases and DNA sequences which code therefor. The phytases are useful in hydrolyzing phytate to inositol and inorganic phosphates. The phytases are valuable feed additives.
6696293 Process for producing carotenoids and biological materials useful therefor February 24, 2004
A process for producing carotenoids, which involves cultivating a microorganism obtained by treating a parent microorganism that produces carotenoids under conditions that induce a reduction in alternative oxidase activity and selecting a microorganism with enhanced carotenoid produc
6677134 Fermentative carotenoid production January 13, 2004
Novel proteins of microorganism E-396 (FERM BP-4283) and the DNA sequences which encode these proteins have been discovered to provide an improved biosynthetic pathway from farnesyl pyrophosphate and isopentyl pyrophosphate to various carotenoids, especially zeaxanthin, astaxanthin,
6673583 Recombinantly producing levodione reductase January 6, 2004
The present invention is directed to genetic material useful for the preparation of actinol, such as an isolated DNA including a nucleotide sequence coding for an enzyme having levodione reductase activity, a polypeptide encoded by such a DNA, recombinant organisms, and the like. The
6664082 Genetically engineered L-sorbose reductase-deficient mutants December 16, 2003
The present invention provides a genetically engineered microorganism belonging to the genus Gluconobacter or Acetobacter, which has an engineered gene for the biological activity of reducing L-sorbose which is more than 90% non-functional in developing the said biological activity.
6656721 Polynucleotide portions of the biotin operon from B. subtilis for use in enhanced fermentation December 2, 2003
The present invention provides a process for producing a target fermentation product. This process includes providing a fermentation medium containing a recombinantly-produced microorganism that over-produces a fermentation product and contains a mutation which causes auxotrophic gro
6653115 D-sorbitol dehydrogenase gene November 25, 2003
Polynucleotides encoding proteins with D-sorbitol dehydrogenase activity or which function to activate D-sorbitol dehydrogenase proteins, in vivo, vectors and recombinant organisms which contain such polynucleotides, and methods of making D-sorbitol dehydrogenase and L-sorbose.
6651898 Method and device for atomizing liquids November 25, 2003
The present invention is a device for atomizing liquids which has: a) a rotatable apparatus for the reception of liquids to be atomized, the apparatus is defined by a cylinder having an interior chamber that runs the length of the cylinder with an internal diameter of about 10 to about
6646135 Continuous process for the enantioselective hydrogenation of alpha ketocarbonyl compounds November 11, 2003
The invention relates to a continuous process for enantioselective catalytic hydrogenation of an alpha ketocarbonyl compound such as alpha ketoesters and alpha ketolactones to produce an alpha hydroxy carbonyl compound.
6623774 Preparation and stabilization of food-grade marine oils September 23, 2003
The present invention relates to stabilizing marine oil by treatment with silica in the presence or absence of carbon and vacuum steam deodorization at a temperature between about 140.degree. C. and about 210.degree. C. in the presence of 0.1-0.4% deodorized rosemary or sage extract If d
6613543 Fermentative carotenoid production September 2, 2003
Novel proteins of Flavobacterium sp. R1534 and the DNA sequences which encode these proteins are disclosed which provide an improved biosynthetic pathway from farnesyl pyrophosphate and isopentyl pyrophosphate to various carotenoid precursors and carotenoids, especially .beta.-carotene,
6599735 Continuous fermentation system July 29, 2003
A fermentation assembly comprising: (a) a vessel for culturing living cells; (b) at least two storage flasks in fluid communication with the vessel for supply of liquids and a first transport means for transferring the liquids from the storage flasks to the vessel; (c) individual app
6586202 Isoprenoid production July 1, 2003
The present invention relates to an isolated DNA sequence encoding an enzyme in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate. Vectors and plasmids including such DNA are also set forth. The invention also includes host cells transform
6579975 Consensus phytases June 17, 2003
A process for obtaining a consensus protein from a group of amino acid sequences of a defined protein family, proteins and polynucleotides so obtained, and compositions containing such proteins.
6573269 Pyrimidine-2,4,6-trione light screening compositions June 3, 2003
The present invention provides compounds of formula I, which are effective in absorbing ultraviolet radiation and can be used as sunscreen agents: ##STR1##wherein R.sup.1 and R.sup.2 are each independently C.sub.2 -C.sub.18 alkyl, C.sub.5 -C.sub.7 cycloalkyl, or C.sub.2 -C.sub.18 alky
6551813 Nutrient medium for bacterial strains which overproduce riboflavin April 22, 2003
Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e.g. at multiple sites and in multiple copies per site. A rib operon having at least five genes is use
6536940 Preparation of liquid dispersions March 25, 2003
A process for mixing or dispersing liquids is provided that includes introducing liquids to be mixed or dispersed into a mixing device having a cylindrical support. The cylindrical support includes an inlet nozzle having a bore which is in fluid communication through a turbulence chamber
6534297 Recombinantly producing levodione reductase March 18, 2003
The present invention is directed to genetic material useful for the preparation of actinol, such as an isolated DNA including a nucleotide sequence coding for an enzyme having levodione reductase activity, a polypeptide encoded by such a DNA, recombinant organisms, and the like. The
6530684 Preparation of liquid dispersions March 11, 2003
A process for mixing or dispersing liquids is provided that includes introducing liquids to be mixed or dispersed into a mixing device having a cylindrical support. The cylindrical support includes an inlet nozzle having a bore which is in fluid communication through a turbulence chamber
6528025 Process of manufacturing equipment for preparing acetals and ketals March 4, 2003
A process for the preparation of acetals and ketals by reacting an aldehyde or Ketone with an alcohol in the presence of solid acid and removing water by pervaporation. Manufacturing equipment for the preparation of acetals and ketones is also provided.
6521564 Modification of a hydrogenation catalyst February 18, 2003
A process for the modification of a hydrogenation catalyst of the Raney nickel, Raney cobalt, nickel-on-carrier or cobalt-on-carrier type, which process includes treating the hydrogenation catalyst at temperatures of about 0.degree. C. to about 120.degree. C. with carbon monoxide, carbon
6489486 2-hydroxyphenyl benzotriazoles as UV-A/B filters December 3, 2002
The present invention relates to a process for the manufacture of compounds of Formula (I): ##STR1##wherein R.sup.1 is alkyl; R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are, independently, hydrogen, alkyl or alkenyl; X is hydrogen, halogen, alkyl or alkoxy; and the dotted bond is
6482961 Method of making (all-rac)-.alpha.-tocopherol November 19, 2002
The present invention is a method of making (all-rac)-.alpha.-tocopherol in a reaction having the following steps: a) reacting trimethylhydroquinone and a phytol selected from the group consisting of isophytol and phytol in the presence of a bis(perfluorinated hydrocarbyl sulphonyl)im
6465698 Catalytic isomerization of Z-pentol to E-pentol October 15, 2002
A process for catalytically isomerizing Z-3-methylpent-2-en-4-yn-1-ol to E-3-methylpent-2-en-4-yn-1-ol is provided. This process includes contacting a stereoisomeric mixture containing Z-3-methylpent-2-en-4-yn-1-ol and E-3-methylpent-2-en-4-yn-1-ol with a source of bromine radicals i
6465228 Levodione reductase October 15, 2002
A levodione reductase having the following physical properties is provided: molecular weight: from about 142,000 to about 155,000.+-.10,000 (consisting of four homologous subunits having a molecular weight of 36,000.+-.5,000); co-factor: nicotinamide adenine dinucleotide (AND/NADH);
6462219 Process for producing 3-hydroxypropionitrile October 8, 2002
A process for the production of 3-hydroxypropionitrile is provided. This process includes (a) reacting acrylonitrile with water at a defined molar ratio in the presence of a weak base under specific temperature and pressure conditions until a conversion in the range of about 40% to about
6455707 Process for the preparation of substitued pyranes September 24, 2002
Substituted pyranes such as 2-ethinyl-tetrahydro-2,6,6-trimethylpyran are prepared from dehydrolinalool or higher homologues thereof by heating or treatment with microwaves in the presence of a solid acid.
6452023 Process for preparing d,l-.alpha.-tocopherol September 17, 2002
A process for the manufacture of d,l-.alpha.-tocopherol by the acid-catalyzed condensation of trimethylhydroquinone with isophytol or phytol in ethylene or propylene carbonate or a mixture of both carbonates, or in a mixture of one or both of the carbonates and a non-polar solvent, c
6444460 Microbial production of actinol September 3, 2002
A process for making (4R, 6R)-4-hydroxy-2,2,6-trimethylcyclohexanone by contacting (6R)-2,2,6-trimethylcyclohexanedione with a microorganism which is selected from microorganisms of the genera Cellulomonas, Corynebacterium, Planococcus and Arthrobacter and which is capable of the sel
6444449 D-sorbitol dehydrogenase gene September 3, 2002
Polynucleotides encoding proteins with D-sorbitol dehydrogenase activity or which function to activate D-sorbitol dehydrogenase proteins, in vivo, vectors and recombinant organisms which contain such polynucleotides, and methods of making D-sorbitol dehydrogenase and L-sorbose.
6444227 Process for preparing fat soluble beadlets September 3, 2002
The invention relates to a process for preparing beadlets containing fat soluble substances in a gelatin matrix which comprises crosslinking the gelatin by radiation or enzymatically. Specifically, the invention relates to a process for preparing beadlets containing fat soluble substance
6444098 Process for the preparation of tocol acylates and tocopherol acylates September 3, 2002
The present invention relates to a process for preparing tocol acylate or tocopherol acylate having the following steps: a) combining tocol or tocopherol with an acylating agent to form a reaction mixture; b) irradiating the reaction mixture with microwave energy to from tocol acyl
6428991 Process for producing levodione August 6, 2002
The present invention provides a process for producing (6R)-2,2,6-trimethylcyclohexene-1,4-dione. This process includes contacting, in a reactor, 2,6,6-trimethyl-2-cyclohexene-1,4-dione with a yeast selected from the group consisting of Saccharomyces rouxii (Zygosaccharomyces rouxii)
6426078 Oil in water microemulsion July 30, 2002
The invention is concerned with a microemulsion of the oil-in water type, containing at least one polyglycerol ester as the emulsifier and at least one lipophilic substance as the internal phase.The emulsifier contains a triglycerol monofatty acid ester and the lipophilic substance is on
6423851 Preparation of d,1-.alpha.-tocopherol July 23, 2002
The present invention provides a process for preparing of d,l-.alpha.-tocopherol by the catalyzed condensation of trimethylhydroquinone with isophytol. This process includes carrying out the condensation in the presence of bis-(trifluoromethylsulphonyl)amine [HN(SO.sub.2 CF.sub.3).su
6416746 Indanylidene compounds July 9, 2002
The invention relates to novel indanylidene compounds which are effective in absorbing ultra violet radiation and to light screening compositions including the indanylidene compounds of the general formula I ##STR1##whereinX is O or NH;R.sup.1 is a C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub
6407203 Cytochrome c and polynucleotides encoding cytochrome c June 18, 2002
This invention is directed to cytochrome c.sub.551 polypeptides and polynucleotides encoding the polypeptides.
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