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Roche Diagnostics Operations, Inc. Patents
Assignee:
Roche Diagnostics Operations, Inc.
Address:
Indianapolis, IN
No. of patents:
195
Patents:


1 2 3 4


Patent Number Title Of Patent Date Issued
RE40198 Method and device for electrochemical immunoassay of multiple analytes April 1, 2008
A method and device for detection and quantification of biologically significant analytes in a liquid sample is described. The method includes contacting a volume of a liquid sample with predetermined amounts of at least a first and second redox reversible species having redox potentials
D571916 Diagnostic instrument June 24, 2008
D569982 Glucose meter May 27, 2008
D562458 Blood analyte meter February 19, 2008
D550363 Lancing device September 4, 2007
D545436 Blood analyte meter June 26, 2007
D542931 Laboratory measuring device housing May 15, 2007
D530424 Meter with docked lancet device October 17, 2006
7615378 Pipetting needle November 10, 2009
A method and a micropipetting apparatus is described for dispensing a liquid volume into a vessel via pipetting needle without any contact between the needle and a liquid contained in the vessel. The method comprises forming a drop at the delivery tip of the pipetting needle, the dro
7608466 Process and device for producing reagent carriers October 27, 2009
The invention concerns a process for producing reagent carriers having a binding capability that are suitable for determining analytes in liquids, wherein the process comprises at least one step of treating a respective reagent carrier body in particular by transferring material between
7608418 NT-proANP and NT-proBNP for diagnosing cardiac diseases October 27, 2009
Described are methods for diagnosing a cardiac disease, particularly an acute cardiac event, in a patient presenting with symptoms of acute cardiac decompensation, comprising the steps of (a) measuring, typically in vitro, the level of NT-proBNP (N-terminal brain natriuretic peptide)
7604935 Soluble rubella E1 envelope protein variants October 20, 2009
A soluble rubella E1 antigen variant is disclosed that comprises amino acids 334-409 of the native rubella E1 peptide, but lacks the C-terminal end and at least the transmembrane region and the anchor segment as well as at least the amino acids 143 to 164. Also described is a recombinant
7604721 System and method for coding information on a biosensor test strip October 20, 2009
The present invention provides a test strip for measuring a concentration of an analyte of interest in a biological fluid, wherein the test strip may be encoded with information that can be read by a test meter into which the test strip is inserted.
7604604 Device for sampling bodily fluids October 20, 2009
A bodily fluid sampling device comprising a lancet which can be advanced against a skin-piercing site to produce a droplet of bodily fluid. A transport medium is positioned sufficiently close to the lancing medium to retain a droplet of bodily fluid therebetween by capillary action. One
7601299 System and method for coding information on a biosensor test strip October 13, 2009
The present invention provides a test strip for measuring a concentration of an analyte of interest in a biological fluid, wherein the test strip may be encoded with information that can be read by a test meter into which the test strip is inserted.
7597793 System and method for analyte measurement employing maximum dosing time delay October 6, 2009
A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined
7592740 Miniature drug delivery pump with a piezoelectric drive system September 22, 2009
A drug delivery pump which uses a piezoelectric drive system to advance a small syringe piston to deliver a liquid drug and a method thereof are disclosed. The present invention has a cost and size advantage compared to traditional pumps and is a very compact and potentially disposable
7586612 Photometric analysis of biological samples using in-plane detection September 8, 2009
On an analytical device for photometric analysis of chemistry and/or fluid samples comprising a rotatable disk-like body, a plurality of receptacles for fluid samples and optics for guiding light beams through the receptacles are arranged. At least part of the optics are designed and/or
7585678 Method and apparatus for positioning a pipetting device September 8, 2009
A method for determining a reference position for a pipetting needle which is part of an automatic analytical apparatus that includes a rotatable conveyor, conveyor driving means, an automatic pipetting unit having a needle transport device, excenter mechanism, a level detection means, a
7582262 Dispenser for flattened articles September 1, 2009
A substantially moisture-proof, airtight dispenser for both storing and dispensing several flattened articles such as diagnostic test strips. The inventive dispenser includes a novel pivotable housing that a user need merely grab and squeeze to eject a test strip. Independent movement of
7582258 Body fluid testing device September 1, 2009
Body fluid testing device for analyzing a body fluid comprises a test media tape adapted to collect the body fluid. The test media tape comprises a tape and test media portions. A free tape portion without test medium is located between successive test media portions. The testing dev
7579158 Cellular retinoic acid binding protein II as a marker for breast cancer August 25, 2009
The present invention relates to the diagnosis of breast cancer. It discloses the use of protein cellular retinoic acid binding protein II in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by meas
7569678 Protease inhibitor conjugates and antibodies useful in immunoassay August 4, 2009
Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an a
7569676 Ecstasy-class derivatives, immunogens, and antibodies and their use in detecting ecstasy-class d August 4, 2009
The present invention comprises novel analogs of ecstasy-class compounds and novel ecstasy-class immunogens leashed out of, i.e., derived from, the methylenedioxy position. The invention also comprises unique monoclonal antibodies generated using MDO-leashed MDMA immunogens as well a
7569367 Nucleic acid preparation from whole blood for use in diagnosis of transmissible spongiform encep August 4, 2009
The present invention deals with a method of preparing nucleic acids, particularly RNA, from a whole blood sample. The nucleic acids purified by the method of the invention are particularly suited for detection of nucleic acid marker molecules. Preferred are markers for the diagnosis of
7569126 System and method for quality assurance of a biosensor test strip August 4, 2009
The present invention provides a test strip for measuring a signal of interest in a biological fluid when the test strip is mated to an appropriate test meter, wherein the test strip and the test meter include structures to verify the integrity of the test strip traces, to measure th
7566549 Immunoassay for LSD and 2-oxo-3-hydroxy-LSD July 28, 2009
The present invention provides hapten derivatives useful for the preparation of antigens, antibodies and reagents for use in immunoassays for the detection of LSD and 2-oxo-3-hydroxy LSD. In the present invention, the 2-oxy LSD nucleus is derivatized out of the indole nitrogen to for
7566542 Use of protein ASC as a marker for breast cancer July 28, 2009
The present invention relates to the diagnosis of breast cancer. It discloses the use of protein ASC in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring ASC in the sample. Measurement of
7566419 Magazine for holding test elements July 28, 2009
A portable analysis appliance includes a housing and a magazine for holding test elements. A delivery device is provided for delivering the test elements from a first position in the interior of the magazine to a second position lying at least partially outside the magazine and inside
7565249 Method for the determination of a light transport parameter in a biological matrix July 21, 2009
A method is proposed for the selective determination of a light transport parameter which is characteristic for the light scattering in a biological matrix (5), in particular for the purpose of the non-invasive determination of the glucose concentration in the biological matrix. The
7563902 Chemiluminescent compounds and their use July 21, 2009
The present invention relates to novel chemiluminescent compounds, to a method for synthesizing these compounds, to derivatives and conjugates comprising these compounds, to the use of these compounds or conjugates thereof in chemiluminescence based assays, especially in immunoassays.
7556723 Electrode design for biosensor July 7, 2009
A test strip for measuring a signal of interest in a biological fluid when the test strip is mated to an appropriate test meter, wherein the test strip and the test meter include structures to verify the integrity of the test strip traces, to measure the parasitic resistance of the test
7556613 Array and method for dosing a hormone regulating blood sugar in a patient July 7, 2009
The invention concerns an array and a method for dosing a hormone regulating the blood glucose, especially insulin of a diabetic patient (10). In order to improve the administration of the hormone, the invention provides the following characteristic combination: a) a measuring device
7553615 Compounds, methods, complexes, apparatuses and uses relating to stabile forms of NAD/NADH June 30, 2009
The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives, enzyme complexes of these derivatives and their use in biochemical detection methods and reagent matrices.
7547535 Forms of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase June 16, 2009
The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH), to genes encoding mutated s-GDH, to mutant proteins of s-GDH with improved substrate specificity for glucose, and to different applications of these
7547533 Use of intramolecularly, covalently cross-linked proteins as binding partners in immunoassays June 16, 2009
The invention concerns the use of intramolecularly, covalently cross-linked proteins and covalently cross-linked reverse transcriptase from HIV as immunological binding partners in immunoassays. It also concerns immunological test procedures for detecting an analyte in a sample in wh
7547524 Genetically engineered pyrroloquinoline quinone dependent glucose dehydrogenase comprising an am June 16, 2009
The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH) comprising an amino acid insertion between positions 428 and 429 as corresponding to the amino acid sequence known from Acinetobacter calcoaceticus, t
7531336 Methods for producing recombinant histidine-tagged inosine nonophosphate dehydrogenase polypepti May 12, 2009
The invention relates to a modified IMPDH polypeptide wherein the IMPDH polypeptide has a histidine tag and where the subdomain of the IMPDH polypeptide is modified so that the rate stability of the histidine-tagged, modified IMPDH polypeptide is maintained relative to the wild-type
7527740 Method and separating module for the separation of particles from a dispersion, in particular of May 5, 2009
A method for separating particles from a fluid dispersion, particularly for separating corpuscular components from biological samples, above all from blood. A separating module suitable for performing the method has a substrate with flow channels, comprising a feed channel for supplying
7517700 Core-shell particles April 14, 2009
Colloidal metal particles having a coating comprising non cross-linked, SH-activated dextran or aminodextran. Biomolecules may be linked directly or indirectly to the particles, which are useful as detection reagents in immunological assays.
7517664 Inactivated enzyme variants and associated process and reagent system April 14, 2009
The present invention relates to oxidoreductase apoenzyme variants which are enzymatically inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences encoding these oxidoreductase apoenzyme variants, expression vectors containing such DNA s
7516847 Biocidal blood glucose strip and lancet or sharps disposal device April 14, 2009
A disposal receptacle having a biocidal interior surface for storing contaminated biotesting devices therein. The receptacle contains a one-way opening or valve to prevent used biotesting devices and bodily fluid from escaping or being removed from the receptacle; however, the one-wa
7510682 Test element analysis system March 31, 2009
This invention relates to test element analysis system for the analytical investigation of body liquids. An evaluation instrument, pertaining to the system, comprises a storage container, where a plurality of test elements is held ready for use, a sample application position, where one
7510643 Sensor system March 31, 2009
A sensor strip comprises an electrode substrate, an electrode set, on the electrode substrate, and a heat conducting layer, on the electrode substrate opposite the electrode set. A sensor instrument for use with this sensor strip comprises a temperature sensor, at a side of a gap for
7507550 Analytical sandwich test for determining NT-proBNP March 24, 2009
The present invention concerns an immunological test for determining NT-proBNP comprising at least two antibodies to NT-proBNP, wherein at least one of the antibodies to NT-proBNP is a monoclonal antibody. One of these antibodies is directed at least against parts of the epitope of N
7501097 Positioning device for a test element March 10, 2009
The invention relates an analysis system having a positioning device for positioning a test element and a method for positioning the test element in the analysis system. The positioning device has a support surface for supporting the test element. A first switch component sits on the sup
7499738 Subcutaneous analyte sensor March 3, 2009
Assembly and method for measuring the concentration of an analyte in a biological matrix. The assembly includes an implantable optical-sensing element that comprises a body, and a membrane mounted on the body in a manner such that the membrane and the body define a cavity. The membrane
7494797 Recombinant terminal deoxynucleotidyl transferase with improved functionality February 24, 2009
Truncated terminal deoxynucleotidyl transferase (TdT) derivative from calf thymus, characterized in that the derivative in comparison to the native TdT is N-terminally truncated by up to 161 amino acids and has a 20- to 30-fold higher enzyme activity in solutions containing Co.sup.2+ ion
7491495 Adsorption of nucleic acids to a solid phase February 17, 2009
The present invention is directed to a method for adsorbing, i.e. non-covalently binding, nucleic acids to a solid phase using a two-step procedure. Furthermore, the present invention pertains to a method for isolating nucleic acids from a biological sample. In the first step of the
7491175 Method and device for measuring blood gas parameters February 17, 2009
The invention relates to a method and device for measuring blood gas parameters, preferably pH, pCO.sub.2, and pO.sub.2, in a blood sample, where the blood sample of a patient is fed into at least one measuring cell of an analyzer. In order to obtain accurate values for the blood gas
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