| Patent Number |
Title Of Patent |
Date Issued |
| RE39915 |
Method for the determination of HDL cholesterol by means of a rapid diagnostic agent with an int |
November 6, 2007 |
| An apparatus comprising a first porous carrier and a second porous carrier for evaluating biological fluid samples is disclosed. The apparatus is used for separating non high density lipoprotein (non-HDL) from a lipoprotein in a body sample and for determining high density lipoprotein |
| 7410782 |
Thermostable enzyme promoting the fidelity of thermostable DNA polymerases--for improvement of n |
August 12, 2008 |
| A purified thermostable enzyme is derived form the thermophilic archaebacterium Archaeoglobus fulgidus. The enzyme can be native or recombinant, is stable under PCR conditions and exhibits double strand specific exonuclease activity. It is a 3'-5' exonuclease and cleaves to produce 5 |
| 7390624 |
Metal chelate-labelled peptides |
June 24, 2008 |
| The invention concerns a process for the production of metal chelate-labelled peptide antigens, peptides obtainable by this process and their use in an immunological method of detection. |
| 7371830 |
Method for separating biological material from a fluid using magnetic particles |
May 13, 2008 |
| Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface or having pores with a diameter of less than 10 nm. The particles are used for separating biological material such as nucleic acids. A preferred process |
| 7347971 |
Spreading layers and their use in test strips |
March 25, 2008 |
| A spreading material is described which comprises a porous flat-shaped structure impregnated with a wetting agent, wherein the wetting agent is N-oleoyl-sarcosinate. |
| 7344717 |
Use of erythropoietin in the treatment of rheumatoid arthritis |
March 18, 2008 |
| A novel use of the known protein Erythropoietin (EPO) and/or a derivative and/or a fragment thereof is disclosed. EPO is used as a pharmaceutical for the treatment of chronic inflammations. A particularly beneficial result is seen in patients suffering from rheumatoid arthritis (RA). |
| 7322998 |
Device for withdrawing blood for diagnostic applications |
January 29, 2008 |
| A device for withdrawing blood for diagnostic purposes including a lancet and a lancet drive having a loadable elastic drive spring provided within an elongated housing. A relaxing motion of the drive spring is converted into a puncturing motion to move the lancet at high speed in a punc |
| 7315752 |
Method and device for determining a light transport parameter in a biological matrix |
January 1, 2008 |
| A method for the selective determination of the scattering index .mu..sub.s of a scattering biological matrix, in particular for the purpose of non-invasive determination of the concentration of glucose in the skin, by means of detection measurements, in each of which light in the fo |
| 7300525 |
Device for cleaning pipette probes or stirrers |
November 27, 2007 |
| The invention concerns a device for cleaning pipette needles or stirrers, the device comprising a trough which holds cleaning fluid and whose lower region has a fluid duct for filling and/or emptying purposes and whose upper region has at least one feed pipe which leads into at least one |
| 7267992 |
Method for the determination of an analyte in a liquid |
September 11, 2007 |
| A method is provided to determine the presence of an analyte in a sample. The method provides an element with a sample application zone, a detection zone, a zone containing immobilized analyte or analyte analogue, a conjugate that has a first bioaffine binding partner capable of a sp |
| 7262061 |
Test element analysis system |
August 28, 2007 |
| Test element analysis system for the analytical investigation of a sample, in particular of a body liquid of human beings or animals, comprising test elements (2) with a carrier film (5) and a test field (7) fixed to the flat side (6) of the carrier film (5), the test field (7) containin |
| 7255859 |
Monoclonal antibodies against the epitope YPYDVPDYA, a process for their production and their us |
August 14, 2007 |
| The invention concerns monoclonal antibodies against the epitope YPYDVPDYA (SEQ ID NO: 1) which is derived from the haemagglutinin of the human influenza virus and are suitable for the detection and isolation of native haemagglutinin of the human influenza virus, of modified haemaggl |
| 7244602 |
Polymerase chimeras |
July 17, 2007 |
| The invention concerns polymerase chimeras which are composed of amino acid fragments representing domains and which combine properties of naturally occurring polymerases that are advantageous with regard to a particular application. It has surprisingly turned out that the domains fr |
| 7238534 |
Capillary active test element having an intermediate layer situated between the support and the |
July 3, 2007 |
| The invention concerns a device for withdrawing samples of liquid samples for analytical elements. The capillary-device channel is essentially formed by a carrier, a cover and optionally an intermediate layer between the cover and carrier. A notch is located in one of the surfaces formin |
| 7229771 |
Polyethylene glycol-derivatized biomolecules and their use in heterogeneous detection methods |
June 12, 2007 |
| The use of polyalkylene oxide modified reagents is disclosed in a method for the detection of an analyte or in suitable reagent kits for such methods. |
| 7214532 |
Methods for identifying human cell lines useful for endogenous gene activation, isolated human c |
May 8, 2007 |
| The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process |
| 7214514 |
Identification of human cell lines for the production of human proteins by endogenous gene activ |
May 8, 2007 |
| A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a process for producing |
| 7211437 |
Method for removing consumable analytic products from a storage container |
May 1, 2007 |
| A method and a device for removing an analytic consumable product, in particular a test element, from a storage container having chambers which are sealed by foils from which the consumable product is pushed out by means of a plunger (7) can be optimized in that the magnitude of the |
| 7211096 |
Lancet dispenser |
May 1, 2007 |
| A system suitable for collecting a body fluid, in particular blood from a body region of a person to be examined which comprises a lancing device which is suitable for holding a lancet, a lancet magazine for storing two or several lancets which has a transport device for the lancets and |
| 7186529 |
Preparation of erythropoietin by endogenous gene activation |
March 6, 2007 |
| The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical preparation. The invention furthermore |
| 7172999 |
Method and preparations for stabilizing biological materials by drying methods without freezing |
February 6, 2007 |
| The present invention concerns processes for the production of dry, partially amorphous products containing biologically active and in particular therapeutically active material which are macroscopically homogeneous substance mixtures, the substance mixtures being selected from at le |
| 7172890 |
Inactivated enzyme variants and associated process and reagent system |
February 6, 2007 |
| The present invention relates to oxidoreductase apoenzyme variants which are enzymatically inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences encoding these oxidoreductase apoenzyme variants, expression vectors containing such DNA s |
| 7169600 |
Device for determining a glucose concentration in a tissue fluid |
January 30, 2007 |
| The invention concerns an arrangement for determining the concentration of glucose in a tissue fluid. In the microdialysis technology used for this purpose, perfusate-containing glucose is transported in intermittent delivery pulses through a microdialysis probe inserted into the tissue |
| 7169553 |
2-Azapurine compounds and their use |
January 30, 2007 |
| Within oligonucleotides 2-azapurine and especially 2-azaadenine bases form specifically base pairs with guanine. This base pair is of analogous stability as an adenine-thymine but less stable than a guanine-cytosine base pair. Therefore, the incorporation of 2-azaadenine residues into |
| 7160510 |
Operation checking device and checking method for dispenser |
January 9, 2007 |
| An object is to provide a dispenser operation verification apparatus and verification method that enables operation with high reliability and high accuracy.The construction is such that with a dispenser comprising: one or a plurality of transparent or semi-transparent liquid passages cap |
| 7132270 |
Forms of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase |
November 7, 2006 |
| The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH), to genes encoding mutated s-GDH, to mutant proteins of s-GDH with improved substrate specificity for glucose, and to different applications of these |
| 7105318 |
Specific and sensitive nucleic acid detection method |
September 12, 2006 |
| Method for the detection of a nucleic acid comprising the production of a plurality of amplificates of a section of this nucleic acid with the aid of two primers, one of which can bind to a binding sequence A of the nucleic acid and the other can bind to a binding sequence C' which is |
| 7077828 |
Device for withdrawing blood for diagnostic applications |
July 18, 2006 |
| A device for withdrawing blood for diagnostic purposes including a lancet and a lancet drive having a loadable elastic drive spring provided within an elongated housing. A relaxing motion of the drive spring is converted into a puncturing motion to move the lancet at high speed in a punc |
| 7064190 |
Antigen-specific, activated T lymphocytes, detection and use |
June 20, 2006 |
| The invention concerns autoreactive peptides, peptide-MHC complexes, T cell subpopulations that react thereto as well as diagnostic and therapeutic applications of these compounds. |
| 7030220 |
Thermostable enzyme promoting the fidelity of thermostable DNA polymerases-for improvement of nu |
April 18, 2006 |
| A purified thermostable enzyme is derived from the thermophilic archaebacterium Archaeoglobus fulgidus. The enzyme can be native or recombinant, is stable under PCR conditions and exhibits double strand specific exonuclease activity. It is a 3' 5' exonuclease and cleaves to produce 5 |
| 7026002 |
Element, method and kit for the determination of an analyte in a liquid |
April 11, 2006 |
| The invention concerns an element for the determination of an analyte in a liquid by means of a specific binding reaction of two bioaffine binding partners containing in or on material which enables liquid transport between the zones. The element comprises a sample application zone; a |
| 7025836 |
Modification of surfaces in order to increase the surface tension |
April 11, 2006 |
| A process is provided for the production of a surface coating as well as the use of surface coatings to increase the surface tension of objects. The surface coating is obtained by depositing a layer of at least one element that can be oxidized with water or an alloy that can be oxidized |
| 7008799 |
Analytical test element with a capillary channel |
March 7, 2006 |
| The invention concerns an analytical test element for the determination of an analyte in a liquid containing an inert carrier, a detection element and a channel capable of capillary liquid transport which has a sample application opening at one end and a vent opening at the other end of |
| 7008764 |
Optimization of cells for endogenous gene activation |
March 7, 2006 |
| The invention concerns a process for optimizing the gene expression in cells. A first aspect concerns a process for changing the expression of a nucleic acid sequence which is present endogenously in a eukaryotic cell by introduction of a heterologous expression control sequence into the |
| 6986754 |
Needleless hypodermic injection system, application device and medication cartridge therefor |
January 17, 2006 |
| A needleless hypodermic injection system for injecting a liquid medication, which system comprises a disposable cartridge which contains a medication and which includes a propellant and an igniter, and a reusable application device which comprises a pressure chamber for receiving the |
| 6925393 |
System for the extrapolation of glucose concentration |
August 2, 2005 |
| A system for the extrapolation of a glucose concentration has a data input device for entering administered insulin doses and their times of administration, a data input device for entering the carbohydrates consumed or to be consumed, a unit for determining an actual glucose concent |
| 6921513 |
System for processing samples in a multichamber arrangement |
July 26, 2005 |
| System for processing samples, in particular samples containing nucleic acids comprising a multichamber arrangement the chambers of which are used to receive liquids and it also concerns a pipetting device for removing liquids from the chambers and/or dispensing liquid into the chambers, |
| 6919444 |
Magnetic particles for purifying nucleic acids |
July 19, 2005 |
| Preparations of particles having a glass surface, wherein more than 75% by weight of these particles have a particle size between 0.5 .mu.m and 15 .mu.m and a glass surface which contains between 2 and 6 mole % zinc oxide, have proven to be particularly advantageous in processes for the |
| 6919175 |
System for releasing and isolating nucleic acids |
July 19, 2005 |
| A procedure for the release and isolation of nucleic acids from biological compartments of a sample always uses an instrument that can hold one or more sample processsing vessels, maintain the sample processing vessels at a constant temperature, shake the sample processing vessels and se |
| 6911553 |
Osteoblast-specific mitogens and drugs containing such compounds |
June 28, 2005 |
| The invention is directed to compounds of formula (I) wherein R.sup.1 alkyl, alkenyl or alkynyl having from 6 to 24 carbon atoms; n=0-12; X=oxygen or NH; and the physiologically safe salts, esters, optically active forms, racemates and derivatives thereof which can be metabolized in |
| 6908769 |
Dye pair for fluorescence resonance energy transfer (FRET) measurements |
June 21, 2005 |
| The present invention concerns new fluorescent dye systems especially for fluorescence resonance energy transfer determinations for example combined with the time-resolved measurement of the resulting fluorescence. The invention also concerns the use of these dyes to label biomolecules a |
| 6887427 |
Coated biosensor |
May 3, 2005 |
| The invention concerns a process for coating a metallic or semimetallic surface in which coating molecules containing reactive groups are bound covalently to the surface by irradiation with light and it also concerns a structured coated surface. |
| 6881559 |
Mutant B-type DNA polymerases exhibiting improved performance in PCR |
April 19, 2005 |
| The present invention relates to thermostable mutants of B-type DNA polymerases comprising a Y-GG/A amino acid motif between the N-terminal 3'-5'-exonuclease domain and the C-terminal polymerase domain whereas the tyrosine of the Y-GG/A amino acid motif is mutated and whereas these m |
| 6881378 |
Multilayered analytical device |
April 19, 2005 |
| The invention concerns an analytical device containing at least two components in which at least two of the components are joined together with the aid of an adhesive, which is characterized in that the adhesive contains an adsorptive material. The invention additionally concerns the |
| 6880968 |
Test element analysis system |
April 19, 2005 |
| Test element analysis system (1) for the analytical investigation of a sample (8), in particular of a body liquid, of human beings or of animals, comprising test elements (3) with a test zone (7), to be brought in contact with the sample to be investigated for the purpose of performing |
| 6875859 |
Heterocyclic compounds and their use in the detection of nucleic acids |
April 5, 2005 |
| The invention concerns compounds of the general formula (I) in which the residues R.sub.1 to R.sub.7 have the meanings given in the application as well as methods for their preparation. The compounds are in particular suitable as substrates for RNA or DNA polymerases and can thus be |
| 6870047 |
Magnetic pigment |
March 22, 2005 |
| Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free class surface or having pores with a diameter offices than 10 nm. The particles are used for separating biological material such as nucleic acids. A preferred process of |
| 6852500 |
Method for determining the concentration of glucose in a body fluid with glucose-containing perf |
February 8, 2005 |
| The invention concerns a method and an arrangement for determining the concentration of glucose in a body fluid. In the microdialysis technology used for this purpose, perfusate containing glucose is transported in intermittent delivery pulses through a microdialysis probe (10) inserted |
| 6852337 |
Carvedilol-galenics |
February 8, 2005 |
| The invention relates to a process for the preparation of fast-dissolving pharmaceutical preparations from difficultly soluble active substances, wherein an aqueous suspension is made from the active substance and one or more water-soluble adjuvants and then the resulting aqueous suspens |
| 6846673 |
Identification of human cell lines for the production of human proteins by endogenous gene activ |
January 25, 2005 |
| A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a process for producing |
