| Patent Number |
Title Of Patent |
Date Issued |
| 7452879 |
Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds |
November 18, 2008 |
| The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated o |
| 7449458 |
Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
November 11, 2008 |
| The present disclosure provides prodrugs of biologically active 2,4-pyrimidinediamine compounds of structural formula shown below, compositions comprising these compounds, intermediates and methods for synthesizing these compounds, and methods for using these compounds in a variety o |
| 7435814 |
2,4-Pyrimidinediamine compounds and their uses |
October 14, 2008 |
| The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contex |
| 7432047 |
Method for selective inactivation of viral replication |
October 7, 2008 |
| Method for screening for an antiviral agent, by determining whether a potential agent interacts with a virus or cellular component which allows or prevents preferential translation of a virus RNA compared to a host RNA under virus infection conditions; and determining whether any int |
| 7425418 |
Compounds that modulate processes associated with IgE production |
September 16, 2008 |
| The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a retinoid X receptor as a surrogate analyte and methods of using the compo |
| 7423118 |
IAPS associated cell cycle proteins, compositions and methods of use |
September 9, 2008 |
| The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the |
| 7422867 |
Methods of identifying compounds that modulate IL-4 receptor mediated IgE synthesis utilizing a |
September 9, 2008 |
| The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a CLLD8 protein as a surrogate analyte and methods of using the compounds i |
| 7420045 |
IAPs associated cell cycle proteins, compositions and methods of use |
September 2, 2008 |
| The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also, provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the |
| 7419779 |
Modulators of angiogenesis |
September 2, 2008 |
| The present invention relates to regulation of angiogenesis. More particularly, the present invention is directed to nucleic acids encoding "angiogenesis regulatory proteins and nucleic acids" which are involved in modulation of angiogenesis. The invention further relates to methods |
| 7410979 |
Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin |
August 12, 2008 |
| The present invention relates to anti-HCV dihaloacetamide compounds in synergistic combination with an interferon and/or ribavirin and pharmaceutical compositions thereof for inhibition of the replication of HCV virus. The present invention also relates to the use of the compositions |
| 7384761 |
Methods of identifying an agent capable of interfering with Rad9 dephosphorylation |
June 10, 2008 |
| The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells polypeptides of the present invention fused to heterologous polypeptide sequences, an |
| 7378251 |
Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a |
May 27, 2008 |
| The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a thioredoxin-like 32 kDa protein (TXNL) as a surrogate analyte and methods |
| 7378248 |
In vivo production of cyclic peptides for inhibiting protein-protein interaction |
May 27, 2008 |
| The present invention relates to methods and compositions utilizing inteins to generate libraries of cyclic peptides in vivo. The prevent invention also relates to methods for inhibiting protein-protein interaction. |
| 7374894 |
Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a |
May 20, 2008 |
| The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL 4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a chloride intracellular channel 1 (CLIC1) as a surrogate analyte and metho |
| 7371537 |
Modulators of B-lymphocyte activation, myosin-1F compositions and methods of use |
May 13, 2008 |
| The present invention provides compositions and methods for modulating B-lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating B-lymphocyte activation are provided. Compositions and methods for the treatment of disorders related |
| 7358259 |
HCV inhibitors and methods of using them |
April 15, 2008 |
| The present invention comprises tetrazoloquinoline-compounds that are inhibitors of HCV. Compositions comprising the compounds in combination with a pharmaceutically acceptable carrier are also disclosed, as are methods of using the compounds and compositions to inhibit HCV infection |
| 7332602 |
Pyridyl substituted heterocycles useful for treating or preventing HCV infection |
February 19, 2008 |
| The present invention relates to pyridyl substituted heterocycles and hydro isomers thereof and pharmaceutical compositions thereof that inhibit replication and/or proliferation of HCV virus. The present invention also relates to the use of the pyridyl heterocycles and hydro isomers |
| 7332484 |
2,4-pyrimidinediamine compounds and their uses |
February 19, 2008 |
| The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contex |
| 7329672 |
2,4-pyrimidinediamine compounds and their uses |
February 12, 2008 |
| The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contex |
| 7329671 |
2,4-pyrimidinediamine compounds and their uses |
February 12, 2008 |
| The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contex |
| 7326790 |
Diphenylisoxazole compounds and hydro isomers thereof |
February 5, 2008 |
| The present invention relates to substituted diphenylisoxazole compounds and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of compounds and/or compositions to inhibit HCV replication and/or proliferation and to tr |
| 7300780 |
Germinal center kinase proteins, compositions, and methods of use |
November 27, 2007 |
| The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic adds encoding proteins and proteins so encoded which are capable of modulating proliferation, survival, morphology and migration in mammalian cells are |
| 7297482 |
Structurally biased random peptide libraries based on different scaffolds |
November 20, 2007 |
| The invention relates to the use of scaffold proteins, particularly green fluorescent protein (GFP), in fusion constructs with random and defined peptides and peptide libraries, to increase the cellular expression levels, decrease the cellular catabolism, increase the conformational |
| 7285383 |
Method for selective inactivation of viral replication |
October 23, 2007 |
| Method for screening for an antiviral agent, by determining whether a potential agent interacts with a virus or cellular component which allows or prevents preferential translation of a virus RNA compared to a host RNA under virus infection conditions; and determining whether any int |
| 7265214 |
Germinal center kinase proteins, compositions and methods of use |
September 4, 2007 |
| The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating proliferation, survival, morphology and migration in mammalian cells are |
| 7252952 |
In vivo production of cyclic peptides for inhibiting protein--protein interaction |
August 7, 2007 |
| The present invention relates to methods and compositions utilizing inteins to generate libraries of cyclic peptides in vivo. The prevent invention also relates to methods for inhibiting protein-protein interaction. |
| 7244576 |
Modulators of angiogenesis |
July 17, 2007 |
| The present invention relates to regulation of angiogenesis. More particularly, the present invention is directed to nucleic acids encoding C1-angiogenesis protein, also called integrin-linked kinase associated protein ("ILKAP") and ILKAP protein, which is involved in modulation of a |
| 7243112 |
Multidimensional biodata integration and relationship inference |
July 10, 2007 |
| This invention provides an advanced platform for the analysis of biological data that emphasizes pathway mapping and relationship inference based upon data acquired from multiple diverse sources. The platform employs a bioinformatic system that integrates data from the diverse source |
| 7241581 |
Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a |
July 10, 2007 |
| The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a c-Myc protein as a surrogate analyte and methods of using the compounds i |
| 7223850 |
Apoptosis proteins |
May 29, 2007 |
| The present invention is directed to novel apoptosis polypeptides such as the Apop1, and Apop3 proteins and related molecules which are involved in modulating apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided here are vectors and host cells comprising |
| 7208571 |
In vivo production of cyclic peptides |
April 24, 2007 |
| The present invention relates ti methods and compositions utilizing inteins to generated libraries of cyclic peptides in vivo. |
| 7208289 |
Methods of identifying compounds that modulate IL-4 receptor mediated IgE synthesis utilizing a |
April 24, 2007 |
| The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a CLLD8 protein as a surrogate analyte and methods of using the compounds i |
| 7205130 |
Bi-directionally cloned random cDNA expression vector libraries, compositions and methods of use |
April 17, 2007 |
| The present invention provides random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in sense and antisense orientation, which are useful for the delivery and expression of a combination of genetic effector types to host cells. |
| 7189523 |
Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a |
March 13, 2007 |
| The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a BAP-37 as a surrogate analyte and methods of using the compounds in a var |
| 7157473 |
Pyridyl substituted heterocycles useful for treating or preventing HCV infection |
January 2, 2007 |
| The present invention relates to pyridyl substituted heterocycles and hydro isomers thereof and pharmaceutical compositions thereof that inhibit replication and/or proliferation of HCV virus. The present invention also relates to the use of the pyridyl heterocycles and hydro isomers |
| 7153880 |
Substituted diphenyl heterocycles useful for treating HCV infection |
December 26, 2006 |
| The present invention relates to substituted diphenyl heterocycle compounds and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication and/or proliferatio |
| 7153665 |
Methods and compositions for screening for modulators of IgE synthesis, secretion and switch rea |
December 26, 2006 |
| The invention relates to methods and compositions useful in screening for modulators of IgE synthesis, secretion and switch rearrangement. |
| 7141434 |
Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing an |
November 28, 2006 |
| The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize an adenosine kinase as a surrogate analyte and methods of using the compoun |
| 7132234 |
Methods and compositions for the identification of anti-poxvirus agents |
November 7, 2006 |
| The invention provides methods for identifying an anti-poxviral agents. In many embodiments, the methods involve contacting a poxviral p28 polypeptide with a candidate agent, and determining an effect of the agent on a ubiquitin ligase activity of the p28 polypeptide. The effect of t |
| 7122630 |
SYK-UBP polypeptides and methods of making and isolating same |
October 17, 2006 |
| The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the |
| 7122542 |
Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds |
October 17, 2006 |
| The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated o |
| 7122332 |
Modulators of leukocyte activation, compositions and methods of use |
October 17, 2006 |
| The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to l |
| 7118854 |
PAK2: modulators of lymphocyte activation |
October 10, 2006 |
| The present invention relates to regulation of lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding PAK2, which is involved in modulation of lymphocyte activation. The invention further relates to methods for identifying and using agents, |
| 7115642 |
Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection |
October 3, 2006 |
| The present invention relates to substituted diphenyl heterocycle compounds and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication and/or proliferatio |
| 7105341 |
In vivo production of cyclic peptides |
September 12, 2006 |
| The compositions relate to retroviral vectors encoding intein containing polypeptides which, when expressed in an eukaryotic cell, are capable of generating cyclic peptides. The retroviral vectors are used in methods for producing cyclic peptides and for identifying peptides capable of |
| 7090990 |
NP95: methods of assaying for cell cycle modulators |
August 15, 2006 |
| The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding NP95, which is involved in modulation of cell cycle arrest. The invention further relates to methods for identifying and using agents, |
| 7090976 |
Methods and compositions comprising Renilla GFP |
August 15, 2006 |
| The invention relates to methods and compositions utilizing Renilla green fluorescent proteins (rGFP), and Ptilosarcus green fluorescent proteins (pGFP). In particular, the invention relates to the use of Renilla GFP or Ptilosarcus GFP proteins as reporters for cell assays, particularly |
| 7071190 |
Inhibitors to tubulin polymerization |
July 4, 2006 |
| The invention relates to the inhibition of tubulin polymerization. The invention provides compounds and methods for inhibiting tubulin polymerization. The invention also provides compositions and methods for treating cell proliferative diseases and conditions. |
| 7070996 |
Production of cultured human mast cells and basophils for high throughput small molecule drug di |
July 4, 2006 |
| Provided are methods for producing and screening proliferated populations of CD34-negative progenitor cells, mucosal mast cells, connective tissue-type mast cells and basophil cells. The methods generate uniform proliferated populations of cells. The proliferated populations contain a |
| 7067266 |
Modulators of leukocyte activation, Hck compositions and methods of use |
June 27, 2006 |
| The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to l |
