| Patent Number |
Title Of Patent |
Date Issued |
| D258517 |
Insect trap cross-member support |
March 10, 1981 |
|
| D256094 |
Bottle |
July 29, 1980 |
|
| D253454 |
Bottle |
November 20, 1979 |
|
| D245762 |
Hinged display box |
September 13, 1977 |
|
| 4483988 |
Substituted derivatives of 4-t-alkoxycarbonyl-piperazin-2-ones |
November 20, 1984 |
| Novel analgesic and antipsychotic agents having the formula ##STR1## in which R.sub.1 is hydrogen, hydroxy or halogen and R.sub.4 is hydrogen or, R.sub.1 and R.sub.4 are both hydroxy; Z is hydrogen or straight chain lower alkyl having from 1 to 4 carbon atoms and X is methylene, carb |
| 4439443 |
Snake bite therapy |
March 27, 1984 |
| A method of reducing local hemorrhage and tissue necrosis resulting from the bite or sting of a venomous animal whereby an envenomated mammal is treated with a compound of the formula ##STR1## or a corresponding disulfide wherein n is 1, 2 or 3; Z is O, S or NH; R is H, a straigh |
| 4435571 |
5-(Substituted benzyl)-6-oxo-2-piperazine carboxylic acids and esters |
March 6, 1984 |
| The present invention relates to compounds of the formula ##STR1## wherein R' is hydrogen, straight or branched chain lower alkyl having from 1 to 4 carbon atoms or benzyl, Z is hydrogen or straight chain lower alkyl having from 1 to 4 carbon atoms, Y is hydrogen or a nitrogen blocki |
| 4411905 |
Antisecretory 1,2,4-triazole-3-thiols |
October 25, 1983 |
| Compounds of the formula ##STR1## wherein R.sub.1 is H or NH.sub.2 ; R.sub.2 is C.sub.1-6 straight or branched chain alkyl; --CH.sub.2 OH; --(CH.sub.2).sub.n --O--(CH.sub.2).sub.m --CH.sub.3 ; phenyl; or --(CH.sub.2).sub.p NH.sub.2 ;n is 1-3;m is 0-3; andp is 1-5;and the pharmace |
| 4347255 |
Snake bite therapy |
August 31, 1982 |
| A method of reducing local hemorrhage and tissue necrosis resulting from the bite or sting of a venomous animal whereby an envenomated mammal is treated with a compound of the formula: ##STR1## or a corresponding disulfide wherein n is 1, 2 or 3; Z is O, S or NH; R is H, a straig |
| 4341698 |
Enkaphalin derivatives |
July 27, 1982 |
| Novel analgesic and antipsychotic agents having the formula ##STR1## wherein Q is ##STR2## in which R.sub.1 is hydrogen, hydroxy or halogen and R.sub.4 is hydrogen or, R.sub.1 and R.sub.4 are both hydroxy; Z is hydrogen or straight chain lower alkyl having from 1 to 4 carbon |
| 4325877 |
Production of intermediates for enzyme inhibitors |
April 20, 1982 |
| 5-Amino-4-oxo-pentanoic acids of the formula ##STR1## wherein R is CF.sub.3, CHF.sub.2 or CH.sub.2 F; R.sub.1 is H or akyl of 1-4 carbon atoms; and R.sub.2 is H or alkyl or 1-4 carbon atoms or benzyl, which are intermediates to ACE inhibitors or elastase inhibitors, are produced |
| 4321382 |
2-Amino-11b-aryl-benzo[a]quinolizines |
March 23, 1982 |
| Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, a straight or branched chain alkyl of 1-5 carbon atoms or a straight or branched chain alkanoyl of 1-5 carbon atoms;R.sub.2 is hydrogen, a straight or branched chain alkyl of 1-5 carbon atoms, phenyl, phenyl substituted w |
| 4317818 |
Method of treating prostatic carcinoma |
March 2, 1982 |
| Compounds of the following general formula are useful in treating prostatic carcinoma: ##STR1## wherein R is --CHO or --CH.sub.2 OR.sub.1 ; each of R.sub.1 and R.sub.2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, b |
| 4317817 |
Novel steroid 5.alpha.-reductase inhibitors |
March 2, 1982 |
| Compounds of the following general formula are testosterone 5.alpha.-reductase inhibitors rendering the compounds useful in the treatment of acne and oily skin and benign prostatic hypertrophy: ##STR1## wherein R is: .dbd.O, --OH, --OCO--alkyl C.sub.1-5, --COOH, --CH.sub.2 OH, -- |
| 4312879 |
Clonidine and lofexidine as antidiarrheal agents |
January 26, 1982 |
| Clonidine and lofexidine and the pharmaceutically acceptable salts thereof, which are, inter alia, known antihypertensives, also possess very potent antidiarrheal activity which is non-narcotic and more potent than that of conventional antidiarrheal drugs, such as diphenoxylate. |
| 4310524 |
TCA Composition and method for rapid onset antidepressant therapy |
January 12, 1982 |
| A method is provided for treating depression in a patient therefrom and requiring rapid symptomatic relief, which comprises administering to said patient concurrently (a) an effective antidepressant amount of a tricyclic antidepressant or a pharmaceutically effective acid addition salt t |
| 4309426 |
Muscle-relaxant 1,3,4-thiadiazin-2-amines |
January 5, 1982 |
| A method of achieving a muscle-relaxing effect in a patient comprises administering to a patient in which a muscle relaxing effect is desired an amount effective to achieve a muscle-relaxing effect of a compound of the formula ##STR1## wherein R is H, or C.sub.1-7 straight or bra |
| 4302581 |
7-(1,3-Dithiolan-2-imino)cephalosporanic acid derivatives |
November 24, 1981 |
| Novel 7-(1,3-dithiolan-2-imino)cephalosporin derivatives are described which are particularly useful for their antibacterial properties. |
| 4291160 |
7-(1,3-Dithiolan-2-imino)-.DELTA..sup.2 -cephalosporanic acid derivatives |
September 22, 1981 |
| Novel 7-(1,3-dithiolan-2-imino)-.DELTA..sup.2 -cephalosporanic acid derivatives are described which possess useful antibacterial properties. |
| 4289767 |
5-(Chlorophenyl)-6H-1,3,4-thiadiazine-2-amines |
September 15, 1981 |
| Compounds of the formula ##STR1## wherein R is H, C.sub.1-5 or 7 -straight or branched chain alkyl or allyl and R.sub.1 is H or Cl andthe pharmacologically acceptable acid addition salts thereof are pharmacologically active as anticonvulsant and anxiolytic agents. |
| 4285958 |
1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof |
August 25, 1981 |
| Pharmaceutically useful compounds of the following formula: ##STR1## wherein R.sub.1 represents hydrogen or hydroxy; R.sub.2 represents hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ; n is a positive whole |
| 4285957 |
1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof |
August 25, 1981 |
| Novel compounds of the following formula: ##STR1## wherein R.sub.1 is hydrogen or hydroxy; R.sub.2 is hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ; n is an integer of from 1 to 5; R.sub.3 is --CH.sub.3, - |
| 4284636 |
Cinnamoylpiperidinobutyrophenone antipsychotic agents |
August 18, 1981 |
| Cinnamoylpiperidinobutyrophenone derivatives and pharmaceutically acceptable salts thereof of the following general structure: ##STR1## wherein R is hydrogen, alkyl, alkoxy, halogen or trifluoromethyl; and R' is hydrogen or halogen; are useful as antipsychotic agents. The novel c |
| 4283404 |
Aroylethenylpiperidinobutyrophenone antipsychotic agents |
August 11, 1981 |
| 4-Aroylethnyl-1-piperidinobutyrophenone derivatives and pharmaceutically acceptable salts thereof of the following general structure: ##STR1## wherein R is hydrogen, alkyl, alkoxy, halogen or trifluoromethyl; and R' is hydrogen or halogen, are useful as antipsychotic agents. The nove |
| 4283385 |
Dentifrices with improved soluble fluoride availability |
August 11, 1981 |
| Dentifrice preparations having improved soluble fluoride availability are obtained by incorporation of ethylenediamine tetraacetic acid and sodium salts thereof. |
| 4281006 |
2-(Diphenylalkylimino)piperidine-3-carboxanilides as inhibitors of gastrointestinal hypersecreti |
July 28, 1981 |
| Compounds having the formula ##STR1## wherein A is a bond or C.sub.1-4 alkylene; R.sup.1, R.sup.2 and R.sup.3 are independently a halogen atom, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, CF.sub.3, SCF.sub.3 or OCF.sub.3 ; R.sup.4 is a hydrogen atom or C.sub.1-4 alkyl |
| 4280936 |
Denture adhesive of sodium carboxymethylcellulose, poly(ethylene oxide) homopolymer and mineral |
July 28, 1981 |
| An improved denture adhesive contains a particular amount of a specified ratio of sodium carboxymethylcellulose and poly(ethylene oxide) in a mineral oil base. |
| 4277395 |
Novel enzyme inhibitors |
July 7, 1981 |
| Compounds of the following general formula are irreversible inhibitors of pancreatic elastase: ##STR1## wherein M is hydroxy, lower alkoxy, benzyloxy or --NY.sub.1 Y.sub.2 wherein each of R.sub.4 and R.sub.5 is hydrogen or lower alkyl; R is CF.sub.3, CHF.sub.2 or CH.sub.2 F; R.su |
| 4272532 |
5-(Optionally substituted phenyl)-6H-1,3,4-thiadiazine-2-amines |
June 9, 1981 |
| A method of inducing sedation in a patient comprises administering to a patient in which sedation is desired an amount effective for inducing sedation of a compound of the formula ##STR1## wherein R is H, or C.sub.1-5 or 7 -straight or branched chain alkyl:R.sub.1 is H, C.sub.1-5 or |
| 4260626 |
Tetrahydro and imidazoline antisecretory compounds |
April 7, 1981 |
| Novel antisecretory compounds of the formula: ##STR1## wherein R is ##STR2## and pharmaceutically acceptable salts, diasteriomers and individual optical isomers thereof. |
| 4255575 |
2-Hydroxy-5-(1-hydroxy-2-piperazinylethyl)-benzoic acid derivatives |
March 10, 1981 |
| Derivatives of 2-hydroxy-5-(1-hydroxy-2-piperazinylethyl)benzoic acid are prepared which are useful for their blocking action on .alpha. and .beta.-adrenergic receptors. In addition, these compounds are useful as spasmolytic and antihypertensive agents. |
| 4254130 |
Piperidine derivatives |
March 3, 1981 |
| Pharmaceutically useful compounds of the following formula: ##STR1## wherein R.sub.1 represents hydrogen or hydroxy; R.sub.2 represents hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ; n is a positive whole |
| 4254129 |
Piperidine derivatives |
March 3, 1981 |
| Novel compounds of the following formula: ##STR1## wherein R.sub.1 is hydrogen or hydroxy; R.sub.2 is hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ; n is an integer of from 1 to 5; R.sub.3 is --CH.sub.3, - |
| 4246268 |
Neuroleptic-4-(naphthylmethyl)piperidine derivatives |
January 20, 1981 |
| Novel compounds of the formula ##STR1## wherein n is an integer of from 2 to 5, R is hydrogen, alkyl, alkoxy, halogen or trifluoromethyl, R.sub.1 is hydrogen, alkyl, alkoxy or halogen, X is carbonyl, hydroxymethylene or methylene, and Z is carbonyl or hydroxymethylene and their p |
| 4244955 |
2,4a-Ethanobenz[g]isoquinolin-5(1H)-ones and their use as anti-fertility and analgesic agents |
January 13, 1981 |
| 2,4a-Ethanobenz[g]isoquinolin-5(1H)-one derivatives are described which are useful as analgesic and anti-fertility agents. |
| 4239681 |
Androst-4-en-19-ols |
December 16, 1980 |
| Derivatives of androst-4-en-19-ol are useful for enhancing libido and related psychic attitudes. |
| 4230715 |
1,2,4-Triazole-3-thiols as antisecretory agents |
October 28, 1980 |
| Compounds of the formula ##STR1## wherein R.sub.1 is H or NH.sub.2 ;R.sub.2 is C.sub.1-6 straight or branched chain alkyl; --CH.sub.2 OH; --(CH.sub.2).sub.n --O--(CH.sub.2).sub.m --CH.sub.3 ; phenyl; or --(CH.sub.2).sub.p NH.sub.2 ;n is 1-3;m is 0-3; andp is 1-5;and the pharmaceutica |
| 4229575 |
7-(2,3-Dihydrobenzo-5-furanyl)-acetamido cephalosporin derivatives |
October 21, 1980 |
| This invention is directed to new 7-(2,3-dihydrobenzo-5-furanyl)acetamido cephalosporin derivatives and methods for preparing them. |
| 4229467 |
Alkoxy benzofuran carboxylic acids and salts and esters thereof as hypolipidemic agents |
October 21, 1980 |
| Compounds of the Formula ##STR1## wherein R is H or C.sub.1-4 alkyl; R.sub.1 is H or C.sub.1-4 alkyl; and R.sub.2 is straight or branched chain alkyl of 10-20 carbon atoms, straight or branched chain alkenyl of 10-20 carbon atoms, straight or branched chain alkadienyl of 10-20 ca |
| 4224310 |
Dentifrice compositions |
September 23, 1980 |
| Dentifrice composition having strontium disodium ethylenediamine tetraacetate formed in situ. |
| 4221808 |
Novel antihypertensive agent |
September 9, 1980 |
| This invention is to the compound 5-[2-[[3-(1,3-benzodioxol-5-yl)-1-methylpropyl]amino]-1-hydroxyethyl]-2-me thoxybenzamide having the formula, ##STR1## pharmaceutically acceptable salts and individual optical isomers thereof, pharmaceutical compositions comprising as the active i |
| 4219648 |
7-[[Amino(1,3-dihydrobenzo[c]thienyl)acetyl]amino]cephalosporin derivatives |
August 26, 1980 |
| This invention is directed to new 7-[[amino(1,3-dihydrobenzo[c]thien-5-yl)acetyl]amino]cephalosporin derivatives useful as antibiotics. |
| 4215130 |
Antihypertensive compositions of N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine and |
July 29, 1980 |
| Therapeutic antihypertensive compositions containing N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine and N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine or their non-toxic, pharmaceutically acceptable salts are described as well as a method of reducing blood pr |
| 4208516 |
7-(1,3-Dithiolan-2-imino)-.DELTA..sup.2 -cephalosporanic acid derivatives |
June 17, 1980 |
| Novel 7-(1,3-dithiolan-2-imino)-.DELTA..sup.2 -cephalosporanic acid derivatives are described which possess useful antibacterial properties. |
| 4206305 |
7-(1,3-Dithiolan-2-imino)cephalosporanic acid derivatives |
June 3, 1980 |
| Novel 7-(1,3-dithiolan-2-imino)cephalosporin derivatives are described which are particularly useful for their antibacterial properties. |
| 4206125 |
5-[2-[(2,3-Dihydro-1,4-benzodioxan-2-ylmethyl)amino]-1-hydrox yethyl]-2-hydroxybenzoic acid deriv |
June 3, 1980 |
| Derivatives of 5-[2-[(2,3-dihydro-1,4-benzodioxan-2-ylmethyl)amino]-1-hydroxyethyl]-2-hyd roxybenzoic acid are prepared which are useful for their blocking action on .alpha. and .beta.-adrenergic receptors. In addition, these compounds are useful as antihypertensive agents. |
| 4206119 |
6-(1,3-Dithiolan-2-imino)penicillanic acid derivatives |
June 3, 1980 |
| Novel 6-(1,3-dithiolan-2-imino)penicillanic acid derivatives are described which are particularly useful for their antibacterial properties. |
| 4200755 |
2-Hydro xy-5-[1-hydroxy-2-[4-(2-oxo-1-benzimidazolinyl)piperidino]ethyl]benzoic acid derivati |
April 29, 1980 |
| Derivatives of 2-hydroxy-5-[1-hydroxy-2-[4-(2-oxo-1-benzimidazolinyl)piperidino]ethyl]ben zoic acid are prepared which are useful for their blocking action on .alpha. and .beta.-adrenergic receptors. In addition, these compounds are useful for their spasmolytic and anti-hypertensive a |
| 4192895 |
Antirhinovirus agents |
March 11, 1980 |
| Compounds of the following general structure are useful as antirhinovirus agents: ##STR1## wherein Y is a bond, oxygen or divalent sulfur; R is a straight or branched hydrocarbon chain having from 6 to 20 carbon atoms and is saturated or unsaturated having from 1 to 4 double bond |
| 4191828 |
Process for preparing 2-(2,2-dicyclohexylethyl)piperidine |
March 4, 1980 |
| 2-(2,2-Dicyclohexylethyl)piperidine is prepared via the catalytic hydrogenation of 2-(2,2-diphenylethenyl)pyridine in a single step. High yields are obtained using a rhodium supported catalyst. |
