| Patent Number |
Title Of Patent |
Date Issued |
| 5766918 |
Enantioselective amidases and uses thereof |
June 16, 1998 |
| The present invention concerns polypeptides that possess an enantioselective amidase activity. It also concerns the genetic material required for the expression of these polypeptides as well as a microbiological procedure for their preparation. Finally, this invention concerns the ut |
| 5426117 |
N-methyl-2-(3-pyridyl)-tetrahydrothio-pyran-2-carbothioamide 1-oxide to the preparation of medic |
June 20, 1995 |
| Application of N-Methyl-2-(3-pyridyl)tetrahydrothiopyran-2-carbothioamide 1-oxide, in the form of a racemic mixture of the 1S,2S and 1R,2R isomers or in the form of the 1R,2R isomer, to the preparation of a medicinal product intended for the treatment of coronary insufficiency. |
| 5298248 |
Method for continuous liberation of active constituents into water |
March 29, 1994 |
| An apparatus is provided for continuous and regular liberation of active constituents into domestic water supplies. The apparatus comprises a receptacle having a body portion which is impermeable to water and to the active constituent. The receptacle is provided with an aperture closed b |
| 5274178 |
Terpene derivatives, their preparation and their use |
December 28, 1993 |
| Terpene derivatives of formula I, their preparation and their use. In formula I, R represents a hydrogen atom or an alkanoyl radical and R' represents a hydrogen atom or an aliphatic hydrocarbon radical. ##STR1## |
| 5260208 |
Enantioselective amidases, DNA sequences encoding them, method of preparation and utilization |
November 9, 1993 |
| The present invention concerns a DNA sequence coding for a polypeptide with enantioselective amidase activity. |
| 5202460 |
Terpene derivatives, their preparation and their use |
April 13, 1993 |
| Terpene derivatives of formula I, their preparation and their use. In formula I, R represents a hydrogen atom or an alkanoyl radical and R' represents a hydrogen atom or an aliphatic hydrocarbon radical. ##STR1## |
| 5188841 |
Sustained release pharmaceutical formulations |
February 23, 1993 |
| The invention provides a sustained release formulation of ketoprofen comprising granules each of which comprises a core comprising ketoprofen and microcrystalline cellulose and a coating comprising a water-soluble and a water-insoluble cellulose derivative. |
| 5177265 |
Process for the preparation of citral |
January 5, 1993 |
| An improved method for preparing citral in liquid phase from prenol and prenal, wherein, in a single reaction enclosure, the prenol and prenal are condensed in the presence of a mineral acid at a concentration of about 5.10.sup.-3 mole for one mole of prenal, 90 to 95% of the acid is |
| 5151436 |
Derivatives of thioformamide |
September 29, 1992 |
| Therapeutically useful thioformamide derivatives of the formula: ##STR1## wherein R represents alkyl, Het represents pyrid-3-yl, isoquinolin-4-yl, tetrahydroquinolin-3-yl, quinolin-3-yl, pyridazin-4-yl, pyrimid-5-yl, thiazol-5-yl, thieno[2,3-b]-pyridin-5-yl, pyrazin-2-yl, indol-3-yl |
| 5137690 |
Process and apparatus for the determination of the iodine content of drinking water |
August 11, 1992 |
| A process and apparatus for the determination of the iodine content of drinking water by comparing the coloration of the water to be analyzed with that of an iodine reference solution in the presence of a fixed amount of cerium and arsenic. |
| 5135900 |
Palladium-based catalyst and its use |
August 4, 1992 |
| A catalyst system comprising an aqueous solution of a derivative of palladium and of a water-soluble ligand associated with a nitrile, and its use, for example, for effecting allyl substitution reactions in a two-phase system with easy recycling of the catalyst after phase separation |
| 5130313 |
Serotonin antagonists, their preparation and medications containing them |
July 14, 1992 |
| This invention relates to compounds of formula: ##STR1## in which R.sub.1 denotesa 1,2,3,6-tetrahydro-1-pyridyl radical substituted in the 4-position by an optionally substituted phenyl, optionally substituted 3-indolyl or 3-(5-hydroxyindolyl) radical,a 1-piperazinyl radical substitu |
| 5130171 |
Process for encapsulating particles with a silicone |
July 14, 1992 |
| Particles of active substance are encapsulated by spraying them with a thermoplastic silicone copolymer in solution in an organic solvent or in an aqueous dispersion or emulsion and removing the solvent or water by drying with hot air. The spraying/drying process employed is, for example |
| 5124459 |
Process for the preparation of 3-(3-pyridyl)-1H,3H-pyrrolo[1,2-c]thiazole-7-carbonitrile |
June 23, 1992 |
| 3-(3-Pyridyl)-1H,3H-pyrrolo[1,2-c]thiazole-7-carbonitrile is prepared by the action of 2-chloroacrylonitrile on a salt of 3-formyl-2-(3-pyridyl)-4-thiazolidinecarboxylic acid with an organic base in the presence of an acid chloride in an organic solvent capable of dissolving the salt |
| 5120852 |
Process for preparing (1R,2R)-2-(3-pyridyl)-tetrahydrothiopyran-2-carbothioamide 1-oxides th |
June 9, 1992 |
| Process for preparing (1R,2R)-2-(3-pyridyl)tetrahydrothiopyran-2-carbothioamide 1-oxides of general formula: ##STR1## (R.sub.1 =alkyl containing 1 to 4 carbon atoms), by the action of an alkyl isothiocyanate on the 1R,2R and 1R,2S sulphoxides of formulae: ##STR2## employe |
| 5116999 |
Process for the preparation of cyclic sulphates |
May 26, 1992 |
| Cyclic sulphates of formula: ##STR1## are prepared by oxidation of a cyclic sulphite of formula: ##STR2## with a hypohalite of an alkali or alkaline-earth metal and a catalytic quantity of a ruthernium derivative (RuO.sub.2, RuCl.sub.3). In formulae (I) and (II), R.sub.1, R.s |
| 5114949 |
Heterocyclic derivatives, their preparation and medicinal products containing them |
May 19, 1992 |
| Compounds are disclosed of formula:in which R.sub.1 represents a residue of formula ##STR1## X represents a hydrogen atom or an alkyl radical, Y represents a hydrogen atom or an alkyl or alkoxy radical,Z represents an alkyl radical,n is equal to 2 or 3,Het represents a substituted piperi |
| 5102890 |
Pyrrole derivatives, their preparation and pharmaceutical compositions which contain them |
April 7, 1992 |
| This invention relates to pyrrole derivatives of formula: ##STR1## in which A forms with the pyrrole ring an isoindoline, 6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine, 2,3,6,7-tetrahydro-5H-[1,4]oxathiino[2,3-c]pyrrole or 2,3,6,7-tetrahydro-5H-[1,4]dithiino[2,3-c]pyrrole ring-system and |
| 5102667 |
Isoindolone derivatives, their preparation and the pharmaceutical compositions containing them |
April 7, 1992 |
| This invention relates to isoindolone derivatives of general formula (I) in which the radicals R are hydrogen atoms or together form a bond, the symbols R' are phenyl radicals which can be substituted by a halogen atom or a methyl radical in position 2 or 3, X is an oxygen or sulphur ato |
| 5102581 |
Process for the preparation of pseudoionone using oxidative decarboxylation |
April 7, 1992 |
| Process for the preparation of: ##STR1## by oxidative decarboxylation of an allyl .beta.-ketoester: ##STR2## in an organic solvent, in the presence of a palladium-based catalyst. The organic solvent selected from an amide, a nitrile, or a dinitrile. |
| 5098718 |
Enzymatically degradable coating compositions for feed additives intended for ruminants |
March 24, 1992 |
| Enzymatically degradable compositions for the coating of feed additives intended for ruminants, including zein, at least one hydrophobic substance, optionally at least one non-water-soluble polymer and at least one inorganic filler. The compositions are used to coat feed additives su |
| 5097064 |
Process for preparing optically active 2-arylpropionic acids |
March 17, 1992 |
| This invention relates to a process for preparing an optically active 2-arylpropionic acid of general formula (I), by the hydrogenation, in a heterogeneous aqueous-organic medium, of a 2-arylacrylic acid of general formula (II) in the presence of a catalyst consisting of a rhodium de |
| 5093243 |
Process for the separation and recovery of nosiheptide |
March 3, 1992 |
| Nosiheptide is recovered from a cultivation mixture obtained by cultivating a Nosiheptide-producing strain of Streptomyces by adding a water-miscible organic solvent, removing mycelia, precipitating Nosiheptide by adding water, which may be acidified, and recovering the Nosiheptide. |
| 5091388 |
Pyridobenzoindole derivatives, their preparation and compositions which contain them |
February 25, 1992 |
| New pyridobenzoindole derivatives of general formula (I), in which R is H or alkyl (1 or 2 C), alk is straight or branched alkylene (2 to 4 C), R.sub.1 denotes a hydrogen atom or an alkyl radical (1 or 2 C), R.sub.2 denotes a hydroxy or methoxy radical, and R.sub.3 is methyl or ethyl and |
| 5089527 |
Pentamidine solutions |
February 18, 1992 |
| The invention provides a stabilized aqueous solution of a water soluble pentamidine salt comprising an acetate buffer, and having a total acetate concentration of 0.01-0.06M, and a pH of 4.0-5.0 at room temperature. |
| 5089405 |
Process for the preparation of optically active 2-arylpropionic acids and pharmaceutical composi |
February 18, 1992 |
| S Enantiomers of 2-arylpropionic acids are made by enantioselective hydrolysis of the corresponding racemic 2-arylpropionamides in the presence of a microorganism, or of an enzyme derived therefrom, able selectively to hydrolyze racemic .alpha.-phenylpropionamide to S .alpha.-phenylp |
| 5086051 |
1H, 3H-pyrrolo[1,2-c]thiazole-7-carboxamide derivatives and pharmaceutical compositions containi |
February 4, 1992 |
| New derivatives of formula (I) in which R.sub.1 =H, halogen, alkyl, alkyloxy, CF.sub.3, NH.sub.2, alkylamino, dialkylamino, OH, CH, phenyl or phenoxy, Ar=phenyl, naphthyl, pyridyl, quinolyl, isoquinolyl, thienyl, thieno[2,3-b]thienyl or thieno[3,2-b]thienyl (these groups optionally s |
| 5077052 |
Chitosan derivatives useful in compositions for coating feedstuff additives intended for ruminan |
December 31, 1991 |
| Novel organosoluble derivatives of chitosan, useful in coating biologically active feedstuff additives intended for ruminants, to provide coatings which are stable at a pH greater than 5 and which release the biologically active substance at a pH below 3.5, consist of a random chain of u |
| 5068238 |
2-alkyliminobenzothiazoline derivatives, processes for preparing them and medicinal products con |
November 26, 1991 |
| Compounds of formula: ##STR1## R.sub.1 represents a polyfluoroalkoxy radical, R.sub.2 represents an alkylthioalkyl, alkylsulphinylalkyl or alkylsulphonylalkyl radical, andR.sub.3 represents an alkyl radical,as well as the salts of these compounds with an inorganic or organic acid, pr |
| 5068214 |
Process for the preparation of a catalyst |
November 26, 1991 |
| This invention relates to a process for preparation of a platinum-cobalt bi-metallic catalyst having an alloy structure. |
| 5064843 |
Pyrid-3-yl thioformamide compounds which have useful pharmaceutical utilities |
November 12, 1991 |
| This invention relates to a thioformamide derivative of the formula I ##STR1## wherein: R and R.sup.1 each independently represent an alkyl group;A represents either:(1) a phenyl group which is optionally substituted; or(2) a heteroaromatic group (e.g. pyrid-3-yl, quinolin-3-yl); andY repres |
| 5049669 |
Analgesic phenothiazine derivatives |
September 17, 1991 |
| Phenothiazine derivatives of general formula (I), in which R is a linear or branched (1 to 6 C) alkyl radical and R.sub.1 and R.sub.2, which may be identical or different, are linear or branched (1 to 4 C) alkyl radicals or form, with the nitrogen atom to which they are attached, a 4- to |
| 5049574 |
5-trifluormethoxy-2-benzimidazolamine compounds |
September 17, 1991 |
| 5-Trifluoromethoxy-2-benzimidazolamine and its salts with an inorganic or organic acid, its preparation and medicinal products containing it. |
| 5036075 |
Derivatives of (AZA) naphthalensultam, their preparation and compositions containing them |
July 30, 1991 |
| This invention relates to a compound of the formula: ##STR1## in which R.sub.1 representsa 1,2,3,6-tetrahydro-1-pyridyl radical substituted in the 4-position.a 1-piperazinyl radical substituted in the 4-position.a piperidino radical substituted in the 4-positioneither:R.sub.2 and R.sub.3, wh |
| 5034329 |
Process for the preparation of optically active 2-arylalkanoic acids |
July 23, 1991 |
| Optically active 2-arylalkanoic acids are made by enantioselective hydrolysis of the corresponding racemic amides in the presence of a microorganism, or of an enzyme derived therefrom, able selectively to hydrolyse racemic .alpha.-phenylpropionamide to S .alpha.-phenylpropionic acid. |
| 5026846 |
Process for the preparation of diaryl sulphides and diaryl selenides |
June 25, 1991 |
| Diaryl sulphides and diaryl selenides of formula:where X=S or Se and Ar=aryl are made by the action of sulphur and sulphur dioxide or selenium and selenium dioxide on a compound of formula:The process is especially useful for the preparation of phenothiazines of formula ##STR1## in w |
| 5026717 |
2-imino-6-polyfluoroalkoxybenzothiazole derivatives, and pharmaceutical compositions containing |
June 25, 1991 |
| Compounds of formula: ##STR1## and their salts, in which R.sub.1 represents polyfluoroalkoxy, and R.sub.2 represents alkyl, alkenyl (3-6 C), [cycloalkyl (3-6 C)]-alkyl, carbamoylalkyl, dialkylcarbamoylalkyl, acylaminoalkyl, phenylthioalkyl, hydroxyalkyl, cyanoalkyl, sulphamoyleth |
| 5025013 |
Benzopyran derivatives, their preparation and pharmaceutical compositions containing them |
June 18, 1991 |
| New benzopyran derivatives of general formula (I) in which:R.sub.1 represents a hydrogen or halogen atom or a hydroxy, alkyloxy, nitro, amino, alkylsulphonamido or acylamino radical,R represents(1) radical ##STR1## R.sub.2 and R.sub.3, which may be identical or different, being H, h |
| 5023361 |
Process for preparing hydroxyalkylating agents, the agents so obtained, and their use |
June 11, 1991 |
| Hydroxyalkylating agents of formula: ##STR1## in which R denotes alkyl, n is 2 or 3, R.sub.1 denotes hydrogen or alkyl and R.sub.2 denotes alkyl an unsubstituted or substituted phenyl or ##STR2## are useful inter alia for the preparation of 1-(hydroxyalkyl)imidazoles. They ar |
| 5021420 |
Derivatives of (AZA)naphthalenesultam, their preparation and compositions containing them |
June 4, 1991 |
| This invention relates to a compound ##STR1## in which R.sub.1 representsa 1,2,3,6-tetrahydro-1-pyridyl radical substituted in the 4-position by (a) a phenyl radical, (b) a phenyl radical substituted by a halogen atom or an alkyl, hydroxy or alkoxy radical, (c) a 3-indolyl radical, ( |
| 5017576 |
Quinolyloxyacetamides |
May 21, 1991 |
| Quinoline derivatives of formula: ##STR1## in which either R.sub.1 denotes trifluoromethyl, R.sub.2 and R.sub.3 form, together with the nitrogen atom to which they are attached, morpholino and R.sub.4 denotes a 4-methylphenyl, 4-chlorophenyl, 2-, 3- or 4-fluorophenyl, 4-methoxyph |
| 5013855 |
Process for the preparation of aromatic ethers |
May 7, 1991 |
| A process for the preparation of an aromatic ether of general formula: ##STR1## by the action of 3-chloro-1,2-propanediol sulfate on a phenol of general formula:in the presence of an inorganic base.Use of a product obtained according to the process for the preparation of adrenergic . |
| 5008280 |
2-iminobenzothiazoline derivatives, their preparation and pharmaceutical compositions containing |
April 16, 1991 |
| Compounds of the formula: ##STR1## in which - R.sub.1 denotes a polyfluoroalkoxy or polyfluoroalkyl radical, and - R.sub.2 denoteseither a chain --CH.sub.2 --(CH(R.sub.4)).sub.n --R.sub.3, in which R.sub.3 denotes a dialkylamino, piperidino, 1-pyrrolidinyl, mercapto, acylthio, al |
| 5006546 |
Imidazole derivatives |
April 9, 1991 |
| The invention provides: (2S,4R,6S)-6-[(4,5-diphenylimidazol-2-yl)thiomethyl]-4-hydroxy-2-methoxy-3 ,4,5,6-tetrahydro-2H-pyran and (2R,4R,6S)-6-[(4,5-diphenylimidazol-2-yl)thiomethyl]-4-hydroxy-2-methoxy-3 ,4,5,6-tetrahydro-2H-pyran or a mixture thereof; the compounds are anti-ather |
| 5003110 |
Process for the preparation of saturated aldehydes by hydrogenation of .alpha.,.beta.-unsaturate |
March 26, 1991 |
| Saturated aldehydes are prepared by hydrogenation of .alpha.,.beta.-unsaturated aldehydes in a two-phase medium in the presence of a catalyst consisting of a rhodium derivative combined with a water-soluble ligand or of a rhodium complex with a water-soluble ligand. |
| 4994569 |
5,6-dihydro-4H-1,3-oxa(or thia)zine derivatives, their preparation and compositions containing t |
February 19, 1991 |
| Compounds of formula: ##STR1## in which R.sub.1 denotes 2-indolyl, 2-thienyl, 3-furyl, naphthyl, phenyl, or phenyl substituted with one or two halogen atoms, with alkoxy, alkyl, nitro, acylamino, alkylthio, acyl, trifluoromethoxy, morpholino, piperidino, amino, mono- or dialkylam |
| 4994470 |
Benzopyran derivatives and pharmaceutical compositions containing them |
February 19, 1991 |
| New benzopyran derivatives of general formula (I) in which:R.sub.1 denotes a hydrogen or halogen atom or a hydroxy, alkyloxy, nitro, amino, alkylsulphonamido, bis(alkylsulphonyl)amino, or acylamino radical,R denotes a radical of general formula: ##STR1## in which A denotes a single bond |
| 4990441 |
Process for separating 2-keto-L-gulonic acid from a fermented medium |
February 5, 1991 |
| 2-Keto-L-gulonic acid is separated from a fermented medium containing the calcium salt of 2-keto-L-gulonic acid, by carrying out the following operations: separation of insolubles; removal of inorganic cations; and separation of the 2-keto-L-gulonic acid. |
| 4983403 |
Granules for feeding ruminants with an enzymatically degradable coating |
January 8, 1991 |
| Granules containing feed additives for ruminants are coated with an enzymatically degradable composition, consisting of: zein in combination with a non-water-soluble polymer and optionally a plasticizing agent, or zein in combination with a hydrophobic substance and optionally a non- |
| 4973768 |
Process for the preparation of unsaturated alcohols |
November 27, 1990 |
| Unsaturated alcohols are prepared by hydrogenation of the corresponding carbonyl compounds in the presence of a platinum-cobalt bi-metallic catalyst having an alloy structure. |
