| Patent Number |
Title Of Patent |
Date Issued |
| 6312946 |
Viable contaminant particle free adenoviruses, their prepartion and use |
November 6, 2001 |
| Novel adenovirus-derived viral vectors, the preparation thereof, and their use in gene therapy, are disclosed. In particular, recombinant adenoviruses including an adenovirus genome wherein (i) the E1 region is inactivated, (ii) the genomic organization is modified, and (iii) optional |
| 6300375 |
Sodium oxamate for the treatment of diabetic conditions |
October 9, 2001 |
| The present invention relates to mixtures which can be isolated from grains of Eugenis Jambolana Lamarck, the preparation of such mixtures, the medicaments containing said mixtures or constituents of said mixtures, and the use of these mixtures and constituents for the preparation of a |
| 6294377 |
Adenoviral vectors of canine origin |
September 25, 2001 |
| The present invention resides in use of a recombinant adenovirus of animal origin containing a heterologous DNA sequence for the preparation of a pharmaceutical composition intended for the therapeutic and/or surgical treatment of the human body. |
| 6291679 |
Process for preparing benzoperhydroisoindole compounds |
September 18, 2001 |
| The present invention relates to a novel process for the preparation of benzoperhydroisindole compounds. |
| 6288075 |
Thiazolo[5,4,3-ij]quinolines, preparation and medicines containing the same |
September 11, 2001 |
| Compounds of formula (I): ##STR1##their racemates, enantiomers, diastereoisomers and inorganic acid salts and organic acid salts thereof, processes for preparing them and the medicaments containing them are discussed. |
| 6287762 |
Purification of a triple helix formation with an immobilized oligonucleotide |
September 11, 2001 |
| Method for double-stranded DNA purification, by which a solution containing said DNA in a mixture with other components is passed over a support on which is covalently coupled in oligonucleotide capable of hybridizing with a specific sequence present on said DNA to form a triple helix. |
| 6261807 |
Method for preparing a recombinant adenovirus genome |
July 17, 2001 |
| A novel method for preparing recombinant adenoviruses and the use of such adenoviruses in gene therapy are disclosed. Plasmids used in the construction of said adenoviruses are also disclosed. |
| 6239270 |
Nucleic acids encoding human calcium sensor protein |
May 29, 2001 |
| The present invention relates to the isolation of a cDNA clone encoding the calcium sensor in human placenta and subsequent Northern blots confirming the mRNA expression also in human parathyroid and kidney tubule cells. Close sequence similarity is demonstrated with the rat Heymann neph |
| 6235497 |
Recombinant expression of the rat vesicular acetylcholine transporter |
May 22, 2001 |
| A nucleic sequence coding for a protein involved in the vesicular transport of acetylcholine, the corresponding protein and the promoter sequences implicated in expressing said protein are disclosed. The invention also discloses expression vectors containing said sequence and the therape |
| 6210963 |
Recombinant cells from the monocyte-macrophage cell line for gene therapy |
April 3, 2001 |
| Cell compositions containing mononuclear phagocyte systems cells, and their use in cell therapy, e.g. adoptive immunotherapy, are disclosed. |
| 6210879 |
Method for diagnosing schizophrenia |
April 3, 2001 |
| The present invention relates to a method for diagnosing schizophrenia, said method being based on the detection in vitro of the presence of the allele Ep of the microsatellite HUNTH01 in the gene TH. The invention also relates to the primers used for implementing said method. |
| 6207675 |
Pyrrole derivatives, their preparation and pharmaceutical compositions containing them |
March 27, 2001 |
| The invention concerns pyrrole derivatives of general formula (I) useful for treatment and prevention of diseases in which are involved viruses of the herpes family and/or cytokines in particular TNF.alpha.. ##STR1## |
| 6200798 |
Defective recombinant adenoviruses with inactivated IVa2 gene |
March 13, 2001 |
| The present invention relates to new viral vectors derived from adenoviruses, their preparation and utilization in gene therapy. It relates particularly to defective recombinant adenoviruses wherein the Iva2 gene at least is inactivated. |
| 6197980 |
4-Acetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1.beta.,7.beta.,10.beta.-tri hydroxy-9-oxo-11-taxe |
March 6, 2001 |
| 4-acetoxy-2.alpha.-benzoyloxy-5.beta., 20-epoxy-1.beta., 7.beta., 10.beta.-trihydroxy-9-oxo-11-taxen-13.alpha.-y1(2R,3S)-3-t-butoxycarbonyla mino-3-phenyl-2-hydroxypropionate trihydrate obtained by a process of centrifugal partition chromatography. |
| 6194582 |
Taxoids, their preparation and pharmaceutical compositions containing them |
February 27, 2001 |
| New taxoids of general formula (I), their preparation, and pharmaceutical compounds containing them. ##STR1##In general formula (I), for example,Ar represents an aryl radical,R represents an alkoxyacetyl radical,R.sub.1 represents a benzoyl radical or a radical of formula R.sub.2 --O--CO |
| 6194412 |
Mixtures derived from grains of Eugenia Jambolana Lamarck preparation and use of said mixtures a |
February 27, 2001 |
| The present invention relates to mixtures which can be isolated from grains of Eugenis Jambolana Lamarck, the preparation of such mixtures, the medicaments containing said mixtures or constituents of said mixtures, and the use of these mixtures and constituents for the preparation of a |
| 6187746 |
Pharmaceutical compositions based on dalfopristine and on quinupristine, and preparation thereof |
February 13, 2001 |
| The present invention relates to injectable compositions containing a dalfopristine/quinupristine combination comprising an aqueous solution containing the dalfopristine/quinopristine combination and an additive intended to avoid or reduce the intolerance effects at the site of injec |
| 6180362 |
Peptides which inhibit ras protein activity, their preparation and use |
January 30, 2001 |
| Peptides capable of inhibiting the transforming activity of activated p21 proteins, their preparation and compositions containing them are disclosed. Particular regions of the GAP protein have been identified and characterized that are involved in the transduction of activation signals |
| 6160135 |
Taxoids, preparation thereof and pharmaceutical compositions containing same |
December 12, 2000 |
| Novel taxoids of general formula (I), the preparation thereof and pharmaceutical compositions containing same, are disclosed. In general formula (I), Z is a hydrogen atom or a radical of general formula (H), wherein R.sub.1 is an optionally substituted benzoyl radical or a radical R. |
| 6156789 |
Method for treating abnormal cell proliferation in the brain |
December 5, 2000 |
| This invention relates to a method for treating abnormal cell proliferation in the brain by administering a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof: ##STR1## in which R represents a hydrogen atom or an acetyl, alkoxyacetyl or alkyl radical |
| 6156545 |
Biosynthesis method enabling the preparation of cobalamins |
December 5, 2000 |
| The present invention relates to a biosynthetic process for preparing cobalamines. More precisely, it relates to a process for amplifying the production of cobalamines and, more specifically, of coenzyme B.sub.12 by means of recombinant DNA techniques and/or by means of adding a novel |
| 6150387 |
Heterocyclic carboxamide compounds effective in the treatment of drug abuse |
November 21, 2000 |
| This invention relates to the use of heterocyclic carboxamide compounds for preventing or reducing self-administration, by a human or animal patient, of a drug or a substance capable of giving rise to pharmacomania or to overuse. The preferred types of drugs or substances are nicotine, |
| 6146663 |
Stabilized nanoparticles which may be filtered under sterile conditions |
November 14, 2000 |
| This invention relates to stabilized nanoparticles which may be filtered under sterile conditions, comprising at least one hydrophobic, water-insoluble and non-water-dispersible polymer or copolymer (and optionally an active principle) which is emulsified in an aqueous solution or su |
| 6143530 |
Circular DNA expression cassettes for in vivo gene transfer |
November 7, 2000 |
| Double-stranded DNA molecules characterised in that they are circular and in that they essentially include one or more genes of interest. |
| 6143518 |
Method for the production of recombinant proteins, plasmids and modified cells |
November 7, 2000 |
| Expression plasmids comprising a nucleic acid sequence of interest controlled by a T7 bacteriophage promoter and a stabilizing region comprising all or part of the par region of the RP4 plasmid or a derivative thereof. The invention also concerns the use of said plasmids in the produ |
| 6140112 |
Pharmaceutical compositions and their use, namely for the treatment of neurodegenerative disease |
October 31, 2000 |
| The present invention pertains to the use of compounds affecting the activity of transcription factors for the preparation of a pharmaceutical composition for the treatment of neurodegenerative diseases. |
| 6127175 |
Cells for the production of recombinant adenoviruses |
October 3, 2000 |
| The invention relates to cells usable for the production of defective adenoviruses comprising, inserted into their genome, a portion of the region E4 of an adenovirus genome carrying the reading phase ORF6 under the control of a functional promoter. |
| 6120805 |
Microspheres, process for their preparation and their use |
September 19, 2000 |
| Biocompatible microspheres containing one or more active principals, a biodegradable and biocompatible polymer and a surface-active agent which is also biodegradable and biocompatible, contain less than 10 ppm of heavy metals. These microspheres are prepared by providing a solution of th |
| 6117649 |
Genetically engineered yeast strains |
September 12, 2000 |
| Yeast strains expressing human genes coding regulating cytochrome P450 expression, a method for making same and applications thereof are described. |
| 6114550 |
Method for the stereo-selective preparation of a derivative of .beta.-phenyl-isoserine and its u |
September 5, 2000 |
| A .beta.-phenylisoserine derivative of general formula (I): ##STR1## in the form of a salt or an ester, in which Ar represent an aryl radical, R represents a phenyl or naphthyl or a O--R.sub.1 radical and G.sub.1 represents --CH.sub.2 --Ph radical; and a method of using the same for |
| 6107286 |
Lipopolyamines as transfection agents and pharamaceutical uses thereof |
August 22, 2000 |
| Cationic lipids of general formula (I), wherein m is an integer from 2 to 6 inclusive; n is an integer from 1 to 9 inclusive, preferably 1-5, where, when n is 2-9, a single R grouping other than hydrogen is present in the general formula, and m has variable or identical values within the |
| 6100264 |
5H, 10H-imidazo [1,2-A] indeno [1,2-E] pyrazin-4-one derivatives, their preparation, their inter |
August 8, 2000 |
| A compound of the formula ##STR1## in which Ra represents an -alk-COOalk' radical, a --CH.sub.2 --PO(Oalk).sub.2 radical, a --CH.dbd.CH--COOalk' radical or a phenyl radical substituted with an alkoxycarbonyl radical. |
| 6057454 |
1-oxo-1H-inden-2-yl-1H-imidazole-2-carboxylic acid intermediates |
May 2, 2000 |
| A compound of formula (II): ##STR1## in which R is a hydrogen atom or a carboxy, alkoxycarbonyl, --CO--NR.sub.4 R.sub.5, --PO.sub.3 H.sub.2 or --CH.sub.2 OH radical, and R.sub.1 is an -alk-NH.sub.2, -alk-NH--CO--R.sub.3, -alk-COOR.sub.4, -alk-CO--NR.sub.5 R.sub.6 or --CO--NH--R.s |
| 6043375 |
Process for the preparation of an oxazolidinecarboxylic acid which is useful for preparing thera |
March 28, 2000 |
| A method of preparing a taxoid of formula III by esterifying protected baccatin III or deacetylbaccatin III using an oxazolidinecarboxylic acid, or an acid halide, or an acid anhydride thereof. |
| 6040466 |
Taxoids, their preparation and pharmaceutical compositions containing them |
March 21, 2000 |
| New taxoids and methods of preparing new taxoids of general formula (I): ##STR1## in which: R.sub.4 represents an alkanoyloxy radical in which the alkanoyl portion contains 2 to 6 carbon atoms in an unbranched or branched chain, this radical unsubstituted or substituted with one or m |
| 6033885 |
Integrative recombinant adenoviruses, preparation thereof and therapeutical uses thereof |
March 7, 2000 |
| The present invention relates to recombinant adenoviruses having a cassette capable of integrating into the genome of infected cells, their preparation, pharmaceutical compositions containing them, and their use. In particular, the cassette contains at least one inverted terminal repeat |
| 6028245 |
Transgenic animals overexpressing MDM2 |
February 22, 2000 |
| The present invention relates to transgenic, non-human animals overexpressing a MDM2 gene. These animals model MDM2 over-expression associated with human tumors, display a major phenotype characterized by the severe skin disorder ichthyosis, and are useful for identifying compounds f |
| 6022985 |
Process for the preparation of 4-acetoxy-2.alpha.-benzoyloxy-5.beta., 20-epoxy-1, 7.beta.-10 |
February 8, 2000 |
| Process for the preparation of 4-acetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1,7.beta., 10.beta.-trihydroxy-9-oxo-tax-11-en-13.alpha.-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate, characterized in that the 4-acetoxy-2.alpha.-benzoyloxy-5.beta.,20 |
| 6017966 |
Stabilized pharmaceutical compositions containing dobutamine |
January 25, 2000 |
| The present invention concerns stable injectable pharmaceutical compositions comprising dobutamine and ascorbic acid, or a salt thereof, and processes to prepare such compositions. |
| 6013662 |
Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contai |
January 11, 2000 |
| Novel products of formula (I), their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments. ##STR1## In the formula (I), the following substituents are among the preferred: Ar represents a substituted or condensed phenyl r |
| 6013240 |
Nucleic acid containing composition, preparation and uses of same |
January 11, 2000 |
| Compositions containing one or more nucleic acids and cationic polymers, and their use in gene therapy, particularly for in vivo nucleic acid transfer. |
| 6008385 |
Process for the purification of taxoids |
December 28, 1999 |
| A method for purifying taxoids (Taxotere, 10-deacetylbaccatin III) by centrifugal partition chromatography. |
| 6002022 |
Method for preparing 4, 10-diacetoxy-2.alpha.-benzoyloxy-5.beta., 20-Epoxy-1, 7.beta.-dihydr |
December 14, 1999 |
| A process for the preparation of 4,10-diacetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1,7.beta.-dihydroxy-9- oxo-tax-11-en-13.alpha.-yl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropionate trihydrate by crystallization from a water/alcohol solution. |
| 6001631 |
Topoisomerase IV, corresponding nucleotide sequences and uses thereof |
December 14, 1999 |
| A novel topoisomerase IV, nucleotide sequences coding for said enzyme, corresponding vectors, and the use of said enzyme for screening biologically active materials. |
| 5994338 |
Stabilized pharmaceutical compositions, with quinupristine and dalfopristine base and their prep |
November 30, 1999 |
| A stabilized pharmaceutical composition having a combined quinupristine/dalfopristine base and containing an at least stoichiometric amount of methanesulphonic acid or hydrochloric acid and being characterized in that its pH ranges from about 3.5 to about 5. Methods of making and usi |
| 5994299 |
Cyclosporin compounds, their preparation and the pharmaceutical compositions which contain them |
November 30, 1999 |
| Cyclosporin compounds of formula (I): ##STR1## wherein Alk and R are as defined herein, or a pharmaceutically acceptable salt thereof, which derivatives are useful in the treatment and/or prophylaxis of retrovirus infections. |
| 5990108 |
5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one derivatives, preparation thereof, intermediates |
November 23, 1999 |
| Compounds of formula (I), wherein R is a hydrogen atom or a --COOH, -alk-COOH, --PO.sub.3 H.sub.2, --CH.sub.2 --PO.sub.3 H.sub.2, or --CH.dbd.CH--COOH radical, or a phenyl radical substituted by a carboxy radical, R.sub.1 is an alk-CN, -alk-COOH, -alk-Het, alk-PO.sub.3 H.sub.2 or -al |
| 5977375 |
Esters of baccatin III and 10-deacetylbaccatin III |
November 2, 1999 |
| A compound of the formula I: ##STR1## wherein Ar represents an aryl radical;R.sub.1 represents a hydrogen atom, an aroyl radical, or a radical of the formula R.sub.4 --O--CO;R.sub.2 and R.sub.3 together form a 5- or 6-membered saturated heterocycle;G.sub.1 represents an acetyl radical or |
| 5977067 |
Cyclosporin derivatives, their preparation and the pharmaceutical compositions which contain the |
November 2, 1999 |
| Cyclosporin derivatives of formula (I) in which R is H or a radical (Ia) or (Ib) as defined herein; R' is a radical (Ic) or (Id) as defined herein; and R"represents H or OH, with the proviso that R and R" are not simultaneously H, and pharmaceutically acceptable salts thereof, when they |
| 5972342 |
Mixtures derived from grains of eugenia jambolana lamarck, preparation and use of said mixtures |
October 26, 1999 |
| The present invention relates to mixtures which can be isolated from grains of Eugenis Jambolana Lamarck, the preparation of such mixtures, the medicaments containing said mixtures or constituents of said mixtures, and the use of these mixtures and constituents for the preparation of a |
