| Patent Number |
Title Of Patent |
Date Issued |
| 7276348 |
Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof |
October 2, 2007 |
| The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of condi |
| 7268148 |
Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading e |
September 11, 2007 |
| Acne-affected skin has been found to be accompanied by the presence of matrix-degrading enzymes such as MMPs and neutrophil elastase, induction of neutrophils, and a reduction in procollagen biosynthesis. This invention treats scarring and inflammation accompanying acne by administer |
| 7267954 |
Methods for the detection of variant cayman ataxia nucleic acids |
September 11, 2007 |
| The present invention relates to ataxia, in particular to protein and nucleic acids encoding proteins associated with ataxia. The present invention provides assays for the detection of ataxia polymorphisms and mutations associated with disease or disease carrier states. |
| 7256277 |
Nucleotide and protein sequence of mammastatin and methods of use |
August 14, 2007 |
| A nucleic acid sequence encoding Mammastatin, a specific mammary cell growth inhibitor. Mammastatin is encoded by a single nucleic acid sequence and has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phospho |
| 7253271 |
BSND nucleic acids and proteins |
August 7, 2007 |
| The present invention relates to the BSND (barttin) protein and nucleic acids encoding the BSND protein. The present invention provides assays for the detection of BSND and barttin polymorphisms and mutations associated with disease states. |
| 7244557 |
Method of screening modulators of Nod1 signaling |
July 17, 2007 |
| The present invention relates to intracellular signaling molecules, in particular the Nod1 protein. The present invention provides methods of identifying modulators of Nod1 signaling. The present invention further provides methods of altering Nod1 signaling. |
| 7229814 |
Nucleic acids and polypeptides involved in the production of cryptophycin |
June 12, 2007 |
| The present invention provides polypeptides involved in cryptophycin biosynthesis and the nucleic acid molecules that encode such polypeptides. The nucleic acid molecules and polypeptides of the invention or variants thereof can be used in the methods of the invention to produce cryp |
| 7229774 |
Expression profile of prostate cancer |
June 12, 2007 |
| The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. Genes identified as cancer markers using the methods of |
| 7220739 |
Therapeutic application of pro-apoptotic benzodiazepines |
May 22, 2007 |
| Benzodiazepine compounds, and methods for using those compounds are provided. Some of the benzodiazepine compounds include 1,4-benzodiazepine-2-one and 1,4-benzodiazepine-2,5-dione compounds of the following structures: ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 ar |
| 7211654 |
Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on |
May 1, 2007 |
| A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surfac |
| 7208154 |
Methods and compositions for the treatment of MHC-associated conditions |
April 24, 2007 |
| The present invention relates to methods and compositions for counteracting and reversing disease-causing signaling defects in disorders with underlying signal transduction aberrations, including but not limited to rheumatoid arthritis. |
| 7202045 |
Detection and treatment of cancers of the lung |
April 10, 2007 |
| The present invention relates to compositions and methods for cancer therapies and diagnostics, including but not limited to, cancer markers. In particular, the present invention provides tumor antigens associated with specific cancers and diagnostic assays for the detection of such |
| 7189865 |
Thiomolybdate analogues and uses thereof |
March 13, 2007 |
| The current invention provides novel thiomolybdate derivatives, methods of making novel thiomolybdate derivatives, pharmaceutical compositions of novel thiomolybdate derivatives, methods of using novel thiomolybdate derivatives to treat diseases associated with aberrant vascularization, |
| 7186712 |
Compositions and methods relating to novel compounds and targets thereof |
March 6, 2007 |
| The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of condi |
| 7175843 |
Methods for selectively stimulating proliferation of T cells |
February 13, 2007 |
| Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous |
| 7173010 |
Orphanin FQ receptor |
February 6, 2007 |
| The present invention provides Orphanin FQ receptor nucleic acids and polypeptides and uses thereof. In particular, the present invention provides nucleic acid sequences of differentially expressed splice variants of the Orphanin FQ receptor. The present invention also provides metho |
| 7147863 |
UVA (> 360-400) and UVB (300-325) specific sunscreens |
December 12, 2006 |
| UVB radiation of about 300-310 nm wavelength and UVA radiation of about 380-390 nm wavelength, each of which exists in solar light, induces MMPs (matrix metalloproteinases) in human skin that degrade the collagen of the dermal matrix. This degradation contributes to photoaging of human |
| 7144880 |
Compositions relating to novel compounds and targets thereof |
December 5, 2006 |
| The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of condi |
| 7135611 |
Compositions and methods for characterizing and regulating Wnt pathways |
November 14, 2006 |
| The present invention relates to transgenic animal models for altered Wnt expression. The present invention also provides methods for generating animal models and screening methods for identifying biologically active compounds. |
| 7125866 |
Therapeutic applications of pro-apoptotic benzodiazepines |
October 24, 2006 |
| Benzodiazepinc compounds, and methods for using those compounds are provided. Some of the benzodiazepine compounds include 1,4-benzodiazepine-2-one and 1,4-benzodiazepine-2,5-dione compounds of structures (I) or (II): wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined. The |
| 7115360 |
Isolation and use of solid tumor stem cells |
October 3, 2006 |
| A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give |
| 7112658 |
Orphanin FQ receptor polypeptides |
September 26, 2006 |
| The present invention provides Orphanin FQ receptor nucleic acid sequences. Specifically, the present invention provides nucleic acid sequences of differentially expressed splice variants of the Orphanin FQ receptor. The present invention also provides methods of using the Orphanin F |
| 7108975 |
Atlastin |
September 19, 2006 |
| The present invention relates to methods and compositions of a novel gene and the peptide encoded by the gene. Mutations in the gene, named atlastin, are factors in the disease Hereditary Spastic Paraplegia and related disorders. The present invention will be used for the in the rese |
| 7097972 |
Method and composition for regulating apoptosis |
August 29, 2006 |
| This invention provides non-naturally occurring and isolated naturally occurring nucleic acid molecules which encode proteins designated pro-Yama, p11 Yama and p20 Yama. This invention also provides recombinant polynucleotides coding for these proteins. Also provided by this inventio |
| 7092492 |
Universal radiologic patient positioning marker |
August 15, 2006 |
| The present invention relates to autoradiographic marking devices. In particular, the present invention provides compositions useful for marking X-ray films. |
| 7087582 |
Combination for site-specifically transforming cells in vivo comprising a double-balloon cathete |
August 8, 2006 |
| The present invention provides a combination including a double-balloon catheter and a nucleic acid encoding the cyclin dependent kinase inhibitor p21. The nucleic acid may also encode HLA-B7, an immunotherapeutic agent, a cytokine or a prodrug converting enzyme. |
| 7074893 |
Methods and compositions for the treatment of diseases associated with signal transduction aberr |
July 11, 2006 |
| The present invention relates generally to therapeutic methods and compositions. More particularly, methods and compositions to counteract and reverse disease-causing signaling defects in diseases with underlying signal transduction aberrations, including but not limited to Alzheimer's |
| 7069151 |
Mapping of differential display of proteins |
June 27, 2006 |
| The present invention relates to protein separation systems and methods capable of resolving and characterizing large numbers of cellular proteins. In particular, the present invention provides a novel mass mapping system and methods for the differential display of proteins. The pres |
| 7060493 |
Nod2 nucleic acids and proteins |
June 13, 2006 |
| The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, |
| 7060442 |
Modulators on Nod2 signaling |
June 13, 2006 |
| The present invention relates to intracellular signaling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides methods of identifying modulators of Nod2 signaling. In particular, the present invention additionally provides |
| 7056741 |
Surface transfection and expression procedure |
June 6, 2006 |
| The present invention relates to a method of transfecting cells comprising applying cells directly onto nucleic acids which are immobilized in transfection complexes on a surface and which transfect the cells. Preferably, the nucleic acids are immobilized in an array. In another aspe |
| 7056503 |
Enclosures housing cell-coated supports for treating tumors |
June 6, 2006 |
| The present invention relates to devices, systems and methods for treating tumors. In particular, the present invention relates to enclosures housing cell-coated supports for promoting regression of tumors, such as cancerous tumors, papillomas, and warts. In preferred embodiments, the |
| 7048856 |
Ultrafiltration membrane, device, bioartificial organ, and methods |
May 23, 2006 |
| The present invention relates to ultrafiltration. In particular, the present invention provides a compact ultrafiltration device and methods for generating an ultrafiltrate, both of which can be used for a variety of applications, including, but not limited to filtering blood, diagno |
| 7041491 |
NOD nucleic acids and polypeptides |
May 9, 2006 |
| The present invention relates to the NOD proteins and nucleic acids encoding the NOD proteins. The present invention further provides assays for the detection of NOD polymorphisms and mutations associated with disease states, as well as methods of screening for ligands and modulators |
| 7018841 |
Compositions and methods for the inhibition of neurotransmitter uptake of synaptic vesicles |
March 28, 2006 |
| Compositions and methods for treating neurosynaptic disorder in a subject are described. More specifically, compositions and methods for inhibiting glutamate uptake by synaptic vesicles in a subject are set forth. In one embodiment, the composition is inhibitory protein factor (IPF) and |
| 7001884 |
Eglin c based drugs for treatment of disease |
February 21, 2006 |
| The present invention relates to eglin c variants which inhibit proteases, and in particular to eglin c mutants at adventitious contact sites. The present invention also relates to eglin c variants which comprise mutations in both adventitious contact sites and at reactive loop sites. |
| 6984522 |
Isolation and use of solid tumor stem cells |
January 10, 2006 |
| A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give |
| 6931325 |
Three dimensional protein mapping |
August 16, 2005 |
| The present invention relates to multi-phase protein separation methods capable of resolving and characterizing large numbers of cellular proteins, including methods for efficiently facilitating the transfer of protein samples between separation phases. In particular, the present inv |
| 6916472 |
PON3 and uses thereof |
July 12, 2005 |
| The present invention relates to paraoxonase genes, in particular PON3. The present invention provides isolated nucleotide sequence encoding PON3, wild type and mutant PON3 peptides. The present invention also provides methods for using PON3 to screen compounds for the ability to alter P |
| 6905681 |
Methods for selectively stimulating proliferation of T cells |
June 14, 2005 |
| Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous |
| 6905680 |
Methods of treating HIV infected subjects |
June 14, 2005 |
| Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous |
| 6902933 |
Surface transfection and expression procedure |
June 7, 2005 |
| The present invention relates to a method of transfecting cells comprising applying cells directly onto nucleic acids which are immobilized in transfection complexes on a surface and which transfect the cells. Preferably, the nucleic acids are immobilized in an array. In another aspe |
| 6897067 |
Surface transfection and expression procedure |
May 24, 2005 |
| The present invention relates to a method of transfecting cells comprising applying cells directly onto nucleic acids which are immobilized in transfection complexes on a surface and which transfect the cells. Preferably, the nucleic acids are immobilized in an array. In another aspe |
| 6894154 |
hKIS compositions and methods of use |
May 17, 2005 |
| Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing mutations that prevent their inhibition with serine/threonine kinases. |
| 6890552 |
Manufacturing therapeutic enclosures |
May 10, 2005 |
| Devices and methods for enhancing the healing of wounds, especially chronic wounds (e.g., diabetic wounds), involving the use of keratinocytes are described. Keratinocytes are grown on a transplantable solid support (e.g., collagen-coated beads), and the keratinocyte-coated solid support |
| 6887466 |
Methods for selectively stimulating proliferation of T cells |
May 3, 2005 |
| Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous |
| 6869777 |
Mini-dystrophin nucleic acid sequences |
March 22, 2005 |
| The present invention relates to compositions and methods for expressing mini-dystrophin peptides. In particular, the present invention provides compositions comprising nucleic acid sequences that are shorter than wild-type dystrophin cDNA and that express mini-dystrophin peptides that |
| 6867022 |
Replication deficient adenovirus vectors and methods of making and using them |
March 15, 2005 |
| The invention provides novel replication deficient adenovirus vectors and methods for making and using these viruses. The invention also provides vector systems and kits using a serotype specific strategy for making adenoviral vector preparations substantially free of replication compete |
| 6858391 |
Nod2 nucleic acids and proteins |
February 22, 2005 |
| The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, meth |
| 6855340 |
Copper lowering treatment of inflammatory and fibrotic diseases |
February 15, 2005 |
| The present invention relates generally to the field of prophylaxis and therapy for inflammatory and/or fibrotic diseases which include responses to injuries. In particular, the present invention is related to agents that can bind or complex copper such as thiomolybdate, and to the use o |
