| Patent Number |
Title Of Patent |
Date Issued |
| 7553675 |
Diagnostic assay device having an apparent non-signal line |
June 30, 2009 |
| A test device and method for determining the presence or absence of one or more analytes in a fluid sample, the test device including a support or member bearing a mark thereon, and a matrix or member containing a capture zone. In operation, an observation area in the test device bec |
| 7537937 |
Lateral flow assay device |
May 26, 2009 |
| A test device and method for determining the presence or absence of an analyte in a fluid sample, the test device including a support bearing a mark thereon, and a matrix defining an axial flow path. In operation, an observation area in the test device becomes transparent, thereby allowi |
| 7491551 |
Quantitative lateral flow assays and devices |
February 17, 2009 |
| This invention provides solid phase specific binding lateral flow assay methods, devices and kits for quantitating high and low molecular weight analytes. The methods and devices of the invention employ labelled reagents which are either analyte analogs or complementary specific bind |
| 7291481 |
Assays for trichomonal and other hydrolases |
November 6, 2007 |
| The release by trichomonads of a hydrolase that hydrolyzes a narrowly defined class of substrates at a low pH without interference from hydrolases that are unrelated to trichomoniasis is the basis for a selective diagnostic assay for trichomoniasis that measures hydrolysis of any of |
| 7255832 |
Iconic colorimetric test device with reduced susceptibility to false positive and false negative |
August 14, 2007 |
| Laminated test devices in which positive results are detected by the appearance of a symbol on the surface of the device due to a color change in an indicator in the device are improved by placing the indicator lamina on one side of a light-transmissive substrate sheet and a pigment |
| 7226793 |
Method for adding an apparent non-signal line to a lateral flow assay |
June 5, 2007 |
| A test device and method for determining the presence or absence of an analyte in a fluid sample, the test device including a support bearing a mark thereon, and a matrix defining an axial flow path. In operation, an observation area in the test device becomes transparent, thereby allowi |
| 7179657 |
Method for adding an apparent non-signal line to a rapid diagnostic assay |
February 20, 2007 |
| A test device and method for determining the presence or absence of one or more analytes in a fluid sample, the test device including a support or member bearing a mark thereon, and a matrix or member containing a capture zone. In operation, an observation area in the test device bec |
| 7144742 |
Quantitative lateral flow assays and devices |
December 5, 2006 |
| This invention provides solid phase specific binding lateral flow assay methods, devices and kits for quantitating high and low molecular weight analytes. The methods and devices of the invention employ labelled reagents which are either analyte analogs or complementary specific bind |
| 7041469 |
Assays for trichomonal and other hydrolases |
May 9, 2006 |
| The release by trichomonads of a hydrolase that hydrolyzes a narrowly defined class of substrates at a low pH without interference from hydrolases that are unrelated to trichomoniasis is the basis for a selective diagnostic assay for trichomoniasis that measures hydrolysis of any of |
| 6924153 |
Quantitative lateral flow assays and devices |
August 2, 2005 |
| This invention provides solid phase specific binding lateral flow assay methods, devices and kits for quantitating high and low molecular weight analytes. The methods and devices of the invention employ labelled reagents which are either analyte analogs or complementary specific bind |
| 6855561 |
Method for adding an apparent non-signal line to a lateral flow assay |
February 15, 2005 |
| A test device and method for determining the presence or absence of an analyte in a fluid sample, the test device including a support bearing a mark thereon, and a matrix defining an axial flow path. In operation, an observation area in the test device becomes transparent, thereby allowi |
| 6716593 |
Pyridinium crosslinks assay |
April 6, 2004 |
| Disclosed is a method for measuring a level of pyridinoline and/or deoxypyridinoline in a sample. In the method, a non-hydrolyzed sample containing one or more peptide-bound collagen pyridinium crosslinks selected from the group consisting of pyridinoline, deoxypyridinoline, or both, |
| 6706539 |
Enzyme substrate delivery and product registration in one step enzyme immunoassays |
March 16, 2004 |
| One-step enzyme immunoassays in which enzyme-antibody conjugate or label and enzyme substrate are separated until separation of bound and free enzyme conjugate or label is complete. This separation is accomplished by using variable flow paths, immobilization of substrate at the test line |
| 6656744 |
One-step lateral flow assays |
December 2, 2003 |
| The efficiency and accuracy of one-step lateral flow assays can be improved by employing more efficient binding between participants in labeling and capture. Thus, in addition to analyte/anti-analyte interactions, specific binding is achieved through members of an irrelevant specific bin |
| 6306642 |
Enzyme substrate delivery and product registration in one step enzyme immunoassays |
October 23, 2001 |
| One-step enzyme immunoassays in which enzyme-antibody conjugate or label and enzyme substrate are separated until separation of bound and free enzyme conjugate or label is complete. This separation is accomplished by using variable flow paths, immobilization of substrate at the test line |
| 5939331 |
Red blood cell separation means for specific binding assays |
August 17, 1999 |
| A method and device for detecting the presence, absence or amount of an analyte in a whole blood sample is disclosed. The device comprises four zones, a sample receiving zone, a labeling zone, a capture zone and an absorbent zone. The sample receiving zone contains an irreversibly im |
| 5846751 |
Test kits and methods for detecting H. pylori |
December 8, 1998 |
| A sensitive and specific antigen preparation for the detection of Helicobacter pylori in biological samples is disclosed. The preparation uses a range of antigens derived from size exclusion chromatography of detergent-solubilized H. pylori cells. Serological assays such as ELISA, la |
| 5814455 |
Antigen preparation for detecting H. pylori |
September 29, 1998 |
| A sensitive and specific antigen preparation for the detection of Helicobacter pylori in biological samples is disclosed. The preparation uses a range of antigens derived from size exclusion chromatography of detergent-solubilized H. pylori cells. Serological assays such as ELISA, la |
| 5804452 |
One step urine creatinine assays |
September 8, 1998 |
| The present invention provides devices and methods for the detection of creatinine in biological fluids using lateral flow methodologies. The invention is particularly useful in providing one step creatinine assays for correcting urinary steroid hormone assays. |
| 5786220 |
Assays and devices for distinguishing between normal and abnormal pregnancy |
July 28, 1998 |
| Methods and devices for distinguishing between normal and abnormal pregnancies are provided. The methods rely on determining the concentration of progesterone or progesterone metabolite in a patient sample, where a concentration above a threshold value is indicative of a normal pregn |
| 5783401 |
Immunoenzymatic detection device |
July 21, 1998 |
| A device for detecting the presence of substances, particularly biological materials, contained in a liquid sample is formed of a series of layers of film materials. A first film has a cut-out which forms an upper reservoir for receiving the liquid sample. A first reagent is provided in |
| 5773234 |
Method and device for chlamydia detection |
June 30, 1998 |
| A lateral flow assay device for detecting the presence of Chlamydia antigen in patient's samples comprises a flow matrix including a labelling zone and a capture zone. Labelling complex comprising antibodies specific for an epitope on the lipopolysaccharide antigen of Chlamydia is presen |
| 5770460 |
One-step lateral flow nonbibulous assay |
June 23, 1998 |
| A particularly efficient design for a nonbibulous lateral flow one step assay for an analyte in a biological sample is disclosed. In the improved device of the invention, three zones which are in nonbibulous lateral flow contact are employed: a sample receiving zone, a labeling zone, and |
| 5766961 |
One-step lateral flow nonbibulous assay |
June 16, 1998 |
| A particularly efficient design for a nonbibulous lateral flow one step assay for an analyte in a biological sample is disclosed. In the improved device of the invention, three zones which are in nonbibulous lateral flow contact are employed: a sample receiving zone, a labeling zone, and |
| 5763262 |
Immunodiagnostic device |
June 9, 1998 |
| A device for assaying biological fluids for molecules contained therein comprising a container, material situated in the container for absorbing fluid and in communication with an antibody or antigen impregnated matrix, wherein the matrix is accessible to the exterior of the container th |
| 5741662 |
Direct stain specific binding assays for microorganisms |
April 21, 1998 |
| The present invention provides specific binding solid phase assay methods and kits for the detection of the presence or absence of a microorganism by directly staining the microorganism and specifically capturing the stained microorganism on a solid support. The methods find particular |
| 5686315 |
Assay device for one step detection of analyte |
November 11, 1997 |
| A "one step" device for the detection of analytein clinical assays is disclosed. A visible label comprising a visible moiety and a ligand that binds to or competes with analyte is contained in a fluid conducting membrane or prefilter; and the analyte and associated ligand are conducted |
| 5541069 |
Assay having improved dose response curve |
July 30, 1996 |
| An assay for determining the presence of a threshold concentration of an analyte in a sample comprises first reacting the sample with an amount of anti-analyte selected to reduce the free analyte to a marginally detectable concentration. The sample is then contacted with anti-analyte |
| 5536646 |
Simplified extraction method for bacterial antigens using dried reagents |
July 16, 1996 |
| Polysaccharide antigens characteristic of Group A or B Streptococci are extracted for use in immunodiagnostic assays by a simplified method. The method involves the use of two dried reagents, sodium nitrite and Tris base, and a liquid reagent, acetic acid. |
| 5521102 |
Controlled sensitivity immunochromatographic assay |
May 28, 1996 |
| An improved one-step immunochromatographic assay which involves the binding of a predetermined amount of analyte to an antibody, enabling the control of the assay sensitivity, is disclosed. The system is especially useful as a controlled sensitivity fecal occult blood assay. Antibodies t |
| 5434057 |
Sperm motility assay and devices |
July 18, 1995 |
| The present invention provides devices, methods and kits for assessing fertility potential of semen samples. Semen samples may be assayed by the present invention to identify those samples having more than 20.times.10.sup.6 motile sperm per milliliter, a concentration associated with |
| 5424193 |
Assays employing dyed microorganism labels |
June 13, 1995 |
| The present invention relates generally to test articles and assays for the detection of analytes in biological fluid samples. More particularly, the present invention relates to test articles an assays which employ dyed microorganisms as visual labels to detect suspected analytes. |
| 5415994 |
Lateral flow medical diagnostic assay device with sample extraction means |
May 16, 1995 |
| The present invention provides devices, methods, and kits for treatment and detection of analytes requiring pretreatment in samples. One-step treatment and detection is possible utilizing the devices and methods of the present invention. |
| 5225328 |
Stable alkaline phosphatase compositions with color enhancement and their use in assays |
July 6, 1993 |
| Methods and compositions for membrane flow-through assays using substrate and enzyme conjugate is described. A preferred method of the present invention comprises providing E. coli alkaline phosphatase (ECAP) conjugate, with additional color enhancement provided by combining lithium |
| 5221616 |
Prevention of spontaneous complement activation in mammalian biological fluids |
June 22, 1993 |
| Selected polyhydroxyl compounds, comprising monosaccharides, disaccharides and oligosaccharides, as well as certain of their derivatives, are effective in preventing the spontaneous activation of complement in vitro. The effect is enhanced in the presence of an anticoagulant together wit |
| 5118630 |
Method for determining periodic infertility in females |
June 2, 1992 |
| A natural birth control method comprises observance of the first day of menses followed by measurement of urinary progesterone metabolite levels beginning a predetermined number of days after the first day of menses. Urinary progesterone metabolite measurement is performed on days of |
| 5079170 |
Method of sample transfer using a filter applicator |
January 7, 1992 |
| A sample applicator for use in performing immunoassays comprises a tube defining an internal lumen and having a filter matrix at one end thereof. Sample is drawn into the applicator tube, either using a vacuum bulb or an automated assay device. The sample is filtered as it enters the tub |
