| Patent Number |
Title Of Patent |
Date Issued |
| 7598316 |
Preparation of polymer particles |
October 6, 2009 |
| A process for the preparation of polymer magnetic particles, which comprises: providing a water phase containing magnetic components homogeneously dispersed therein, wherein the water phase is contacted with or further contains a polymerisable metal-containing or organic monomer whic |
| 7553619 |
Detection method using dissociated rolling circle amplification |
June 30, 2009 |
| Disclosed are compositions and methods for detecting small quantities of analytes such as proteins and peptides. The method involves associating a DNA circle with the analyte and subsequent release and rolling circle replication of the circular DNA molecule. In the method, an amplificati |
| 7517969 |
Process for isolating nucleic acid with chaotrope agents and ammonium compounds |
April 14, 2009 |
| A process for isolating nucleic acid from a nucleic acid-containing sample, which comprises: (a) providing a chaotrope; (b) providing a nucleic acid binding solid phase capable of binding nucleic acid in the presence of the chaotrope; (c) providing a source of NH4+ or NH3; (d) contac |
| 7510826 |
Process for the depletion or removal of endotoxins |
March 31, 2009 |
| A process for the depletion or removal of endotoxins from preparations containing active ingredients designated for therapeutical use which are obtained from natural sources by genetic engineering and/or biotechnology by treatment with chromatographic material wherein said natural sour |
| 7456392 |
Use of ultraphobic surfaces having a multitude of hydrophilic areas for analyzing samples |
November 25, 2008 |
| The invention relates to the use of surfaces having hydrophilic and/or oleophilic areas, each of which being completely surrounded by the ultraphobic areas, for analyzing samples. The invention also relates to a method for precisely dosing liquids without contaminating them. |
| 7358047 |
Methods of forming circular nucleic acid probes and uses thereof |
April 15, 2008 |
| The present invention relates generally to a method of amplifying closed circular nucleic acid probes and, more particularly, to a method of amplifying closed circular nucleic acid probes by rolling circle amplification. The method of the present invention is useful in a range of app |
| 7297485 |
Method for nucleic acid amplification that results in low amplification bias |
November 20, 2007 |
| Disclosed are compositions and methods for amplification of nucleic acid sequences of interest. It has been discovered that amplification reactions can produce amplification products of high quality, such as low amplification bias, if performed on an amount of nucleic acid at or over |
| 7285331 |
Ultraphobic surface |
October 23, 2007 |
| The invention relates to a structured surface with ultraphobic properties. Said surface as a surface topography in which the value of the integral of a function S: S(log f)=a(f)f, which gives a relationship between the spatial frequencies f of the individual Fourier components and their |
| 7270953 |
Compositions for isolating and/or stabilising nucleic acids in biological material |
September 18, 2007 |
| The present invention relates to new compositions for isolating and/or stabilising nucleic acids in materials of biological origin. The compositions comprise as an essential ingredient a cationic compound of general formula Y.sup.+R.sub.1R.sub.2R.sub.3R.sub.4X.sup.- wherein Y may rep |
| 7214508 |
Method for coarse purification of cell digests from microorganisms |
May 8, 2007 |
| The present invention relates to the coarse clarification of lysed cell material from microorganisms and particularly to a method of obtaining nucleic acids. In certain embodiments, the present invention provides a method of coarsely clarifying cell lysate from microorganisms that co |
| 7205129 |
Method for reducing artifacts in nucleic acid amplification |
April 17, 2007 |
| Disclosed are compositions and methods useful for reducing the formation of artifacts during nucleic acid amplification reactions. The method uses special oligonucleotides, referred to herein as template-deficient oligonucleotides, that cannot serve as a template for nucleic acid syn |
| 7192744 |
Targeted transfection of cells using a biotinylated dendrimer |
March 20, 2007 |
| The present invention relates to processes for the targeted transfection of cells, compositions which may be used for such processes, and corresponding pharmaceutical compositions for gene therapy. In particular, the invention relates to a process for introducing nucleic acid into ce |
| 7183002 |
Porous ferro- or ferrimagnetic glass particles for isolating molecules |
February 27, 2007 |
| Porous, ferro- or ferrimagnetic, glass particles are described that selectively bind molecules of interest, especially nucleic acid molecules, under appropriate conditions. Methods of preparing the porous, ferro- or ferrimagnetic, glass particles and their use of identifying or separ |
| 7109322 |
Process for the depletion or removal of endotoxins |
September 19, 2006 |
| A process for the depletion or removal of endotoxins from preparations containing active ingredients designated for therapeutical use which are obtained from natural sources by genetic engineering and/or biotechnology by treatment with chromatographic material wherein said natural sour |
| 7074916 |
Process for the separation of double-stranded/single-stranded nucleic acid structures |
July 11, 2006 |
| The present invention pertains to a process for the chromatographic separation of nucleic acid mixtures into their double-stranded and single-stranded nucleic acid fractions by simultaneously absorbing said nucleic acids as a whole to a mineral support, followed by separation into do |
| 7074600 |
Amplification of denatured and stabilized nucleic acids |
July 11, 2006 |
| Disclosed are compositions and a method for amplification of nucleic acid sequences of interest. The disclosed method generally involves replication of a target sequence such that, during replication, the replicated strands are displaced from the target sequence by strand displacemen |
| 7041480 |
Generation of single-strand circular DNA from linear self-annealing segments |
May 9, 2006 |
| The present invention provides a method for the rapid simultaneous production of a plurality of single-stranded DNA circles having a predetermined size and nucleotide sequence using pre-designed hairpin oligonucleotides containing complementary sequences for directing ligation to for |
| 7005266 |
Nucleic acid isolation from stool samples and other inhibitor-rich biological materials |
February 28, 2006 |
| The invention relates to a method for the stabilization, purification or/and isolation of nucleic acids from material samples, in particular, stool samples, which can contain impurities and inhibitors or interfering substances. The invention further relates to a reagent kit for carrying |
| 6992182 |
Method for isolating DNA from biological materials |
January 31, 2006 |
| The invention relates to a method for the stabilization, purification or/and isolation of nucleic acids from biological materials, in particular stool samples which may contain contaminations and interfering substances. Furthermore, a reagent kit suitable for carrying out the method |
| 6959836 |
Dispenser |
November 1, 2005 |
| The invention relates to a dispensing device and a method for dispensing liquids, preferably reagents, in an essentially automated and finely dosed manner. The dispensing device comprises a first duct that is connected to a storage element for storing the liquid to be dispensed. In addit |
| 6946250 |
Process for the separation of double-stranded/single-stranded nucleic acid structures |
September 20, 2005 |
| The present invention pertains to a process for the chromatographic separation of nucleic acid mixtures into their double-stranded and single-stranded nucleic acid fractions by simultaneously absorbing said nucleic acids as a whole to a mineral support, followed by separation into do |
| 6902680 |
Device for selectively filtering under reduced pressure and for vacuum drying sample liquids or |
June 7, 2005 |
| A device for selectively filtering liquid samples in compartments comprising inlet and outlet openings of a carrier body under reduced pressure and vacuum drying of the sample liquid in the area of the outlet openings of the compartments. The device comprises a vacuum pump for produc |
| 6872818 |
Ammonium sulfate for neutralization of inhibitory effects |
March 29, 2005 |
| The present invention provides RNA purification and/or analysis methods that use ammonium sulfate to mitigate or neutralize inhibitory effects of certain molecules. Exemplary inhibitory molecules that interfere with RNA function or analysis are those that bind to or cleave RNA, or stabil |
| 6864100 |
Automated protein purification the multiwell format by vacuum filtration |
March 8, 2005 |
| The invention relates to a process and a reagent kit for obtaining clear solutions containing cell contents from biological samples in a high throughput process, comprising the steps of preparing a plurality of protein-containing solutions which contain insoluble ingredients, in sepa |
| 6861231 |
Suppression of cross-reactivity and non-specific binding by antibodies using protein A |
March 1, 2005 |
| The structure, formation and use of blocked antibodies, especially those blocked with Protein A, or active fragments of Protein A, are disclosed as well as processes of producing such antibodies. The uses of such blocked antibodies to achieve significant reduction in both specific cr |
| 6861213 |
Use of compositions consisting of cationic compounds and proton donors for stabilizing and/or is |
March 1, 2005 |
| The present invention relates to the use of compositions for isolating and/or stabilizing nucleic acids in or from microorganisms--such as prokaryotes, fungi, protozoa or algae. The composition contains, as an essential ingredient, a cationic compound of general formulawherein Y may d |
| 6821757 |
Rapid and simple process for isolation of circular nucleic acids |
November 23, 2004 |
| A method for separating and/or isolating circular nucleic acids from a mixture having different species of nucleic acids other than circular nucleic acids wherein the mixture is treated under alkaline conditions at a pH>8 with a solid matrix consisting essentially of a silica material |
| 6733777 |
Cationic reagents of transfection |
May 11, 2004 |
| Cationic cytofectins and liposomes comprising the same are disclosed which are especially useful for delivering exogenous compounds into cells in vitro and in vivo. The liposomes may comprise (a) a neutral lipid such as dioleoylphosphatidyl-ethanolamine (DOPE) or similar lipid-like compo |
| 6723510 |
Methods for separating particulate substrates from solution while minimizing particle loss |
April 20, 2004 |
| The present invention provides a method for separation of a particulate matrix from a solution while reducing loss of particles during separation steps. Methods are also disclosed for isolation of molecules of interest using affinity particles or beads, wherein at least one step of the |
| 6706858 |
Use of alkanes for contamination-free purification or separation of biopolymers |
March 16, 2004 |
| The present invention relates to the use of alkanes for the contamination-free purification or separation of biopolymers. |
| 6664078 |
Method for the isolation of ccc plasmid DNA |
December 16, 2003 |
| The present invention relates to the production of biomass for the isolation of ccc plasmid DNA comprising culturing a bacterial transformant in a bioreactor containing an antibiotic-free batch medium under batch-conditions and, at the end of the batch phase, feeding under feed-back |
| 6652744 |
Device for filtering and removing fluids |
November 25, 2003 |
| The invention relates to a device for processing, especially for filtering and removing, fluids and fluid remnants in a low-pressure chamber (1). The device comprises a vacuum pump (30) and a separator (16), whereby the low-pressure chamber is connected to the separator via a first line |
| 6617170 |
Method and device for collecting and stabilizing a biological sample |
September 9, 2003 |
| A collection container and method for collecting a predetermined volume of a biological sample, and particularly a whole blood sample, includes at least one gene induction blocking agent in an amount effective to stabilize and inhibit gene induction. The gene induction blocking agent is |
| 6609618 |
Device for the isolation of cell components such as nucleic acids from natural sources |
August 26, 2003 |
| Described is a method of isolating cell components, such as nucleic acids, from natural sources by filtering a sample of the digested natural sources such as cells or cell fragments. The method is characterized in that the sample is passed through a filter, the pore size of which decreas |
| 6602718 |
Method and device for collecting and stabilizing a biological sample |
August 5, 2003 |
| A collection container and method for collecting a predetermined volume of a biological sample, and particularly a whole blood sample, includes an effective amount of at least one stabilizing agent. The stabilizing agent is able to stabilize nucleic acids in the biological sample at the |
| 6586585 |
Method for the size reduction of high-molecular structures |
July 1, 2003 |
| A method for the size reduction of high-molecular structures, in particular high-molecular nucleic acid structures, in samples wherein the high-molecular structures to be size-reduced are passed through a means provided with at least one porous layer the pore size of which decreases |
| 6553824 |
Method for determining pipetted volumes of liquid |
April 29, 2003 |
| A method for determining a volume of liquid is described, wherein the liquid is drawn from a vessel by means of a pipette or is delivered from a pipette into a vessel, respectively. In particular a method is described, wherein as the first step the volume of liquid contained in a vessel |
| 6383393 |
Chromatographic purification and separation process for mixtures of nucleic acids |
May 7, 2002 |
| A method for the purification and separation of nucleic acid mixtures by chromatography including adsorbing the nucleic acids to be separated and purified from a solution with a high concentration of salts (ionic strength) and/or a high concentration of alcohol on a substrate and sub |
| 6315902 |
Device for selectively filtering under reduced pressure and for vacuum drying sample liquids or |
November 13, 2001 |
| A device for selectively filtering liquid samples in compartments comprising inlet and outlet openings of a carrier body under reduced pressure and vacuum drying drops of the sample liquid in the area of the outlet openings of the compartments. The device comprises a vacuum pump for |
| 6300069 |
Generation and amplification of nucleic acids from ribonucleic acids |
October 9, 2001 |
| Novel compositions and methods useful for the generation of nucleic acids from a ribonucleic acid template and further nucleic acid replication are disclosed. It is shown that the generation and amplification of nucleic acids by methods that utilize two or more different polymerases, suc |
| 6297371 |
Process for the preparation of endotoxin-free or endotoxin-depleted nucleic acids and/or oligonu |
October 2, 2001 |
| A process for the isolation and purification of nucleic acids and/or oligonucleotides for use in gene therapy wherein said nucleic acids and/or oligonucleotides are isolated or purified from an essentially biological source, characterized in thatsaid essentially biological sources are ly |
| 6277648 |
Process and a device for the isolation of cell components such as nucleic acids from natural sou |
August 21, 2001 |
| Described is a method of isolating cell components, such as nucleic acids, from natural sources by filtering a sample of the digested natural sources such as cells or cell fragments. The method is characterized in that the sample is passed through a filter, the pore size of which decreas |
| 6274371 |
Process and device for the isolation of cell components, such as nucleic acids, from natural sou |
August 14, 2001 |
| A filtration process for the preparation of nucleic acids from natural sources is disclosed. The sources containing nucleic acids are lysed; the lysate is left to rest for some time; the resulting lysate passes a filter layer. The filter layer is selected from silica gel, aluminum oxide |
| 6258930 |
Process and apparatus for breaking down biological material |
July 10, 2001 |
| The use of multi-well blocks with more than 10 wells is suggested for breaking down biological samples in a ball mill, wherein the process which is to be carried out provides that the biological sample, disposed in a multi-well block with more than 10 wells, is broken down in a ball mill |
| 6242220 |
Method for purifying covalently closed circular DNA |
June 5, 2001 |
| The present invention relates to a method of producing covalently closed circular (ccc) DNA from a cultured cell or unicellular organism, preferably a bacterium, essentially free of genomic DNA. The method of the invention comprises the steps of precipitating a cleared lysate with an |
| 6180778 |
Process for the separation of double-stranded/single-stranded nucleic acid structures |
January 30, 2001 |
| The present invention pertains to a process for the chromatographic separation of nucleic acid mixtures into their double-stranded and single-stranded nucleic acid fractions by simultaneously absorbing said nucleic acids as a whole to a mineral support, followed by separation into do |
| 6150094 |
Use of an osmolyte for reducing or abolishing no-covalent interactions of biological molecules t |
November 21, 2000 |
| The present invention relates to the use of an osmolyte for reducing or abolishing non-covalent interactions of biological molecules to inert surfaces. Furthermore, the present invention relates to kits that may be employed for uses in accordance with the present invention. |
| 6020186 |
Device and process for isolating nucleic acids from cell suspensions |
February 1, 2000 |
| A device and a process for isolating nucleic acids by lysing intact cells and removing nucleic acids emerging from the lysed cells by the following steps:a) the cells are immobilized in a porous matrix, with the size of matrix voids being in the range of the type of cell to be lysed;b) t |
| 5990301 |
Process for the separation and purification of nucleic acids from biological sources |
November 23, 1999 |
| A process for the isolation and purification of nucleic acids and/or oligonucleotides for use in gene therapy wherein nucleic acids and/or oligonucleotides are isolated or purified from an essentially biological source, characterized in thatessentially biological sources are lysed, the f |
| 5795720 |
Process and device for the separation and detection of components of a mixture of materials by t |
August 18, 1998 |
| The invention relates to a process for the separation and detection of components of a mixture of materials by temperature gradient gel electrophoresis, wherein eithera spatial temperature gradient is built up by spatially separated temperature levels, ora time temperature gradient, ora |
