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President and Fellows of Harvard College Patents
Assignee:
President and Fellows of Harvard College
Address:
Cambridge, MA
No. of patents:
799
Patents:


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Patent Number Title Of Patent Date Issued
RE41614 Synthetic analogs of ecteinascidin-743 August 31, 2010
The present invention is directed to the synthesis and characterization of compounds having the formula: ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, .[.R.sub.7, R.sub.8.]. and R.sub.9 are each independently selected from the group consisting of H, OH,
RE32833 Screening vaccines and immunization process January 17, 1989
Mammals are vaccinated against infectious organisms and polypeptides are screened for utility as vaccines by a complementing set of monoclonal antibodies, the first of which antibodies binds specifically to the site on the organism which itself binds specifically to a receptor on a host
RE31672 Polysaccharide antigens September 11, 1984
Culturing Streptococcus agalactiae in a nutrient broth containing at least 10 g/l of glucose while maintaining the pH at 6-8 by the addition of alkaline material produces polysaccharide antigen including a fraction having a molecular size from 8-11.times.10.sup.5 d. By employing a broth
8586131 Liquid films containing nanostructured materials November 19, 2013
The present invention generally relates to liquid films containing nanostructured materials, and, optionally, the use of this arrangement to organize nanostructures and to transfer the nanostructures to a surface. Liquid films containing nanostructures, such as nanoscale wires, can be
8580969 Synthesis of enone intermediate November 12, 2013
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycl
8579842 Enhanced friction of micropatterned surfaces immersed in magnetorheological fluid November 12, 2013
A method and system are provided for that allow for varying stiffness of a system by applying a low magnetic field to magnetorheological (MR) fluid in the system. The method and system include exposed patterns on facing surfaces of sliding structures. The facing patterns contain MR f
8575663 High-sensitivity nanoscale wire sensors November 5, 2013
The present invention generally relates, in some aspects, to nanoscale wire devices and methods for use in determining analytes suspected to be present in a sample. Certain embodiments of the invention provide a nanoscale wire that has improved sensitivity, as the carrier concentrati
8574924 Assay device and method November 5, 2013
An assay method is described, which comprises the steps of immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion of a surface of a microfluidic chamber; passing a fluid sample over the surface and allow
8574837 System for screening agonists/antagonists of cellular signaling pathways November 5, 2013
The present invention identifies a method for investigating the response of a cell membrane-associated protein in a living cell to a drug by labeling the protein with a visual marker, and also selectively labeling the membrane portion of the protein with another visual marker, such that
8569165 Self-aligned barrier and capping layers for interconnects October 29, 2013
An interconnect structure for integrated circuits for copper wires in integrated circuits and methods for making the same are provided. Mn, Cr, or V containing layer forms a barrier against copper diffusing out of the wires, thereby protecting the insulator from premature breakdown, and
8569041 Multiplex automated genome engineering October 29, 2013
The present invention relates to automated methods of introducing multiple nucleic acid sequences into one or more target cells.
8564792 Sub-diffraction limit image resolution in three dimensions October 22, 2013
The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques, including imaging in three dimensions. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less t
8563233 Blood substitute solution October 22, 2013
The invention relates generally to blood substitute solutions and methods for using blood substitute solutions. The solutions may be used in a variety of applications and are particularly suited for use in applications where at least a portion of a host's blood is replaced with a sub
8562998 Targeting of antigen presenting cells with immunonanotherapeutics October 22, 2013
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunof
8299419 Methods, systems, and apparatus for storage, transfer and/or control of information via matter w October 30, 2012
Methods, systems and apparatus for generating atomic traps, and for storing, controlling and transferring information between first and second spatially separated phase-coherent objects, or using a single phase-coherent object. For plural objects, both phase-coherent objects have a m
8298779 Methods, products and treatments for diabetes October 30, 2012
The invention involves assays, diagnostics, kits, and assay components for determining levels of K41-glycated CD59 in subjects. Treatments for subjects based upon levels of K41-glycated CD59 also are provided.
8294891 Non-invasive optical analysis using surface enhanced raman spectroscopy October 23, 2012
In one aspect, a system for use in product packaging is disclosed that includes a polymeric sensing substrate coupled to a package such that a front sensing surface thereof is in contact with a portion of a product, e.g., a fungible product, stored in the package and a back surface t
8293920 Synthesis of enone intermediate October 23, 2012
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycl
8278344 Heterocyclic inhibitors of necroptosis October 2, 2012
The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-.alpha.) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I) and (Ia)-(Ie) and are shown to inhibit TNF-.alpha. induced necroptosis in
8277812 Immunonanotherapeutics that provide IgG humoral response without T-cell antigen October 2, 2012
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides synthetic nanocarriers capable of eliciting an immune system response in the form of antibody production, wherein the nanocarriers lack any T cell
8273532 Capture, recapture, and trapping of molecules with a nanopore September 25, 2012
In a molecular analysis system, there is provided a structure including a nanopore and first and second fluidic reservoirs. The two reservoirs are fluidically connected via the nanopore. A detector is connected to detect molecular species translocation of the nanopore, from one of the tw
8273257 Nanotube processing employing solid-condensed-gas-layers September 25, 2012
In a method for processing a nanotube, a vapor is condensed to a solid condensate layer on a surface of the nanotube and then at least one selected region of the condensate layer is locally removed by directing a beam of energy at the selected region. The nanotube can be processed with
8268879 3-3-di-substituted-oxindoles as inhibitors of translation initiation September 18, 2012
Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative diso
8268564 Methods and applications for stitched DNA barcodes September 18, 2012
Methods of identifying the genotypes of a plurality of single cells, wherein each cell includes a plurality of DNA barcodes, each associated with a genetic mutation or marker, are provided. In particular, methods including linking a plurality of DNA barcodes together to create a stit
8265884 Method to measure the elastic modulus and hardness of thin film on substrate by nanoindentation September 11, 2012
A method of measuring the elastic modulus and hardness of a thin film on substrate using nanoindentation technique is provided. The method includes calculating a series of experimental corrected stiffness and contact radius pairs associated with one or more presumed parameters and in
8262885 Dielectrophoretic tweezers apparatus and methods September 11, 2012
Dielectrophoretic (DEP) tweezers apparatus and methods for various applications, including particle trapping. Two electrodes are disposed on or otherwise constitute an elongated object forming a tip. A voltage is applied across these electrodes to produce a non-uniform electromagnetic
8257931 Regulation of protein synthesis September 4, 2012
A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins. ##STR00001##
8250903 Biological particle collector and method for collecting biological particles August 28, 2012
Provided are devices and methods for the collection of bioaerosols (such as viruses, bacteria, and proteins) from the exhaled breath of humans and/or animals, for the purpose of determining, for example, particle size, generation rate, diseases and interventions for particle release.
8242171 Method for reducing the weight of a subject or inhibiting weight gain in a subject August 14, 2012
Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or
8232584 Nanoscale sensors July 31, 2012
Various aspects of the invention relate to nanoscale wire devices and methods of use for detecting analytes. In one aspect, the invention relates to a nanoscale electrical sensor array device, comprising at least one n-doped semiconductor nanoscale wire and at least one p-doped semic
8231158 Robust compliant adaptive grasper and method of manufacturing same July 31, 2012
A multi-fingered underactuated mechanical grasping system driven by a single actuator, yet can grasp objects spanning a wide range of size, shape, and mass. A member for moving a link relative to a base acts in parallel to a direction of compliance of a joint between the link and the
8227184 Methods for modulating de novo hepatic lipogenesis by modulating XBP-1 activity July 24, 2012
The invention provides methods and compositions for modulating the expression, processing, post-translational modification, stability and/or activity of XBP-1 protein, or a protein in a signal transduction pathway involving XBP-1 to treat dyslipidemias and steatosis disorders. The pr
8222434 Bactobolin analog and synthesis method thereof July 17, 2012
The present inventions are directed to a novel bactobolin analog bactobolin D. The present inventions also are directed to a method of producing a composition comprising at least one bactobolin analog using a bacteria strain comprising a bacterial cell comprising the biosynthetic loc
8222423 Bifunctional histone deacetylase inhibitors July 17, 2012
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel bifunctional, trifunctional, or multifunctional compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts an
8222134 Self-aligned barrier layers for interconnects July 17, 2012
An interconnect structure for integrated circuits incorporates manganese silicate and manganese silicon nitride layers that completely surrounds copper wires in integrated circuits and methods for making the same are provided. The manganese silicate forms a barrier against copper diffusi
8221595 Lift-off patterning processes employing energetically-stimulated local removal of solid-condense July 17, 2012
The invention provides a method for forming a patterned material layer on a structure, by condensing a vapor to a solid condensate layer on a surface of the structure and then localized removal of selected regions of the condensate layer by directing an ion beam at the selected regions,
8211628 Compositions and methods for tissue preservation July 3, 2012
Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of induction of apoptosis
8206992 Cotton thread as a low-cost multi-assay diagnostic platform June 26, 2012
Hydrophilic threads as platforms for inexpensive, low volume, portable diagnostic systems, and methods of making the same are described. A diagnostic system includes a hydrophilic loading thread having an inlet zone at a proximal end; a testing zone at a distal end; and an intermedia
8206914 Evolving new molecular function June 26, 2012
Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of te
8206568 Material deposition techniques for control of solid state aperture surface properties June 26, 2012
The invention provides a method for molecular analysis. In the method, sidewalls are formed extending through a structure between two structure surfaces, to define an aperture. A layer of material is deposited on the aperture sidewalls and the two structure surfaces. The aperture with th
8198405 Stabilized alpha helical peptides and uses thereof June 12, 2012
Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking ("hydrocarbon stapling") moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides
8198059 Activation and transfer cascade for ubiquitin June 12, 2012
A novel activating enzyme for ubiquitin, Uba6, is provided. Compositions and methods for inhibiting ubiquitin via the Uba6 pathway are provided. Methods of identifying novel inhibitors of ubiquitination are also provided. Novel RNAi molecules are also provided.
8193212 Use of huperzine for neuropathic pain June 5, 2012
Methods and compositions containing huperzine are used to prevent and alleviate neuropathic pain. The invention is also directed to methods and compositions for using huperzine for the prevention and/or treatment of neuropathic pain and orthostatic hypotension.
8183178 Iterated branching reaction pathways via nucleic acid-mediated chemistry May 22, 2012
The present invention provides methods and compositions for performing multi-step nucleic acid mediated synthesis of a highly diverse collection of molecules, for example, small molecules and polymers. In the method, in at least two steps, multiple reaction intermediates and/or products
8180717 System for estimating a distribution of message content categories in source data May 15, 2012
A method of computerized content analysis that gives "approximately unbiased and statistically consistent estimates" of a distribution of elements of structured, unstructured, and partially structured source data among a set of categories. In one embodiment, this is done by analyzing
8178907 Nanoscopic wire-based electrical crossbar memory-devices and arrays May 15, 2012
Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction
8178579 Dioxanes and uses thereof May 15, 2012
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): ##STR00001## and pharmaceutically acceptable derivatives thereof, wherein R.sup.1, R.sup.2, R.sup.3
8178316 Evaluating proteins May 15, 2012
The disclosure features methods that include: providing a substrate that includes (i) a nucleic acid (e.g., DNA or RNA) encoding a hybrid amino acid sequence including a test amino acid sequence and an affinity tag, and (ii) a binding agent that recognizes the affinity tag; contacting th
8168159 Compounds for tumor diagnosis and therapy May 1, 2012
The present invention discloses a method for the enzyme-mediated, site-specific, in-vivo precipitation of a water soluble molecule in an animal. The enzyme is either unique to tumor cells, or is produced within a specific site (e.g., tumor) at concentrations that are higher than that
8154354 Nonlinear pulse oscillator methods and apparatus April 10, 2012
Methods and apparatus for implementing stable self-starting and self-sustaining high-speed electrical nonlinear pulse (e.g., soliton, cnoidal wave, or quasi-soliton) oscillators. Chip-scale nonlinear pulse oscillator devices may be fabricated using III-V semiconductor materials (e.g.
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