| Patent Number |
Title Of Patent |
Date Issued |
| D448087 |
Microarray slide cassette |
September 18, 2001 |
|
| 7170597 |
Microplate reader |
January 30, 2007 |
| A method and apparatus for the measurement of radiation, especially fluorescence from samples in assays, wherein a plurality of micro-sample light emitting sites are imaged simultaneously onto a detector array by a plurality of miniature objectives, one for each sample site and focussed |
| 7057726 |
Luminescence imager |
June 6, 2006 |
| A fiber optic epi-fluorescence imaging system in which the optical fibers are rearranged so that the system can be used for measuring luminescence samples. The system comprises at least two optical fibers (32, 46) or bundles of fibers which lead to a CCD camera (74), the fibers or bundle |
| 6969835 |
Imaging assay analysis for microsamples |
November 29, 2005 |
| A system for imaging radiation emitted by assay couples into a photoelectric detector, the system including a fibre optic bundle (100) for conveying light to the detector, wherein a microlens (118), preferably a drum lens, is located at the impact end of the fibre optic bundle to mat |
| 6961125 |
Luminescence imager |
November 1, 2005 |
| A fiber optic epi-fluorescence imaging system in which the optical fibers are rearranged so that the system can be used for measuring luminescence samples. The system comprises at least two optical fibers (32, 46) or bundles of fibers which lead to a CCD camera (74), the fibers or bundle |
| 6791687 |
Imaging system for luminescence assays |
September 14, 2004 |
| Apparatus for detecting light emitted by an assay sample is provided, in which light emitted by the sample is collected for transmission to a photosensitive detector such as a charge coupled device (CCD) (74) by an optical fiber 78 bundle. The cross-sectional area of the optical fiber |
| 6740865 |
Imaging system for luminescence assays |
May 25, 2004 |
| Apparatus for detecting light emitted by assay samples is provided, in which light emitted by the sample is collected for transmission to a charge coupled device camera (74) by an optical fiber bundle. The cross-sectional area of the optical fiber bundle corresponds to the area of th |
| 6646272 |
Fiber optic coupling device for detecting luminescent samples |
November 11, 2003 |
| A fiber optic coupling plate (24) has a sample viewing face for receiving light from a sample (12), an output window (18) for conveying sample originating (emitted) light to an imaging detector and an additional window through which excitation radiation can be projected. A primary li |
| 6635886 |
Biomedical assays |
October 21, 2003 |
| Method of performing a biomedical assay comprising the steps of exciting the sample or samples with incident radiation of a given wavelength, thereby causing the sample to emit radiation of a different wavelength, measuring the quantity of light falling on a detector receiving the em |
| 6608918 |
Method and apparatus for assay analysis |
August 19, 2003 |
| The present invention provides a detection system comprising means (12) for supporting a multiple sample assay (11) in an inspection station, plural addressable photosensitive detector elements in an array (20) which is positioned relative to the inspection station, means (30, 32) for |
| 6592825 |
Microvolume liquid handling system |
July 15, 2003 |
| A microvolume liquid handling system includes a microdispenser employing a piezoelectric transducer attached to a glass capillary, a positive displacement pump for priming and aspirating transfer liquid into the microdispenser, controlling the pressure of the liquid system, and washing |
| 6556299 |
Imaging system for fluorescence assays |
April 29, 2003 |
| An imaging system for fluorescence assays includes a fiber optic coupling plate (20, 24, 26) for transmitting radiation emitted by a sample (18) towards a camera. This is combined with an interference filter (22) so as to enable highly sensitive transmission of radiation to the camera, |
| 6447723 |
Microarray spotting instruments incorporating sensors and methods of using sensors for improving |
September 10, 2002 |
| The disclosed spotting instrument includes one or more sensors that are mechanically fixed to the instrument's printhead. The sensors enable the instrument to detect whether a substrate is mounted in a particular holder of the instrument's substrate station prior to attempting to print s |
| 6422431 |
Microvolume liquid handling system |
July 23, 2002 |
| In one embodiment, a microvolume liquid handling system includes a microdispenser employing a piezoelectric transducer attached to a glass capillary, a positive displacement pump for priming and aspiring transfer liquid into the microdispenser, controlling the pressure of the liquid |
| 6392241 |
Fiber optic coupling device for detecting fluorescence samples |
May 21, 2002 |
| A fibre optic coupling plate (24) has a sample viewing face for receiving light from a sample (12), an output window (18) for conveying sample originating (emitted) light to an imaging detector and an additional window through which excitation radiation can be projected. A primary li |
| 6361745 |
Microarray storage device for use in an automated microarray handling system |
March 26, 2002 |
| A microarray storage device includes a cassette having top, bottom and opposite side walls, the front and rear of the cassette being open. The side walls are formed with a multiplicity of parallel rails spaced along the heights of the walls which define compartments in the cassette for |
| 5457527 |
Microplate forming wells with transparent bottom walls for assays using light measurements |
October 10, 1995 |
| A microplate forms a multiplicity of sample wells for holding samples to be assayed by light emissions or light transmission. The microplate comprises a unitary upper plate and a unitary lower plate. The unitary upper plate forms the side walls of the sample wells, while the unitary lowe |
| 5365783 |
Capacitive sensing system and technique |
November 22, 1994 |
| An arrangement senses a liquid level by monitoring the peak capacitance formed between a probe and the liquid as the probe approaches or departs from the liquid. In an automated system, a computer controls the position of a pipette probe for aspirating or dispensing liquid in the vessel. |
| 5321261 |
Normalization technique for photon-counting luminometer |
June 14, 1994 |
| A normalization system for multi-photodetector single photon counting luminescent measuring systems and a standard for use in the same. The method comprises calculating one or more counting ratios for each photodetector in the single photon counting system and multiplying counts of u |
| 5319436 |
Microplate farming wells with transparent bottom walls for assays using light measurements |
June 7, 1994 |
| A microplate forms a multiplicity of sample wells for holding samples to be assayed by light emissions or light transmission. The plate comprises an upper plate forming the side walls of the sample wells, the side walls being opaque so that light cannot be transmitted between adjacent we |
| 5146093 |
Liquid scintillation measurement system with active guard shield |
September 8, 1992 |
| A low-level liquid scintillation measurement system for counting sample optical events resulting from the radioactive decay of a constituent of a sample to be measured while reducing the counting of background optical events which are optical events produced by background radiation and w |
| 4833326 |
Liquid scintillation measurement system with active guard shield |
May 23, 1989 |
| A low-level liquid scintillation measurement system for counting sample optical events resulting from the radioactive decay of a constituent of a sample to be measured while reducing the counting of background optical events which are optical events produced by background radiation and w |
| 4742226 |
Radionuclide identification in liquid scintillation counting |
May 3, 1988 |
| Apparatus and a method useful for identifying and verifying which radionuclide is present in a test sample for use in a liquid scintillation counter is disclosed. The invention is directed to measuring a quench-indicating parameter of the sample and an external source quench-indicati |
| 4651006 |
Reduced background scintillation counting |
March 17, 1987 |
| A method and apparatus for separating background events from valid sample events in a liquid scintillation counter are disclosed. Upon the detection of a coincident event pulse the number of pulses detected during a short time interval immediately thereafter together with the energy leve |
| 4628205 |
Regionless multiple label scintillation counting |
December 9, 1986 |
| Apparatus and a regionless method of ascertaining the activity of each radionuclide in a dual-label sample. A set of correlation curves is generated utilizing quench standards for both a low energy radionuclide and a high energy radionuclide. A test sample was then counted and the qu |
| 4555629 |
Method and apparatus for determination of sample homogeneity in scintillation counting |
November 26, 1985 |
| A method for ascertaining radiochemical homogeneity in a liquid scintillation sample reliably identifies inaccurate geometries is disclosed so that meaningful activity counts can be determined. The novel method involves measuring the activity level of a set of homogeneous quench stan |
| 4528450 |
Method and apparatus for measuring radioactive decay |
July 9, 1985 |
| Method and apparatus for counting nuclear scintillations of a specimen containing tritium. A simple system using a single photomultiplier tube and suitable circuitry segregates the pulses which are emitted from a scintillator due on interaction with a nuclear particle from the pulses |
| 4258740 |
Fluid flow control device |
March 31, 1981 |
| A fluid flow control device includes a thermally conductive conduit section having both interior and exterior heat exchange surfaces, with the interior surface being adapted to contact fluid flowing thereover. A controllable heat transfer means coupled to the conduit section has a fi |
| 4248259 |
Fluid flow control device |
February 3, 1981 |
| A fluid flow control device includes a thermally conductive conduit section having both interior and exterior heat exchange surfaces, with the interior surface being adapted to contact fluid flowing thereover. A controllable heat transfer means coupled to the conduit section has a fi |
| 4230671 |
Apparatus for processing fluid materials particularly in the preparation of samples for radioact |
October 28, 1980 |
| Method and apparatus for the processing of fluid materials, particularly in the preparation of samples for radioactive isotope tracer studies by combustion of starting materials containing such isotope tracers. The sample is burned in a combustion chamber which tapers upwardly and in |
| 4220855 |
Scintillation counter with rotatable light seal |
September 2, 1980 |
| A light seal for the counting chamber of a scintillation counter comprises a ring shutter mounted in the shielded housing which forms the counting chamber. The ring shutter is mounted for rotation between an open position where an aperture in the ring shutter is aligned with an opening i |
| 4199013 |
Liquid sample aspirating and/or dispensing system |
April 22, 1980 |
| A pipetting system for dispensing multiple liquids into a single receptacle includes a plurality of liquid reservoirs, a plurality of syringes for aspirating preselected quantities of liquids from the reservoirs, and a common dispensing head connected to all the syringes for simultaneous |
| 4148608 |
Method for processing fluid materials particularly in the preparation of samples for radioactive |
April 10, 1979 |
| Method and apparatus for the processing of fluid materials, particularly in the preparation of samples for radioactive isotope tracer studies by combustion of starting materials containing such isotope tracers. The sample is burned in a combustion chamber which tapers upwardly and in |
| 4147250 |
Storage and indexing mechanism for multiple sample containers |
April 3, 1979 |
| A storage and indexing mechanism for a plurality of sample containers includes a portable tray for supporting and guiding the sample containers along preselected indexing paths on the tray. The sample containers can be pre-loaded on the tray with the tray being used for storage and trans |
| 4122936 |
Centering mechanism for movable member within a variable-width passageway |
October 31, 1978 |
| A mechanism for centering a movable member within an elongated passageway of variable width, such as for use in an article transport system of a benchtop scintillation detector or other laboratory sample processor. The centering is performed by a plurality of outwardly bowed guide elemen |
| 4116632 |
Countercurrent combustion system for preparing radioactive samples and the like |
September 26, 1978 |
| A system for combusting materials containing radioactive nuclides to permit recovery of the radioactive nuclides includes a combustion zone for combusting a sample material containing at least one radioactive nuclide. The combustion products are continuously exhausted from one end of the |
| 4002909 |
Data analyzing system having provision for optimizing counting conditions and thus improving sta |
January 11, 1977 |
| A data analyzing system for scintillation spectrometers of the type for measuring activity levels of samples containing radioactive isotopes and subjected to varying degrees of quench, including methods and apparatus for optimizing counting conditions and thereby improving statistical |
| 3999070 |
Composition for use in scintillator systems |
December 21, 1976 |
| A liquid scintillation counting composition of the type comprising ar aromatic hydrocarbon solvent, an ethoxylated alkyl phenol surfactant, and a scintillation solute, contains a small amount of a substituted ethoxylated carboxylate acid and/or a tertiary amine salt or a quaternary a |
| 3979503 |
Method and apparatus for processing fluid materials particularly in the preparation of samples f |
September 7, 1976 |
| Method and apparatus for the processing of fluid materials, particularly in the preparation of samples for radioactive isotope tracer studies by combustion of starting materials containing such isotope tracers. The sample is burned in a combustion chamber which tapers upwardly and in |
| 3957677 |
Composition for use in scintillator systems |
May 18, 1976 |
| A liquid scintillation counting composition of the type comprising an aromatic hydrocarbon solvent, an ethoxylated alkyl phenol surfactant, and a scintillation solute, contains a small amount of a substituted ethoxylated carboxylate acid and/or a tertiary amine salt or a quaternary a |
| 3942938 |
Combustion system for preparing radioactive samples and the like |
March 9, 1976 |
| A combustion system for combusting materials containing radioactive nuclides to permit recovery of the radioactive nuclides. The system comprises a primary combustion zone in which the sample material is initially combusted and from which the combustion products are continuously exha |
