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PDL Biopharma, Inc. Patents
Assignee:
PDL Biopharma, Inc.
Address:
Incline Village, NV
No. of patents:
16
Patents:












Patent Number Title Of Patent Date Issued
7846435 Humanized antibodies that recognize Verotoxin II and cell line producing same December 7, 2010
The invention provides humanized antibodies that specifically bind to, and preferably, neutralize, verotoxin II (VT2). The antibodies are useful for treating patients suffering from, or at risk of suffering, toxic effects of verotoxin.
7435589 Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of October 14, 2008
Described herein are genes whose expression are up-regulated or down-regulated in ovarian cancer. Related methods and compositions that can be used for diagnosis and treatment of ovarian cancer are disclosed. Also described herein are methods that can be used to identify modulators o
7399469 Anti-LFL2 antibodies for the diagnosis, prognosis and treatment of cancer July 15, 2008
Particular anti-LFL2 antibody compositions are provided herein. These antibodies may be used for diagnosis, prognosis, therapeutic monitoring and treatment of cancer, especially breast cancer, head/neck cancer, lung cancer, ovarian cancer, stomach cancer and pancreatic cancer. Furthe
7381803 Humanized antibodies against CD3 June 3, 2008
The invention provides bispecific antibodies with selective cytotoxicity against malignant B-cells. The bispecific antibodies bind to an effector cell antigen and to a 28/32 kDa heterodimeric protein on the surface of malignant B-cells. The invention also includes the monospecific co
7365168 Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis April 29, 2008
The present invention provides for a modified antibody of class IgG, in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250, 314, and 428 is substituted with another amino acid which is different from that p
7361740 Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis April 22, 2008
The present invention provides for a modified antibody of class IgG, in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250, 314, and 428 is substituted with another amino acid which is different from that p
7288248 Antibodies against cancer antigen TMEFF2 and uses thereof October 30, 2007
Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.
7285268 Chimeric and humanized antibodies to .alpha.5.beta.1 integrin that modulate angiogenesis October 23, 2007
The present invention provides chimeric and humanized antibodies that specifically recognize .alpha.5.beta.1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of
7276589 Chimeric and humanized antibodies to .alpha.5.beta.1 integrin that modulate angiogenesis October 2, 2007
The present invention provides chimeric and humanized antibodies that specifically recognize .alpha.5.beta.1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of
7276372 Antibodies against GPR64 and uses thereof October 2, 2007
GPR64 antibody compositions are provided. These antibodies may be used for diagnosis or treatment of cancer, especially ovarian cancer, Ewing's sarcoma, uterine cancer, and other GPR64 expressing tumor types.
7223393 Amphiregulin antibodies and their use to treat cancer and psoriasis May 29, 2007
The present invention is directed to anti-AR antibodies, preferably humanized monoclonal antibodies having the amino acid sequences disclosed herein. The present invention includes a pharmaceutical composition comprising such antibodies. The present invention includes a method of inh
7217798 Alteration of Fc-fusion protein serum half-lives by mutagenesis May 15, 2007
The present invention provides for a modified Fc-fusion protein in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250, 314, and 428 is substituted with another amino acid which is different from that present
7217797 Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis May 15, 2007
The present invention provides for a modified antibody of class IgG, in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250, 314, and 428 is substituted with another amino acid which is different from that p
7189507 Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of March 13, 2007
Described herein are genes whose expression are up-regulated or down-regulated in ovarian cancer. Related methods and compositions that can be used for diagnosis and treatment of ovarian cancer are disclosed. Also described herein are methods that can be used to identify modulators o
7183390 Humanized antibodies to gamma-interferon February 27, 2007
The invention provides humanized immunoglobulins that bind to and neutralize .gamma.-interferon. The antibodies are useful for treatment of diseases of the immune system, particularly autoimmune diseases.
7122185 Anti-CCR5 antibody October 17, 2006
The invention is directed an anti-CCR5 antibody which comprises (i) two light chains, each light chain comprising the expression product of a plasmid designated pVK:HuPRO140-VK (ATCC Deposit Designation PTA-4097), and (ii) two heavy chains, each heavy chain comprising an expression p

 
 
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