| Patent Number |
Title Of Patent |
Date Issued |
| 7455982 |
Automated methods of detecting receptor activity |
November 25, 2008 |
| Methods of detecting G protein-coupled receptor (GPCR) activity in vitro and in vivo are provided. In one embodiment, the method includes providing at least one cell that expresses a GPCR and a plurality of conjugated proteins. Each of the plurality of conjugated proteins is formed b |
| 7387715 |
Sample positioning and analysis system |
June 17, 2008 |
| Systems for positioning and/or analyzing samples such as cells, vesicles, cellular organelles, and fragments, derivatives, and mixtures thereof, for electrical and/or optical analysis, especially relating to the presence and/or activity of ion channels. |
| 7364846 |
Gene expression profiling from FFPE samples |
April 29, 2008 |
| Methods and compositions relating to the generation and use of gene expression data from tissue samples that have been fixed and embedded are provided. The data can electronically stored and implemented as well as used to augment diagnosis and treatment of diseases. |
| 7358064 |
Kits for measuring cellular transmembrane potential changes |
April 15, 2008 |
| The invention encompasses kits for an improved method for measuring membrane potential using compounds of the formula I as potentiometric probes. These probes may be used in combination with other fluorescent indicators such as Indo-1, Fura-2, and Fluo-3, such probes may be used in m |
| 7332292 |
Constitutively translocating cell line |
February 19, 2008 |
| The present invention relates to agonist-independent methods of screening for compounds that alter GPCR desensitization. Included in the present invention are cell lines containing GRKs, in which GPCRs are desensitized in the absence of agonist; the GRKs may be modified. The present |
| 7297503 |
Methods of identifying reduced internalization transmembrane receptor agonists |
November 20, 2007 |
| Described herein are methods of identifying a transmembrane receptor (TMR) agonist and compounds identified by this method. The TMR agonist (TMRA) is capable of activating TMR signaling while exhibiting reduced TMR internalization over a control compound. |
| 7265829 |
Reflective optic system for imaging microplate readers |
September 4, 2007 |
| A reflective light imaging system for use in high-throughput screening of samples disposed in multiple-well plates. The system can include a set of mirrors and lenses. The first mirror has a central aperture through which light from the object passes. The first mirror has a concave refle |
| 7244349 |
Multiaperture sample positioning and analysis system |
July 17, 2007 |
| Systems for positioning and/or analyzing samples such as cells, vesicles, cellular organelles, and fragments, derivatives, and mixtures thereof, for electrical and/or optical analysis, especially relating to the presence and/or activity of ion channels. |
| 7229595 |
Filtration column devices and methods of filtering therewith |
June 12, 2007 |
| This relates to filter columns for isolating nucleic acids. The filter column is adapted for stable placement within the upper portion of standard plastic collection tubes of various sizes. The body of the filter column has a number of surfaces to accommodate placement within various |
| 7201836 |
Multiaperture sample positioning and analysis system |
April 10, 2007 |
| Systems for positioning and/or analyzing samples such as cells, vesicles, cellular organelles, and fragments, derivatives, and mixtures thereof, for electrical and/or optical analysis, especially relating to the presence and/or activity of ion channels. |
| 7163800 |
Methods of screening compositions for G protein-coupled receptor desensitization inhibitory acti |
January 16, 2007 |
| The methods of the present invention allow the screening of a test composition for non-receptor-specific GPCR desensitization inhibitory activity. The methods involve screening a test composition for an indication of GPCR desensitization inhibitory activity against two or more GPCRs |
| 7070921 |
Molecular modification assays |
July 4, 2006 |
| Assays for detecting molecular modifications such as phosphate modifications and the presence and/or activity of enzymes and other agents involved in facilitating or otherwise regulating such modifications. |
| 6995844 |
Determination of light absorption pathlength in a vertical-beam photometer |
February 7, 2006 |
| Disclosed are photometric methods and devices for determining optical pathlength of liquid samples containing analytes dissolved or suspended in a solvent. The methods and devices rely on determining a relationship between the light absorption properties of the solvent and the optical |
| 6992761 |
Broad range light detection system |
January 31, 2006 |
| Broad-range light-detection systems, including components and methods of use thereof. These systems may include apparatus and methods for detecting light with increased speed and/or detection efficiency, particularly in applications involving repeated analysis of the same sample and/ |
| 6982431 |
Sample analysis systems |
January 3, 2006 |
| Systems, and components thereof, for analyzing samples. These systems include apparatus and methods for generating, transmitting, detecting, and/or analyzing light, including without limitation high-throughput optical screening devices for analyzing samples at one or more assay sites |
| 6930314 |
Light detection device |
August 16, 2005 |
| Apparatus and methods for optical illumination and/or detection with improved flexibility and/or read speed. The apparatus and methods may include mechanisms for selecting and switching between multiple excitation wavelengths and/or simultaneously reading from a plurality of sample s |
| 6852504 |
Method for measuring cellular transmembrane potential changes |
February 8, 2005 |
| The invention encompasses an improved method for measuring membrane potential using compounds of the formula I as potentiometric probes. These probes may be used in combination with other fluorescent indicators such as Indo-1, Fura-2, and Fluo-3, such probes may be used in microplate |
| 6825921 |
Multi-mode light detection system |
November 30, 2004 |
| Apparatus and methods for combining multiple modes and methods of optical detection, postprocessing, and/or feedback loops in bioanalytical measurements. The methods may include (1) positioning a composition at an examination site in a multi-mode instrument; (2) detecting light trans |
| 6814454 |
Achromatic beam switch |
November 9, 2004 |
| A light source with multiple parallel beams is combined with a pair of opposing mirrors mounted on a rotating fixture and with a fixed aperture to produce a single output beam. Through the motion of the rotating fixture, the pair of mirrors shifts the location of the output of each i |
| 6800765 |
Fluorescent pH indicators for intracellular assays |
October 5, 2004 |
| Systems, including compositions and methods, for measuring pH, particularly in cells, organelles, and other samples. The compositions include pH-sensitive fluorescent and fluorogenic 2',7'-dialkylfluorescein derivatives and associated nonfluorescent precursor compounds. The compositi |
| 6693709 |
Photometric device |
February 17, 2004 |
| The present invention relates to a photometric device for measuring optical parameters. The invention functions in the ultraviolet light range through use of a monochromator and splits the test light in multiple channels by a rotor assembly, including a mirror. |
| 6550349 |
Pipette tip holder |
April 22, 2003 |
| A pipette nozzle that achieves a consistently high quality seal between the nozzle and the interior surface of a replaceable pipette tip is provided. In one aspect, the end portion of the nozzle is tapered. The tapered nozzle aids pipette tip engagement in an automated system by relaxing |
| 6469311 |
Detection device for light transmitted from a sensed volume |
October 22, 2002 |
| A high-throughput light detection instrument and method are described. In some embodiments, switch mechanisms and optical relay structures permit different light sources and/or detectors to be selected for different applications. In other embodiments, switch mechanisms and optical paths |
| 6404501 |
Determination of light absorption pathlength in a vertical-beam photometer |
June 11, 2002 |
| Disclosed are photometric methods and devices for determining optical pathlength of liquid samples containing analytes dissolved or suspended in a solvent. The methods and devices rely on determining a relationship between the light absorption properties of the solvent and the optical |
| 6320662 |
Determination of light absorption pathlength in a vertical-beam photometer |
November 20, 2001 |
| Disclosed are photometric methods and devices for determining optical pathlength of liquid samples containing analytes dissolved or suspended in a solvent. The methods and devices rely on determining a relationship between the light absorption properties of the solvent and the optical |
| 6316774 |
Optical system for a scanning fluorometer |
November 13, 2001 |
| A method and apparatus for determining the fluorescence, luminescence, or absorption of a sample is provided. The sample may either be contained within a cuvette or within one or more sample wells within a multi-assay plate. A combination of a broadband source, a monochromator, and a ser |
| 6313471 |
Scanning fluorometer |
November 6, 2001 |
| A method and apparatus for determining the fluorescence, luminescence, or absorption of a sample is provided. The sample may either be contained within a cuvette or within one or more sample wells within a multi-assay plate. A combination of a broadband source, a monochromator, and a ser |
| 6291169 |
Hapten derivatized capture membrane and diagnostic assays using such membrane |
September 18, 2001 |
| The present invention encompasses a capture membrane comprising a porous filter membrane having a hapten bound directly or indirectly to the membrane wherein complexes formed by specific binding having an anti-hapten bound to a binding member of the specifically binding complex are r |
| 6236456 |
Optical system for a scanning fluorometer |
May 22, 2001 |
| A method and apparatus for determining the fluorescence, luminescence, or absorption of a sample is provided. The sample may either be contained within a cuvette or within one or more sample wells within a multi-assay plate. A combination of a broadband source, a monochromator, and a ser |
| 6232608 |
Optimization systems in a scanning fluorometer |
May 15, 2001 |
| A method and apparatus for determining the fluorescence, luminescence, or absorption of a sample is provided. The sample may either be contained within a cuvette or within one or more sample wells within a multi-assay plate. A combination of a broadband source, monochromator, and a serie |
| 6188476 |
Determination of light absorption pathlength in a vertical-beam photometer |
February 13, 2001 |
| Disclosed are photometric methods and devices for determining optical pathlength of liquid samples containing analytes dissolved or suspended in a solvent. The methods and devices rely on determining a relationship between the light absorption properties of the solvent and the optical |
| 6151111 |
Photometric device |
November 21, 2000 |
| The present invention relates to a photometric device for measuring optical parameters. The invention functions in the ultraviolet light range through use of a monochromator and splits the test light in multiple channels by a rotor assembly, including a mirror. |
| 6074614 |
Multi-assay plate cover for elimination of meniscus |
June 13, 2000 |
| A constant pathlength multi-assay plate cover for multi-assay plates, comprising, a flat top side and a flat bottom side, the bottom side having solid cylindrical projections of equal length extending downwardly from the flat bottom side, wherein each cylindrical projection is centered |
| 5959738 |
Determination of light absorption pathlength in a vertical-beam photometer |
September 28, 1999 |
| Disclosed are photometric methods and devices for determining optical pathlength of liquid samples containing analytes dissolved or suspended in a solvent. The methods and devices rely on determining a relationship between the light absorption properties of the solvent and the optical |
| 5888728 |
Hapten derivatized capture membrane and diagnostic assays using such membrane |
March 30, 1999 |
| The present invention encompasses a capture membrane comprising a porous filter membrane having a hapten bound directly or indirectly to the membrane wherein complexes formed by specific binding having an anti-hapten bound to a binding member of the specifically binding complex are r |
| 5766875 |
Metabolic monitoring of cells in a microplate reader |
June 16, 1998 |
| The present invention method may be practiced with many different types of biological cells. Biological cells may be either eucaryotic or procaryotic cells. The cells may be in the form of tissue slices or tissue homogenates or may be in the form of suspensions of intact single cells. Th |
| 5614368 |
Chromophoric reagents for incorporation of biotin or other haptens into macromolecules |
March 25, 1997 |
| Compounds and methods for detecting the incorporation of a hapten into a protein or macromolecule are disclosed. The compounds comprise haptens bound directly or indirectly to a chromophoric group and a macromolecule-reactive group, whereby incorporation of the hapten into a protein |
| 5567302 |
Electrochemical system for rapid detection of biochemical agents that catalyze a redox potential |
October 22, 1996 |
| The present invention relates to a system for detecting, in a reliable, precise and highly sensitive manner, biochemical agents such as enzymes that catalyze a redox potential change. One electrode is used to measure redox potential changes in an aqueous electrolyte containing the bi |
| 5557398 |
Photometric device |
September 17, 1996 |
| The present invention relates to a photometric device for measuring optical parameters. The invention functions in the ultraviolet light range through use of a monochromator and splits the test light in multiple channels by a rotor assembly, including a mirror. |
| 5536662 |
Cell assay device |
July 16, 1996 |
| This invention encompasses porous microchambers which contain cells and permit liquid to flow in and out of the chamber while retaining cells within the chamber. These porous microchambers serve as disposable devices for placing cells in a microflowchamber so that properties of the cells |
| 5529752 |
Analytical work station |
June 25, 1996 |
| This invention encompasses a work station for conducting assays which comprises filtering assembly, a slide reading assembly, and a slide with a porous filter membrane wherein the slide has a means for aligning the slide within the filter assembly to filter reagents on predetermined |
| 5501956 |
Polyredox couples in analyte determinations |
March 26, 1996 |
| Enzyme or substrate determinations can be achieved by employing an organic second substrate, which produces a product which may be coupled with a metal inorganic redox couple capable of interacting with and affecting the potential of a metal electrode on a semiconductor surface. Particul |
| 5500188 |
Device for photoresponsive detection and discrimination |
March 19, 1996 |
| Photoresponsive devices including a photoresponsive electrode are provided, and methods for their use to measure changes in environment at a site at or about the surface of the photoresponsive device. By employing a source of light for irradiating a site on the surface and means for bias |
| 5496697 |
Methods and apparatus for detecting the effect of cell affecting agents on living cells |
March 5, 1996 |
| Methods and apparatus are disclosed for detecting the effects of cell affecting agents on living cells. The method steps include providing living cells that are retained in a micro flow chamber. The micro flow chamber is adapted for either continuous or intermittent flow of solutions |
| 5395503 |
Zero volume electrochemical cell |
March 7, 1995 |
| Methods and apparatuses are described for determining the presence of an analyte in a sample suspected of containing the analyte. The method comprises contacting a concentrate of a determinable element capable of being detected by means of a semiconductive electrode with the electrode |
| 5278048 |
Methods for detecting the effect of cell affecting agents on living cells |
January 11, 1994 |
| Methods are disclosed for detecting the effects of cell affecting agents on living cells. The method steps include providing living cells that are retained in a micro flow chamber. The micro flow chamber is adapted for either continuous or intermittent flow of solutions or suspensions in |
| 5180828 |
Chromophoric reagents for incorporation of biotin or other haptens into macromolecules |
January 19, 1993 |
| Compounds and methods for detecting the incorporation of a hapten into a protein or macromolecules are disclosed. The compounds comprise haptens bound directly or indirectly to a chromophoric group and a macromolecules-reactive group, whereby incorporation of the hapten into a protei |
| 5164319 |
Multiple chemically modulated capacitance determination |
November 17, 1992 |
| Apparatus and methods are provided for multiple detection of analytes employing semiconductor capacitance as the signal modulated by the analyte. A plurality of semiconductor capacitors are organized for detection (at individual sites) of changes in capacitance which are related to c |
| 5160702 |
Analyzer with improved rotor structure |
November 3, 1992 |
| An analyzer with an improved rotor structure for analyzing solid-containing and solid free liquids having an improved rotor design that utilizes chambers and channels that operate by centrifugal force and capillary action to separate and meter the liquids for testing purposes. |
| 5112134 |
Single source multi-site photometric measurement system |
May 12, 1992 |
| A multibeam photometric measuring device includes a light assembly comprising a single modulated light source along with a filter assembly for passing only a desired band of wavelengths and an optical system for suitably focusing light from the light source. A plurality of light tran |
