| Patent Number |
Title Of Patent |
Date Issued |
| 7576173 |
Single solvent polymer extraction methods |
August 18, 2009 |
| The present invention provides methods for isolating a PHA. The method comprises combining the PHA, a first solvent and a second solvent to form a combination, the first solvent and the second solvent being capable of forming an azeotrope with the second solvent; and heating the combinat |
| 7553923 |
Medical devices and applications of polyhydroxyalkanoate polymers |
June 30, 2009 |
| Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws |
| 7504556 |
Transgenic systems for the manufacture of poly(2-hydroxy-butyrate-co-3-hydroxyhexanoate) |
March 17, 2009 |
| Methods for engineering transgenic organisms that synthesize polyhydroxyalkanoates (PHAs) containing 3-hydroxyhexanoate as comonomer have been developed. These processes are based on genetically engineered bacteria such as Escherichia coli or in plant crops as production systems whic |
| 7455999 |
Transgenic systems for the manufacture of poly (3-hydroxy-butyrate-co-3-hydroxyhexanoate) |
November 25, 2008 |
| Methods for engineering transgenic organisms that synthesize polyhydroxyalkanoates (PHAs) containing 3-hydroxyhexanoate as comonomer have been developed. These processes are based on genetically engineered bacteria such as Escherichia coli or in plant crops as production systems whic |
| 7268205 |
Medical devices and applications of polyhydroxyalkanoate polymers |
September 11, 2007 |
| Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws |
| 7252980 |
Polymer extraction methods |
August 7, 2007 |
| Polymer extraction methods are disclosed. |
| 7244442 |
Method for making devices using polyhydroxyalkanoate having pyrogen removed |
July 17, 2007 |
| Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided for use in numerous biomedical applications. PHAs which have been chemically modified to enhance physical and/or chemical properties, for targeting or to modify biodegradability or clearance by the reticulo |
| 7230144 |
Methods of making intermediates from polyhydroxyalkanoates |
June 12, 2007 |
| Methods of forming intermediates from PHAs are disclosed. |
| 7229804 |
Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids |
June 12, 2007 |
| The gene encoding a 4-hydroxybutyryl-CoA transferase has been isolated from bacteria and integrated into the genome of bacteria also expressing a polyhydroxyalkanoate synthase, to yield an improved production process for 4HB-containing polyhydroxyalkanoates using transgenic organisms, |
| 7208535 |
PHA compositions and methods for their use in the production of PHA films |
April 24, 2007 |
| PHA pellet compositions are provided which are processible into blown and cast free-standing films. The Mw of the PHA in the pellets used to produce the films is at least 470,000, at least 435,000 if PHA thermal stabilizers of the invention are used. In order to achieve a stable, uns |
| 7202064 |
Polyhydroxyalkanoate biopolymer compositions |
April 10, 2007 |
| Several novel PHA polymer compositions produced using biological systems include monomers such as 3-hydroxybutyrate, 3-hydroxypropionate, 2-hydroxybutyrate, 3-hydroxyvalerate, 4-hydroxybutyrate, 4-hydroxyvalerate and 5-hydroxyvalerate. These PHA compositions can readily be extended t |
| 7179883 |
Medical devices and applications of polyhydroxyalkanoate polymers |
February 20, 2007 |
| Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws |
| 7166743 |
Methods of making intermediates from polyhydroxyalkanoates |
January 23, 2007 |
| Methods of forming acrylic acid by heating a PHA are disclosed. The PHA can be derived from a biomass of a non-fossil source. The PHA can be, for example, poly 3-hydroxypropionate or a 3-hydroxypropionate containing polymer. The methods can include, for example, heating the PHA to a |
| 7094840 |
Compositions comprising low molecular weight polyhydroxyalkanoates and methods employing same |
August 22, 2006 |
| Polyhydroxyalkanoate compositions including hot melt adhesive compositions, biodegradable wax compositions, and protective coating compositions are provided and include a low molecular weight polyhydroxyalkanoate, a terminally-modified polyhydroxyalkanoate, or both. The compositions |
| 7081357 |
Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids |
July 25, 2006 |
| The gene encoding a 4-hydroxybutyryl-CoA transferase has been isolated from bacteria and integrated into the genome of bacteria also expressing a polyhydroxyalkanoate synthase, to yield an improved production process for 4HB-containing polyhydroxyalkanoates using transgenic organisms, |
| 7026526 |
Multi-gene expression constructs containing modified inteins |
April 11, 2006 |
| Methods and constructs for the introduction of multiple genes into plants using a single transformation event are described. Constructs contain a single 5' promoter operably linked to DNA encoding a modified intein splicing unit. The splicing unit is expressed as a polyprotein and co |
| 7001969 |
Methods of making intermediates from polyhydroxyalkanoates |
February 21, 2006 |
| Methods of forming intermediates from PHAs are disclosed. |
| 6933404 |
Methods of making intermediates from polyhydroxyalkanoates |
August 23, 2005 |
| In some embodiments, this invention relates to a method that includes contacting a PHA with an aprotic catalyst to form an ester. The ester has only one monomer unit from the PHA. In certain embodiments, this invention relates to a method that includes treating a PHA-containing non-l |
| 6913911 |
Transgenic microbial polyhydroxyalkanoate producers |
July 5, 2005 |
| Transgenic microbial strains are provided which contain the genes required for PHA formation integrated on the chromosome. The strains are advantageous in PHA production processes, because (1) no plasmids need to be maintained, generally obviating the required use of antibiotics or o |
| 6897338 |
Methods of making intermediates from polyhydroxyalkanoates |
May 24, 2005 |
| Methods of forming acrylic acid from a PHA, such as, for example, poly 3-hydroxypropionate or a 3-hydroxypropionate containing polymer are disclosed. The methods can include, for example, heating a biomass containing the PHA to form acrylic acid. The methods can include, for example, |
| 6878758 |
Polyhydroxyalkanoate compositions having controlled degradation rates |
April 12, 2005 |
| Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or inc |
| 6867248 |
Polyhydroxyalkanoate compositions having controlled degradation rates |
March 15, 2005 |
| Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or inc |
| 6867247 |
Medical devices and applications of polyhydroxyalkanoate polymers |
March 15, 2005 |
| Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws |
| 6844447 |
Methods of making intermediates from polyhydroxyalkanoates |
January 18, 2005 |
| Methods of forming intermediates from PHAs are disclosed. In general, the methods include forming a pyrrolidone from a PHA, such as poly 4-hydroxybutyrate or a 4-hydroxybutyrate containing polymer. The methods can include, for example, treating (e.g., heating) the PHA to form a pyrro |
| 6841603 |
Polymer blends containing polyhydroxyalkanoates and compositions with good retention of elongati |
January 11, 2005 |
| Biodegradable polymer blend compositions are provided which contain oligomeric esters. The oligoester compound can compatibilize blends of two or more biodegradable polymers resulting in excellent ductility and reduced tendency to embrittlement of products produced from therefrom. In |
| 6838493 |
Medical devices and applications of polyhydroxyalkanoate polymers |
January 4, 2005 |
| Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws |
| 6828357 |
Polyhydroxyalkanoate compositions having controlled degradation rates |
December 7, 2004 |
| Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or inc |
| 6780911 |
Low molecular weight polyhydroxyalkanoate molding compositions |
August 24, 2004 |
| Molding compositions including low molecular weight polyhydroxyalkanoates are provided. The use of the low molecular weight polyhydroxyalkanoates as a binder in molding compositions provides improved binder removal in the finished molded product, and offers a wide range of physical prope |
| 6770464 |
Methods for producing poly(hydroxy) fatty acids in bacteria |
August 3, 2004 |
| The present invention relates to a process for the production of poly (hydroxy fatty acids) as well as recombinant bacterial strains for carrying out the process. In addition, new poly(hydroxy fatty acids) and new substrates for the production of conventional and new poly(hydroxy fat |
| 6759219 |
Methods for the biosynthesis of polyesters |
July 6, 2004 |
| Coexpression of a polyhydroxyalkanoic acid synthase and either a fatty acid: acyl-CoA transferase or an acyl-CoA synthetase in cells enables the biosynthesis of polyester materials. Plasmids, bacteria, materials, and methods for the preparation of polyesters are disclosed. |
| 6753384 |
Polyurethanes obtained from hydroxyalkanoates and isocyanates |
June 22, 2004 |
| A polyurethane is described which is a reaction product of at least one isocyanate containing material having at least two isocyanate groups and at least one compound having at least two hydrogen atoms capable of reacting with the isocyanate. The compound having the at least two hydr |
| 6709848 |
Methods for isolating polyhydroxyalkanoates from plants |
March 23, 2004 |
| Methods are provided for separating polyhydroxyalkanoates ("PHAs") from plants, such as transgenic oil crop plants. The methods advantageously permit both the oil and the PHAs to be recovered from the plant biomass. To isolate the PHAs, in one embodiment, a biomass derived from an oil cr |
| 6689589 |
Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids |
February 10, 2004 |
| The gene encoding a 4-hydroxybutyryl-Co A transferase has been isolated from bacteria and integrated into the genome of bacteria also expressing a polyhydroxyalkanoate synthase, to yield an improved production process for 4HB-containing polyhydroxyalkanoates using transgenic organisms, i |
| 6623749 |
Medical device containing polyhydroxyalkanoate treated with oxidizing agent to remove endotoxin |
September 23, 2003 |
| Polyhydroxyalkanoate (PHA) that contains a pyrogen such as an endotoxin due to a process of producing the PHA is treated to remove the pyrogen by a process that does not affect the inherent chemical and physical properties of the PHA to obtain a biocompatible PHA. PHA produced by ferment |
| 6623730 |
Therapeutic uses of polymers and oligomers comprising gamma-hydroxybutyrate |
September 23, 2003 |
| Oligomers and polymer compositions are provided which comprise GHB and produce GHB after administration in vivo. Devices for the storage and delivery of these polymers and oligomers are also provided. These oligomers and polymer compositions are useful in a variety of applications. T |
| 6620869 |
PHA compositions and methods for their use in the production of PHA films |
September 16, 2003 |
| PHA pellet compositions are provided which are processible into blown and cast free-standing films. The Mw of the PHA in the pellets used to produce the films is at least 470,000, at least 435,000 if PHA thermal stabilizers of the invention are used. In order to achieve a stable, unsuppo |
| 6610764 |
Polyhydroxyalkanoate compositions having controlled degradation rates |
August 26, 2003 |
| Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or inc |
| 6605262 |
Methods and apparatus for the production of amorphous polymer suspensions |
August 12, 2003 |
| Methods and apparati have been developed for producing a suspension of predominately amorphous polymer particles, wherein the method includes thermally treating a suspension that includes crystalline or semi-crystalline polymer particles. The thermal treatment includes (a) heating a |
| 6593116 |
Transgenic microbial polyhydroxyalkanoate producers |
July 15, 2003 |
| Transgenic microbial strains are provided which contain the genes required for PHA formation integrated on the chromosome. The strains are advantageous in PHA production processes, because (1) no plasmids need to be maintained, generally obviating the required use of antibiotics or o |
| 6586658 |
Modification of fatty acid metabolism in plants |
July 1, 2003 |
| Methods and systems to modify fatty acid biosynthesis and oxidation in plants to make new polymers are provided. Two enzymes are essential: a hydratase such as D-specific enoyl-CoA hydratase, for example, the hydratase obtained from Aeromonas caviae, and a .beta.-oxidation enzyme sys |
| 6576450 |
Polyhydroxyalkanoate production from polyols |
June 10, 2003 |
| Organisms are provided which express enzymes such as glycerol dehydratase, diol dehydratase, acyl-CoA transferase, acyl-CoA synthetase .beta.-ketothiolase, acetoacetyl-CoA reductase, PHA synthase, glycerol-3-phosphate dehydrogenase and glycerol-3-phosphatase, which are useful for the |
| 6548569 |
Medical devices and applications of polyhydroxyalkanoate polymers |
April 15, 2003 |
| Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws |
| 6495152 |
Sulfur containing polyhydroxyalkanoate compositions and method of production |
December 17, 2002 |
| A class of biopolymer including sulfur in the form of a thioester in the polymer backbone or a thioether in the polymer side chains has been developed. These are preferably produced by fermentation of bacteria with appropriate sulfur containing substrates, which are incorporated by a |
| 6429285 |
Polymer compositions providing low residue levels and methods of use thereof |
August 6, 2002 |
| Polymer emulsion compositions presenting low levels of residue after thermolytic decomposition are provided. The compositions, based on polyhydroxyalkanoates or acrylics, are useful in a variety of applications, including the metallization of cathode ray tube phosphor screens, where |
| 6380244 |
Nutritional and therapeutic uses of 3-hydroxyalkanoate oligomers |
April 30, 2002 |
| Nutritional or therapeutic compositions are provided for increasing ketone body levels in the blood of mammals by providing a source of ketone bodies in the form of linear or cyclic oligomers and/or derivatives of 3-hydroxyacids. The 3-hydroxyacid can be in the form of a linear oligomer |
| 6368836 |
Method of decolorizing or deodorizing polyhydroxyalkanoates from biomass with ozone |
April 9, 2002 |
| Methods for the recovery and cation of polyhydroxyalkanoates (PHAs)from biomass containing PHAs, wherein the methods include treating the biomass or partially purified PHA with ozone, in at least one step of a purification process, have been developed. Treatment of PHA-containing bio |
| 6340580 |
Methods for purifying polyhydroxy alkanoates |
January 22, 2002 |
| A method is provided for isolating and purifying PHA from microbial or plant biomass that contains PHA. The method includes the step of extracting PHA from the biomass using at least one solvent while simultaneously subjecting the biomass to a filtration process to remove cells. In a |
| 6329183 |
Polyhydroxyalkanoate production from polyols |
December 11, 2001 |
| Organisms are provided which express enzymes such as glycerol dehydratase, diol dehydratase, acyl-CoA transferase, acyl-CoA synthetase .beta.-ketothiolase, acetoacetyl-CoA reductase, PHA synthase, glycerol-3-phosphate dehydrogenase and glycerol-3-phosphatase, which are useful for the |
| 6323276 |
Methods and apparatus for the production of amorphous polymer suspensions |
November 27, 2001 |
| Methods and apparati have been developed for producing a suspension of predominately amorphous polymer particles, wherein the method includes thermally treating a suspension that includes crystalline or semi-crystalline polymer particles. The thermal treatment includes (a) heating a |
| 6323010 |
Polyhydroxyalkanoate biopolymer compositions |
November 27, 2001 |
| Several novel PHA polymer compositions produced using biological systems include monomers such as 3-hydroxybutyrate, 3-hydroxypropionate, 2-hydroxybutyrate, 3-hydroxyvalerate, 4-hydroxybutyrate, 4-hydroxyvalerate and 5-hydroxyvalerate. These PHA compositions can readily be extended to |
