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Merrell Dow Pharmaceuticals Inc. Patents
Assignee:
Merrell Dow Pharmaceuticals Inc.
Address:
Cincinnati, OH
No. of patents:
418
Patents:


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Patent Number Title Of Patent Date Issued
D316914 Tablet May 14, 1991
5529996 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and June 25, 1996
The present invention relates to novel 2-substituted indane-2-mercaptoacetylamide derivatives which are useful as inhibitors of enkephalinase and ACE.
5529995 Aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE June 25, 1996
The present invention relates to novel aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE.
5525633 Triaryl-ethylene derivatives June 11, 1996
The present invention relates to novel triaryl-ethylene derivatives that are useful as anti-neoplastic agents, antiatherosclerotic agents, and hypocholesterolemic agents.
5514688 Carbocyclic adenosine analogs useful as immunosuppressants May 7, 1996
This invention relates to carbocyclic adenosine compounds of the formula (1) ##STR1## wherein the hydroxy substituent on the cyclopentanyl ring is in the CIS configuration relative to the bicyclic substituent,Y.sub.3, Y.sub.7, Y.sub.8 and Y.sub.9 are each independently nitrogen or a
5512177 Narrow poly- and mono-dispersed anoinic oligomers, and their uses, formulations and process April 30, 1996
The narrow poly- or mono-dispersed oligomers of the present invention are polyureas, polycarbonates, polyesters or polyamides having a recurring unit of from 3 to 50. These oligomers are water-soluble, preferably have a rigid backbone, have recurring units coupled by carbonyl linking moi
5504078 .alpha.-glucosidase inhibitors April 2, 1996
This invention relates to novel polyglycosidyl derivatives of 1-deoxy-nojirimycin, to the processes for their preparation and to their end-use applications, particularly as to their use in the treatment of diabetes.
5500419 NMDA antagonists March 19, 1996
The present invention is directed to a new neuroprotective agent. The agent is R-4-oxo-5-phosphononorvaline. This agent is useful in the treatment of ischemic and hypoxic conditions such as stroke.
5498778 Cyclic nitrone compounds useful in treating stroke March 12, 1996
The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
5494932 Sulfonic stilbene derivatives in the treatment of viral disease February 27, 1996
Sulfonic acid stilbenes block the infection of cells by HSV, and CMV and these compounds can be used to treat viral infection.
5491153 3-amidoindolyl derivative February 13, 1996
The present invention is directed to a new class of 3-amido and 3-sulfamido-indolyl NMDA antagonists and their use in the treatment of a number of disease states.
5491143 Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE February 13, 1996
The present invention relates to certain novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and of ACE.
5491142 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkepha February 13, 1996
The present invention relates to novel 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives which are useful as inhibitors of Enkephalise.
5491141 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkepha February 13, 1996
The present invention relates to novel 2-substitited indane-2-mercaptoacetylamide tricyclic derivatives which are useful as inhibitors of Enkephalise.
5491136 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase, 19-hydroxylaser inhibito February 13, 1996
The present invention is directed to a method of using a certain compounds which are 2,19-methyleneoxy or 2,19 methylenethio bridged steroids, and related steroidal compounds as inhibitors of the enzyme steroid aromarase, 19-hydroxylase and as treatment for various estrogen dependent/med
5489579 Potentation of NMDA antagonists February 6, 1996
The present invention is directed to a method for poteniating the therapeutic effects of selected NMDA antagonists.
5488188 Process for the preparation of (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, novel January 30, 1996
The present invention relates to a novel process for preparing (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, also known in the art as (E)-(p-fluorophenethyl)-3-fluoroallylamine, novel intermediates thereof, a novel process for the preparing (E)-2-(fluoromethylene)-4-(p-fl
5488048 Aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ace January 30, 1996
The present invention relates to novel aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE.
5488047 Carboxyalkyl tricylic derivatives useful as inhibitors of enkephalinase and ace January 30, 1996
The present invention relates to compounds of the formula ##STR1## wherein B.sub.1 and B.sub.2 are each independently hydrogen; hydroxy; --OR.sub.2 wherein R.sub.2 is a C.sub.1 -C.sub.4 alkyl or an Ar-Y group wherein Ar is aryl and Y is a hydrogen or C.sub.1 -C.sub.4 alkyl; or, w
5486513 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors or enkephalinase and January 23, 1996
The present invention relates to novel 2-substituted indane-2-mercaptoacetylamide derivatives which are useful as inhibitors of enkephalinase and ACE.
5486511 4-amino-17.beta.-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17.beta.-(cyclopropylamino)androst- January 23, 1996
This invention is directed to 4-amino-17.beta.-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17.beta.-(cyclopropylylamino)androst-4-en-3-one and related compounds, a process for their synthesis, a pharmaceutical composition having C.sub.17-20 lyase and 5.alpha.-reductase inhibitory act
5484814 NMDA antagonists January 16, 1996
The present invention is directed to a class of 4,6-disubstituted tryptophan derivatives, 4,6-disubstituted kynurenines, their use as NMDA antagonists and to pharmaceutical compositions containing these compounds.
5484810 Tissue protective tocopherol analogs January 16, 1996
This invention relates to alkylated sulfonium alkylene derivatives of certain 2H-1-benzopyrans, to the intermediates and processes useful for their preparation, to their free-radical scavenger and cardioprotective properties and to their end-use application as therapeutic agents.
5484783 Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzaza January 16, 1996
The present invention relates to the use of certain mercaptoacetylamide and benzazapine derivatives in treating patients suffering from hypertriglyceridemia, atherosclerosis and hypercholesterolemia.
5478846 1-piperidinyl alkanoylanyl sulfonamides for treatment of cardiac arrhythmia December 26, 1995
The present invention is direct to a new class of 1-piperidinyl alkanoarylsulfonamides of the formula I ##STR1## wherein R, X, m, n, and Alk are defined in the specification, and their use as antiarrhythmic agents.
5478811 Orally-active elastase inhibitors December 26, 1995
This invention relates to novel morpholinourea and related derivatives of pentafluoroethyl peptides which are orally active elastase inhibitors. These compounds are useful in the treatment of various inflammatory diseases and emphysema.
5473099 Ethyl 4-trichloroacetamido-4-hexenoate December 5, 1995
This invention relates to a novel synthesis of 4-amino-5-hexenoic acid by thermal rearrangements, and to the novel intermediates produced thereby.
5472959 Carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace December 5, 1995
The invention relates to compounds of the formula ##STR1## wherein B.sub.1 and B.sub.2 are each independently hydrogen; hydroxy; --OR.sub.2 wherein R.sub.2 is a C.sub.1 -C.sub.4 alkyl or an Ar--Y group wherein Ar is aryl and Y is a hydrogen or C.sub.1 -C.sub.4 alkyl; or, where B.
5470870 NMDA antagonists November 28, 1995
The present invention is directed to a class of 4,6-disubstituted tryptophan derivatives, 4,6-disubstituted kynurenines, their use as NMDA antagonists and to pharmaceutical compositions containing these compounds.
5470844 Heterocyclic-NMDA antagonists November 28, 1995
The present invention is directed to a class of 3-phosphono-pyrrolidine derivatives as described by Formula I and their use as NMDA antagonists. ##STR1##
5470837 5'-vinylhalo-aristeromycin/adenosine analogs and immunosuppressants November 28, 1995
The present invention relates to a method of effecting immunosuppression in a patient in need thereof comprising administering to said patient an effective immunosuppressive amount of certain 5'-vinylhalo-aristeromycin/adenosine analogs.
5468745 Amino and nitro containing tricyclic compounds useful as inhibitors of ace November 21, 1995
The present invention relates to compounds of the formula ##STR1## wherein A is methylene, oxygen, sulfur or N--B wherein B is R.sub.1 or COR.sub.2 wherein R.sub.1 is hydrogen, a C.sub.1 -C.sub.4 alkyl or an Ar--Z--group wherein Ar is aryl and Z is a C.sub.0 -C.sub.4 alkyl and R.
5463181 Farnesyl: protein transferase inhibitors as anticancer agents October 31, 1995
The present invention relates to certain inhibitors of farnesyl:protein transferase which are useful as antineoplastic agents.
5460807 Antiproliferative oligomers October 24, 1995
The oligomers of the present invention are polyureas or polyamides having a number average molecular weight of <10,000. These oligomers are water-soluble, have a rigid backbone with a predictable anion spacing, and are pharmaceutically-acceptable. The oligomers are useful for inhibiti
5457196 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE October 10, 1995
The present invention relates to novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE.
5455242 Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace October 3, 1995
The present invention relates to compounds of the formula ##STR1## wherein B.sub.1 and B.sub.2 are each independently hydrogen; hydroxy; --OR.sub.2 wherein R.sub.2 is a C.sub.1 -C.sub.4 alkyl or an Ar--Y group wherein Ar is aryl and Y is a hydrogen or C.sub.1 -C.sub.4 alkyl; or,
5447911 Ghilanten antimetastatic principle from the south american leech, Haementeria ghilianii September 5, 1995
A method for the inhibition of tumor metastases is described herein. The method makes use of the administration of an antimetastatic factor isolated from the leech Haementeria ghilianii.
5446068 1-phenyl-3-phenyl-2-propyne-1-ones as calcium uptake inhibitors August 29, 1995
This invention relates to 1-phenyl-3-phenyl-2-propyne-1-ones, the use of these compounds as calcium uptake inhibitors in leukocytes and thrombocytes, and pharmaceutical compositions containing these compounds as active ingredients, and the process of their preparation.
5440065 Process for preparing 4-amino-5-hexenoic acid August 8, 1995
This invention relates to a novel synthesis of 4-amino-5-hexenoic acid by thermal rearrangements, and to the novel intermediates produced thereby.
5438069 Glucohydrolase inhibitors useful as antidiabetic agents August 1, 1995
The invention provides the compounds 1,2-dideoxy-2-(hydroxymethyl)-1-(methylamino)-myo-inositol hydrochloride, 1,2-dideoxy-2-(hydroxymethyl)-1-(methylamino)-scyllo-inositol, 1,6-dideoxy-6-(hydroxymethyl)-1-(methylamino)-myo-inositol.
5437873 Superior tasting pharmaceutical composition having porous particles and the process of preparing August 1, 1995
The present invention is directed towards a process for producing a superior tasting pharmaceutical composition having porous granules produced through in situ gas generation using effervescence-producing ingredients. The method disclosed herein is especially suitable for producing s
5436252 5-aryl-3H-1,2,4-triazol-3-ones and their use in the treatment of neurodegenerative disorders July 25, 1995
This invention relates to neuroprotective 5-aryl-3H-1,2,4-triazol-3-ones and to their use in the treatment of neurodegenerative disorders such as cerebral ischemia, stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease.
5436237 Method of using 4-amino-.DELTA..sup.4 -steroids in the treatment of benign prostatic hyperplasia July 25, 1995
The present invention relates to 4-amino-.DELTA..sup.4 -steroids which are useful as inhibitors of 5.alpha.-reductase. The compounds are prepared by the reaction of an appropriate 4-azido steroid with triphenylphosphine in an aqueous inert solvent with heating.
5434145 N-alkythio polyamine derivatives as radioprotective agents July 18, 1995
The present invention relates to certain polyamine thiols which are useful as radioprotective agents.
5430145 Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace July 4, 1995
The present invention relates to certain novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and of ACE.
5428158 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and June 27, 1995
The present invention relates to novel 2-substituted indane-2-mercaptoacetylamide derivatives which are useful as inhibitors of enkephalinase and ACE.
5428045 5-acyl-2-(1H)-pyridinoes June 27, 1995
Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic
5428019 Bombesin analogs June 27, 1995
Agonists and Antagonist of bombesin are derivatives of naturally occurring bombesin possessing a methyl sulfide or a methyl amide bond connecting the two amino acids on the carboxy terminal end. Agonist and antagonist activities are confirmed using conventional competitive binding and
5428018 Phenylalanine analogs of bombesin June 27, 1995
Disclosed are Agonists and Antagonists of bombesin which are derivatives of naturally occurring bombesin possessing modified derivatives of phenylalanine. Agonist and antagonist activities are confirmed using conventional competitive binding and biochemical assays as well as conventi
5426101 2-substituted adenosines with A-2 receptor affinity June 20, 1995
The compound (R)-2-[(phenylisopropyl)amino]adenosine whose structure is given below: ##STR1## (R)-2-[(phenylisopropyl)amino]adenosine is about two orders of magnitude greater in its selectivity between the A-1 and A-2 adenosine receptors than its diastereoisomer. This compound is
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