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Merck Patent GmbH Patents
Assignee:
Merck Patent GmbH
Address:
Darmstadt, DE
No. of patents:
566
Patents:


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Patent Number Title Of Patent Date Issued
RE41008 Method for producing 5-aryl nicotinaldehydes November 24, 2009
The invention relates to a process for the preparation of 5-arylnicotinaldehydes by reduction of the corresponding 5-arylnicotinic acids by catalytic hydrogenation in the presence of carboxylic anhydrides in which the catalyst used is a palladium/ligand complex, characterized in that
RE39605 Combination of optical elements May 1, 2007
The invention relates to a combination of optical elements comprising at least one optical retardation film and at least one broadband reflective polarizer, characterized in that the optical retardation film is comprising at least one layer of an anisotropic polymer material having a
RE36849 Anisotropic compounds and liquid crystal mixtures therewith September 5, 2000
Anisotropic compounds of the formula (1) specified in claim 1 are suitable, owing to their low .DELTA..epsilon./.epsilon..perp. values for liquid crystal displays which have high information densities of for examples up to 10.sup.6 image dots and accordingly need to be highly multiplexib
D493220 Inhaler July 20, 2004
7622165 Liquid-crystalline medium November 24, 2009
Disclosed are a liquid-crystalline medium, which contains one or more compounds of formula I ##STR00001## their use for electro-optical purposes, to displays containing this medium, and to novel LC compounds for use in LC media and displays.
7619115 Ortho-substituted N'-benzylidene-(3-hydroxyphenyl)acethydrazides November 17, 2009
Novel ortho-substituted N'-benzylidene-(3-hydroxyphenyl)acetohydrazides of the formula (I), in which R.sup.1-R.sup.9 have the meanings indicated in claim 1, are SGK inhibitors and can be used for the treatment of SGK-induced diseases and conditions, such as diabetes, obesity, metabolic
7615615 Modified interferon beta with reduced immunogenicity November 10, 2009
The present invention relates a modified human interferon beta (INF.beta.) which is less immunogenic than human INF.beta. (SEQ ID NO: 1) when administered in vivo to a human. The modified human INF.beta. comprises an amino acid residue sequence that differs from SEQ ID NO: 1 by an amino
7615217 Artificial proteins with reduced immunogenicity November 10, 2009
The invention relates to artificial modified proteins, preferably fusion proteins, having a reduced immunogenicity compared to the parent non-modified molecule when exposed to a species in vivo. The invention relates, above all, to novel immunoglobulin fusion proteins which essential
7612243 Cyclopenta[b]naphthalene derivatives November 3, 2009
The present invention relates to cyclopenta[b]naphthalene derivatives to the use thereof in liquid-crystalline or mesogenic media, to liquid-crystalline or mesogenic media comprising at least one of these cyclopenta[b]naphthalene derivatives, and to electro-optical display elements c
7601814 Reducing the immunogenicity of fusion proteins October 13, 2009
Disclosed are compositions and methods for producing fusion proteins with reduced immunogenicity. Fusion proteins of the invention include a junction region having an amino acid change that reduces the ability of a junctional epitope to bind to MHC Class II, thereby reducing its inte
7598274 Pyrrole derivatives October 6, 2009
Compounds of the formula (I), in which X, Y, Z and Ar have the meanings indicated in claim 1, are inhibitors of Raf kinase and can be employed, inter alia, for the treatment of tumours ##STR00001##
7598241 Carboxamide derivatives and their use as factor Xa inhibitors October 6, 2009
Novel compounds of the formula (I) in which R.sup.1, D, X, W, Y and T have the meaning indicated in Patent Claim (1), e.g. (II), are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
7598196 Vapor-deposition material for the production of layers of high refractive index October 6, 2009
The present invention relates to vapor-deposition materials comprising Ta.sub.2O.sub.x, where x=4.81 to 4.88, to processes for the preparation of the vapor-deposition materials, and to the use thereof for the production of layers of high refractive index.
7597942 Polymerisable liquid crystal material October 6, 2009
The invention relates to a polymerisable liquid crystal (LC) material, to optically biaxial films prepared thereof, to novel polymerisable compounds used therein and to the use of the material and films in optical devices like compensators and LC displays (LCDs).
7595101 Liquid-crystalline medium September 29, 2009
Disclosed are a liquid-crystalline medium, which contains a compound of formula I ##STR00001## and the use thereof for electro-optical purposes, in particular for TN, TFT, IPS or OCB displays.
7592622 Polymers for use in organic electroluminescent devices September 22, 2009
A polymer comprising an optionally substituted first repeat unit off formula (1): wherein F is a divalent residue; each G in each occurrence is independently a divalent residue; r is at least 1; each p is independently 0 or 1 and each corresponding q is the other of 0 or 1; and G com
7592000 Method of tanning human body by mysting or immersion at elevated temperature September 22, 2009
The present invention relates to the use of self-tanning substances for application to the human skin, with application taking place at elevated temperature, to corresponding methods of application to the human skin and to a cosmetic formulation which is suitable for said purpose.
7589224 Method for producing iridium(III) keto ketonates September 15, 2009
Process for the preparation of rhodium(III) and iridium(III) ketoketonates. The present invention describes a process for the preparation of rhodium and iridium compounds which are used as starting compound for various organorhodium compounds and organoiridium compounds, in which the
7589203 Rhodium and iridium complexes September 15, 2009
The present invention relates to novel organometallic compounds which are phosphorescence emitters. Such compounds can be used as active components (=functional materials) in a series of different types of application which can be classed within the electronics industry in the broadest
7589179 IL-7 variants with reduced immunogenicity September 15, 2009
Modified interleukin-7 (IL-7) polypeptides are disclosed. The modified IL-7 polypeptides have alterations to one or more potential T-cell epitopes, thereby to reduce a T-cell response.
7589112 Methylene urea derivatives September 15, 2009
The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administe
7588783 Flavonoid derivative September 15, 2009
The invention relates to a novel flavonoid derivative, to an extract comprising the flavonoid derivative, to the cosmetic and pharmaceutical use thereof, to preparations comprising the flavonoid derivative or extract, and to a process for the preparation of the flavonoid derivative o
7585994 Process for the preparation of compounds containing perfluoroalkanesulfonic acid groups September 8, 2009
The invention relates to a method for producing perfluoroalkanesulfonic acid esters and for further transforming the same into the salts thereof. The invention also relates to the use of the produced compounds in electrolytes, batteries, capacitors, supercapacitors, and galvanic cells.
7582288 Methods of targeting multiple cytokines September 1, 2009
The invention relates to protein complexes and fusion proteins including at least two different cytokine molecules. The protein complexes and fusion proteins may further include a targeting moiety such as a region of an immunoglobulin. Methods of using the protein complexes and fusion
7582227 Optical film inside a liquid crystal display September 1, 2009
The invention relates to an optical film for use in a liquid crystal display that is positioned inside the liquid crystal cell of the display comprising the switchable liquid crystal material, and to an LCD comprising such a film.
7579484 Method for the production of monoalkylamino ketones August 25, 2009
The invention relates to monoalkylaminoketones of the formula (I), in which R.sup.1 and R.sup.2 have the meanings indicated. ##STR00001##
7579346 Carboxamides August 25, 2009
Novel compounds of the formula (I), in which D, W, X, Y, T, m and R.sup.1 have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
7579079 UV-stabilised particles August 25, 2009
The present invention relates to UV-stabilised particles which are distinguished by the fact that they reflect or absorb light having wavelengths of from 290 to 500 nm. The invention furthermore relates to a process for the production of the particles according to the invention and t
7579053 Liquid crystalline medium and liquid crystal display August 25, 2009
Dielectrically positive liquid crystalline media comprising a dielectrically neutral component, component A, comprising a dielectrically neutral compound of formula I ##STR00001## wherein the parameters have the meaning given in the specification, in a high concentration, and a diel
7578879 Effect pigments that are surface-modified with LCST and/or UCST polymers August 25, 2009
The present invention relates to surface-modified effect pigments based on flake-form substrates which are distinguished by the fact that they are sheathed with one or more layers of immobilized LCST and/or UCST polymers. The invention furthermore relates to a process for the product
7576242 Process for the preparation of organic salts containing bis(perfluoroalkyl) phosphinate anions August 18, 2009
The invention relates to a method for the production of organic salts containing bis(perfluoroalkyl)phosphinate anions. According to said method, a tris(perfluoroalkyl)phosphine oxide is reacted with an alcohol and an organic base, which is stronger than the alcohol. The invention al
7576208 Organic semiconductor layers August 18, 2009
A compound of formula 9 ##STR00001## and uses thereof in various electronic devices and in a formulation for ink jet printing and in an organic semiconducting layer formulation.
7576193 Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation August 18, 2009
Disclosed are methods for producing fusion proteins with the heterodimeric cytokine, interleukin-12. In order to insure that the proper ratio of fused and non-fused subunits are obtained in the fusion protein, a specific stepwise approach to genetic engineering is used. This consists
7575785 Cyclopenta[a]naphthaline derivatives August 18, 2009
The present invention relates to cyclopenta[a]naphthalene derivatives of the general formulae I to V ##STR00001## in which B, Z, A, n, R, X.sup.1, X.sup.1a, X.sup.1b, X.sup.2, X.sup.3, E.sup.1 and E.sup.2 are as defined in the claims, to the use thereof in liquid-crystalline media, to
7572796 Substituted indoles August 11, 2009
Substituted indoles of the formula (I) and physiologically acceptable derivatives and salts thereof, in which R.sup.1, D, E, R.sup.12, p, X.sup.1, E, G, X.sup.2 and Z are as defined in claim 1, exhibit particular actions on the central nervous system, especially 5HT reuptake-inhibiti
7566789 Benzimidazole derivatives July 28, 2009
Novel compounds of the formula I ##STR00001## in which D, X, X', W, Y, T and R.sup.1 are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
7566709 1,3,4-Substituted pyrazoles as 5-HT receptor antagonists for the treatment of psychoses and neur July 28, 2009
Compounds of the formula (I) and salts and solvates thereof, in which X, R.sup.1, R.sup.2, R.sup.5 and Q have the meanings indicated in Claim 1, are suitable as ligands of 5 HT receptors; as well as intermediate compounds of the formula (IA). ##STR00001##
7563790 Pyridazine derivatives July 21, 2009
Pyridazine derivatives of the formula (I) act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumors, cachexia, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, inflammatory processes, allergies, asthma, autoimmune
7563491 Liquid crystalline medium and liquid crystal display July 21, 2009
A dielectrically positive liquid crystalline media comprising: a first dielectrically positive component, component A, comprising a dielectrically neutral compound of formula I ##STR00001## wherein the parameters have the meanings defined herein; a second dielectrically positi
7560147 Liquid-crystal medium July 14, 2009
The invention relates to a liquid-crystalline medium based on a mixture of polar compounds which comprises at least one compound of the formula I ##STR00001## in which R.sup.11, R.sup.12, A.sup.1, A.sup.2, Z.sup.1, Z.sup.2, m and n have the meanings indicated in claim 1, and to the us
7557222 1-[(4-Ethynylphenyl)]-2-[(phenyl)]-pyrrolidine-1,2-dicarboxamide derivatives as inhibitors of co July 7, 2009
Novel compounds of the formula (I), in which R, R.sup.1, R.sup.2 and R.sup.3 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
7557102 Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor Xa inhibitors for the July 7, 2009
Novel compounds of the formula (I), in which R, R.sup.1, R.sup.2 and R.sup.3 have the meanings indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors. ##STR
7553523 Liquid crystal medium June 30, 2009
Disclosed are a liquid crystal medium having a birefringence at 20.degree. C. that is lower than 0.08 and contains 1-30% by weight of one or more compounds of formula IA, 1-10% by weight of one or more compounds of formula IB, 0-9% by weight of one or more compounds of formula IC,
7553522 LC-mixtures with low frequency dependence for TFT-displays June 30, 2009
The present invention relates to dielectrically positive, nematic liquid crystalline media having a small frequency dependence of the dielectric anisotropy. The media are particularly well suited for application in active matrix displays. The present invention relates to the use of the
7553406 Process for removing polar impurities from hydrocarbons and mixtures of hydrocarbons June 30, 2009
This invention relates to a process for removing polarizable impurities from hydrocarbons and mixtures of hydrocarbons using ionic liquids as an extraction medium. By way of extraction, the degree of contamination of the hydrocarbon or mixture of hydrocarbons is reduced to a low or very
7550491 Ionic liquids having [N(CF.sub.3).sub.2].sup.- anions June 23, 2009
The present invention relates to salts comprising bis(trifluoromethyl)imide anions and saturated, partially or fully unsaturated, heterocyclic cations, to a process for the preparation thereof, and to the use thereof as ionic liquids.
7550447 Method for precipitating nucleic acid with visible carrier June 23, 2009
A suitable carrier molecule useful in a nucleic acid precipitation method is modified by coupling a suitable visualizable indicator molecule to the carrier molecule. The conjugated carrier facilitates nucleic acid precipitation because the presence and location of nucleic acid in a s
7547695 Pyridopyrimidinones June 16, 2009
The invention relates to compounds of formula (I) wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, X and X' have the designations cited in patent claim 1. Said compounds are inhibitors of tyrosine kinases, especially TIE-2, and Raf kinases, and
7544807 Ionic liquids June 9, 2009
Low melting ionic compounds of the general formula (cation) (R'SO.sub.4) in which R' is a branched or linear, saturated or unsaturated, aliphatic or alicyclic functionalized or non-functionalized hydrocarbon chain with 3-36 carbon atoms are provided. These compounds can serve as ionic
7544684 Hydrazono-malonitriles June 9, 2009
Hydrazono-malonitrile derivatives of the formula (I) in which R.sup.1, R.sup.2, R.sup.3, R.sup.3' and R.sup.4 have the meanings given in Claim 1 act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumors, cachexia, atherosclerosis, rheumatoid
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