| Patent Number |
Title Of Patent |
Date Issued |
| 7368259 |
Method for generating diversity |
May 6, 2008 |
| The invention relates to a method for preparing an antibody-producing cell line capable of directed constitutive hypermutation of a specific nucleic acid region, comprising the steps of: a) screening a clonal cell population for V gene diversity; b) isolating one or more cells which |
| 7368111 |
Human antibodies specific for TGF.beta.2 |
May 6, 2008 |
| Specific binding members comprising human antibody antigen binding domains specific for human transforming growth factor beta (TGF.beta.) bind specifically isoforms TGF.beta.2 and TGF.beta.1 or both, preferentially compared with TGF.beta.3. Specific binding members may be isolated and |
| 7344870 |
3-phosphoinositide-dependent protein kinase |
March 18, 2008 |
| The present invention provides for a substantially pure human or rabbit 3-phosphoinositide-dependent protein kinase. |
| 7297506 |
Assay for nucleotide triphosphate using a modified nucleoside diphosphate kinase comprising a fl |
November 20, 2007 |
| Nucleoside diphosphates (NDPs) are detected or measured by following the dephosphorylation of the phosphoenzyme form of nucleoside diphosphate kinase (NDPK), and nucleoside triphosphates (NTPs) are detected or measured by following the phosphorylation of NDPK to its phosphoenozyme fo |
| 7279300 |
Protozoan rhomboid proteins |
October 9, 2007 |
| Protozoan Rhomboid Proteins. The invention relates to the identification of protozoan Rhomboid proteins that are involved in the invasive processes of protozoan pathogens, such as P falciparum. Modulation of these Rhomboid proteins may this be useful in treating protozoan pathogen in |
| 7252943 |
In Vitro sorting method |
August 7, 2007 |
| The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: compartmentalizing genetic elements into microcapsules; expressing the genetic elements to produce their respective gene products |
| 7218393 |
Rotary stage for imaging a specimen |
May 15, 2007 |
| A rotary stage (10) for use in optical projection tomography includes a stepper motor (42) with a rotatable vertical shaft (44) the lower end of which carries a specimen (28) to be imaged so that the specimen is rotated about a substantially vertical axis. The stepper motor (42) is m |
| 7205390 |
Enzyme |
April 17, 2007 |
| A substantially pure 3-phosphoinositide dependent protein kinase that phosphorylates and activates protein kinase B.alpha.. A recombinant polynucleotide encoding a protein kinase as defined. Uses of the protein kinase and polynucleotide, especially in screening for new drugs. |
| 7195866 |
Production of anti-self antibodies from antibody segment repertoires and displayed on phage |
March 27, 2007 |
| Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such |
| 7189841 |
Method for tapping the immunological repertoire |
March 13, 2007 |
| The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated. |
| 7179786 |
Variants of the NK1 fragment of hepatocyte growth factor/scatter factor (HGF/SF) and their use |
February 20, 2007 |
| Variants of the NK1 fragment of the polypeptide growth factor HGF/SF which act as agonists of the MET receptor and their use are disclosed. The agonists comprise at least one substitution at positions equivalent to 132, 134, 170 and 181 of full length HGF/SF (SEQ ID NO:2) and these s |
| 7138233 |
IN vitro sorting method |
November 21, 2006 |
| The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene |
| 7135281 |
Screening for papilloma viruses |
November 14, 2006 |
| The invention relates to a method of screening for precursor lesions which can lead to cervical malignancy, methods of detecting and typing human papilloma virus infections, and reagents of use in these methods. |
| 7122646 |
Multivalent and multispecific binding proteins, their manufacture and use |
October 17, 2006 |
| Polypeptides comprising a first domain, which comprises a binding region of an immunoglobulin heavy chain variable region, and a second domain, which comprises a binding region of an immunoglobulin light chain variable region, the domains being linked but incapable of associating wit |
| 7122339 |
Method for generating diversity |
October 17, 2006 |
| The invention relates to a method for preparing an antibody-producing cell line capable of directed constitutive hypermutation of a specific nucleic acid region, comprising the steps of: a) screening a clonal cell population for V gene diversity; b) isolating one or more cells which |
| 7109189 |
Mitochondrially targeted antioxidants |
September 19, 2006 |
| The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to a glutathione peroxidase mimetic. These compounds can be used to treat patients who would benefit from the reduction of oxidative stress. |
| 7098238 |
Degradation fragments |
August 29, 2006 |
| A pharmaceutical composition comprising a compound of formula (I) wherein X is an electron withdrawing group, Y.sup.1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, --SO.sub.2R.sup.4, --CO.sub.2R.sup.4, --CONHR.sup.4 or --COR.sup.4, and each of R.sup.1, R.sup.2 and R.sup.4, |
| 7079956 |
Crystal structure of antibiotics bound to the 30S ribosome and its use |
July 18, 2006 |
| The invention provides high resolution X-ray crystal structures of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P4.sub.12.sub.12 to which are bound an antibiotic selected from the group paromomycin, streptomycin, spectinomycin, tet |
| 7078043 |
Malaria vaccine |
July 18, 2006 |
| A non-naturally occurring variant of a C-terminal fragment of a Plasmodium merozoite surface protein-1 (MSP-1) wherein said variant has (i) a reduced affinity, compared with a naturally occurring Plasmodium MSP-1.sub.19, for at least one first antibody capable of blocking the binding |
| 7049303 |
Inhibition of viruses |
May 23, 2006 |
| Disclosed is a pharmaceutical composition comprising a ribonucleoside analogue in accordance with general formula I or II as herein defined, in admixture with a physiologically acceptable excipient diluent or carrier. |
| 7044082 |
Environmental enrichment of caged animals |
May 16, 2006 |
| A cage or an item of cage furniture for use by a caged rodent comprises a coloured material which is transparent or translucent to a human observer, but is perceived as being substantially darkened or opaque by the caged rodent. The cage or item of cage furniture typically comprises, |
| 6998472 |
Obesity gene |
February 14, 2006 |
| The invention describes a previously unknown gene, termed 5'OT-EST, which is responsible for inducing an obesity and/or infertility phenotype in transgenic animals, and transgenic animals comprising mutants of 5'OT-EST which are useful for assaying compounds for the treatment of obesity |
| 6992760 |
Apparatus and method for imaging a histological sample |
January 31, 2006 |
| A method of imaging a histological sample is provided which comprises stimulating autofluorescence in a sample using electromagnetic radiation of wavelength 750 nm. Detection of the autofluorescence is undertaken by a CCD camera, typically with an excitation filter of 510 nm disposed |
| 6982321 |
Altered antibodies |
January 3, 2006 |
| An altered antibody is produced by replacing the complementarity determining regions (CDRs) of a variable region of an immunoglobulin (Ig) with the CDRs from an Ig of different specificity, using recombinant DNA techniques. The gene coding sequence for producing the altered antibody |
| 6969586 |
Method for tapping the immunological repertoire |
November 29, 2005 |
| The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated. |
| 6925394 |
Crystal structure of the 30s ribosome |
August 2, 2005 |
| The invention provides an X-ray crystal structure of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P4.sub.1 2.sub.1 2 with unit cell dimensions of a=401.4.+-.4.0 .ANG., b=401.4.+-.4.0 .ANG., c=175.9.+-.5.0 .ANG.. An advantageous feature |
| 6916605 |
Methods for producing members of specific binding pairs |
July 12, 2005 |
| A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package |
| 6808882 |
Optical sorting method |
October 26, 2004 |
| The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene product |
| 6806079 |
Methods for producing members of specific binding pairs |
October 19, 2004 |
| A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package |
| 6797494 |
Self-replicating episomal expression vectors conferring tissue-specific gene expression |
September 28, 2004 |
| Selph-replicating, locus control region (LCR)-containing, episomal expression vectors for tissue-specific gene expression for long-term persistent, tissue-specific expression of a gene of interest are described. |
| 6765014 |
1-Acyl-7-nitroindoline derivatives, their preparation and their use as photocleavable precursors |
July 20, 2004 |
| Photoreleasable compounds comprising a caging moiety linked to an effector moiety represented by structural formula (I) wherein R.sub.1 is hydrogen; C.sub.1-10 alkyl or substituted alkyl; O(CH.sub.2).sub.n --Y; N(COZ)(CH.sub.2).sub.m Y; or N[(CH.sub.2).sub.m Y'[(CH.sub.2).sub.N Y]; R |
| 6746849 |
Assay for nucleoside diphosphate using a modified nucleoside diphosphate kinase comprising a flu |
June 8, 2004 |
| Nucleoside diphosphates (NDPs) are detected or measured by following the dephosphorylation of the phosphoenzyme form of nucleoside diphosphate kinase (NDPK), and nucleoside triphosphates (NTPs) are detected or measured by following the phosphorylation of NDPK to its phosphoenzyme for |
| 6680192 |
Method for producing polymers having a preselected activity |
January 20, 2004 |
| The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated. |
| 6670462 |
Protein fragments for use in protein targeting |
December 30, 2003 |
| A protein is described. The protein comprises a lipid globule targeting sequence linked to a protein of interest (POI) wherein the targeting sequence comprises a hepatitis C virus (HCV) core protein or fragment or homologue thereof. |
| 6617117 |
MAP kinases: polypeptides, polynucleotides and uses thereof |
September 9, 2003 |
| The present invention relates to a method of identifying a compound which blocks the activation of a stress-activated protein kinase selected from the group consisting of SAPK4 and SAPK3 by SKK3. The method includes contacting the stress-activated protein kinase with the compound and |
| 6593081 |
Production of anti-self antibodies from antibody segment repertoires and displayed on phage |
July 15, 2003 |
| Methods are disclosed for the production of human self-antibodies and antibody fragments, which bind human antigens. Methods comprise providing a library of replicable genetic display packages (rgdps), such as filamentous phage, each rgdp displaying at its surface a member of a speci |
| 6582915 |
Production of anti-self bodies from antibody segment repertories and displayed on phage |
June 24, 2003 |
| Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such |
| 6562565 |
Comparative fluorescence hybridization to nucleic acid arrays |
May 13, 2003 |
| The present invention provides methods of determining relative copy number of target nucleic acids and precise mapping of chromosomal abnormalities associated with disease. The methods of the invention use target nucleic acids immobilized on a solid surface, to which a sample comprising |
| 6555313 |
Production of anti-self antibodies from antibody segment repertoires and displayed on phage |
April 29, 2003 |
| Methods are disclosed for the production of human self-antibodies and antibody fragments, which bind human antigens. Methods comprise providing a library of replicable genetic display packages (rgdps), such as filamentous phage, each rgdp displaying at its surface a member of a speci |
| 6544731 |
Production of anti-self antibodies from antibody segment repertories and displayed on phage |
April 8, 2003 |
| Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such |
| 6521404 |
Production of anti-self antibodies from antibody segment repertoires and displayed on phage |
February 18, 2003 |
| Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such |
| 6518413 |
Utrophin gene expression |
February 11, 2003 |
| Nucleic acid from which a polypeptide with utrophin function can be expressed, especially mini-genes and chimaeric constructs. Expression significantly decreases the severity of the dystrophic muscle phenotype in an animal model, indicating usefulness in treatment of muscular dystrophy. |
| 6507640 |
X-ray beam position monitors |
January 14, 2003 |
| An X-ray beam position monitor has a first plate assembly (1, 3) for detecting the position of the X-ray beam in a horizontal plane and a second plate assembly (6, 8) for detecting the position of the X-ray beam in a vertical plane. The first plate assembly (1, 3) and the second plate |
| 6498020 |
Fusion proteins comprising coiled-coil structures derived of bovine IF1 ATPase inhibitor protein |
December 24, 2002 |
| The present invention relates to a fusion protein comprising a first amino acid sequence comprising the sequence of the C-terminal 40 amino acids of bovine IF.sub.1 ATPase inhibitor protein, and a second amino acid sequence not naturally associated with the first region. The invention fu |
| 6495673 |
Method for isolating the DNA encoding an enzyme |
December 17, 2002 |
| A method for isolating the DNA encoding an enzyme is presented. The DNA is contained within a support to which the enzyme is linked, wherein the enzyme is further linked to a substrate. When the enzyme reacts with the substrate, the product remains linked to the enzyme. The product linke |
| 6492160 |
Methods for producing members of specific binding pairs |
December 10, 2002 |
| Methods, recombinant host cells and kits are disclosed-for the production of members of specific binding pairs (sbp), e.g. antibodies, using display on the surface of secreted replicable genetic display packages (rgdps), e.g. filamentous phage. To produce a library of great diversity |
| 6492145 |
Vaccine against mycobacterial infections |
December 10, 2002 |
| A naked nucleic acid construct comprising a coding sequence which encodes a mycobacterial stress protein or proline-rich antigen or an antigenically effective fragment thereof operably linked to a promoter capable of expressing the said coding sequence in a mammalian host cell is useful |
| 6492123 |
Multivalent and multispecific binding proteins and their use |
December 10, 2002 |
| Polypeptides comprising a first domain, which comprises a binding region of an immunoglobulin heavy chain variable region, and a second domain, which comprises a binding region of an immunoglobulin light chain variable region, the domains being linked but incapable of associating with ea |
| 6489103 |
In vitro sorting method |
December 3, 2002 |
| The invention relates to a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene produc |
| 6485960 |
Polycystic kidney disease 1 gene and uses thereof |
November 26, 2002 |
| The present invention relates to the polycystic kidney disease 1 (PKD1) gene and its nucleic acid sequence, mutations thereof in patients having PKD1-associated disorders, the protein encoded by the PKD1 gene or its mutants, and their uses in disease diagnosis and therapy. |
