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Lonza Ltd. Patents
Assignee:
Lonza Ltd.
Address:
Basel, CH
No. of patents:
345
Patents:


1 2 3 4 5 6 7










Patent Number Title Of Patent Date Issued
8563752 Process for the production of carnitine by cycloaddition October 22, 2013
The invention relates to a method for the production of L-carnitine, wherein a chiral .beta.-lactone carnitine precursor is obtained by a [2+2] cycloaddition of ketene with an aldehyde X--CH.sub.2--CHO, wherein X is selected from Cl, Br, I and trimethylamine, in the presence of a chi
8283502 Autocatalytic process for the synthesis of chiral propargylic alcohols October 9, 2012
An autocatalytic process for the synthesis of chiral propargylic alcohols.
8283497 Tricyanoborates October 9, 2012
The present invention relates to novel tricyanoborates of the general formula Cat.sup.n+[B(CN).sub.3(XR.sup.1)]--.sub.n, wherein R.sup.1 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.6-10 aryl or benzyl; X is oxygen or sulfur; and Cat.sup.n+ is a cation with n being 1 or 2, which is s
8222445 Process for preparing and method of purifying alkali metal and alkaline earth metal tricyanometh July 17, 2012
The present invention relates to an industrially usable process for preparing alkali metal and alkaline earth metal tricyanomethanides in particularly high purity.
8168823 Process for the preparation of betaines May 1, 2012
Betaines of formula R.sub.3N.sup.+-Q-COO.sup.- (I), wherein R is C.sub.1-4 alkyl and Q is C.sub.1-4 alkanediyl, optionally substituted with hydroxy, are prepared in one step by adding an .omega.-halocarboxylate of formula X-Q-COOR' (II), wherein Q is as defined above, R' is Cl.sub.1-
8115032 Process for the synthesis of a propargylic alcohol February 14, 2012
A process for the preparation of the compound of formula ##STR00001##
8088351 Process for the preparation of ethanedinitrile January 3, 2012
The invention relates to a process for the preparation of ethanedinitrile, by reading hydrocyanic acid in the liquid phase with nitric acid in the presence of a cupric ion catalyst.
8044246 Process for the selective preparation of acetaldehyde from acrolein and one or more ammonium sal October 25, 2011
The present invention relates to a process for the selective preparation of acetaldehyde, characterized in that acrolein and one or more ammonium salts dissolved in water are reacted continuously under high pressures and at temperatures of 300-400.degree. C.
7973182 Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols July 5, 2011
A process for the preparation of enantiomerically pure 1-substituted-3-amino-alcohols, particularly of (S)-(-)- and (R)-(+)-3-N-methylamino-1-(2-thienyl)-1-propanol, by asymmetrically hydrogenating salts of a carboxylic acids with an aminoketone of the formula: ##STR00001## wherein
7416869 Enzyme delivery systems, application in water based products August 26, 2008
Aqueous enzyme delivery systems as well as aqueous cosmetics and personal care products were provided which comprise at least one stabile enzyme and a polyglycerol containing at least 15 carbons. In addition, stabile non-aqueous enzyme delivery systems which are dispersions of at least o
7368603 Method for purifying compounds containing functional groups May 6, 2008
The present invention relates to a method for producing a saturated organic compound bearing at least one functional group from a mixture which comprises this saturated organic compound containing at least one functional group and also one or more other organic compounds, which compr
7358393 Method for preparing .beta.-alaninamides April 15, 2008
The invention relates to .beta.-alanine amides of general formula (I), wherein: R.sup.1 represents hydrogen or C.sub.1-6 alkyl that is optionally substituted by hydroxy, amino, carboxy, carbamoyl, methylmercapto, guanidino, optionally substituted aryl or heteroaryl, and; R.sup.2 repr
7355048 Process for preparing 1-(6-methylpyridin-3-yl)-2-[4- (methylsulphonyl)phenyl]ethanone April 8, 2008
A four-step process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone of the formula: ##STR00001## starting from 2-methyl-5-ethylpyridine. 1-(6-Methylpyridin-3yl)-2-[4-(methylsulfonyl)phenyl]ethanone is an intermediate for preparing inhibitors.
7348450 Method for the production of 6,6,6-trihalo-3,5-dioxohexanoic acid esters March 25, 2008
A method for the production of 6,6,6-trihalo-3,5-dioxhexanoic acid esters of formula (I): ##STR00001## in addition to the enols thereof and <I>E</I> and <I>Z</I> isomers, wherein X independently represents fluorine, chlorine or bromine and R.sup.1 represents
7169770 Method of enhancing reproductive performance in sows January 30, 2007
The present invention relates to supplementing the diets to sows during the periods of gestation, lactation, and breeding by feeding L-carnitine and chromium. The supplementation enhances pork productivity by increasing the number of pigs born alive in the subsequent reproductive cyc
7145007 Process for the preparation of (pyrimidin-2-yl) methyl ketones December 5, 2006
A process for the preparation, of (pyrimidin-2-yl)methyl ketones of the general formula (I), ##STR00001## in which R.sup.1 is in each case a C.sub.1-10-alkyl group, a C.sub.3-8-cycloalkyl group, an allyl group or an aryl-C.sub.1-4-alkyl group, and R.sup.2 is a C.sub.1-10-alkyl group or
7141670 Process for the preparation of 1-(pyrimidin-2-yl)propan-2-ones November 28, 2006
A process for the preparation of 1-(pyrimidin-2-yl)propan-2-ones of general formula (I), in which R is in each case a C.sub.1-10-alkyl group, a C.sub.3-8-cycloalkyl group, an alkyl group or an aryl-C.sub.1-4-alkyl group. For this, a malondiimidate of the general formula (II), in which R
6696093 Aldehyde donors for stabilizing peroxides February 24, 2004
The present invention is a method of stabilizing hydrogen peroxide in an aqueous solution, such as a circulating water slurry, comprising a peroxide, such as hydrogen peroxide. The aqueous solution may include organic matter. The method comprises adding an aldehyde donor, such as a m
6586631 Acetoacetarylamides July 1, 2003
Novel acetoacetarylamides in the form of a solidified melt which are in a form which can be used in industry and is easy to handle and which has a water content of from 3 to 15 percent by weight. These novel acetoacetarylamides have been used for the preparation of colored pigments o
6476175 Bicyclic amidines, process for their preparation, and their use as catalyst November 5, 2002
A process including preparing a polyurethane in the presence of a catalyst which is a bicyclic amidine of the formula: ##STR1##wherein A is selected from the group consisting of --CR.sup.1 R.sup.2 --CR.sup.3 R.sup.4 --CR.sup.5 R.sup.6 --, --CR.sup.1 R.sup.2 --CR.sup.3 R.sup.4 --CR.su
6476010 Method for increasing intestinal absorption of fat soluble vitamins in post-menopausal women and November 5, 2002
The present invention provides a method for increasing the intestinal (lymphatic) absorption, cellular concentration, biliary secretion, hepatic storage, and/or liver concentration of a fat soluble vitamin in a post-menopausal woman. The method comprises orally administering to a pos
6342526 Method for enhancing or achieving training-induced bradycardia with Carnitine January 29, 2002
Use of Carnitine for achieving or enhancing training-induced bradycardia in a mammal, particularly in a horse, most preferably in a trotter horse.
6169183 Process for preparing pyridinecarboxylic esters January 2, 2001
A process for preparing pyridinecarboxylic esters of the general formula: ##STR1##wherein R.sup.1 is hydrogen, a C.sub.1-6 -alkyl group, a C.sub.1-4 -alkoxycarbonyl group, a C.sub.1-4 -alkoxymethyl group or a fluorinated C.sub.1-6 -alkyl group, R.sup.2 is a C.sub.1-4 -alkyl group and X i
6162921 Process for preparing pyridinecarboxylic esters December 19, 2000
A process for preparing pyridinecarboxylic esters of the general formula: ##STR1## wherein R.sup.1 is hydrogen, a C.sub.1 -C.sub.6 -alkyl group, a C.sub.1 -C.sub.4 -alkoxycarbonyl group or a C.sub.1 -C.sub.4 -alkoxymethyl group, R.sup.2 is a C.sub.1 -C.sub.4 -alkyl group and X is chl
6111106 1,4,5,6-tetrahydropyrazine-2-carboxamides August 29, 2000
1,4,5,6-tetrahydropyrazine-2-carboxamides of formula: wherein R.sup.1 is hydrogen, alkyl, cycloalkyl or arylalkyl; R.sup.2 is alkyl, aryl, or arylalkyl and R.sup.3, R.sup.4 and R.sup.5 are hydrogen, acyl, aryl or arylalkyl or R.sup.2 forms an alicyclic system with R.sup.3 or R.sup.4 and
6103906 Process for the preparation of 2,6-pyridinedicarboxylic acid esters August 15, 2000
A process for the preparation of 2,6-pyridinedicarboxylic acid esters of the general formula: ##STR1## wherein R.sup.1 is a C.sub.1 -C.sub.6 -alkyl group, a C.sub.3 -C.sub.6 -cycloalkyl group, an aryl group or an arylalkyl group, and R.sup.2 and R.sup.3 independently of one anoth
6025519 Process for preparing cyclobutane-1,2-dicarboxylic esters February 15, 2000
Cyclobutane-1,2-dicarboxylic esters of the formula: ##STR1## in which R.sup.1 is a C.sub.1-8 -alkyl group, an optionally substituted mono- or bicyclic cycloaliphatic group having 3 to 10 ring carbon atoms, an optionally substituted aryl or arylalkyl group or an optionally substit
6022974 Process for the production of 2-chloro-5-chloromethyl-pyridine February 8, 2000
A process for the production of 2-chloro-5-chloromethylpyridine of the formula: ##STR1## starting from 6-hydroxynicotinic acid of the formula: ##STR2## In this way 6-hydroxynicotinic acid is reacted with an acid chloride to 6-hydroxynicotinoyl chloride of the formula: ##S
6022973 Process for preparing pyridinecarboxylic esters February 8, 2000
A process for preparing pyridinecarboxylic esters of the general formula: ##STR1## wherein R.sup.1 is hydrogen, a C.sub.1 -C.sub.6 -alkyl group, a C.sub.1 -C.sub.4 -alkoxycarbonyl group or a C.sub.1 -C.sub.4 -alkoxymethyl group, R.sup.2 is a C.sub.1 -C.sub.4 -alkyl group and X is chl
6020515 Process for the preparation of malononitrile February 1, 2000
A novel process for the preparation of malononitrile which involves subjecting a (2-cyano-N-alkoxy)acetimidoyl halide to a high-temperature treatment.
6011178 Process for the preparation of 2-amino-4,5,3',4'-tetramethoxybenzophenone January 4, 2000
2-Amino-4,5,3',4'-tetramethoxybenzophenone of the formula: ##STR1## is prepared by mononitration of 3,3',4,4'-tetramethyoxybenzophenone using nitric acid in the presence of acetic acid, and subsequent reduction of the nitro group. The compound is an intermediate in the synthesis of
5994540 Di-and trisubstituted pyridines and their preparation November 30, 1999
Substituted pyridines of the general formula: ##STR1## wherein R.sup.1 is hydroxyl or chlorine, and a) X is hydrogen or chlorine, R.sup.2 and R.sup.3 together are .dbd.O, R.sup.4 is a group of the formula --OR.sup.5 and R.sup.5 is hydrogen, C.sub.1 -C.sub.4 -alkyl or benzyl orb) X is
5959136 Process for the preparation of malononitrile September 28, 1999
A novel process for the preparation of malononitrile, which involves subjecting an isonitrile, optionally in the presence of a nitrile, to a high-temperature treatment.
5932762 Process for the production of aryl cyanates August 3, 1999
A process for the production of aryl cyanates of the general formula I: ##STR1## A phenol of the general formula II: ##STR2## a tertiary amine and cyanogen chloride, of which at least one of the three components is present as a solution in an organic solvent, are fed essentia
5922869 Bicyclic amidines, process for their preparation, and their use as catalyst July 13, 1999
The process for the preparation of bicyclic amidines of the general formula: ##STR1## wherein A is selected from the group consisting of --CR.sup.1 R.sup.2 --CR.sup.3 R.sup.4 --CR.sup.5 R.sup.6 --, --CR.sup.1 R.sup.2 --CR.sup.3 R.sup.4 --CR.sup.5 R.sup.6 --CR.sup.7 R.sup.8 -- and
5892044 Process for preparing optically active 1-(p-methoxybenzyl)-1,2,3,4,5,3,7,8-octahydroisoquinoline April 6, 1999
Optically active 1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline having the formula (I) is prepared by asymmetric hydrogenation of the corresponding 3,4,5,6,7,8-hexahydro-compound or of the new 1-(p-methoxybenzyl)-3,4,5,6,7,8-hexahydroisoquinoline dihydrogenated phosphate i
5891710 Microorganisms for the stabilization of plasmids April 6, 1999
New microorganisms with plasmids stable relative to betaine utilization. These new microorganisms contain (a) a hybrid plasmid with a DNA fragment that contains a genetic sequence that codes for betaine utilization and (b) a mutation in the chromosomal gene coding for the betaine utiliza
5886181 Process for the preparation of optically active piperazine-2-carboxylic acid derivatives March 23, 1999
Optically active piperazine-2-carboxylic acid derivatives of the general formula: ##STR1## wherein R.sup.1 and R.sup.2 are inter alia hydrogen, alkyl or acyl and X is alkoxy or a (substituted) amino group, are prepared by asymmetric hydrogenation of the corresponding 1,4,5,6-tetr
5760236 Di and trisubstituted pyridines June 2, 1998
Substituted pyridines of the general formula: ##STR1## wherein R.sup.1 is hydroxyl or chlorine, and a) X is hydrogen or chlorine, R.sup.2 and R.sup.3 together are .dbd.O, R.sup.4 is a group of the formula --OR.sup.5 and R.sup.5 is hydrogen, C.sub.1 -C.sub.4 -alkyl or benzyl, orb) X i
5756826 Process for preparing acetoacetates May 26, 1998
A process for preparing acetoacetates of the general formula: ##STR1## They are prepared by the addition of diketene onto an alcohol of the general formula:and further reaction of the adduct with a compound of the general formula: ##STR2##
5756756 Asymmetric hydrogenation of dihyrofuroimidazole derivatives May 26, 1998
A process for the asymmetric hydrogenation of the furoimidazole derivatives of the general formula: ##STR1## wherein R.sub.1 is a protective group, which is cleavable in a known way, and R.sub.2 is hydrogen or a protective group, which is cleavable in a known way, with hydrogen i
5723605 Bicyclic amidines, process for their preparation, and their use as catalyst March 3, 1998
The process for the preparation of bicyclic amidines of the general formula: ##STR1## wherein A is selected from the group consisting of --CR.sup.1 R.sup.2 --CR.sup.3 R.sup.4 --CR.sup.5 R.sup.6 --, --CR.sup.1 R.sup.2 --CR.sup.3 R.sup.4 --CR.sup.5 R.sup.6 --CR.sup.7 R.sup.8 -- and
5714610 Process for the preparation of 3-methylpiperidine and 3-methylpyridine by catalytic cyclization February 3, 1998
In a process for preparing 3-methylpiperidine or 3-methylpyridine from 2-methyl-1,5-diaminopentane in the gaseous phase, the initial product is made to flow over catalysts. In the first step, 3-methylpiperidine is produced, and if required 3-methylpyridine is produced in a second step.
5702930 Microbiological process for the preparation of heteroaromatic carboxylic acids using Alcaligenes December 30, 1997
A microbiological process for the preparation of a heteroaromatic carboxylic acid or one of its physiologically tolerated salts of the formulae I or II: ##STR1## wherein R.sub.1 and R.sub.2 are identical or different and each denotes a hydrogen or halogen atom, and X denotes a ni
5698707 Process for the preparation of optionally 2-substituted 5-chloroimidazole-4-carbaldehydes December 16, 1997
A process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes of the general formula: ##STR1## wherein R is hydrogen, an alkyl group, an alkenyl group, a cycloalkyl group, a benzyl group or a phenyl group. The imidazole compounds are important starting products
5698701 Catalytic composition for the oxidative ammonolysis of alkylpyridines December 16, 1997
A new catalytic composition, comprising the oxides of vanadium, titanium, zirconium and molybdenum is disclosed. The new catalytic composition is applied in the oxidative ammonolysis of alkylpyridines.
5696272 Process for the production of 2-substituted 5-chloroimidazole-4-carbaldehydes December 9, 1997
A process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes of the general formula: ##STR1## in which glycine is reacted with an imido ester of the general formula: ##STR2## and the resultant intermediate is converted into the product by a Vilsmeier reage
5684157 Process for the preparation of optionally 2-substituted 5-chloroimidazole-4-carbaldehydes November 4, 1997
A process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes of the general formula: ##STR1## wherein R is hydrogen, an alkyl group, an alkenyl group, a cycloalkyl group, a benzl group or a phenyl group. The imidazole compounds are important starting products
5614636 Process for the preparation of 2,4-pyridine dicarboxylic acid March 25, 1997
A process for the preparation of carboxamides of nitrogen-containing aromatic heterocyclic compounds from the corresponding N-heterocyclic compounds by reaction thereof with formamide in the presence of peroxodisulfuric acid or a peroxodisulfate.
5610312 Asymmetric hydrogenation of dihydrofuroimidazole derivatives March 11, 1997
A process for the asymmetric hydrogenation of the furoimidazole derivatives of the general formula: ##STR1## wherein R.sub.1 is a protective group, which is cleavable in a known way, and R.sub.2 is hydrogen or a protective group, which is cleavable in a known way, with hydrogen i
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