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Leica Microsystems CMS GmbH Patents
Assignee:
Leica Microsystems CMS GmbH
Address:
Wetzlar, DE
No. of patents:
115
Patents:


1 2 3


Patent Number Title Of Patent Date Issued
D525636 Microscope July 25, 2006
7619732 Method and microscope for high spatial resolution examination of samples November 17, 2009
A method and a microscope, in particular a laser scanning fluorescence microscope, for high spatial resolution examination of samples, the sample (1) to be examined comprising a substance that can be repeatedly converted from a first state (Z1, A) into a second state (Z2, B), the fir
7602824 Device and method for supplying short-wavelength light October 13, 2009
The present invention broadly comprises a device for supplying light at an illumination wavelength shorter than 300 nm. The device includes a first subassembly, having a light source for delivering light at a wavelength that is at least twice as long as the illumination wavelength; a sec
7600926 Device for adjusting an optical fiber or an optical fiber bundle October 13, 2009
Disclosed is a device for adjusting an optical fiber (1) or an optical fiber bundle relative to a coupling point. Said device comprises a holding apparatus (2) for the fiber/s (1) and a mechanism (3) for positioning the fiber/s (1) in said holding apparatus (2). The positioning mecha
7599115 Raster microscope October 6, 2009
A scanning microscope includes an excitation light beam, a stimulation light beam, an objective, an optical component and an optical system, The excitation light beam optically excites a first area of a specimen. The stimulation light beam triggers a stimulated emission or an additional
7596454 Method for separating detection channels of a microscope system September 29, 2009
A method for separating detection channels is disclosed, a sample (15) being equipped with at least two different fluorescent dyes. Firstly the emission spectrum of at least two fluorescent dyes is ascertained. From the emission spectra, the separation points of the wavelength and of the
7586107 Photosensor-chip, laser-microscope comprising a photosensor-chip and method for reading a photos September 8, 2009
A photosensor chip includes a light-sensitive region with a plurality of detector elements and a light-insensitive region including a buffer memory. The light-insensitive region is at least double the light-sensitive region. A charge produced at different points in time in the detect
7583436 Sampler carrier for a confocal microscope and method for fabricating a sample carrier September 1, 2009
A sample carrier (30) for microscopy, in particular for confocal microscopy, and a method for producing the sample carrier (30), are disclosed. The sample carrier (30) has a first coverslip (32) and a second coverslip (33). The second coverslip (33) carries an mirror (29) which is eq
7583435 Tube for a microscope September 1, 2009
The application relates to an ergonomic tube for a microscope. A binocular head is provided on the tube. A deflection element is provided in the tube and a deflection mirror is assigned to the element, the mirror being located behind the optical path of the lens, when viewed from the use
7577484 Device and method for the configuration of a microscope August 18, 2009
A partially or fully automated microscope includes one or more configurable subassemb1y. Each subassembly has at least one element. The element can be configured in various positions. A computer, associated with the microscope and having an input device and display, also includes a d
7576316 Apparatus, microscope with an apparatus, and method for calibration of a photosensor chip August 18, 2009
An apparatus, a microscope having an apparatus, and a method for calibration of a photosensor chip (19) are disclosed. The apparatus has a photosensor chip (19) which has a multiplicity of light-sensitive elements. A reference light source (30) is provided and directs the light at at
7570421 Automated microscope August 4, 2009
An automated microscope includes a stand and a front control panel. The front control panel is disposed on the stand and including a first and a second button. Third and a fourth buttons are associated with the microscope.
7564624 Microscope July 21, 2009
The invention relates to a microscope comprising at least one first and second light sources, a first light-guiding fiber connected to the first light source and a second light-guiding fiber connected to the second light source, wherein the light emitted by corresponding light source is
7561327 Device for setting the divergence and/or convergence of a light beam July 14, 2009
An apparatus for setting a divergence and/or convergence of a light beam includes at least one optical component for influencing the divergence and/or convergence of the light beam. A positioning device is provided for positioning the optical component. The positioning device includes at
7554726 Objective for evanescent illumination and microscope June 30, 2009
A microscope comprises an objective and a light source that produces an illumination light beam--in particular for evanescent illumination of a sample, which exhibits a focus in the plane of the objective pupil. To adjust the penetration depth, an adjustment mechanism is provided with
7554722 Scanning microscope with scanner frequency derived from pulsed laser June 30, 2009
A scanning microscope (1) and a scanning method are disclosed. The scanning microscope (1) has, arranged in the illuminating light beam path (3), an outcoupling element (60) that couples out at least a fraction of the illuminating light beam (3) and directs it to a detector (61) that
7551351 Microscope with evanescent sample illumination June 23, 2009
A microscope with evanescent sample illumination comprises a device for optically manipulating a sample.
7508507 Device for selecting and detecting at least two spectral regions of a light beam March 24, 2009
An apparatus for selecting and detecting at least two spectral regions of a light beam includes a selection device, a detection device, and a light suppression device. The light suppression device suppresses reflected and/or scattered light of an illuminating light of a microscope. The
7505200 Phase shift method and apparatus for implementing phase-contrast or modulation-contrast observat March 17, 2009
The invention concerns an apparatus for implementing phase-contrast or modulation-contrast observation on microscopes with the aid of a modulator (7) arranged in each pupil plane in the observation beam path and containing at least one layer modifying the phase or amplitude, and of a
7495778 Method and device for optically examining an object February 24, 2009
A device for optically examining an object includes a lens, an object stage for receiving the object, and an image-recording apparatus for recording a series of individual images of the object in a number of planes. A piezo-controlled apparatus is provided for adjusting the distance
7495236 Apparatus and method for detection with a scanning microscope February 24, 2009
An apparatus and a method for detection with a scanning microscope (1) are disclosed. The scanning microscope (1) encompasses a scanning device (7) that guides an illuminating light beam (3) through a scanning optical system (12) and a microscope optical system (13) and over or through a
7492511 Scanning microscope February 17, 2009
The invention relates to a scanning microscope comprising a beam deflecting device (11), which directs an illuminating light beam (5) over or through a sample (21), and comprising a detector (33) for receiving detection light (23) exiting the sample. The scanning microscope comprises
7486441 Objective and microscope February 3, 2009
An objective for total internal reflection microscopy includes a diaphragm disposed near to or in the plane of the objective pupil. The diaphragm includes a middle area impermeable to illumination light and permeable to detection light of a microscope, and includes an edge area permeable
7485878 Laser microdissection unit February 3, 2009
A laser microdissection unit for cutting a microscopic sample using a laser beam of a laser includes a microscope and a fluorescence device. The microscope includes an illumination beam path directed onto the sample, and an imaging beam path configured to image the sample. The fluore
7485846 Scanning microscope and method for scanning microscope February 3, 2009
A scanning microscope with a first and at least one other detection channel is disclosed. The first detection channel comprises at least one first detector and the other detection channel comprises at least one other detector to detect the detection light given off by a sample. A swi
7483207 Apparatus for mounting multiple lasers, and microscope January 27, 2009
An apparatus for mounting for multiple lasers (16a, 16b, 16c) is disclosed. The multiple lasers (16a, 16b, 16c) generate light that is guided via a light-guiding fiber to an optical system (10). Provided for that purpose on the mounting plate (15) is a combining unit (18) that compri
7482600 Method for investigating transport processes January 27, 2009
A method for investigating transport processes in a preferably biological specimen, a laser light beam (2, 3) being guided by means of a scanning apparatus line by line over the specimen within definable specimen regions, and the light proceeding from the specimen being detected by m
7480046 Scanning microscope with evanescent wave illumination January 20, 2009
A scanning microscope includes a light source for evanescently illuminating a sample disposed on a slide. A point detector receives detection light emanating from a scanning point of the sample. A beam deflection device disposed in an optical path of the detection light can shift a p
7477449 Scanning microscope January 13, 2009
A scanning microscope, having a detector, arranged in a detection beam path, for receiving detection light proceeding from a sample, has between the sample and the detector an optical shutter means with which the detection beam path can be blocked. A control means for controlling the
7477448 Device and method for adjusting two objective lenses in 4Pi-system January 13, 2009
A method for adjusting two objective lenses in a 4Pi system of a scanning microscope includes imaging a reference object in respective pupils of the objective lenses so as to form a respective Fourier image for each of the objective lenses from a respective image of the reference object.
7477380 Scanning microscope comprising a confocal slit scanner for imaging an object January 13, 2009
A scanning microscope for imaging an object includes a light source and a spectrally selective detection device. An illumination beam path extends from the light source to the object. A detection beam path extends from the object to the detection device. A spectrally selective element
7474462 Microscope with evanescent wave illumination January 6, 2009
A microscope with a first and a second illumination light beam for illuminating a sample, wherein the first and/or the second illumination light beam evanescently illuminates the sample. For the purpose of CARS testing, the first illumination light beam can be a pump light beam, and
7471817 Method for performing interactions on microscopic subjects that change in space and time, and sy December 30, 2008
The method and the system simplify moving interactions by means of virtual reference subjects and flux-based coordinate transformations in order to generate a changeable frame of reference.
7468833 Ergonomic microscope and microscope carrier December 23, 2008
An ergonomic microscope (1) and a microscope carrier (2) are disclosed. The microscope encompasses a stand (3) which possesses a stand base (3a) that defines an external contour (3b). The microscope (1) is placed onto the microscope carrier (2). The microscope carrier (2) comprises a bod
7466885 Light source comprising a plurality of microstructured optical elements December 16, 2008
The invention relates to a light source comprising a microstructured optical element (11) that receives and spectrally spreads the light from a primary light source (3). The inventive light source is characterized in that the spectrally spread light penetrates at least one other micr
7463414 Microscope December 9, 2008
A microscope includes an adjustment device for positioning a specimen stage. An objective, an objective changer and/or an objective turret is coupled to the adjustment device so that a position of the objective element is adjustable by the adjustment device. A holder for the objectiv
7457331 Optical arrangement November 25, 2008
An optical arrangement includes a laser, and a chromatic error correcting device arranged in a beam path of the laser. The chromatic error correcting device includes a pulse stretcher.
7453578 4Pi microscope November 18, 2008
A 4Pi microscope provided with an interferometer wherein two lenses (31, 33) are arranged in such a way that they are opposite to each other on different sides of a sample plane (35); also comprising an optical element (19) which is used to inject illuminating light (3) into the inte
7450302 Microscope with image brightness equalization November 11, 2008
A microscope (10) is disclosed, having a revolving nosepiece (12) on which are mounted multiple objectives. The objectives (11) comprise multiple components 21.sub.1, . . . 21.sub.n). A light-intensity-reducing layer (40) is applied onto at least one component of an objective. The li
7446936 Illumination device in a microscope November 4, 2008
An illumination device in a microscope includes multiple light sources arranged on a mirror housing. A mirror is provided which is rotatably or displaceably arranged in the mirror housing for selectably switching each of the light sources into an illumination beam path. At least one driv
7446322 Method and device for recognizing dark states during the spectroscopic or microscopic examinatio November 4, 2008
A method for recognizing dark states during the spectroscopic or microscopic examination of fluorescent specimens includes varying an intensity distribution of excitation light by varying an excitation/illumination volume over a plurality of mutually independent measurements. A deter
7440183 Indexable microscope October 21, 2008
An indexable microscope is described, that comprises a microscope stand and an optical beam path, having a plurality of optical components that are switchable into and out of the beam path, which are arranged on at least two independent mechanical assemblies to be indexed separately and
7433129 Optical arrangement for microscope and microscope October 7, 2008
An optical arrangement for a microscope, in particular for a scanning microscope, with a beam splitter 1 arranged in a divergent and/or convergent beam path for separating an illumination light 2 that is produced by an illumination source from a detection light 3 that is emitted by a
7433119 Scanning microscope October 7, 2008
In a scanning microscope that impinges upon a sample with a first light pulse and a second light pulse, a dispersive medium that modifies the time offset between the first and the second light pulse is provided in the beam path of at least one of the light pulses.
7428104 Optical device for the combination of light beams September 23, 2008
An optical device for combining a first light beam and at least one second light beam includes a first beam splitting device, a second beam splitting device and a position detector. The first beam splitting device splits a first reference beam from the first light beam and a second r
7428043 Apparatus for ascertaining the light power level of a light beam, and scanning microscope September 23, 2008
An apparatus for ascertaining properties of a light beam, comprises a means for splitting a measured beam out from the light beam and comprises at least one detector that at least partially receives the measured beam. A polarization-influencing means is arranged in the beam path of the
7411665 Method for wavelength calibration of an optical measurement system August 12, 2008
An optical measurement system having a spectrophotometer and a ellipsometer is calibrated, the spectrophotometer and the ellipsometer first being calibrated independently of one another. A spectrophotometer layer thickness (d.sub.photo) of a specimen is then determined at an initial
7405874 Microscope for epi fluorescence and total internal reflection microscopy July 29, 2008
The invention relates to a microscope for conventional fluorescence microscopy (Epi fluorescence) and for total internal reflection microscopy, including at least one light source (1) for the conventional fluorescence illumination and at least one light source (2) for the evanescent
7394482 Microscope system and method for the analysis and evaluation of multiple colorings of a microsco July 1, 2008
A microscope system and a method that record spectra (60a, 61a, 62a, 63a, and 66a) of the dyes present in the specimen (15) using an SP module (20) are disclosed. A transformation of the data of the ascertained spectra, and of the dye spectra (60b, 61b, 62b, 63b, and 66b) stored in a
7394063 Microscope for investigating the lifetime of excited states in a sample July 1, 2008
A microscope for investigating the lifetime of excited states in a sample has a light source that generates excitation light, and has a detector that receives detected light proceeding from the sample. The light source contains a semiconductor laser which emits pulsed excitation light. A
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