| Patent Number |
Title Of Patent |
Date Issued |
| RE38332 |
Selected soluble esters of hydroxyl-containing indolocarbazoles |
November 25, 2003 |
| Esters of hydroxyl-containing indolocarbazoles and acids containing selected solubilizing groups are provided. Compositions including the indolocarbazole esters and methods for the use of the indolocarbazole esters are also provided. |
| RE29369 |
Method for preparing acylated products |
August 23, 1977 |
| Acylation of nitrogen containing compounds utilizing esters as acylation agents in the presence of salts of substituted pyridine compounds. |
| RE28886 |
Method for preparing cytidine diphosphate choline |
June 29, 1976 |
| Cytidine diphosphate choline is prepared by culturing an aqueous reaction liquor containing (a) at least one of the class consisting of choline or phosphoryl choline; (b) at least one of the class consisting of cytidine, cytidine-5'-monophosphate, cytidine-5'-diphosphate or cytidine- |
| D282148 |
Bottle |
January 14, 1986 |
|
| D280801 |
Bottle |
October 1, 1985 |
|
| D280708 |
Bottle |
September 24, 1985 |
|
| 7560461 |
Quinazoline derivatives as kinase inhibitors |
July 14, 2009 |
| The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibi |
| 7541365 |
Chemokine receptor antagonists and methods of use therefor |
June 2, 2009 |
| Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: ##STR00001## or physiologically acceptable sal |
| 7538241 |
Hsp90 family protein inhibitors |
May 26, 2009 |
| ##STR00001## (wherein n is an integer of 0 to 10; R.sup.1 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted lower alkoxycarbonyl, substituted or unsubstituted heterocy |
| 7538224 |
Hsp90 family protein inhibitors |
May 26, 2009 |
| The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): ##STR00001## (wherein n represents an integer of 0 to 10; R.sup.1 represents substituted or unsubstituted lower alkoxy, substituted |
| 7531333 |
Process for producing isoprenoid compounds by microorganisms and a method for screening compound |
May 12, 2009 |
| The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for c |
| 7524852 |
Bicyclic pyrimidine derivatives |
April 28, 2009 |
| ##STR00001## [wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; R.sup.1 represents --NR.sup.4R.sup.5 (wherein R.sup.4 and R.sup.5 may be the same or different and each represents a hydrogen atom, substituted or unsubstitu |
| 7521079 |
Process for producing an extract of Hydrangea containing plant powder |
April 21, 2009 |
| The present invention relates to a method for producing a liquid plant extract containing plant powder, which includes concentrating a liquid extract containing an active ingredient in the presence of the plant powder, the liquid extract being obtained from a plant containing the act |
| 7517673 |
Process for producing alpha1,4-galactosyltransferase and galactose-containing complex carbohydra |
April 14, 2009 |
| The present invention can provide a process for producing a protein having .alpha.1.4-galactosyltransferase activity using a transformant comprising a DNA encoding a protein having .alpha.1.4-galactosyltransferase activity derived from a microorganism belonging to the genus Pasteurella a |
| 7514243 |
Process for producing dipeptides |
April 7, 2009 |
| The present invention provides a process for producing a dipeptide which comprises culturing in a medium a microorganism which has the ability to produce a protein having the activity to form the dipeptide from one or more kinds of amino acids and which has the ability to produce at leas |
| 7514242 |
Process for producing dipeptides |
April 7, 2009 |
| The present invention provides a protein which catalyzes the synthesis of a dipeptide different from L-Ala-L-Ala, a process for producing the protein which catalyzes the synthesis of a dipeptide, a process for producing a dipeptide using the protein which catalyzes the synthesis of a |
| 7504256 |
Process for producing polypeptide |
March 17, 2009 |
| The present invention relates to a process for producing a desired polypeptide using rat cells. Specifically, the present invention relates to a process for producing the polypeptide which comprises culturing rat cells such as YB2/3HL.P2.G11.16Ag.20 (hereinafter referred to as YB2/0), |
| 7504104 |
Human CDR-grafted antibody and antibody fragment thereof |
March 17, 2009 |
| A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically |
| 7498415 |
Recombinant antibody against human insulin-like growth factor |
March 3, 2009 |
| It is demanded that pharmaceutical agents for therapeutic treatment of diseases such as cancer, acromegaly and diabetic complications, of which IGF is involved in the progress of the conditions.The present invention provides a recombinant antibody or an antibody fragment thereof which |
| 7485662 |
Therapeutic agent for diabetes mellitus |
February 3, 2009 |
| An object of the present invention is to provide a therapeutic agent for diabetes mellitus or insulin resistance improving agent, or to provide foods and drinks, food and drink additives, and feeds or feed additives for treating diabetes mellitus or improving insulin diabetes.In order to |
| 7479371 |
Method of judging leukemia, pre-leukemia or aleukemic malignant blood disease and diagnostic the |
January 20, 2009 |
| The present invention relates to a method for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases, a method of discriminating leukemia from pre-leukemia or aleukemic malignant blood diseases, a method of discriminating aplastic anemia from myelodysplastic syndrome |
| 7470717 |
Indazole derivatives |
December 30, 2008 |
| The present invention provides a compound represented by Formula (I): ##STR00001## [wherein R.sup.1 represents CONR.sup.1aR.sup.1b (wherein R.sup.1a and R.sup.1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or |
| 7470528 |
DNA encoding hydroxylase |
December 30, 2008 |
| The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): ##STR00001## wherein R.sup.1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or |
| 7445915 |
Mutant isopropylmalate isomerase |
November 4, 2008 |
| The present invention provides a polypeptide comprising an amino acid sequence in which at least one amino acid is deleted, substituted or added in an amino acid sequence of isopropylmalate isomerase derived from a microorganism belonging to coryneform bacteria, wherein a coryneform |
| 7438911 |
Antibody against human insulin-like growth factor |
October 21, 2008 |
| For the effective treatment of diseases such as cancer in which hIGF participates, there have been desired to be developed antibodies which strongly bind to both factors hIGF-I and hIGF-II and inhibit their functions and fragments of these antibodies. The present invention provides a |
| 7425636 |
Thiadiazoline derivative |
September 16, 2008 |
| ##STR00001## (wherein R.sup.1 and R.sup.4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; R.sup.5 represents a substituted or |
| 7425446 |
Antibody composition-producing cell |
September 16, 2008 |
| The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the |
| 7422878 |
Process for microbial production of ubiquinone-10 using Rhodobacter |
September 9, 2008 |
| The present invention provides a process for producing ubiquinone-10 using a microorganism having the ability to form ubiquinone-10 and having one or more properties selected from the group consisting of the property wherein geranylgeranyltransferase activity is reduced or defective, the |
| 7404953 |
Methods using eosinophil-specific apoptosis inducer |
July 29, 2008 |
| The present invention provides an apoptosis inducer and a therapeutic agent for eosinophilic diseases which comprises, as an active ingredient, an antibody which reacts specifically with eosinophils and induces apoptosis of eosinophils; and a method for inducing eosinophil apoptosis |
| 7393683 |
Mammalian host cell modified by RNAi to inhibit .alpha. 1,6-fucosyltransferase |
July 1, 2008 |
| The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the |
| 7364885 |
Process for producing isoprenoid compounds by microorganisms and a method for screening compound |
April 29, 2008 |
| The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for c |
| 7358348 |
.beta.-catenin nuclear localized protein |
April 15, 2008 |
| The present invention provides a novel .beta.-catenin nuclear localizing protein and DNA encoding the protein. Furthermore, the use of the .beta.-catenin nuclear localizing protein and the DNA encoding the protein provides a diagnostic agent and therapeutic agent for diseases such as |
| 7354949 |
Therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia |
April 8, 2008 |
| The present invention provides a therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia comprising, as an active ingredient, a tricyclic compound represented by formula (I): ##STR00001## [wherein R.sup.1 represents a hydrogen atom, substituted or |
| 7332522 |
Liver function protecting or ameliorating agent |
February 19, 2008 |
| A liver function protecting or improving agent which comprises a compound represented by the formula (I) ##STR00001## {in the formula (I), R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 may be the same or different, and represent hydrogen, halogen |
| 7332475 |
Preventive or therapeutic composition for viral infectious disease |
February 19, 2008 |
| The invention provides a composition for preventing or treating infectious diseases of a virus belonging to the Coronavirus family or Flavivirus family, the composition containing one or more substances selected from reduced glutathione or oxidized glutathione or pharmaceutically acc |
| 7332310 |
Mutant of homoserine dehydrogenase from Corynebacterium and DNA encoding thereof |
February 19, 2008 |
| Novel polynucleotides derived from microorganisms belonging to coryneform bacteria and fragments thereof, polypeptides encoded by the polynucleotides and fragments thereof, polynucleotide arrays comprising the polynucleotides and fragments thereof, recording media in which the nucleo |
| 7329655 |
Nitrogenous heterocyclic compounds |
February 12, 2008 |
| The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibi |
| 7329514 |
Process for producing n-acetylneuraminic acid |
February 12, 2008 |
| In the process for producing N-acetylneuraminic acid by using a microorganism having the ability to produce N-acetylneuraminic acid, the present invention provides economical and efficient process for producing N-acetylneuraminic acid by using a microorganism in which the activity to |
| 7294448 |
Composition sensitive to visible light |
November 13, 2007 |
| The present invention provides a visible light-sensitive composition which is highly sensitive to a visible light and is useful as an electronic circuit forming material, a lithographic printing material, etc., said visible light-sensitive composition comprising (a) a polymer comprising |
| 7291713 |
Branched polyalkylene glycols |
November 6, 2007 |
| The present invention provides a branched polyalkylene glycol wherein three or more single-chain polyalkylene glycols and a group having reactivity with an amino acid side chain, the N-terminal amino group or the C-terminal carboxyl group in a polypeptide or a group convertible into |
| 7291491 |
Polypeptides |
November 6, 2007 |
| The present invention provides pharmaceutical preparations for anti-inflammation, anti-infection, inhibition of cancer metastasis etc., foods such as dairy products etc., and a method for improving proteins, as well as a method for diagnosis of inflammatory diseases and cancer malign |
| 7279310 |
Process for producing sugar chains using .beta.1,3-N-acetylglucosaminyltransferase |
October 9, 2007 |
| The present invention provides a novel polypeptide having a .beta.1,3-N-acetylglucosaminyltransferase activity, an agent for synthesizing a sugar chain comprising the polypeptide, a process for producing a sugar chain or a complex carbohydrate using the agent for synthesizing a sugar |
| 7276532 |
Remedies for vesical hyperactivity |
October 2, 2007 |
| The present invention provides a therapeutic agent for overactive bladder comprising, as an active ingredient, a tricyclic compound represented by formula (I): ##STR00001## [wherein R.sup.1 represents a hydrogen atom, substituted or unsubstituted lower alkyl, and the like; X.sup.1-- |
| 7271176 |
Chemokine receptor antagonists and methods of use thereof |
September 18, 2007 |
| Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt |
| 7262039 |
Polypeptide |
August 28, 2007 |
| This invention relates to a novel polypeptide having an .alpha.1,3-fucosyltransferase activity, a method for producing the polypeptide, a DNA encoding the polypeptide, a method for producing the DNA, a recombinant vector obtained by inserting the DNA thereinto, a transformant having |
| 7258855 |
Polypeptides having phospholipase A.sub.2 activity |
August 21, 2007 |
| The present invention relates to a novel phospholipase A.sub.2 polypeptide, DNA encoding the polypeptide, a vector comprising the DNA, a transformant transformed with the vector, and a process for producing the phospholipase A.sub.2 polypeptide. The present invention also relates to |
| 7253263 |
Complementarity determining region-grafted antibody against ganglioside GD3 and derivative of an |
August 7, 2007 |
| The present invention relates to a human CDR-grafted antibody against ganlioside GD3 (hereinafter referred to "GD3"), derivatives of an anti-GD3 antibody and cytokine, and use for treatment and diagnosis of the antibody and the derivatives. |
| 7250488 |
Transcriptional activation inhibitory protein |
July 31, 2007 |
| A protein binding to .beta.-catenin and thus inhibiting the transcriptional activation induced by the formation of a complex of .beta.-catenin with a protein belonging to the TCF/Lef family; a DNA encoding this protein; an antibody recognizing this protein; a therapeutic agent contai |
| 7247466 |
Amino acid racemase having low substrate specificity and process for producing racemic amino aci |
July 24, 2007 |
| The present invention provides a protein having low-substrate-specific amino acid racemase activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a process for producing the protein by using the transformant; and a proce |
| 7241605 |
Polypeptide |
July 10, 2007 |
| According to the present invention, there can be provided a novel polypeptide having .beta.1,3-galactosyltransferase activity involved in the synthesis of type 1 sugar chains, a DNA coding for said polypeptide, a recombinant vector comprising said DNA, a transformant carrying said re |
