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Kyowa Hakko Kogyo Co., Ltd. Patents
Assignee:
Kyowa Hakko Kogyo Co., Ltd.
Address:
Tokyo, JP
No. of patents:
711
Patents:


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Patent Number Title Of Patent Date Issued
RE38332 Selected soluble esters of hydroxyl-containing indolocarbazoles November 25, 2003
Esters of hydroxyl-containing indolocarbazoles and acids containing selected solubilizing groups are provided. Compositions including the indolocarbazole esters and methods for the use of the indolocarbazole esters are also provided.
RE29369 Method for preparing acylated products August 23, 1977
Acylation of nitrogen containing compounds utilizing esters as acylation agents in the presence of salts of substituted pyridine compounds.
RE28886 Method for preparing cytidine diphosphate choline June 29, 1976
Cytidine diphosphate choline is prepared by culturing an aqueous reaction liquor containing (a) at least one of the class consisting of choline or phosphoryl choline; (b) at least one of the class consisting of cytidine, cytidine-5'-monophosphate, cytidine-5'-diphosphate or cytidine-
D282148 Bottle January 14, 1986
D280801 Bottle October 1, 1985
D280708 Bottle September 24, 1985
8034820 Pharmaceutical composition October 11, 2011
The present invention provides pharmaceutical compositions, which are useful for treatment of depression and the like, and which comprises a compound having an adenosine A.sub.2A receptor antagonistic activity such as (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine
7560461 Quinazoline derivatives as kinase inhibitors July 14, 2009
The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibi
7541365 Chemokine receptor antagonists and methods of use therefor June 2, 2009
Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: ##STR00001## or physiologically acceptable sal
7538241 Hsp90 family protein inhibitors May 26, 2009
##STR00001## (wherein n is an integer of 0 to 10; R.sup.1 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted lower alkoxycarbonyl, substituted or unsubstituted heterocy
7538224 Hsp90 family protein inhibitors May 26, 2009
The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): ##STR00001## (wherein n represents an integer of 0 to 10; R.sup.1 represents substituted or unsubstituted lower alkoxy, substituted
7531333 Process for producing isoprenoid compounds by microorganisms and a method for screening compound May 12, 2009
The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for c
7524852 Bicyclic pyrimidine derivatives April 28, 2009
##STR00001## [wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; R.sup.1 represents --NR.sup.4R.sup.5 (wherein R.sup.4 and R.sup.5 may be the same or different and each represents a hydrogen atom, substituted or unsubstitu
7521079 Process for producing an extract of Hydrangea containing plant powder April 21, 2009
The present invention relates to a method for producing a liquid plant extract containing plant powder, which includes concentrating a liquid extract containing an active ingredient in the presence of the plant powder, the liquid extract being obtained from a plant containing the act
7517673 Process for producing alpha1,4-galactosyltransferase and galactose-containing complex carbohydra April 14, 2009
The present invention can provide a process for producing a protein having .alpha.1.4-galactosyltransferase activity using a transformant comprising a DNA encoding a protein having .alpha.1.4-galactosyltransferase activity derived from a microorganism belonging to the genus Pasteurella a
7514243 Process for producing dipeptides April 7, 2009
The present invention provides a process for producing a dipeptide which comprises culturing in a medium a microorganism which has the ability to produce a protein having the activity to form the dipeptide from one or more kinds of amino acids and which has the ability to produce at leas
7514242 Process for producing dipeptides April 7, 2009
The present invention provides a protein which catalyzes the synthesis of a dipeptide different from L-Ala-L-Ala, a process for producing the protein which catalyzes the synthesis of a dipeptide, a process for producing a dipeptide using the protein which catalyzes the synthesis of a
7504256 Process for producing polypeptide March 17, 2009
The present invention relates to a process for producing a desired polypeptide using rat cells. Specifically, the present invention relates to a process for producing the polypeptide which comprises culturing rat cells such as YB2/3HL.P2.G11.16Ag.20 (hereinafter referred to as YB2/0),
7504104 Human CDR-grafted antibody and antibody fragment thereof March 17, 2009
A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically
7498415 Recombinant antibody against human insulin-like growth factor March 3, 2009
It is demanded that pharmaceutical agents for therapeutic treatment of diseases such as cancer, acromegaly and diabetic complications, of which IGF is involved in the progress of the conditions.The present invention provides a recombinant antibody or an antibody fragment thereof which
7485662 Therapeutic agent for diabetes mellitus February 3, 2009
An object of the present invention is to provide a therapeutic agent for diabetes mellitus or insulin resistance improving agent, or to provide foods and drinks, food and drink additives, and feeds or feed additives for treating diabetes mellitus or improving insulin diabetes.In order to
7479371 Method of judging leukemia, pre-leukemia or aleukemic malignant blood disease and diagnostic the January 20, 2009
The present invention relates to a method for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases, a method of discriminating leukemia from pre-leukemia or aleukemic malignant blood diseases, a method of discriminating aplastic anemia from myelodysplastic syndrome
7470717 Indazole derivatives December 30, 2008
The present invention provides a compound represented by Formula (I): ##STR00001## [wherein R.sup.1 represents CONR.sup.1aR.sup.1b (wherein R.sup.1a and R.sup.1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or
7470528 DNA encoding hydroxylase December 30, 2008
The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): ##STR00001## wherein R.sup.1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or
7445915 Mutant isopropylmalate isomerase November 4, 2008
The present invention provides a polypeptide comprising an amino acid sequence in which at least one amino acid is deleted, substituted or added in an amino acid sequence of isopropylmalate isomerase derived from a microorganism belonging to coryneform bacteria, wherein a coryneform
7438911 Antibody against human insulin-like growth factor October 21, 2008
For the effective treatment of diseases such as cancer in which hIGF participates, there have been desired to be developed antibodies which strongly bind to both factors hIGF-I and hIGF-II and inhibit their functions and fragments of these antibodies. The present invention provides a
7425636 Thiadiazoline derivative September 16, 2008
##STR00001## (wherein R.sup.1 and R.sup.4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; R.sup.5 represents a substituted or
7425446 Antibody composition-producing cell September 16, 2008
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
7422878 Process for microbial production of ubiquinone-10 using Rhodobacter September 9, 2008
The present invention provides a process for producing ubiquinone-10 using a microorganism having the ability to form ubiquinone-10 and having one or more properties selected from the group consisting of the property wherein geranylgeranyltransferase activity is reduced or defective, the
7404953 Methods using eosinophil-specific apoptosis inducer July 29, 2008
The present invention provides an apoptosis inducer and a therapeutic agent for eosinophilic diseases which comprises, as an active ingredient, an antibody which reacts specifically with eosinophils and induces apoptosis of eosinophils; and a method for inducing eosinophil apoptosis
7393683 Mammalian host cell modified by RNAi to inhibit .alpha. 1,6-fucosyltransferase July 1, 2008
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
7364885 Process for producing isoprenoid compounds by microorganisms and a method for screening compound April 29, 2008
The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for c
7358348 .beta.-catenin nuclear localized protein April 15, 2008
The present invention provides a novel .beta.-catenin nuclear localizing protein and DNA encoding the protein. Furthermore, the use of the .beta.-catenin nuclear localizing protein and the DNA encoding the protein provides a diagnostic agent and therapeutic agent for diseases such as
7354949 Therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia April 8, 2008
The present invention provides a therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia comprising, as an active ingredient, a tricyclic compound represented by formula (I): ##STR00001## [wherein R.sup.1 represents a hydrogen atom, substituted or
7332522 Liver function protecting or ameliorating agent February 19, 2008
A liver function protecting or improving agent which comprises a compound represented by the formula (I) ##STR00001## {in the formula (I), R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 may be the same or different, and represent hydrogen, halogen
7332475 Preventive or therapeutic composition for viral infectious disease February 19, 2008
The invention provides a composition for preventing or treating infectious diseases of a virus belonging to the Coronavirus family or Flavivirus family, the composition containing one or more substances selected from reduced glutathione or oxidized glutathione or pharmaceutically acc
7332310 Mutant of homoserine dehydrogenase from Corynebacterium and DNA encoding thereof February 19, 2008
Novel polynucleotides derived from microorganisms belonging to coryneform bacteria and fragments thereof, polypeptides encoded by the polynucleotides and fragments thereof, polynucleotide arrays comprising the polynucleotides and fragments thereof, recording media in which the nucleo
7329655 Nitrogenous heterocyclic compounds February 12, 2008
The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibi
7329514 Process for producing n-acetylneuraminic acid February 12, 2008
In the process for producing N-acetylneuraminic acid by using a microorganism having the ability to produce N-acetylneuraminic acid, the present invention provides economical and efficient process for producing N-acetylneuraminic acid by using a microorganism in which the activity to
7294448 Composition sensitive to visible light November 13, 2007
The present invention provides a visible light-sensitive composition which is highly sensitive to a visible light and is useful as an electronic circuit forming material, a lithographic printing material, etc., said visible light-sensitive composition comprising (a) a polymer comprising
7291713 Branched polyalkylene glycols November 6, 2007
The present invention provides a branched polyalkylene glycol wherein three or more single-chain polyalkylene glycols and a group having reactivity with an amino acid side chain, the N-terminal amino group or the C-terminal carboxyl group in a polypeptide or a group convertible into
7291491 Polypeptides November 6, 2007
The present invention provides pharmaceutical preparations for anti-inflammation, anti-infection, inhibition of cancer metastasis etc., foods such as dairy products etc., and a method for improving proteins, as well as a method for diagnosis of inflammatory diseases and cancer malign
7279310 Process for producing sugar chains using .beta.1,3-N-acetylglucosaminyltransferase October 9, 2007
The present invention provides a novel polypeptide having a .beta.1,3-N-acetylglucosaminyltransferase activity, an agent for synthesizing a sugar chain comprising the polypeptide, a process for producing a sugar chain or a complex carbohydrate using the agent for synthesizing a sugar
7276532 Remedies for vesical hyperactivity October 2, 2007
The present invention provides a therapeutic agent for overactive bladder comprising, as an active ingredient, a tricyclic compound represented by formula (I): ##STR00001## [wherein R.sup.1 represents a hydrogen atom, substituted or unsubstituted lower alkyl, and the like; X.sup.1--
7271176 Chemokine receptor antagonists and methods of use thereof September 18, 2007
Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt
7262039 Polypeptide August 28, 2007
This invention relates to a novel polypeptide having an .alpha.1,3-fucosyltransferase activity, a method for producing the polypeptide, a DNA encoding the polypeptide, a method for producing the DNA, a recombinant vector obtained by inserting the DNA thereinto, a transformant having
7258855 Polypeptides having phospholipase A.sub.2 activity August 21, 2007
The present invention relates to a novel phospholipase A.sub.2 polypeptide, DNA encoding the polypeptide, a vector comprising the DNA, a transformant transformed with the vector, and a process for producing the phospholipase A.sub.2 polypeptide. The present invention also relates to
7253263 Complementarity determining region-grafted antibody against ganglioside GD3 and derivative of an August 7, 2007
The present invention relates to a human CDR-grafted antibody against ganlioside GD3 (hereinafter referred to "GD3"), derivatives of an anti-GD3 antibody and cytokine, and use for treatment and diagnosis of the antibody and the derivatives.
7250488 Transcriptional activation inhibitory protein July 31, 2007
A protein binding to .beta.-catenin and thus inhibiting the transcriptional activation induced by the formation of a complex of .beta.-catenin with a protein belonging to the TCF/Lef family; a DNA encoding this protein; an antibody recognizing this protein; a therapeutic agent contai
7247466 Amino acid racemase having low substrate specificity and process for producing racemic amino aci July 24, 2007
The present invention provides a protein having low-substrate-specific amino acid racemase activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a process for producing the protein by using the transformant; and a proce
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