| Patent Number |
Title Of Patent |
Date Issued |
| 7135559 |
Proteins and novel genes encoding the same |
November 14, 2006 |
| Novel proteins, novel genes encoding the same, plasmids respectively comprising these genes, transformants respectively comprising these plasmids, antibodies or fragments thereof against the above novel proteins, methods of detecting a bacterial infection, and novel polynucleotides a |
| 7098215 |
Nitrogenous compounds and antiviral drugs containing the same |
August 29, 2006 |
| The present invention provides novel compounds having antiviral activities and antiviral drugs containing the compounds as the active ingredient. The compounds are shown by the following general formula (1), wherein typically A.sup.1 and A.sup.2 are each guanidine or a group of the g |
| 6921609 |
Gradient cathode material for lithium rechargeable batteries |
July 26, 2005 |
| A composition suitable for use as a cathode material of a lithium battery includes a core material having an empirical formula Li.sub.x M'.sub.z Ni.sub.1-y M".sub.y O.sub.2. "x" is equal to or greater than about 0.1 and equal to or less than about 1.3. "y" is greater than about 0.0 and e |
| 6843948 |
Vinylidene fluoride resin compositions and articles molded therefrom |
January 18, 2005 |
| A vinylidene fluoride resin composition which is stable to heat at molding temperatures and is free from foaming and coloration, and molded products made by forming the vinylidene fluoride resin composition are provided. The vinylidene fluoride resin composition may comprise 100 parts by |
| 6830753 |
Adsorbent for oral administration |
December 14, 2004 |
| An adsorbent for an oral administration, comprising a porous spherical carbonaceous substance wherein a diameter is 0.01 to 1 mm, a specific surface area determined by a BET method is 700 m.sup.2 /g or more, a volume of pores having a pore diameter of 20 to 15000 nm is from not less |
| 6750249 |
Controlled release oral preparations of esculetin and its derivatives |
June 15, 2004 |
| The present invention relates to an oral preparation of esculetin with controlled release. The oral preparation of esculetin with controlled release of the present invention comprises a gel-forming polymer base, preferably hydroxypropylmethylcellulose. The preparation may be coated w |
| 6749940 |
Moistureproof multilayered film |
June 15, 2004 |
| A moistureproof multilayer film, including a composite film having a non-moisture absorbing resin layer and a vapor deposited film of an inorganic oxide or a metal formed on at least one side of the non-moisture absorbing resin layer, the multilayer film having such a layer structure |
| 6746762 |
Film selectively permeable to carbon dioxide gas and food packaging film comprising the same |
June 8, 2004 |
| A film selectively permeable to carbon dioxide gas which includes chitosan having a degree of deacetylation of 70 mol % or higher and in which the ratio of the carbon dioxide gas transmission (CO.sub.2 TR) to the oxygen gas transmission (O.sub.2 TR), (CO.sub.2 TR/O.sub.2 TR), is 15 or hi |
| 6605344 |
Gas-barrier films |
August 12, 2003 |
| The present invention provides a gas-barrier film which is produced through applying a layer containing a metallic compound to a surface of a processed-polymer layer produced from a mixture of a polyalcohol and at least one poly(meth)acrylic polymer selected from the group consisting of |
| 6592975 |
Laminated packaging material and process for producing the same |
July 15, 2003 |
| A laminated packaging material which comprises at least three layers of polymer materials comprising a surface layer, one or more intermediate layers adjacent thereto, and another surface layer, characterized in that the intermediate layer adjacent to each surface layer contains a lu |
| 6583118 |
Chondroprotective agents |
June 24, 2003 |
| A chondroprotective agent comprising a flavonoid compound of the general formula (I): ##STR1##wherein R.sup.1 to R.sup.9 are, independently, a hydrogen atom, hydroxyl group, or methoxyl group and X is a single bond or a double bond, or a stereoisomer thereof, or a naturally occurring |
| 6565858 |
Human ADAMTS-1 protein and pharmaceutical composition |
May 20, 2003 |
| A human ADAMTS-1 protein, a gene encoding the same, a pharmaceutical composition containing the protein as an active ingredient, and a method for immunologically analyzing the human ADAMTS-1 protein are disclosed. The protein can decrease the number of leukocytes and platelets, and at |
| 6565846 |
Microbial strains of pseudomonas, bacillus and enterobacter/in agricultural chemical composition |
May 20, 2003 |
| A method for screening a bacterium antagonistic to pathogenic bacteria that emerge during raising of seedlings of gramineous plants utilizing tropolone resistance and tropolone non-producing property as indices, and a microbial pesticide containing as an active ingredient the bacterium |
| 6558667 |
Method for treating renal disease, and pharmaceutical composition for treating renal disease |
May 6, 2003 |
| A method for treating a patient suffering from a renal failure progressed to a stage at which an initiation of a dialysis therapy is required, comprising combining a peritoneal dialysis and an administration of a spherical carbon, is disclosed. |
| 6512032 |
Vinylidene fluoride resin compositions and articles molded therefrom |
January 28, 2003 |
| A vinylidene fluoride resin composition which is stable to heat at molding temperatures and is free from foaming and coloration, and molded products made by forming the vinylidene fluoride resin composition are provided. The vinylidene fluoride resin composition of the present invention |
| 6333408 |
Oligonucleotides inhibitors of PAI-1 MRNA |
December 25, 2001 |
| An oligonucleotide containing a sequence of SEQ ID NO: 1: CAGTGAGTGG GTGGGGCTGG AACA, or SEQ ID NO: 2: TTAAGCTTTT ACCATGGTAA CCCC; a pharmaceutical composition comprising the oligonucleotide; and a method for treating or preventing a disease accompanied by an extracellular matrix dep |
| 6242445 |
Benzimidazole derivative |
June 5, 2001 |
| ##STR1##A novel benzimidazole derivative [specifically, for example, 2-ethoxy-1-[{4'-(2"-N,N-dimethylaminoethoxycarbonyl)phenyl}methyl]-1H-benz imidazole-6-carboxylic acid morpholide] represented by formula (I) and a salt thereof. The compound exhibits satisfactory curative effects for |
| 6143384 |
Container for retort packaging, resin composition, and gas-barrier film prepared therefrom |
November 7, 2000 |
| The present invention provides a container for retort packaging comprising a laminated film having an outermost layer comprising a layer formed of a cross-linked structure containing ester bonds between poly(meth)acrylic acid (A) and polyalcoholic polymer (B); a resin composition having |
| 6022913 |
Container for retort packaging, resin composition, and gas-barrier film prepared therefrom |
February 8, 2000 |
| The present invention provides a container for retort packaging comprising a laminated film having an outermost layer comprising a layer formed of a cross-linked structure containing ester bonds between poly(meth)acrylic acid (A) and polyalcoholic polymer (B); a resin composition having |
| 5932575 |
Cardiac diseases improving agents |
August 3, 1999 |
| This invention relates to cardiac diseases improving agents substantially free from antagonistic action to type 1 receptor of angiotensin II which participates to hypotensive action. Particularly, this invention relates to cardiac diseases improving agents composed of effective ingredien |
| 5863913 |
Aromatic compound and pharmaceutical composition |
January 26, 1999 |
| An aromatic compound of the formula (I): ##STR1## specifically, for example, 3-[[(4-carboxyphenyl)methyl]valeramido]-4-dimethylaminobenzoic acid 4'-methylpiperazide, or a salt thereof, and a pharmaceutical composition comprising said aromatic compound or pharmaceutically acceptab |
| 5811555 |
Method for substitution of an amino group of a primary amine by a chlorine atom and a synthetic |
September 22, 1998 |
| This invention relates to methods for substitution of an amino group of a heterocyclic primary amine by a chlorine atom and synthesis of 2-chloro-5-methylthiazole and its derivatives by application thereof.Typically, a heterocyclic primary amine and sodium nitrite are caused to react in |
| 5739131 |
Benzene derivatives and pharmaceutical composition |
April 14, 1998 |
| A benzene derivative of the formula (I): ##STR1## wherein R.sup.1 is hydrogen, C.sub.1-6 -alkyl, C.sub.1-6 -haloalkyl, --NH.sub.2, --NHR.sup.21 ; R.sup.2 is hydroxyl, --OR.sup.22, three- to seven-membered saturated cycloaliphatic amino optionally interrupted by one or more nitrog |
| 5736522 |
Esculetin derivatives and method for manufacture thereof, use thereof, and pharmaceutical compos |
April 7, 1998 |
| A compound of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are, independently, a hydrogen atom, a monosaccharide residue, a protected monosaccharide residue, or a protecting group for hydroxyl group, but at least one of R.sup.1 and R.sup.2 is a monosaccharide residue or |
| 5731310 |
Benzene derivatives and pharmaceutical composition |
March 24, 1998 |
| A benzene derivative of the formula (I): ##STR1## wherein R.sup.1 is hydrogen, C.sub.1-6 -alkyl, C.sub.1-6 -haloalkyl, --NH.sub.2, --NHR.sup.21 ; R.sup.2 is hydroxyl, --OR.sup.22, three- to seven-membered saturated cycloaliphatic amino optionally interrupted by one or more nitrog |
| 5731293 |
Esculetin derivatives, method for manufacture thereof, and pharmaceutical composition |
March 24, 1998 |
| A compound of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are, independently, --CON(R.sup.4)R.sup.5, or a monosaccharide, or acylated monosaccharide group, with the proviso that at least one of R.sup.1 and R.sup.2 is --CON(R.sup.4)R.sup.5, and R.sup.4 and R.sup.5 are, i |
| 5698575 |
Chromone compounds, pharmaceutical compositions containing the same, and use of the same |
December 16, 1997 |
| A chromone derivative of the formula (I): ##STR1## wherein R.sup.11 is a pyrazolyl, pyrrolyl, triazolyl, benzotriazolyl, benzimidazolyl, indazolyl, or indolyl group, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 is independently a hydrogen or halogen atom, or a hydroxy or alkoxy group, |
| 5696118 |
Benzene derivatives and pharmaceutical composition |
December 9, 1997 |
| A benzene derivative of the formula (I): ##STR1## wherein R.sup.1 is hydrogen, C.sub.1-6 -alkyl, C.sub.1-6 -haloalkyl, --NH.sub.2, --NHR.sup.21 ; R.sup.2 is hydroxyl, --OR.sup.22, three- to seven-membered saturated cycloaliphatic amino optionally interrupted by one or more nitrog |
| 5693610 |
Binding agent for growth factor |
December 2, 1997 |
| A binding agent for a growth factor selected from the group consisting of transforming growth factor-.beta. (TGF-.beta.) and platelet-derived growth factor (PDGF), comprising a protein-bound polysaccharide which is obtained from a fungus belonging to Coriolus, and contains about 18 to 38 |
| 5684061 |
Bone inducing material |
November 4, 1997 |
| A bone inducing material comprising a piezoelectric porous membrane having through-holes of an average pore size of about 0.1 to 5 .mu.m is disclosed. When the bone inducing material according to the present invention is used, bone is rapidly regenerated, and new formation of bone oc |
| 5672688 |
Immunoglobulin F.sub.c fragment bound to an alkylating, antibiotic, or antimetabolic antitum or |
September 30, 1997 |
| A composition comprising as an active ingredient a compound consisting of an immunoglobulin F.sub.c fragment and an alkylating, antibiotic, or antimetabolic antitumor substance bound thereto, and a pharmaceutically acceptable carrier is disclosed. The Fc fragment moiety in the compound i |
| 5650433 |
Chondroprotective agents |
July 22, 1997 |
| A chondroprotective agent comprising a flavonoid compound of the general formula (I): ##STR1## wherein R.sup.1 to R.sup.9 are, independently, a hydrogen atom, hydroxyl group, or methoxyl group and X is a single bond or a double bond, or a stereoisomer thereof, or a naturally occu |
| 5646291 |
Process for the manufacture of 2-phenyl-4,5-oxazoledione 4-phenylhydrazone derivatives |
July 8, 1997 |
| A process for manufacturing derivatives of 2-phenyl-4,5-oxazoledione 4-phenylhyrazone is disclosed. The process comprises reacting a derivative of a benezenediazonium salt, a hippuric acid derivative, and acetic anhydride in the presence of a neutralizing agent to effect the cyclizat |
| 5637586 |
Benzimidazolesulfonamide derivatives and pharmaceutical composition |
June 10, 1997 |
| A benzimidazolesulfonamide derivative of the formula (I): ##STR1## wherein R.sup.1 is an alkyl group of 1 to 6 carbon atoms or a haloalkyl group of 1 to 6 carbon atoms; R.sup.2 is a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, a haloalkyl group of 1 to 6 carbon atoms, -- |
| 5633356 |
3-deoxyglucosone derivatives |
May 27, 1997 |
| For determining 3-deoxyglucosone derivatives which are intermediate metabolites of the Maillard reaction in body fluids such as blood, urine, serum, plasma and the like in gas chromatography/mass spectrometry, .sup.13 C-labelled compounds or .sup.14 C-labelled compounds are useful as |
| 5626805 |
Process of making vinylidene fluoride porous membrane |
May 6, 1997 |
| A method of making a polyvinylidene fluoride porous membrane having an asymmetric structure, excellent mechanical strength and a narrow range of pore diameter distribution comprises: blending (i) 100 parts by weight of a vinylidene fluoride resin having an inherent viscosity, measured in |
| 5623063 |
3-Deoxyglucosone derivatives and method for determining the same |
April 22, 1997 |
| For determining 3-deoxyglucosone derivatives which are intermediate metabolites of the Maillard reaction in body fluids such as blood, urine, serum, plasma and the like in gas chromatography/mass spectrometry, .sup.13 C-labelled compounds or .sup.14 C-labelled compounds are useful as |
| 5621009 |
Chondroprotective agents |
April 15, 1997 |
| A chondroprotective agent comprising a carboxylic acid compound of the general formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are, independently, a hydrogen atom or an alkyl group of 1 to 6 carbon atoms, or a cis- or trans-isomer thereof, or a pharmaceutically acceptable salt |
| 5618734 |
Method for measuring 3-deoxyglucosone derivatives in a sample |
April 8, 1997 |
| For determining 3-deoxyglucosone derivatives which are intermediate metabolites of the Maillard reaction in body fluids such as blood, urine, serum, plasma and the like in gas chromatography/mass spectrometry, .sup.13 C-labelled compounds or .sup.14 C-labelled compounds are useful as |
| 5585381 |
Pyrimidine derivatives and pharmaceutical composition |
December 17, 1996 |
| A pyrimidine derivative of the formula (I): ##STR1## wherein R.sup.1 is a hydrogen atom, alkyl of 1 to 6 carbon atoms, haloalkyl of 1 to 6 carbon atoms, or --NHR.sup.11 group; R.sup.2 is a hydrogen or halogen atom, alkyl of 1 to 6 carbon atoms, haloalkyl of 1 to 6 carbon atoms, - |
| 5578589 |
Method for suppressing an immunoresponse with an estradiol derivative-chlorambucil conjugate |
November 26, 1996 |
| The invention is drawn to a method for suppressing an immunoresponse in animals by administering an estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R.sup.1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R.sup.2 is acyl, dansyl, or alkyl; R.sup.3, R.s |
| 5576309 |
Estradiol derivative-chlorambucil conjugate, process for preparing the same, and pharmaceutical |
November 19, 1996 |
| An estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R.sup.1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R.sup.2 is acyl, dansyl, or alkyl; R.sup.3, R.sup.4, and R.sup.5 independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; and n is an in |
| 5573761 |
Agent for reducing nephrotoxicity due to medicine |
November 12, 1996 |
| An agent for reducing nephrotoxicity due to a platinum complex compound, comprising an activated spherical carbon as an active ingredient is disclosed. |
| 5571831 |
Imidazole derivative, and pharmaceutical composition |
November 5, 1996 |
| A novel imidazole derivative of the formula (I): ##STR1## wherein X.sub.1 is a chlorine or fluorine atom, or a hydroxy group or a salt thereof, and a pharmaceutical composition containing the same as the active ingredient. |
| 5569524 |
Laminated sheet and a bonded laminated sheet |
October 29, 1996 |
| A laminated sheet suitable for high-frequency welding comprises a vinylidene fluoride resin layer (A), a bonding layer (B) consisting of a blend of vinylidene fluoride resin and a copolymer resin consisting of methyl methacrylate and alkyl ester of acrylate, whose alkyl group has 3-5 |
| 5565341 |
Process for producing trehalose |
October 15, 1996 |
| A process for producing trehalose from inexpensive saccharide raw materials via an enzymic method uses stable enzymes with high productivity. The process includes incubating a saccharide raw material and an inorganic phosphoric acid and/or a salt thereof in the presence of phosphorylase |
| 5547973 |
Method of inhibiting aromatase |
August 20, 1996 |
| A method of inhibiting aromatase, comprising administering to a mammal in need thereof a pharmaceutical composition comprising an effective aromatase inhibiting amount of a compound of the formula (I): ##STR1## wherein X.sub.1 is a chlorine or fluorine atom, or a hydroxy group, or a |
| 5519160 |
Alkyl 3-(substituted or unsubstituted benzylidene)-1-alkyl-2-oxocyclopentanecarboxylate derivati |
May 21, 1996 |
| Derivatives of alkyl 3-(substituted or unsubstituted benzylidene)-1-alkyl-2-oxocylopentanecarboxylate of the following formula (I), ##STR1## wherein R.sup.1 and R.sup.2 individually represent a lower alkyl group; X is a halogen atom, a cyano group, an alkyl group, a haloalkyl gro |
| 5514461 |
Vinylidene fluoride porous membrane and method of preparing the same |
May 7, 1996 |
| A polyvinylidene fluoride porous membrane has an asymmetrical structure, excellent mechanical strength such as tensile strength at break and elongation at break, and a desirable narrow range of pore diameter distribution. A method of preparing the porous membrane is also disclosed. T |
| 5508298 |
Azole derivative and pharmaceutical composition |
April 16, 1996 |
| A novel azole derivative of the general formula (I): ##STR1## wherein R.sub.1 and R.sub.2 are, independently from each other, a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, x.sub.1 and x.sub.2 are, independently from each other, a hydrogen or halogen atom, or hydro |
