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Kudos Pharmaceuticals Limited Patents |
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Assignee: Kudos Pharmaceuticals Limited
Address: Cambridge, GB
No. of patents: 10
Patents:
| Patent Number |
Title Of Patent |
Date Issued |
| 7449464 |
Phthalazinone derivatives |
November 11, 2008 |
| Compounds of the formula (I): ##STR00001## wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NR.sup.X or CR.sup.XR.sup.Y; if X=NR.sup.X then n is 1 or 2 and if X=CR.sup.XR.sup.Y then n is 1; R.sup.X is selected from the group consisting of H |
| 7429660 |
ATM inhibitors |
September 30, 2008 |
| A compound of formula I: ##STR00001## and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R.sup.1 and R.sup.2 together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 r |
| 7407957 |
Phthalazinone derivatives |
August 5, 2008 |
| A compound of formula (I): ##STR00001## for use in treating cancer or other diseases ameliorated by the inhibition of PARP, wherein: A and B together represent an optionally substituted, fused aromatic ring; X can be NR.sup.X or CR.sup.XR.sup.Y; if X=NR.sup.X then n is 1 or 2 and if |
| 7402607 |
DNA-PK inhibitors |
July 22, 2008 |
| A compound of formula I: ##STR00001## and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R.sup.1 and R.sup.2 are independently selected from hydrogen, an optionally substituted C.sub.1-7 alkyl group, C.sub.3-20 heterocyclyl group, or C.sub.5-2 |
| 7196085 |
Phthalazinone derivatives |
March 27, 2007 |
| A compound of formula: ##STR00001## or an isomer, salt, solvate, chemically protected form, or prodrug thereof, wherein A and B together represent an optionally substituted, fused aromatic ring; R.sup.L is a C.sub.5-7 aryl group substituted in the meta position by the group R.sup.2, |
| 7151102 |
Phthalazinone derivatives |
December 19, 2006 |
| A method of treatment of a disease of the human or animal body mediated by PARP comprising administering to such a subject a therapeutically effective amount of a compound of formula: ##STR00001## or an isomer, salt, solvate, chemically protected form, and prodrug thereof, wherein: A |
| 7138236 |
Interactions of ATM, ATR or DAN-PK with p53 |
November 21, 2006 |
| The interaction of ATM and related protein kinases such as ATR and DNA-PK with p53 is disclosed, in particular the phosphorylation of Ser15 and Thr18 by these proteins. The activity of the proteins is shown to increase in the presence of DNA. Assays for modulators of phosphorylation |
| 6753158 |
Assays, agents, therapy and diagnosis relating to modulation of cellular DNA repair activity |
June 22, 2004 |
| A yeast homologue of mammalian DNA ligase IV is provided and a role for DNA ligase IV established in the Ku-associated DNA repair pathway. Additionally interactions between DNA ligase IV and XRCC4, and interaction between XRCC4 and DNA-PKcs/Ku are established, providing for assays for |
| 6753151 |
Interactions of Ku polypeptides and applications thereof |
June 22, 2004 |
| Ku is a protein found in a wide range of organisms. It comprises two tightly-associated subunits termed Ku70 and Ku80. The present invention relates to the discovery and characterisation of an interaction between Ku70 and Ku80 and DNA-PK.sub.CS. Various applications based on this int |
| 6242175 |
Methods and means relating to retrotransposon and retroviral integration |
June 5, 2001 |
| Ku(Ku70 and Ku80) of yeast and mammalian cells and other components of the Ku-associated DNA repair pathway are involved in retrotransposon and retroviral integration into cellular nucleic acids. Agents which inhibit activity of the pathway are useful for inhibition of retroviruses. Such |
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