| Patent Number |
Title Of Patent |
Date Issued |
| 7425564 |
Quinoline derivative and quinazoline derivative inhibiting self-phosphorylation of hepatocytus p |
September 16, 2008 |
| An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: ##STR00001## wherein X=CH or N; Z=O or S; L=O or S; M=CR.su |
| 7414170 |
Transgenic bovines capable of human antibody production |
August 19, 2008 |
| The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the |
| 7385048 |
Promoters and utilization thereof |
June 10, 2008 |
| The present invention relates to improved promoters and utilization thereof, in particular to promoters which are improved so as not to undergo methylation in the course of constructing transformants, and utilization thereof. According to the present invention, the expression efficie |
| 7320880 |
Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell a |
January 22, 2008 |
| A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic |
| 7319141 |
Stem cell growth factor-like polypeptides |
January 15, 2008 |
| The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from hum |
| 7282219 |
Powdery preparation for transmucosal administration containing a polymeric form of drug and exhi |
October 16, 2007 |
| A powdery preparation for transmucosal administration comprising a medicine of high molecular weight, a cationic polymer and, as needed, a viscous polymer, further comprising an effective amount of a basic amino acid. The powdery preparation for transmucosal administration has an imp |
| 7262278 |
Anti-HLA-DR antibody |
August 28, 2007 |
| This invention provides an anti-HLA-DR monoclonal antibody. This invention relates to an antibody binding to HLA-DR or a functional fragment thereof having (a) life-extending effects in nonhuman animals bearing HLA-DR-expressing cancer cells and (b) activity of suppressing immune res |
| 7247327 |
Process for producing wort for fermented malt drinks |
July 24, 2007 |
| The present invention provides a process for producing a wort with reduced content of a stale flavor-causing substance for the production of fermented malt beverages such as beer and the like in which generation of a stale flavor is suppressed, and it also provides fermented malt bev |
| 7238355 |
Coated material and process for producing the coated material |
July 3, 2007 |
| A coated material and a process for producing the coated material which includes providing a coating agent comprising yeast cell wall fractions, as a primary constituent, consisting of cell residue of yeast which has been treated with enzymes, optionally subsequently with acidic solution |
| 7217722 |
Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
May 15, 2007 |
| An objective of the present invention is to provide compounds having Rho kinase inhibitory activity. The compounds according to the present invention are those represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: Het--X--Z (I) wherein Het represents a |
| 7211587 |
Quinoline derivatives and quinazoline derivatives having azolyl group |
May 1, 2007 |
| An object of the present invention is to provide compounds having potent antitumor activity. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: ##STR00001## wherein X and Z represent CH or N |
| 7195915 |
Vectors for animal cells and use thereof |
March 27, 2007 |
| Protein synthesis inhibitor resistance genes (typified by a cycloheximide resistance gene) are capable of imparting resistance to a protein synthesis inhibitor (typified by cycloheximide) to animal cells sensitive to the inhibitor. The genes have a sequence mutated by substitution in a |
| 7193064 |
Anti-CD40 monoclonal antibody |
March 20, 2007 |
| An antibody or a functional fragment thereof, acting agonistically or antagonistically on CD40. |
| 7169789 |
Quinoline derivatives and quinazoline derivatives |
January 30, 2007 |
| An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said co |
| 7166722 |
N-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-n'-(5-methyl-3-isoxaz- olyl)urea salt in cry |
January 23, 2007 |
| The present invention provides a crystal of a pharmaceutically acceptable salt of N-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N'-(5-methyl- -3-isoxazolyl) urea. This crystal of salt is usable for the therapy of a disease selected from the group consisting of tumors, diabetic |
| 7135466 |
Quinoline and quinazoline derivatives and drugs containing the same |
November 14, 2006 |
| There are provided compounds which can be used in the treatment of diseases mediated by the autophosphorylation of a PDGF receptor, specifically, compounds which can inhibit neointima formation hypertrophy. The compounds are those represented by formula (I) or pharmacologically accep |
| 7115717 |
Anti-TRAIL-R antibodies |
October 3, 2006 |
| Anti-TRAIL-R1 and R2 antibodies or functional fragments thereof, having at least one property selected from the following (a) to (c) of:(a) having activity to induce apoptosis in carcinoma cells expressing TRAIL-R1 and/or TRAIL-R2;(b) not having effect on normal human cells expressing |
| 7115420 |
Promoters and utilization thereof |
October 3, 2006 |
| The present invention relates to improved promoters and utilization thereof, in particular to promoters which are improved so as not to undergo methylation in the course of constructing transformants, and utilization thereof. According to the present invention, the expression efficie |
| 7074983 |
Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin |
July 11, 2006 |
| The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by |
| 7064194 |
Vectors for animal cells and utilization thereof |
June 20, 2006 |
| Protein synthesis inhibitor resistance genes (typified by a cycloheximide resistance gene) are capable of imparting resistance to a protein synthesis inhibitor (typified by cycloheximide) to animal cells sensitive to the inhibitor. The genes have a sequence mutated by substitution in a |
| 6964975 |
Isoxazole and thiazole compounds and use thereof as medicine |
November 15, 2005 |
| The present invention relates to novel isoxazole and thiazole compounds having an excellent lysophosphatidic acid (LPA) receptor antagonistic activity represented by general formula [1] or salts thereof: ##STR1##wherein R1 and R2 represents an optionally substituted alkyl group or the |
| 6919082 |
Pharmacological composition containing yeast cell wall fraction |
July 19, 2005 |
| The present invention provides a pharmacological composition as a composition as a raw material capable of preventing or treating the symptoms of inflammatory bowel diseases such as ulcerative colitis, constipation, allergic diseases such as atopic dermatitis, and so on, and which ha |
| 6890531 |
Neuronal growth factor galectin-1 |
May 10, 2005 |
| This invention relates to a remedy for neuropathy, such as nerve injury, nerve degeneration, and hypofunction upon nerve grafting, which contains as the active ingredient galectin-1 having an amino acid sequence represented by SEQ ID NO:1 or its derivative; a protein having the amino |
| 6875884 |
Urea derivatives as inhibitors for CCR-3 receptor |
April 5, 2005 |
| Urea and thiourea derivatives inhibit cell function of the chemokine receptor CCR-3. These compounds offer an effective means for treating a range of diseases thought to be mediated by the CCR-3 receptor. A variety of useful urea and thiourea derivatives can be synthesized using liquid |
| 6843842 |
Glass coating agent and method for coating glass material using the same |
January 18, 2005 |
| A glass coating agent is provided which is adapted for application onto the surface of a glass substrate and, upon heating, forms a metal oxide layer. The glass coating agent comprises a metallic compound represented by formula (I):Further, there is provided a glass coating method using |
| 6824973 |
Method of promoting stem cell proliferation or survival by contacting a cell with a stem cell fa |
November 30, 2004 |
| The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from hum |
| 6821987 |
Quinoline derivatives and quinazoline derivatives having azolyl group |
November 23, 2004 |
| An object of the present invention is to provide compounds having potent antitumor activity. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: ##STR1##wherein X and Z represent CH or N; |
| 6821749 |
Methods of producing carotenoids using DNA molecules encoding isopentenyl pyrophosphate isomeras |
November 23, 2004 |
| The production of carotenoid is accomplished using a DNA molecule that encodes a polypeptide as obtained from Haematococcus pluvialis, Phaffia rhodozyma, or Saccharomyces cerevisiae, having isopentonyl pyrophosphate (IPP) isomerase activity, or DNA molecule having a nucleotide sequence |
| 6815191 |
Endo-.beta.-N-acetylglucosaminidase gene |
November 9, 2004 |
| An endo-.beta.-N-acetylglucosaminidase gene encoding the following protein (a) or (b): (a) a protein comprising the amino acid sequence represented by SEQ ID NO: 3; and (b) a protein comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 3 by |
| 6805931 |
Plastic container coated with carbon film |
October 19, 2004 |
| A plastic container has a diamond like carbon film 20b formed on the inner surface of the container 20 made of plastic material 20a. The thickness of the diamond like carbon film 20b is within a range from 0.05 to 5 .mu.m. The container 20 coated with the diamond like carbon film can be |
| 6797823 |
Quinoline derivatives and quinazoline derivatives |
September 28, 2004 |
| An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said co |
| 6777092 |
Coating and material for forming vitreous coating film, method of coating with the same, and coa |
August 17, 2004 |
| The present invention relates to a a glassy-film forming coating agent, a method of coating a substrate with the a glassy-film forming coating agent, a bottle coated with the glassy-film forming coating agent, and a coating system for coating a substrate with the glassy-film forming |
| 6747010 |
NKT cell-activating agents containing .alpha.-glycosylceramides |
June 8, 2004 |
| An objective of the present invention is to provide NKT cell-activating agents, therapeutic agents for autoimmune diseases (for example, systemic lupus erythematosus, systemic sclerosis, ulcerative colitis, encephalomyelitis, multiple sclerosis and human type I diabetes), and abortif |
| 6673904 |
Stem cell growth factor-like polypeptides |
January 6, 2004 |
| The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human and mouse secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from |
| 6660837 |
Modified protein derived from protein kinase N |
December 9, 2003 |
| A object of the present invention is to provide a peptide inhibiting tumorigenesis or metastasis. The present invention is a peptide or derivatives thereof comprising a modified amino acid sequence of Protein Kinase N having the activated Rho protein binding activity and not having p |
| 6632976 |
Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a huma |
October 14, 2003 |
| A chimeric, non-human animal can be produced by a method that entails providing a microcell that contains one or more foreign chromosomes or fragment(s) thereof and then fusing the microcell with a pluripotent cell, thereby introducing the foreign chromosome(s) or fragment(s) into the |
| 6610514 |
Yeast vector and method of producing proteins using the same |
August 26, 2003 |
| An object of the present invention is to provide a vector which can be integrated into a yeast chromosome in a high number of copies. Another object of the present invention is to provide a modified vector which can be integrated into the yeast chromosome in a high number of copies and o |
| 6589619 |
Recycling method |
July 8, 2003 |
| A plastic container has a diamond like carbon film 20b formed on the inner surface of the container 20 made of plastic material 20a. The thickness of the diamond like carbon film 20b is within a range from 0.05 to 5 .mu.m. The container 20 coated with the diamond like carbon film can be |
| 6565905 |
Silica gel for stabilization treatment of beer, a method of manufacturing the silica gel and a m |
May 20, 2003 |
| There is proposed a silica gel for preventing the generation of haze in beer, a method of manufacturing the silica gel and a method of stabilization treatment of beer. The silica gel is provided with a specific surface area of 700-1000 m.sup.2 /g, a pore volume of 1.1-1.6 ml/g and a |
| 6555372 |
Composition for enhancing cellular immunogenicity comprising alpha-glycosylceramides |
April 29, 2003 |
| A composition for enhancing immunogenicity of tumor cells or pathogen-infected cells comprising a compound having an .alpha.-glycosylceramide structure or a salt or solvate thereof is provided. Tumor cells of which immunogenicity is enhanced by the compound having an .alpha.-glycosyl |
| 6475533 |
Substance containing proteins and insoluble dietary fibers derived from the germinated seed of a |
November 5, 2002 |
| There is provided a substance which was isolated from the germinated seed of a grass family plant and which contains proteins and insoluble dietary fibers. There are also provided a pharmaceutical composition comprising as an active ingredient said substance which was isolated from the g |
| 6423510 |
Candida boidini dihydroxyacetone synthase promoter |
July 23, 2002 |
| This invention relates to a promoter for dihydroxyacetone synthase gene from Candida boidinii; an expression cassette or vector comprising the promoter and a heterologous gene; a transformant transformed with this vector; and a method for producing an expression product of the hetero |
| 6419930 |
Pharmacological composition having blood pressure reductive activity |
July 16, 2002 |
| A pharmacological composition including a component having pressure reductive activity obtained from Mycoleptodonoides aitchisonii fruit body which is safe and cheap, harvested constantly year-round by artificial cultivation, with equal quality, and useful for prevention and/or ameli |
| 6417167 |
Lyophilized compositions containing shingoglycolipid and process for preparing them |
July 9, 2002 |
| The object of the present invention is to improve the solubility of sphingoglycolipids having low solubility in water. Disclosed is a lyophilized composition comprising the .alpha.-glycosylceramide represented by the following formula (A) or a salt thereof, a polyoxysorbitan fatty ac |
| 6391595 |
Transferase and amylase, process for producing the enzymes, use thereof, and gene coding for the |
May 21, 2002 |
| The invention provides a novel transferase that acts on a saccharide, as a substrate, composed of at least three sugar units wherein at least three glucose residues on the reducing end are linked .alpha.-1,4 so as to transfer the .alpha.-1,4 lingages to a .alpha.-1,.alpha.-1 linkages; a |
| 6348221 |
Substance originating in germinating seeds of gramineous plant and containing proteins and insol |
February 19, 2002 |
| There is provided a substance which was isolated from the germinated seed of a grass family plant and which contains proteins and insoluble dietary fibers. There are also provided a pharmaceutical composition comprising as an active ingredient said substance which was isolated from the g |
| 6338955 |
.beta.1-4 N-acetylglucosaminyltransferase and gene encoding |
January 15, 2002 |
| The present invention relates to a novel enzyme having .beta.1.fwdarw.4 N-acetylglucosaminyltransferase (GnT-IV) activity; a gene encoding the enzyme; a recombinant DNA comprising the gene; a host cell comprising the recombinant DNA; a method for producing an enzyme protein having GnT-IV |
| 6320099 |
Virus resistant plants expressing animal cell-derived (2'-5')oligadenylate synthetase and ribonu |
November 20, 2001 |
| The present invention relates to a method for creating a plant having resistance to RNA viruses, comprising incorporating a DNA sequence encoding an animal cell-derived (2'-5')oligoadenylate synthetase and a DNA sequence encoding an animal cell-derived ribonuclease L into a chromosom |
| 6294226 |
Method and apparatus for producing plastic container having carbon film coating |
September 25, 2001 |
| There is provided an apparatus for manufacturing a plastic container coated with a diamond-like carbon film comprising; an outer electrode in which a chamber is formed, the shape of the chamber being comparable to an outline of the plastic container, the plastic container being received |
| 6284534 |
Yeast vector comprising a shortened promoter sequence |
September 4, 2001 |
| An object of the present invention is to provide a vector which can be integrated into a yeast chromosome in a high number of copies. Another object of the present invention is to provide a modified vector which can be integrated into the yeast chromosome in a high number of copies and o |
