| Patent Number |
Title Of Patent |
Date Issued |
| 7604989 |
Inhibition of apoptosis process and improvement of cell performance |
October 20, 2009 |
| The present invention relates to preventing or delaying programmed cell death by expressing one or more anti-apoptotic polypeptides in a cell such that programmed cell death in the cell is prevented or delayed. The present invention also relates to increasing production of a cell-related |
| 7576323 |
Point-of-care mass spectrometer system |
August 18, 2009 |
| A point-of-care mass spectrometer system has a sampling system, an ionization component structured to receive a sample for analysis from the sampling system, a mass analyzer structured to receive a source of ions for analysis from the ionization component, and a detector structured to |
| 7557200 |
Superior molecular vaccine based on self-replicating RNA, suicidal DNA or naked DNA vector, that |
July 7, 2009 |
| Improved molecular vaccines comprise nucleic acid vectors that encode a fusion polypeptide that includes polypeptide or peptide physically linked to an antigen. The linked polypeptide is one that (a) promotes processing of the expressed fusion polypeptide via the MHC class I pathway and/ |
| 7517680 |
Production of clavulanic acid by genetic engineering of Streptomyces clavuligerus |
April 14, 2009 |
| Genetically engineered Streptomyces clavuligerus strains with improved capabilities to produce clavulanic acid are provided. The strains are genetically engineered by disrupting newly identified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) genes. This results in an increased intr |
| 7514579 |
Boronic chalcone derivatives and uses thereof |
April 7, 2009 |
| The present invention relates to novel boronic chalcone derivatives which are useful as antitumor/anticancer agents. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good inhibitors of the growth of human breast cancer cells. The present invention also |
| 7508999 |
Fiber optic sensor device for measuring chromophoric compounds in biological fluid |
March 24, 2009 |
| A fiber optic sensor device for detecting the presence of a chromophoric compound in a biological fluid is disclosed. The fiber optic sensor device includes at least one fiber optic member having an unclad portion, the fiber optic member having a proximal end and a distal end for tra |
| 7494494 |
Controllable motorized device for percutaneous needle placement in soft tissue target and method |
February 24, 2009 |
| Featured is an apparatus that places or locates a proximal end portion of a penetrating member in a target area of a body. Such an apparatus or needle driver is particularly suited for locating a percutaneous needle in a soft tissue target area of a body particularly a body having in |
| 7485113 |
Method for drug delivery through the vitreous humor |
February 3, 2009 |
| Devices and devices for the treatment of the eye are disclosed. Preferred devices of the invention include a piercing member that is inserted into the eye to create a pathway for a cannula. The cannula is slidably mounted to the piercing member and is adapted to reach a treatment site |
| 7417156 |
Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers |
August 26, 2008 |
| In only two steps and in 65% overall yield, natural trioxane artemisinin (I) was converted on gram scale into C-10-carba trioxane dimer (3). This new, very stable dimer was then transformed easily in one additional step into four different dimers (4-7). Alcohol and diol dimers (4 and 5) |
| 7399830 |
Synaptic activation protein compositions and method |
July 15, 2008 |
| Disclosed are nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are characterized by induction in the central nervous system following neuronal activity in rat hippocampus. Such proteins are identified by (i) substantial homology at t |
| 7375520 |
Method for spectrally selective B1 insensitive T2 preparation contrast enhancement for high fiel |
May 20, 2008 |
| A T.sub.2 preparation sequence uses a segmented BIR-4 adiabatic pulse with two substantially equal delays and is insensitive to B.sub.1 field variations and can simultaneously suppress fat signals with low specific absorption rate (SAR). An adiabatic reverse half passage pulse is applied |
| 7361412 |
Nanostructured soldered or brazed joints made with reactive multilayer foils |
April 22, 2008 |
| Self-propagating formation reactions in nanostructured multilayer foils provide rapid bursts of heat at room temperature and therefore can act as local heat sources to melt solder or braze layers and join materials. This reactive joining method provides very localized heating to the |
| 7344887 |
Methods and products for delivering biological molecules to cells using multicomponent nanostruc |
March 18, 2008 |
| This invention is predicated on the present applicants' discovery that nanostructures comprising discrete regions of different composition can be used to deliver to a biological cell a desired combination of molecules in close proximity. Different molecules can be selectively bonded |
| 7282476 |
Proaerolysin containing protease activation sequences and methods of use for treatment of prosta |
October 16, 2007 |
| Disclosed herein are modified proaerolysin (PA) peptide. In some examples, the proteins include a prostate-specific protease cleavage site and can further include a prostate-tissue-specific binding domain which functionally replaces the native PA binding domain. In other examples, th |
| 7256182 |
Gene delivery compositions and methods |
August 14, 2007 |
| The present provides methods and compositions that enable effective delivery of nucleic acids to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout |
| 7236816 |
Biopsy and sampling needle antennas for magnetic resonance imaging-guided biopsies |
June 26, 2007 |
| Herein is disclosed a magnetic resonance imaging antenna, including an inner conductor, an outer shield slideably displaceable with respect to the inner conductor, and an insulator electrically insulating the inner conductor from the outer shield. Herein is disclosed a biopsy needle |
| 7214772 |
Sialoadhesin family member-2 (SAF-2) |
May 8, 2007 |
| SAF-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SAF-2 polypeptides and polynucleotides in therapy, and diagnostic assays for such. |
| 7192579 |
Methods of gene therapy using nucleic acid sequences for ATP-binding cassette transporter |
March 20, 2007 |
| The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP b |
| 7185550 |
Time domain resolving chemical sampler using sorbent material |
March 6, 2007 |
| A fluid sampling device is provided comprising an elongated housing having a longitudinal axis, a plurality of alternating sorbent units and spacer units disposed longitudinally through the housing and slidably movable therethrough along the longitudinal direction, and means for individu |
| 7176691 |
Switched coil receiver antenna for metal detector |
February 13, 2007 |
| A pulse induction metal detector includes a pulse transmitter coil for generating and transmitting a first electromagnetic signal and a receiver coil for detecting and amplifying a second electromagnetic signal emitted by a nearby metal target due to eddy currents generated in response t |
| 7166585 |
24-Sulfur-substituted analogs of 1.alpha.,25-dihydroxy vitamin D.sub.3 |
January 23, 2007 |
| The present invention provides novel C24-sulfone analogs of 1.alpha.,25-dihydroxy vitamin D.sub.3, compositions comprising these compounds and methods of using these compounds as selective inhibitors of CYP24. In particular, the compounds of the invention are useful for treating dise |
| 7148706 |
Embeddable corrosion rate meters for remote monitoring of structures susceptible to corrosion |
December 12, 2006 |
| An embeddable corrosion rate meter (ECRM) for detecting and measuring corrosion in metal and concrete structures is provided. The system comprises an electrochemical cell with at least one working electrode evenly separated from a counter electrode, wherein a separation distance betw |
| 7138242 |
Olfactory receptor expression libraries and methods of making and using them |
November 21, 2006 |
| This invention provides novel libraries of olfactory receptor odorant/ligand-binding domains and methods of making and using them. The invention also provides libraries of vectors and cells comprising these nucleic acid constructs. The compositions and methods of the invention are us |
| 7118888 |
Gene expression vaccine |
October 10, 2006 |
| An effective prophylactic mucosal gene expression vaccine (GXV), made up of a cocktail of at least 4 different plasmid DNAs encoding corresponding RSV antigens, coacervated with chitosan to formulate nanospheres. In a murine model of RSV infection, intranasal administration with GXV resu |
| 7108704 |
Percutaneous mechanical fragmentation catheter system |
September 19, 2006 |
| A percutaneous thrombolytic device, also referred to herein as a percutaneous mechanical fragmentation catheter system, that includes a wire cage or basket attached to a rotational drive motor. The fragmentation basket, ensheathed in an outer catheter, is introduced into the clotted |
| 7107824 |
Apparatus for the separation of cystic parasite forms from water |
September 19, 2006 |
| A continuous flow centrifuge adapted with an insert of glass beads, sand or the like is used to concentrate cysts of microorganisms such as giardia or cryptosporidium from large volumes of water. The apparatus and methods are useful for the detection of contaminating microoorganisms in |
| 7087583 |
Sequence specific DNA binding by p53 |
August 8, 2006 |
| Specific sequences in the human genome are the sites of strong binding of wild-type p53 protein, but not mutant forms of the protein. These sequences are used diagnostically to detect cells in which the amount of wild-type p53 is diminished. The sequences can also be used to screen for |
| 7078903 |
Steady state free precession based magnetic resonance thermometry |
July 18, 2006 |
| Disclosed is a method and system for steady state free precession based magnetic resonance thermometry that measures changes in temperature on a pixel by pixel basis. The method comprises generating an RF pulse sequence used to find the proton resonance frequency shift, which is prop |
| 7067659 |
Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof |
June 27, 2006 |
| A reactive oxygen generating enzyme inhibitor with NO donor bioactivity, e.g., nitrated allopurinol, e.g., 1,5-bis(3-nitrooxypropyyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one is useful to treat heart failure, stable angina, ischemic disorder, ischemic reperfusion injury, athero |
| 7060457 |
Aberrant glutamate transporters and methods of use |
June 13, 2006 |
| In one aspect, the present invention features methods for detecting at least one neurological disorder in a patient, the method comprising obtaining a biological sample from the patient; and detecting at least one aberrant human glutamate transporter 2 (EAAT 2) mRNA in the sample as |
| 7045617 |
Bisbubstrate inhibitors of kinases |
May 16, 2006 |
| Protein kinase inhibitors have applications as anti-cancer therapeutic agents and biological tools in cell signalling. Potent and selective bisubstrate inhibitors for the insulin receptor tyrosine kinase are based on a phosphoryl transfer mechanism involving a dissociative transition |
| 7030219 |
B7-DC, Dendritic cell co-stimulatory molecules |
April 18, 2006 |
| A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells express |
| 7030100 |
Isoform specific inhibition for treatment of pain and reduction of anesthetic threshold |
April 18, 2006 |
| Several lines of evidence have shown a role for the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway in the development of spinal hyperalgesia. However, the roles of effectors for cGMP are not fully understood in the processing of pain in the spinal cord. cGM |
| 6991856 |
Methods of making and using freestanding reactive multilayer foils |
January 31, 2006 |
| Reactive foils and their uses are provided as localized heat sources useful, for example, in ignition, joining and propulsion. An improved reactive foil is preferably a freestanding multilayered foil structure made up of alternating layers selected from materials that will react with |
| 6991855 |
Reactive multilayer foil with conductive and nonconductive final products |
January 31, 2006 |
| Reactive foils and their uses are provided as localized heat sources useful, for example, in ignition, joining and propulsion. An improved reactive foil is preferably a freestanding multilayered foil structure made up of alternating layers selected from materials that will react with |
| 6982258 |
Low-calcemic oxime analogs of 1.alpha.,25-dihydroxy vitamin D3 |
January 3, 2006 |
| The present invention provides novel 16-ene-C25-oxime and 16-ene-C-25-oxime ether analogs of 1.alpha.,25-dihydroxy vitamin D.sub.3, compositions comprising these compounds and methods of using these compounds as inhibitors of CYP24. In particular, the compound of Formula I are useful |
| 6958411 |
Nordihydroguaiartic derivatives for use in treatment of tumors |
October 25, 2005 |
| Nordihydroguaiaretic acid derivatives and methods of use thereof for the treatment of tumors. |
| 6936639 |
Nitroxyl progenitors in the treatment of heart failure |
August 30, 2005 |
| Administration of an HNO/NO.sup.- donating compound, such as Angeli's salt, increases myocardial contractility while concomitantly lowering left ventricular preload in subjects experiencing heart failure Moreover, administration of the HNO/NO.sup.- donating compound isopropylamine (I |
| 6918973 |
Alloy and method of producing the same |
July 19, 2005 |
| In accordance with a preferred embodiment of the invention, an alloy or other composite material is provided formed of a bulk metallic glass matrix with a microstructure of crystalline metal particles. The alloy preferably has a composition of (X.sub.a Ni.sub.b Cu.sub.c).sub.100-d-c |
| 6913885 |
Association of dopamine beta-hydroxylase polymorphisms with bipolar disorder |
July 5, 2005 |
| A central role for the gene encoding dopamine beta-hydroxylase in neuropsychiatric disorders is disclosed. Use of single nucleotide polymorphisms in the dopamine beta-hydroxylase gene for diagnosis, prediction of clinical course and treatment response, development of new treatments a |
| 6906182 |
Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers |
June 14, 2005 |
| A conjugate of formula A-L-P, in which: A represents a glycosylated/galactosylated peptide that binds to a cell-surface receptor, L represents a bifunctional linker, which does not comprise a naturally occurring amino acid and is covalently bonded to A and P in a regiospecific mann |
| 6892089 |
Cardiac motion tracking using cine harmonic phase (HARP) magnetic resonance imaging |
May 10, 2005 |
| The present invention relates to a method of measuring motion of an object such as a heart by magnetic resonance imaging. A pulse sequence is applied to spatially modulate a region of interest of the object and at least one first spectral peak is acquired from the Fourier domain of the s |
| 6867288 |
Polycystic kidney disease gene |
March 15, 2005 |
| The present invention provides methods and compositions for treating cyst formation in PKD1-associated epithelial cells. Such methods encompass administering an isolated human PKD1 gene, or fragments of the gene, under conditions that result in expression of therapeutically effective amo |
| 6863992 |
Composite reactive multilayer foil |
March 8, 2005 |
| Reactive foils and their uses are provided as localized heat sources useful, for example, in ignition, joining and propulsion. An improved reactive foil is preferably a freestanding multilayered foil structure made up of alternating layers selected from materials that will react with |
| 6858415 |
Human glycosylation enzymes |
February 22, 2005 |
| The present invention relates to novel human glycosylation enzyme polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human glycosylatio |
| 6855515 |
Autoantigenic fragments, methods and assays |
February 15, 2005 |
| The present invention provides a method of producing autoantigens, compositions comprising autoantigenic fragments and methods of using autoantigenic fragments in the treatment of a condition associated with an autoimmune response. Also provided are assays for the detection or assess |
| 6852709 |
Biologically useful polyphosphates |
February 8, 2005 |
| The present invention provides biodegradable polymers, polymer compositions, particles composed thereof and methods of using same for the controlled release of a biologically active substance to a specified tissue or cells. Preferred polymers include biodegradable, amphiphilic polyph |
| 6846651 |
Nucleotide sequence of the Haemophilus influenzae Rd genome, fragments thereof, and uses thereof |
January 25, 2005 |
| The present invention provides the sequencing of the entire genome of Haemophilus influenzae Rd, SEQ ID NO:1. The present invention further provides the sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use. In addition |
| 6824551 |
Percutaneous mechanical fragmentation catheter system |
November 30, 2004 |
| A percutaneous thrombolytic device, also referred to herein as a percutaneous mechanical fragmentation catheter system, that includes a wire cage or basket attached to a rotational drive motor. The fragmentation basket, ensheathed in an outer catheter, is introduced into the clotted |
| 6805972 |
Method of forming nanoporous membranes |
October 19, 2004 |
| The present invention is directed to nanoporous metal membranes and methods of making nanoporous metal membranes from metal leaf. At least a portion of the metal leaf is freely supported by a de-alloying medium for a time effective to de-alloy the metal leaf. After the porous membrane is |
