| Patent Number |
Title Of Patent |
Date Issued |
| RE40793 |
Bicyclic benzamides of 3-or 4-substituted 4-(aminomethyl)-piperidine derivatives |
June 23, 2009 |
| The present invention of compounds of formula (I) ##STR00001## a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R.sup.1 and R.sup.2 taken together form a bivalent radical of formula wherein in said bivale |
| RE33833 |
Novel N-(bicyclic heterocyclyl)-4-piperidinamines |
February 25, 1992 |
| Novel N-(bicyclic heterocyclyl)-4-piperidinamines having anti-histamimic and serotonin-antagonistic properties which are useful in the treatment of allergic diseases. |
| 7618786 |
Method for identifying modulators of human orexin-2 receptor |
November 17, 2009 |
| The present invention provides a new method for identifying modulators of human orexin-2 receptor without utilizing recombinantly produced nucleic acid molecules encoding human orexin receptor protein. This method combines and utilizes known methods and cell lines selected for their |
| 7615553 |
Inhibitors of histone deacetylase |
November 10, 2009 |
| This invention comprises the novel compounds of formula (I) wherein n, R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine. ##ST |
| 7615533 |
TPO peptide compounds for treatment of anemia |
November 10, 2009 |
| Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed. |
| 7612211 |
Benzimidazole TRPV1 inhibitors |
November 3, 2009 |
| The invention is directed to compounds of Formula (I): ##STR00001## to pharmaceutical compositions containing such compounds and to methods of treatment using them. |
| 7612163 |
Prokineticin 2.beta. peptide and its use |
November 3, 2009 |
| A PK2.beta. peptide is described, which, as an agonist of prokineticin receptor 1, is useful for treating lung and gastrointestinal diseases or disorders mediated by PKR1 activity. |
| 7608712 |
Pyridine imidazoles and aza-indoles as progesterone receptor modulators |
October 27, 2009 |
| The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or more estrogen receptors. The compounds of the invention are useful in the treatment of |
| 7605154 |
Substituted Thiazolo [4,5-d]pyrimidines as protein kinase inhibitors |
October 20, 2009 |
| The present invention is directed to novel thiazolopyrimidine compounds of Formula (I) or a form or composition thereof ##STR00001## and the use thereof as inhibitors of ATP-protein kinase interactions. |
| 7598416 |
4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
October 6, 2009 |
| The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia. |
| 7598292 |
4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
October 6, 2009 |
| The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia. |
| 7598249 |
Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase |
October 6, 2009 |
| Certain piperazinyl and piperidinyl urea compounds are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the com |
| 7595409 |
3,4-diamino-3-cyclobutene-1,2-dione derivatives as potassium channel openers |
September 29, 2009 |
| The present invention is directed to novel 3,4-diamino-3-cyclobutene-1,2-dione derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to potassium channel. |
| 7592450 |
Piperazinyl-, piperidinyl- and morpholinyl-derivatives as inhibitors of histone deacetylase |
September 22, 2009 |
| This invention comprises the novel compounds of formula (I) wherein t, R.sup.1, R.sup.2, L, Q, X, Y, Z and (a) have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine. ##STR00001## |
| 7592356 |
Triazoles as farnesyl transferase inhibitors |
September 22, 2009 |
| ##STR00001## a prodrug, N-oxide, addition salt, quaternary amine or stereochemically isomeric form thereof, wherein L.sup.1 and L.sup.2 are R.sup.1--Y-- wherein each (R.sup.1--Y)-- substituent is defined independently of the other; Y is C.sub.1-4alkanediyl, C.sub.2-4alkenediyl, C.su |
| 7589104 |
Tricyclic-bridged piperidinyline derivatives as .sctn.-opioid modulators |
September 15, 2009 |
| Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows: ##STR00001## wherein A, G, Y, R.sub.3, R.sub.4, and R.sub.5 are defined herein. |
| 7589103 |
Tricyclic-bridged piperidinylidene derivatives as 8-opioid modulators |
September 15, 2009 |
| Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows: ##STR00001## wherein A, Z, Y, R.sub.1-R.sub.5 are defined herein. |
| 7589087 |
Benzoimidazol-2-yl pyridines as modulators of the histamine H.sub.4receptor |
September 15, 2009 |
| Benzoimidazol-2-yl pyridines, pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H.sub.4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis. |
| 7585861 |
HIV inhibiting 1,2,4-triazines |
September 8, 2009 |
| The present invention relates to HIV replication inhibitors of formula (I) as defined in the specification their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them. ##STR00001## |
| 7582753 |
Process for the preparation of benzotriazepine derivatives |
September 1, 2009 |
| The present invention is directed to a novel process for the preparation of benzo[e][1,2,4]triazepin-2-one derivatives, useful in the preparation of gastrin and cholecystokinin receptor ligands. |
| 7582650 |
Tricyclic opioid modulators |
September 1, 2009 |
| The invention is directed to compounds of Formula (I) useful as delta and mu opioid receptor modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described. |
| 7582649 |
Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment |
September 1, 2009 |
| The present invention is directed to novel hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula ##STR00001## wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein cou |
| 7579470 |
Fused heterocyclic compounds |
August 25, 2009 |
| Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases. |
| 7579356 |
Thia-tetraazaacenaphthylene kinase inhibitors |
August 25, 2009 |
| The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): ##STR00001## and pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions. |
| 7576238 |
Process for the preparation of substituted tetralin and substituted indane derivatives |
August 18, 2009 |
| The present invention relates to novel processes for the preparation of substituted tetralin and substituted indane derivatives. The present invention is further directed to novel processes for the preparation of intermediates in the preparation of the substituted tetralin and substi |
| 7576105 |
Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives |
August 18, 2009 |
| The present invention is directed to N-benzyl substituted (piperidin-4-yl)aminobenzamido derivatives which are delta-opioid receptor modulators. |
| 7576092 |
Benzofuro- and benzothienopyrimidine modulators of the histamine H.sub.4 receptor |
August 18, 2009 |
| Benzofuro- and benzothienopyrimidine compounds are described, which are useful as H.sub.4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H.sub.4 receptor activity, s |
| 7575882 |
Compositions and methods for identifying modulators of TRPV2 |
August 18, 2009 |
| It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2. |
| 7572916 |
Diastereoselective synthesis process with 6-bromo-4-(3-chlorophenyl)-2-methoxy-quinoline |
August 11, 2009 |
| A diastereoselective synthesis process for the preparation of (R)-(+)-6-[amino(4chlorophenyl)(1-methyl-1H-imidazol-5-yl) methyl]-4-(3-chlorophenyl)-1-methyl2(1H)-quinolinone which comprises the preparation of a compound of formula (XVII): and the stereochemically isomeric forms there |
| 7572786 |
Substituted 1-piperidin-3-yl-4-piperidin-4-yl-piperazine derivatives and their use as neurokinin |
August 11, 2009 |
| This invention concerns substituted 1-piperidin-3-yl-4-piperidin-4-yl-piperazine derivatives having neurokinin antagonistic activity, in particular NK.sub.1 antagonistic activity, a combined NK.sub.1/NK.sub.3 antagonistic activity and a combined NK.sub.1/NK.sub.2/NK.sub.3 antagonisti |
| 7566733 |
Benzimidazole derivatives useful as selective androgen receptor modulators (sarms) |
July 28, 2009 |
| The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor. |
| 7566722 |
Triazolopyrimidine derivatives as ADP P2Y.sub.12 receptor antagonists |
July 28, 2009 |
| The present invention is directed to novel bicyclic triazolopyrimidine compounds of Formula (I) or a form thereof: ##STR00001## wherein R.sub.1 and R.sub.2 are as defined herein, and their methods of preparation and use as ADP inhibitors. |
| 7563922 |
Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidi |
July 21, 2009 |
| Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]amino- ]benzonitrile of formula (I), a N-oxide, a pharmaceutically acceptable acid addition salt, a quaternary amine or a stereochemically isomeric form thereof are provided, said proc |
| 7560459 |
Substituted sulfamate anticonvulsant derivatives |
July 14, 2009 |
| The present invention is directed to novel compounds of the formula (I) ##STR00001## wherein X, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as described in the specification, processes for the preparation of and pharmaceutical compositions comprising said derivatives. |
| 7560458 |
Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors |
July 14, 2009 |
| This invention concerns compounds of formula ##STR00001## N-oxides, pharmaceutically acceptable addition salts, quaternary amines and stereochemically isomeric forms thereof, their use, pharmaceutical compositions comprising them, and processes for their preparation. |
| 7550492 |
Benzo[1,2,5]thiadiazole compounds |
June 23, 2009 |
| Certain amidophenyl-sulfanylamino-benzo[1,2,5]thiadiazole compounds are CCK2 modulators useful in the treatment of CCK2 mediated diseases. |
| 7547452 |
Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
June 16, 2009 |
| Sustained-release microparticle composition. The microparticle composition can be formulated to provide extended release over a period of from about 7 days to about 200 days. The microparticles may be formulated with a biodegradable and biocompatible polymer, and an active agent, such as |
| 7544698 |
Indoles and benzoimidazoles as modulators of the histamine H.sub.4 receptor |
June 9, 2009 |
| Benzoimidazole and indole compounds are described, which are useful as H.sub.4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H.sub.4 receptor activity, such as allergy, |
| 7544694 |
Substituted diaza-spiro-[5.5]-undecane derivatives and their use as neurokinin antagonists |
June 9, 2009 |
| This invention concerns substituted diaza-spiro-[5.5]-undecane derivatives having neurokinin antagonistic activity, in particular NK.sub.1 antagonistic activity, a combined NK.sub.1/NK.sub.2 antagonistic activity, a combined NK.sub.1/NK.sub.3 antagonistic activity and a combined NK.s |
| 7541476 |
Radiolabeled astemizole and method of making |
June 2, 2009 |
| The present invention provides a radiolabeled astemizole of formula (III) ##STR00001## and a process for preparing the radiolabeled astemizole of formula III. |
| 7541369 |
Amino-derivatives as novel inhibitors of histone deacetylase |
June 2, 2009 |
| This invention comprises the novel compounds of formula (I) ##STR00001## wherein n, m, t, R.sup.1, R.sup.2, L, Q, X, Y, Z and ##STR00002## have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use a |
| 7541367 |
3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders |
June 2, 2009 |
| The present invention is directed to novel 3-benzoimidazolyl-pyrazolopyridine compounds of formula (I): ##STR00001## and pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of serine-threonine protein kinases and tyrosine protein kinases and interacti |
| 7538124 |
Biphenylcarboxamides useful as lipid lowering agents |
May 26, 2009 |
| Biphenylcarboxamide compounds of formula (I) ##STR00001## methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes. |
| 7531671 |
Dihydroisoindolones as allosteric modulators of glucokinase |
May 12, 2009 |
| The present invention relates to compounds of Formula (I), ##STR00001## methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating glucokinase mediated disorders. More particularly, the compounds of the present invention are glucokinase |
| 7531565 |
Imidazolidin-2-one derivatives as selective androgen receptor modulators (SARMS) |
May 12, 2009 |
| The present invention is directed to novel imidazolidin-2-one derivatives having a structure according to Formula I ##STR00001## wherein a, b, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as defined above, pharmaceutical compositions containing them and their use in the treatment of d |
| 7531545 |
2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives useful as inhibitors of .beta.-secretase |
May 12, 2009 |
| The present invention is directed to novel 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of .beta.-se |
| 7528149 |
Respiratory syncytial virus replication inhibitors |
May 5, 2009 |
| This invention concerns compounds of formula (I) ##STR00001## prodrugs, addition salts, or stereochemically isomeric forms thereof for use as, inter alia, respiratory syncytial virus replication inhibitors; their preparation, compositions containing them and methods of their use in t |
| 7524964 |
Tetrahydrothiopyrano pyrazole cannabinoid modulators |
April 28, 2009 |
| The invention relates to a CB modulator compound of Formula (I) ##STR00001## or a pharmaceutically acceptable form thereof and a method for use in treating, ameliorating or preventing a CB receptor mediated syndrome, disorder or disease. |
| 7524961 |
Diastereoselective addition of lithiated N-methylimidazole on sulfinimines |
April 28, 2009 |
| A diastereoselective synthesis process for the preparation of (R)-(+)-6-[amino(4-chlorophenyl) (1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2 (1H)-quinolinone which comprises the preparation of a compound of formula (VIII) ##STR00001## and the stereochemically isom |
| 7524858 |
Substituted pyrroline kinase inhibitors |
April 28, 2009 |
| The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder. |
