| Patent Number |
Title Of Patent |
Date Issued |
| RE39464 |
Oligonucleolotides having site specific chiral phosphorothioate internucleoside linkages |
January 9, 2007 |
| Novel chiral compounds that mimic and/or modulate the activity of wild-type nucleic acids are disclosed. In general, the compounds are phosphorothioate oligonucleotides wherein the 5', and the 3'-terminal internucleoside linkages are chirally Sp and internal internucleoside linkages |
| RE39324 |
Pyrimidine derivatives and oligonucleotides containing same |
October 3, 2006 |
| Compounds having structure (1) ##STR00001## wherein R.sup.1 is --H a protecting group, a linker or a binding partner; and R.sup.2 and R.sup.34 are as defined in the specification. The invention also provides intermediates and methods make the structure (1) compounds, as well as met |
| 7622455 |
Methods for slowing familial ALS disease progression |
November 24, 2009 |
| Methods for slowing disease progression in an individual suffering from familial ALS are provided. Also provided are methods of increasing the survival time of an individual suffering from familial ALS. These methods employ antisense oligonucleotides targeted to SOD1, for use in inhibiti |
| 7618947 |
Modulation of HIF-1 beta expression |
November 17, 2009 |
| Compounds, compositions and methods are provided for modulating the expression of HIF1-beta. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1-beta. Methods of using these compounds for modulation of HIF1-beta expression and for diagnosis and treatmen |
| 7601700 |
Modulation of eIF4E expression |
October 13, 2009 |
| Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for d |
| 7598227 |
Modulation of apolipoprotein C-III expression |
October 6, 2009 |
| Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expressi |
| 7592440 |
Methods of obtaining active antisense compounds |
September 22, 2009 |
| Methods for obtaining antisense oligonucleotides with activity against a desired target are provided. Methods of identifying oligonucleotide sequence motifs which are predictive of antisense oligonucleotide activity are provided, as are motifs identified according to this method. Met |
| 7585968 |
Compositions and their uses directed to thymus and activation-regulated chemokine (TARC) |
September 8, 2009 |
| Disclosed herein are compounds, compositions and methods for modulating the expression of TARC in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment |
| 7576119 |
Supports for oligomer synthesis |
August 18, 2009 |
| Universal linkers, their facile processes of manufacture and methods of using the same are provided. |
| 7576067 |
Pulsatile release compositions and methods for enhanced intestinal oligonucleotide drug absorpti |
August 18, 2009 |
| Delayed release oral pharmaceutical formulations and methods for enhanced intestinal drug absorption. The formulation comprises a first population of carrier particles comprising a drug and a penetration enhancer which are released at a first location in the intestine, and a second p |
| 7569686 |
Compounds and methods for synthesis of bicyclic nucleic acid analogs |
August 4, 2009 |
| The present invention provides compounds and methods of using them for preparing bicyclic nucleosides. The bicyclic nucleosides are useful for preparing chemically modified oligomeric compounds. Oligomeric compounds comprising these bicyclic nucleosides have enhanced properties such as |
| 7563885 |
Modulation of Tudor-SN expression |
July 21, 2009 |
| Compounds, compositions and methods are provided for modulating the expression of Tudor-SN. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Tudor-SN. Methods of using these compounds for modulation of Tudor-SN expression and for diagnosis and treatment o |
| 7563884 |
Antisense modulation of PTP1B expression |
July 21, 2009 |
| Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expressi |
| 7547684 |
5'-modified bicyclic nucleic acid analogs |
June 16, 2009 |
| The present invention provides 5'-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 5'-carbon. These bicyclic nucleoside analogs are |
| 7541344 |
Modulation of survivin expression |
June 2, 2009 |
| Compounds and compositions are provided for modulating the expression of survivin. The compounds, exemplified by those acting through an RNAi antisense mechanism of action, include double-stranded and single-stranded constructs, as well as siRNAs, canonical siRNAs, blunt-ended siRNAs |
| 7507810 |
Compositions and their uses directed to IL-4R alpha |
March 24, 2009 |
| Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for tre |
| 7507808 |
Modulation of endothelial lipase expression |
March 24, 2009 |
| Compounds, compositions and methods are provided for modulating the expression of endothelial lipase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding endothelial lipase. Methods of using these compounds for modulation of endothelial lipase expression and |
| 7491815 |
Antisense modulation of C-reactive protein expression |
February 17, 2009 |
| Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds |
| 7491524 |
Human RNase III and compositions and uses thereof |
February 17, 2009 |
| The present invention provides polynucleotides encoding human RNase III and polypeptides encoded thereby. Methods of using said polynucleotides and polypeptides are also provided. |
| 7468431 |
Modulation of eIF4E-BP2 expression |
December 23, 2008 |
| Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP2. Methods of using these compounds for modulation of eIF4E-BP2 expression and for diagnosis and treatmen |
| 7446193 |
Methods for detection of chloral hydrate in dichloroacetic acid |
November 4, 2008 |
| Methods for detecting chloral hydrate in dichloroacetic acid are described. |
| 7432264 |
Antimicrobial biaryl compounds |
October 7, 2008 |
| Provided are antibacterial biaryl compounds having micromolar MIC activity against Gram-negative and Gram-positive pathogens, including a methicillin-resistant S. aureus strain. |
| 7432250 |
Oligoribonucleotides and ribonucleases for cleaving RNA |
October 7, 2008 |
| Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinit |
| 7432249 |
Oligoribonucleotides and ribonucleases for cleaving RNA |
October 7, 2008 |
| Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinit |
| 7427675 |
Compounds and methods for the characterization of oligonucleotides |
September 23, 2008 |
| The present invention relates to oligonucleotide synthesis. In particular, the present invention provides methods for characterizing samples useful for making oligonucleotides. |
| 7427470 |
Antisense modulation of helicase-moi expression |
September 23, 2008 |
| Antisense compounds, compositions and methods are provided for modulating the expression of helicase-moi. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding helicase-moi. Methods of using these compounds for modu |
| 7425545 |
Modulation of C-reactive protein expression |
September 16, 2008 |
| Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and |
| 7425544 |
Modulation of eIF4E expression |
September 16, 2008 |
| Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for d |
| 7414033 |
Modulation of diacylglycerol acyltransferase 1 expression |
August 19, 2008 |
| Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 1. Methods of using these compounds for modulation of diacy |
| 7407943 |
Antisense modulation of apolipoprotein B expression |
August 5, 2008 |
| Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for |
| 7399845 |
6-modified bicyclic nucleic acid analogs |
July 15, 2008 |
| The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 6-position. These bicyclicnucleoside analogs are useful for enhancin |
| 7378516 |
Synthesis of sulfurized oligonucleotides |
May 27, 2008 |
| Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having |
| 7375212 |
Modulation of Aurora B expression |
May 20, 2008 |
| Compounds, compositions and methods are provided for modulating the expression of Aurora B. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Aurora B. Methods of using these compounds for modulation of Aurora B expression and for diagnosis and treatment o |
| 7348391 |
Polymeric beads for oligomer synthesis |
March 25, 2008 |
| The present invention provides solid support media for use in oligomer synthesis, methods of producing the media, and methods of using the media. In some embodiments, the processes of the invention comprise (a) providing an organic phase comprising an olefin monomer, a cross-linker, |
| 7339051 |
Compositions and methods for the treatment of severe acute respiratory syndrome (SARS) |
March 4, 2008 |
| The present invention provides design and synthesis of oligomeric compounds and compositions that can be administered to reduce the activity of SARS virus in vivo or in vitro, to prevent or treat SARS virus-associated disease, to detect AARS virus, and to diagnose SARS virus-associat |
| 7335764 |
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression |
February 26, 2008 |
| Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl CoA cholesterol acyltran |
| 7326693 |
Antisense modulation of c-reactive protein expression |
February 5, 2008 |
| Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds |
| 7323453 |
Methods of inhibiting orthopoxvirus replication with nucleoside compounds |
January 29, 2008 |
| The present invention provides methods of inhibiting orthopoxvirus replication and/or treating orthopoxvirus infection with certain nucleoside compounds and derivatives thereof. These compounds are particularly useful as inhibitors of vaccinia virus and variola virus replication and/ |
| 7323449 |
Thionucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
January 29, 2008 |
| The present invention provides thionucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infect |
| 7321828 |
System of components for preparing oligonucleotides |
January 22, 2008 |
| Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is provided or selected, |
| 7312036 |
Compositions for use in identification of viral hemorrhagic fever viruses |
December 25, 2007 |
| The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses that cause viral hemorrhagic fevers by amplification of a segment of viral nucleic acid followed by molecular mass analysis. |
| 7307069 |
Antisense oligonucleotide modulation of STAT3 expression |
December 11, 2007 |
| Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression and for promotion o |
| 7288530 |
Antisense modulation of survivin expression |
October 30, 2007 |
| Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using these compounds for modulation o |
| 7285537 |
Oligonucleotide therapeutic agent and methods of making same |
October 23, 2007 |
| For use in controlling biologic functions in an organism, a stabilized oligonucleotide, preferably in a phosphotriester form, having a base sequence substantially complementary to a portion of messenger ribonucleic acid coding for a biological component, such as a protein, of the org |
| 7276599 |
Oligonucleotide synthesis with alternative solvents |
October 2, 2007 |
| The invention provides for methods of manufacturing an oligonucleotide comprising a pentavalent phosphate triester. In particular, the method comprises providing a 5' blocked-nucleoside, deblocking the 5' blocked-nucleoside to form a 5' OH-nucleoside, coupling the 5' OH-nucleoside wi |
| 7273933 |
Methods for synthesis of oligonucleotides |
September 25, 2007 |
| Improved methods for synthesis of oligonucleotides and other phosphorus-linked oligomers are disclosed. The methods include the use of aromatic solvents, alkyl aromatic solvents, halogenated aromatic solvents, halogenated alkyl aromatic solvents, or aromatic ether solvents to achieve |
| 7259150 |
Modulation of apolipoprotein (a) expression |
August 21, 2007 |
| Compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein(a). Methods of using these compounds for modulation of apolipoprotein(a) expression and fo |
| 7255992 |
Methods for rapid detection and identification of bioagents for environmental and product testin |
August 14, 2007 |
| The present invention provides methods for rapid detection of bioagents for environmental and product testing. The methods can be used for testing air, water, soil, surfaces of buildings, containers, towers and the like, as well as testing of foodstuff and cosmetics. |
| 7244847 |
Benzimidazole compounds |
July 17, 2007 |
| The present invention is directed to novel benzimidazoles according to representative structures I and II, and their derivatives that possess antibacterial activity. This invention is also directed to compositions including the benzimidazole derivatives, and methods for using the same. |
| 7235653 |
Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
June 26, 2007 |
| Compositions and methods for the treatment of asthma with oligonucleotides which specifically hybridize with nucleic acids encoding B7 proteins. |
