| Patent Number |
Title Of Patent |
Date Issued |
| RE40120 |
Process for the preparation of taxanes from 10-deacetylbaccatin III |
February 26, 2008 |
| A process for the preparation of taxane derivatives by reacting 10-deacetylbaccatin III protected at the 7-and 1-positions with trichloroacetyl groups with a compound of formula ##STR00001## and subsequent removal of the protective groups and hydrolysis of the oxazolidine ring. |
| RE39723 |
Semi-synthetic taxanes with antitumor and antiangiogenetic activities |
July 10, 2007 |
| Seco-baccatin III derivatives of formula: ##STR00001## wherein R, R.sub.1-R.sub.4, .[.R.sup.1.]. .Iadd.R'.Iaddend., .[.R.sup.11.]. .Iadd.R''.Iaddend., and .[.R.sup.111.]. .Iadd.R'''.Iaddend. are disclosed herein; pharmaceutical compositions comprising seco-baccatin III derivative; |
| 7399788 |
N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them |
July 15, 2008 |
| Disclosed is a series of N-deacetylthiocolchicine derivatives of formula (I) in which: the linker is a bivalent straight or branched C.sub.1-C.sub.8 alkyl residue, C.sub.3-C.sub.8 cycloalkyl, a phenylene or heterocyclic C.sub.4-C.sub.6 ring; the G.sub.1 and G.sub.2 junctions, which c |
| 7374748 |
Pharmaceutical and cosmetic compositions for the protection of the skin from damages induced by |
May 20, 2008 |
| Pharmaceutical and cosmetic compositions for the protection of the skin from damages induced by sun radiations, containing ingredients of vegetable origin, in addition to conventional sun filters and excipients. |
| 7371886 |
Process for the preparation of ferutinine from Ferula genus plants |
May 13, 2008 |
| The invention relates to a process for the preparation of ferutinine (Ia) from Ferula spp extracts comprising basic hydrolysis of the extracts and treatment with p-pivaloyloxybenzoic acid. The invention relates also to the use of the extracts and ferutinine in the cosmetic and dermatolog |
| 7361370 |
Formulations useful in the treatment of male and female impotence |
April 22, 2008 |
| Pharmaceutical compositions containing: extracts of Tribulus terrestris, Epimedium koreanum, Cinnamon cassia in the weight ratio of 1.5-3.5:1-2:0.1-0.4 respectively; and optionally arginine or a physiologically equivalent ester, salt or precursor thereof. The compositions are useful |
| 7354610 |
Pharmaceutical and cosmetic composition against skin aging |
April 8, 2008 |
| Pharmaceutical and cosmetic compositions for the prevention of skin aging, containing phospholipid complexes of extracts of Vitis vinifera, and phospholipid complexes of standardized extract from Centella asiatica. |
| 7323441 |
Use of lupin conglutin for the treatment of type II diabetes |
January 29, 2008 |
| A method for the use of lupin conglutin gamma or of proteins showing homology higher than 50% with lupin conglutin gamma, for the preparation of a medicament, food supplements or foods for the treatment of type II diabetes, pharmaceutical and nutritional compositions containing lupin |
| 7317113 |
Process for the preparation of the 14.beta.-hydroxy-baccatin III-1,14-carbonate |
January 8, 2008 |
| A process for the preparation of 14.beta.-hydroxy-baccatin III-1,14-carbonate useful for the preparation of novel taxane derivatives with antitumor activity. |
| 7232916 |
Process for the preparation of a taxane derivative |
June 19, 2007 |
| The invention relates to an improved process for the synthesis of 13-(N-Boc-.beta.-isobutylserinyl)-14-.beta.-hydroxybaccatin III-1,14-carbonate (I), wherein carbonation of the 1,14-hydroxy groups of the baccatin skeleton is carried out with bis(trichloromethylcarbonate and the 7-hyd |
| 7214395 |
Pharmaceutical and cosmetic composition against skin aging |
May 8, 2007 |
| Pharmaceutical and cosmetic compositions for the prevention of skin aging, containing phospholipid complexes of extracts of Vitis vinifera, and phospholipid complexes of standardized extract from Centella asiatica. |
| 7201931 |
Oral compositions for the treatment of scalp disorders |
April 10, 2007 |
| Pharmaceutical and/or cosmetic compositions for the treatment and the prevention of scalp disorders, containing as active components extracts of Serenoa repens and of Vitis vinifera. |
| 7153884 |
C-2' methylated derivatives of paclitaxel for use as antitumour agents |
December 26, 2006 |
| Taxane derivatives of formula (I) in which: R is trifluoromethyl, phenyl, 2-furyl, 2-thienyl; R.sup.1 is t-butoxycarbonyl or benzoyl; R.sub.2 is hydroxy; R.sub.3 is hydrogen or, together with R.sub.2, it forms the residue of a cyclic carbonate of formula: II with the proviso that when |
| 7128932 |
Formulations useful in the treatment of male and female impotence |
October 31, 2006 |
| Disclosed are pharmaceutical compositions containing: extracts of Tribulus terrestris, Turnera diffusa and Cinnamon cassia in the weight ratio of 1.5 3.5:1 2:0.1 0.4 respectively; Ginkgo biloba extract, and optionally arginine or a physiologically equivalent esters salts or precursor |
| 7112687 |
Methods for obtaining paclitaxel from taxus plants |
September 26, 2006 |
| Methods for obtaining paclitaxel from plants containing paclitaxel are disclosed. Plant material is first obtained from plants containing paclitaxel. Paclitaxel is then extracted from the plant material. Subsequently, paclitaxel is separated from the paclitaxel extract using a series |
| 7108871 |
Methods of treatment using a soya extract |
September 19, 2006 |
| A soya extract having a content of glucoside isoflavones of at least 13% by weight and a content of 0.6 to 1.5 parts by weight of group 3 soya saponins per 1 part by weight of glucoside isoflavones. Also, pharmaceutical compositions containing this extract and methods of administerin |
| 7105705 |
Hyperforin derivatives, the use thereof and formulations containing them |
September 12, 2006 |
| The use of the reduction products of hyperforin and adhyperforin, pharmaceutically acceptable salts or esters thereof, in the pharmaceutical and/or nutritional field, in particular in the treatment of depression and Alzheimer's disease. |
| 7078538 |
Baccatin III derivatives |
July 18, 2006 |
| A process for the preparation of 14 beta-hydroxy-1,4-carbonate-deacetylbaccatin III and intermediates useful for the preparation of novel taxan derivatives with antitumor activity are disclosed. |
| 7078432 |
Process for the preparation of the 14.beta.-hydroxy-baccatin III-1,14-carbonate |
July 18, 2006 |
| A process for the preparation of 14.beta.-hydroxy-baccatin III-1,14-carbonate useful for the preparation of novel taxane derivatives with antitumor activity. |
| 7057078 |
Hyperforin halogenated derivatives, the use thereof and formulations containing them |
June 6, 2006 |
| Hyperforin and adhyperforin halogenated derivatives of general formula (I) in which X, R and R.sub.1 have the meanings as defined in the disclosure, the process for the preparation thereof and the use thereof in the pharmaceutical and/or nutritional field, in particular in the treatment |
| 7053222 |
Semi-synthetic process for the preparation of N-debenzoylpaclitaxel |
May 30, 2006 |
| A process for the preparation of N-debenzoylpaclitaxel (I) through esterification of 7-protected baccatin III with a carboxylic acid reactive derivative of general formula (II), and elimination of the ester-protecting groups in acid conditions and in a single step. In formula (II) R1 |
| 6911325 |
Process for the preparation of derivatives of Ruscus aculeatus steroid glycosides by enzymatic h |
June 28, 2005 |
| A process for the preparation of desglucodesrhamnoruscin which comprises the enzymatic hydrolysis of Ruscus Aculeatus steroid glycosides (ruscosaponins) by means of crude hydrolases from aspergillus niger. |
| 6906101 |
Taxane derivatives and processes for the preparation thereof |
June 14, 2005 |
| A novel taxane derivative with anticancer activity, a process for its preparation and a process for the preparation of 14-.beta.-hydroxy-1,14-carbonate-baccatine III and V derivatives 13-substituted by an isoserine residue. |
| 6881426 |
Echinacea angustifolia extracts |
April 19, 2005 |
| An Echinacea angustifolia extract and a process for the preparation thereof are herein described. The extract is characterized by an alkylamides content lower than 0.1%, an echinacoside content ranging from 1 to 10% and containing from 1 to 15% of a polysaccharide characteristic of Echin |
| 6828445 |
Process for the preparation of baccatin III derivatives |
December 7, 2004 |
| A process for the preparation of 14.beta.-hydroxy-1,4-carbonate-deacetylbaccatin III and intermediates useful for the preparation of novel taxan derivatives with antitumor activity are disclosed. |
| 6818761 |
Polysaccharide of echinacea angustifolia |
November 16, 2004 |
| A polysaccharide of Echinacea angustifolia roots, having molecular weight of 1.3.times.10.sup.5 Da and including rhamnose, arabinose, galactose and galacturonic acid in ratio 0.5:2.5:1.75:10.25, is recovered from spontaneous or cultivated Echinacea angustifolia roots by means process |
| 6768012 |
Process for the preparation of paclitaxel |
July 27, 2004 |
| A process for the preparation of paclitaxel starting from 10-deacetylbaccatine III. |
| 6767916 |
Chalcone coumarins |
July 27, 2004 |
| Disclosed are novel chalcone derivatives having the formula (I). ##STR1##These compounds possess antiproliferative activity, and are useful for the manufacture of a medicament for the treatment or prevention of neoplasms, particularly those located in the uterus, ovary or breast. The com |
| 6737534 |
Process for the preparation of taxan derivatives |
May 18, 2004 |
| A process for the preparation of the compound 13-(N-Boc-.beta.-isobutylisoserinyl)-14.beta.-hydroxybaccatine III 1,14-carbonate. |
| 6683109 |
Condensation derivatives of thiocolchicine and baccatin as antitumor agents |
January 27, 2004 |
| ##STR1##N-deacetyl-thiocolchicine and 10-deacetyl-baccatin III derivatives of formula (I) wherein R and n have the meanings specified in the disclosure, are valuable antitumoral drugs. |
| 6669956 |
Tablets incorporating isoflavone plant extracts and methods of manufacturing them |
December 30, 2003 |
| The invention is directed to novel tablets comprising isoflavone-containing plant extract and water-insoluble polysaccharides, and methods of manufacturing them. |
| 6656510 |
Hyperforin derivatives, use thereof and formulations containing them |
December 2, 2003 |
| The invention relates to compounds of the formula: ##STR1##in which R is a saturated or unsaturated, straight or branched, C.sub.1 -C.sub.22 acyl group, optionally having one or more substituents, which can be the same or different, selected from halogen atoms, nitro, amino, C.sub.1 |
| 6627774 |
N-deacetylthiocolchicine derivatives and pharmaceutical compositions containing them |
September 30, 2003 |
| Derivatives of N-deacetyl-thiocolchicine or of the isoster thereof of formula (I) ##STR1##wherein n is an integer from 0 to 8, Y is a CH.sub.2 group or, when n is 1, can also be a group of formula NH. Compounds of formula (I) have anti-proliferative activity. |
| 6620842 |
Chalcones |
September 16, 2003 |
| Disclosed are novel chalcone derivatives having the formula (I) ##STR1##The compounds possess antiproliferative activity and are useful for the manufacture of a medicament for the treatment or prevention of neoplasms, particularly those located in the uterus, ovary or breast. The compoun |
| 6608089 |
Derivatives of flavones, xanthones and coumarins |
August 19, 2003 |
| Compounds having the formula (I)or a pharmaceutically acceptable salt or solvate thereof wherein Z can represent the formula (1A) or (1B). ##STR1##The compounds possess antiproliferative activity and are useful as modulators of multiple drug resistance in cancer chemotherapy. The com |
| 6607757 |
Soya extract, process for its preparation and pharmaceutical composition |
August 19, 2003 |
| A soya extract having a content of glucoside isoflavones of at least 13% by weight and a content of 0.6 to 1.5 parts by weight of group B soya saponins per 1 part by weight of glucoside isoflavones. Also, pharmaceutical compositions containing this extract and methods of administerin |
| 6589979 |
Semi-synthetic taxanes with antitumor and antiangiogenetic activities |
July 8, 2003 |
| Seco-baccatin III derivatives of formula: ##STR1##wherein R, R.sub.1 -R.sub.4, R.sup.1, R.sup.11, and R.sup.111 are disclosed herein; pharmaceutical compositions comprising seco-baccatin III derivative; and methods for treating cancer, arthritis, and inhibiting angiogenesis in an anim |
| 6528280 |
Process for the preparation of derivatives of ruscus aculeatus steroid glycosides |
March 4, 2003 |
| A process for the preparation of desglucodesrhamnoruscin which comprises the hydrolysis of Ruscus Aculeatus steroid glycosides (ruscosaponins) through fermentation of a substrate containing said glycosides by means of fungi of the aspergillus niger species. |
| 6514732 |
Process for preparing baccatin |
February 4, 2003 |
| A process for preparing baccatin and/or baccatin derivatives is described in which 10-deacetylbaccatin or a 10-deacetylbaccatin derivative is reacted in the presence of an isolated enzyme and an acetyl donor, the enzyme used being an acetyl transferase having a molecular weight of from |
| 6500966 |
Process for the preparation of taxanes from 10-deacetylbaccatin III |
December 31, 2002 |
| A process for the preparation of taxane derivatives by reacting 10-deacetylbaccatin III protected at the 7-and 1-positions with trichloroacetyl groups with a compound of formula ##STR1##and subsequent removal of the protective groups and hydrolysis of the oxazolidine ring. |
| 6479080 |
Tanacetum parthenium extract and method of obtaining same |
November 12, 2002 |
| Extracts of Tanacetum parthenium with a reduced content of .alpha.-unsaturated .gamma.-lactones, particularly of parthenolide, obtainable by elution on basic resins. The extracts of the invention have favorable pharmacological properties together with reduced risks of allergic reacti |
| 6475536 |
Pharmaceutical and cosmetic formulations with antimicrobial activity |
November 5, 2002 |
| The present invention relates to novel antiacne compositions containing extract of Krameria, or a pure compound from the extract, at least one of ximeninic acid or lauric acid, and an anti-inflammatory saponin extracted from Olax dissitiflora, Aesculus hippocastanum, Centella asiatica, |
| 6429202 |
Phospholipid complexes of proanthocyanidin A2 as antiatherosclerotic agents |
August 6, 2002 |
| The present invention relates to complexes of proanthocyanidin A2 and one or more phospholipids, pharmaceutical compositions containing the complex of proanthocyanidin A2 and one or more phospholipids, and methods of treating or preventing atherosclerosis and myocardial and cerebral |
| 6428820 |
Extracts of Hypericum perforatum and formulations containing them |
August 6, 2002 |
| The invention relates to a method for extracting Hypericum perforatum (St.-Johns-wort) by fractioning water-alcohol, alcohol extracts of the plant with esters of water-immiscible C.sub.1 -C.sub.5 alcohols. The extracts have high activity and are stable over time. The invention also r |
| 6423740 |
Chalcones having antiproliferative activity |
July 23, 2002 |
| The invention relates to a novel class of compounds that have structures related to certain naturally occurring or synthetic chalcones. The invention also relates to pharmaceutical compositions comprising the compounds and methods for treating certain disorders using the pharmaceutic |
| 6419950 |
Extracts of zanthoxylum bungeanum, and pharmaceutical and cosmetic formulations containing same |
July 16, 2002 |
| The extract of the pericarp of Zanthoxylum bungeanum, prepared by extraction with carbon dioxide in supercritical conditions, has remarkable analgesic activity without exerting the local anesthetic activity characteristic of the extracts obtained by solvent means. The product of the |
| 6413546 |
Tablets incorporating isoflavone plant extracts and methods of manufacturing them |
July 2, 2002 |
| The invention is directed to novel tablets comprising isoflavone-containing plant extract and water-insoluble polysaccharides, and methods of manufacturing them. |
| 6372458 |
Process for the biotransformation of colchicone compounds into the correspondence 3-glycosyl der |
April 16, 2002 |
| The present invention relates to the microbial biotransformation of colchiconic compounds into derivative compounds, which are glycosylated exclusively at the C-3 position of the six-member ring. The process of the present invention provides the 3-O-glycosyl derivatives in high yields an |
| 6333419 |
Chromatographic separation method of paclitaxel and cephalomannin |
December 25, 2001 |
| A method for separating paclitaxel from cephalomannin and other related compounds by obtaining a starting material that contains paclitaxel and cephalomannin; dissolving the starting material in any one of a number of particularly defined solvents such as butyl formate and butyl acetate |
| 6297218 |
Phospholipid complexes prepared from extracts of Vitis vinifera as anti-atherosclerotic agents |
October 2, 2001 |
| The phospholipid complex extracts of Vitis vinifera useful for the prevention and the treatment of atherosclerotic pathological conditions and are administered to a patient in need of such treatment. |
