| Patent Number |
Title Of Patent |
Date Issued |
| RE37582 |
Cytokine designated LERK-6 |
March 12, 2002 |
| The invention is directed to LERK-6 as a purified and isolated protein, the DNA encoding the LERK-6, host cells transfected with cDNAs encoding LERK-6. |
| RE36755 |
DNA encoding tumor necrosis factor-.alpha. and -.beta. receptors |
June 27, 2000 |
| Tumor necrosis factor receptor DNAs and expression vectors encoding TNF receptors, and processes for producing TNF receptors as products of recombinant cell culture, are disclosed. |
| RE35450 |
Soluble human interleukin-1 receptors, compositions and method of use |
February 11, 1997 |
| Soluble human Interleukin-1 receptor proteins (shuIL-1Rs) and methods of using shuIL-1Rs to suppress immune or inflamatory responses in a mammal. |
| RE33252 |
Hybridoma antibody which inhibits Interleukin 2 activity |
July 3, 1990 |
| A process for producing anti-IL-2 antibody from hybridoma cells generated by fusing activated, IL-2 immunized, murine lymphocyte cells with neoplastic murine myeloma cells. Fusion is accomplished by mixing the two cell lines together in the presence of a fusing agent. After fusion, the |
| 7432237 |
Methods of treating asthma by administering interleukin-17 receptor |
October 7, 2008 |
| Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. |
| 7427669 |
ULBP antibodies |
September 23, 2008 |
| The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polype |
| 7416877 |
Receptor that causes cell death and recombinant production thereof |
August 26, 2008 |
| Isolated apoptosis inducing receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof. |
| 7411055 |
Attractin/mahogany-like polypeptides, polynucleotides, antibodies and methods of use thereof |
August 12, 2008 |
| The present disclosure provides attractin/mahogany-like polypeptides and fragments thereof, polynucleotides encoding such polypeptides and fragments, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides or fragments, and |
| 7411050 |
Monoclonal blocking antibody to human RANKL |
August 12, 2008 |
| Disclosed herein are kits for detecting RANKL protein or nucleic acids, the kits comprising isolated human RANKL polypeptides, RANKL nucleic acids and/or antibodies specific for RANKL. |
| 7405270 |
CD40-Ligand lacking native-pattern glycosylation |
July 29, 2008 |
| There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 re |
| 7405058 |
Human TSLP polynucleotides |
July 29, 2008 |
| The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polype |
| 7402655 |
Molecules designated LDCAM |
July 22, 2008 |
| The invention is directed to LDCAM as a purified and isolated protein, the DNA encoding the LDCAM, host cells transfected with cDNAs encoding LDCAM, processes for preparing LDCAM polypeptides and compositions and methods for treating utilizing LDCAM polypeptides. |
| 7399832 |
Metalloprotease-disintegrin ADAM23 (SVPH3-17) |
July 15, 2008 |
| The invention is directed to purified and isolated novel SVPH3-13 or SVPH3-17 polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived f |
| 7396662 |
C-type lectin polypeptides |
July 8, 2008 |
| Provided herein are polypeptide and polynucleotide sequences for a molecule having homology to the C-type lectin family of polypeptides. Also provided are methods of making and using the polypeptide and polynucleotides. |
| 7384765 |
Cell culture performance with betaine |
June 10, 2008 |
| This invention relates generally to the field of cell culture. More particularly, the invention relates to improving viability of recombinant cell cultures and the yields of secreted polypeptides therefrom by the addition of betaine to the tissue culture medium. |
| 7361330 |
Methods of using flt3-ligand in the treatment of fibrosarcoma |
April 22, 2008 |
| Methods of treating a fibrosacroma using flt-3 ligand are disclosed, as well as methods of increasing the number of dendritic cells in a patient having a fibrosarcoma. |
| 7338930 |
Methods of treating osteoarthritis using IL-17 receptor proteins in combination with TNF-recepto |
March 4, 2008 |
| Methods for regulating levels of nitric oxide are disclosed. The methods utilize IL-17 receptors, which may be used in conjunction with inhibitor of IL-1 and/or TNF. |
| 7329740 |
Flk-1 binding protein |
February 12, 2008 |
| A protein designated flk-1bp binds the vascular endothelial cell surface receptor flk-1. Isolated DNA encoding flk-1bp is provided, along with expression vectors and transformed host cells useful in producing flk-1bp polypeptides. Antibodies that are immunoreactive with flk-1bp are g |
| 7323558 |
Nucleic acids encoding dendritic cell transmembrane serine protease |
January 29, 2008 |
| Isolated Dendritic Cell Transmembrane Serine Proteases (DCTSPs), DNAs encoding such DCTSPs, and pharmaceutical and/or diagnostic compositions made therefrom, are disclosed. The isolated DCTSPs can be used to hydrolyze peptide bonds. The DCTSPs are also useful in screening for inhibit |
| 7317090 |
Antibodies to Interleukin-4 receptors and uses thereof |
January 8, 2008 |
| Methods and comnositions related to antibodies that bind to mammalian Tnterleulcin-4 recentor proteins are disclosed. |
| 7309489 |
Mouse CD40 ligand-specific antibodies and hybridomas |
December 18, 2007 |
| There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 re |
| 7304144 |
Antibodies binding to human TSLP Polypeptides |
December 4, 2007 |
| The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polype |
| 7294331 |
Methods of using flt3-ligand in hematopoietic cell transplantation |
November 13, 2007 |
| Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to Flt3-ligand as an isolated protein, the DNA encoding the Flt3-ligand, host cells |
| 7288633 |
Modified human thymic stromal lymphopoietin |
October 30, 2007 |
| Modified, furin resistant human TSLP polypeptides and polynucleotides encoding the modified human TSLP polypeptides are provided. Pharmaceutical compositions, B and T cell activation agents, assays and methods of use are also described. |
| 7285648 |
IL-1 delta DNA and polypeptides |
October 23, 2007 |
| DNA encoding IL-1 delta polypeptides and methods for using the DNA and encoded polypeptides are disclosed. |
| 7285643 |
Antibodies to novel murine and human kinases |
October 23, 2007 |
| The invention is directed to purified and isolated novel murine and human kinase polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derive |
| 7285634 |
IL-1 receptor accessory protein |
October 23, 2007 |
| DNA encoding IL-1R AcP splice variant polypeptides, the polypeptides and methods for using the encoded polypeptides are disclosed. |
| 7273843 |
Methods of treating allergy by administering interleukin-17 receptor |
September 25, 2007 |
| Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. |
| 7273609 |
Methods for treating autoimmune and chronic inflammatory conditions using antagonists of CD30 or |
September 25, 2007 |
| The invention provides methods of treating autoimmune and chronic inflammatory conditions by administering agents that hinder the CD30/CD30L interaction, combination treatments, and methods of treating conditions resistant to treatment with TNF.alpha. inhibitors by administering agen |
| 7270817 |
ACPL antibodies and methods of use thereof |
September 18, 2007 |
| The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polype |
| 7264809 |
Methods of inhibiting platelet activation and recruitment |
September 4, 2007 |
| The present invention provides soluble CD39 polypeptides and compositions, and methods for inhibiting platelet activation and recruitment in a mammal comprising administering a soluble CD39 polypeptide. |
| 7262274 |
Kits containing rank polypeptides |
August 28, 2007 |
| Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof. |
| 7261894 |
Methods of treating inflammatory and/or autoimmune disease |
August 28, 2007 |
| The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, the use of such polypeptides in |
| 7250507 |
Inhibitory Pellino nucleic acids |
July 31, 2007 |
| There are disclosed novel polypeptides referred to as Pellino polypeptides, as well as fragments thereof, including immunogenic peptides. DNAs encoding such polypeptides as well as methods of using such DNAs and polypeptides are also disclosed. |
| 7250276 |
Human IL-1 epsilon DNA and polypeptides |
July 31, 2007 |
| The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived fro |
| 7244822 |
BTL-II proteins |
July 17, 2007 |
| The invention provides isolated BTL-II proteins, nucleic acids, antibodies, antagonists, and agonists and methods of making and using the same. Diagnostic, screening, and therapeutic methods using the compositions of the invention are provided. For example, the compositions of the in |
| 7238499 |
Trimeric macrophage scavenger receptor fusion proteins and encoding nucleic acids |
July 3, 2007 |
| The present invention relates, in part, to a polypeptide domain having reduced immunogenicity that is capable of inducing trimers in heterologous polypeptides, fusion polypeptides comprising the trimer inducing domain, nucleic acids encoding the polypeptides of the invention and meth |
| 7235637 |
IL-1 eta DNA and polypeptides |
June 26, 2007 |
| The invention is directed to novel, purified and isolated IL-1 eta polypeptides and fragments thereof, the polynucleotides encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, peptides derived |
| 7232660 |
CD30 ligand |
June 19, 2007 |
| There is disclosed a polypeptide (CD30-L) and DNA sequences, vectors and transformed host cells useful in providing CD30-L polypeptides. The CD30-L polypeptide binds to the receptor known as CD30, which is expressed on a number of cell types, among which are Hodgkin's Disease tumor c |
| 7223565 |
IL-1 eta DNA and polypeptides |
May 29, 2007 |
| The invention is directed to novel, purified and isolated IL-1 eta polypeptides and fragments thereof, the polynucleotides encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, peptides derived |
| 7217553 |
Nucleic acids encoding human adamalysin SVPH1-8 |
May 15, 2007 |
| The disclosure provides purified and isolated SVPH1 8 polypeptides, nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against such polypeptide, and fragmented peptides derived from these polypeptide. In |
| 7217540 |
Polynucleotide encoding IL-1 zeta, TDZ.1 isoform polypeptide |
May 15, 2007 |
| The invention is directed to novel, purified and isolated IL-1 zeta and Xrec2 polypeptides and fragments thereof, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented |
| 7214497 |
Viral encoded semaphorin protein receptor DNA and polypeptides |
May 8, 2007 |
| The invention is directed to VESPR polypeptides as a purified and isolated protein, the DNA encoding the VESPR polypeptide, host cells transfected with cDNAs encoding VESPR, and methods for preparing VESPR polypeptides. |
| 7211259 |
4-1BB polypeptides and DNA encoding 4-1BB polypeptides |
May 1, 2007 |
| Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequences, and host cells transfo |
| 7199224 |
Antibodies that bind TNF-.alpha. converting enzyme |
April 3, 2007 |
| A metalloprotease that converts TNF-.alpha. from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an |
| 7196168 |
Metalloprotease-disintegrin ADAM23 (SVPH3-17) |
March 27, 2007 |
| The invention is directed to purified and isolated novel SVPH3-13 or SVPH3-17 polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived f |
| 7193058 |
ULBP antibodies |
March 20, 2007 |
| The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polype |
| 7189521 |
Claudin polypeptides, polynucleotides, and methods of making and use thereof |
March 13, 2007 |
| This invention relates to new members of the human Claudin polypeptide family, to methods of making such polypeptides, and to methods of using them to treat Claudin-associated conditions and to identify agents that alter Claudin polypeptide activities. |
| 7186818 |
DNA encoding soluble variants of human OX2 receptors |
March 6, 2007 |
| Isolated receptors, nucleic acids encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors or agonists thereof. |
| 7186809 |
Methods and compositions relating to anti-interleukin-4 receptor antibodies |
March 6, 2007 |
| Methods for treating medical conditions induced by interleukin-4 involve administering an IL-4 antagonist to a patient afflicted with such a condition. Suitable IL-4 antagonists include, but are not limited to, IL-4 receptors (such as a soluble human IL-4 receptor), antibodies that b |
