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IRM LLC Patents
Assignee:
IRM LLC
Address:
Hamilton, BM
No. of patents:
108
Patents:


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Patent Number Title Of Patent Date Issued
8575168 Compounds and compositions as modulators of GPR119 activity November 5, 2013
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
8563553 Compounds and compositions as protein kinase inhibitors October 22, 2013
The present invention provides compounds of Formula I or II: ##STR00001## wherein R.sup.1, R.sup.1b, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment
8293915 Compounds and compositions as channel activating protease inhibitors October 23, 2012
The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limit
8293757 5-(4-(haloalkoxy)phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors October 23, 2012
The invention provides compounds of formula (1) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In
8288540 2-heteroarylamino-pyrimidine derivatives as kinase inhibitors October 16, 2012
The invention provides compounds of Formula (I) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In
8278452 Heterocyclic compounds and compositions as c-kit and PDGFR kinase inhibitors October 2, 2012
The invention provides a novel class of compounds of Formula I: (I) pharmaceutical compositions comprising such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activa
8268996 Compounds and compositions as cathepsin S inhibitors September 18, 2012
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cathepsin S.
8268850 Pyrimidine derivatives and compositions as C-kit and PDGFR kinase inhibitors September 18, 2012
The invention provides a novel class of pyrimidine derivatives, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disord
8258156 Compounds and compositions as modulators of GPR119 activity September 4, 2012
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
8202876 Compounds and compositions as protein kinase inhibitors June 19, 2012
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that invo
8183248 Substituted pyrrolo[2,3-d]pyrimidines and compositions as protein kinase inhibitors May 22, 2012
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that invo
8178563 Compounds and compositions as hedgehog pathway modulators May 15, 2012
The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-fu
8178526 Compounds and compositions as ITPKb inhibitors May 15, 2012
The invention provides a novel class of compounds of formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or d
8173128 Methods and compositions for inducing apoptosis in cancer cells with an anti-DR5 antibody May 8, 2012
Anti-DR5 antibody agonists, combined with apoptosis-inducing agents, synergistically induce apoptosis in cancer cells.
8158634 Compounds and compositions as inhibitors of cannabinoid receptor 1 activity April 17, 2012
The invention provides compounds having Formula Ia, ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and Y are as defined in the specification; as well as pharmaceutical compositions comprising such compounds and methods of usin
8153671 Heterotetracyclic compounds as TPO mimetics April 10, 2012
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve
8153635 Compounds and compositions as modulators of GPR119 activity April 10, 2012
The invention provides compounds of Formula I: ##STR00001## wherein A, L, m, q, Q, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are defined in the Summary of the Invention. The invention further provides for pharmaceutical compositions comprising such compounds and methods of usi
8106068 Compositions and methods for modulating c-kit and PDGFR receptors January 31, 2012
The invention provides compounds of Formula (2), and pharmaceutical compositions thereof, ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and L are as described herein; as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with a
8097705 Methods and compositions for treating allergic diseases January 17, 2012
Disclosed in the present invention are antibodies that specifically recognize and antagonize human TSLP receptor, and methods of employing these antibodies to treat or ameliorate diseases or disorder mediated by TSLP signaling.
8039479 Compounds and compositions as protein kinase inhibitors October 18, 2011
The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds
7951823 Compounds and compositions as channel activating protease inhibitors May 31, 2011
The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limit
7939547 Compounds and compositions as channel activating protease inhibitors May 10, 2011
The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limite
7928133 Compounds and compositions as hedgehog signaling pathway modulators April 19, 2011
The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-fu
7893074 2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune February 22, 2011
Novel pyrimidine derivatives of formula I ##STR00001## to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
7888483 Antagonists of protease activated receptor-1 (PAR1) February 15, 2011
The present invention provides antibodies or antigen-binding molecules that specifically recognize and antagonize human PAR1 receptor. Also provided in the invention are polynucleotides and vectors that encode such molecules and host cells that harbor the polynucleotides or vectors.
7868018 Compounds and compositions as protein kinase inhibitors January 11, 2011
The invention provides compounds of Formula I: ##STR00001## wherein R.sub.1-R.sub.6 are described in the Summary of the Invention; the pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with a
7846949 Compounds and compositions as LXR modulators December 7, 2010
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of liver X receptors (LXRs).
7846923 Compounds and compositions as protein kinase inhbitors December 7, 2010
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that invo
7820705 Compounds and compositions as PPAR modulators October 26, 2010
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activ
7816542 Compounds and compositions as TPO mimetics October 19, 2010
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve
7807841 Spiro-containing compounds and compositions as modulators of steroid hormone nuclear receptors October 5, 2010
Described herein are compounds that have a spiro structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of steroid hormone nuclear receptors, and pharmaceutical compositions and medicaments comprising
7750032 Compounds and compositions as PPAR modulators July 6, 2010
The invention provides trisubstituted pyrazoles and imidazoles of Formula I: ##STR00001## wherein L.sup.2, q, R.sup.13, R.sup.14, R.sup.15, R.sup.16, Z.sub.1 and Z.sub.2 are as described in the Summary of the Invention; and methods of using such compounds to treat or prevent disease
7750021 Immunosuppressant compounds and compositions July 6, 2010
The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte intera
7745445 Compounds and compositions as PPAR modulators June 29, 2010
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activ
7745437 Compounds and compositions as protein kinase inhibitors June 29, 2010
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that invo
7732449 Inhibitors of cathepsin S June 8, 2010
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a
7718704 Immunosuppressant compounds and compositions May 18, 2010
The invention provides a novel class of cyclic oximes of Formula I: ##STR00001## wherein A, X, Y, Z, W, R.sub.1, R.sub.2, R.sub.3 and n are as described in the summary of the invention; useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions,
7713958 Compounds and compositions as protein kinase inhibitors May 11, 2010
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases and disorders associated with kinase activity, particularly diseases associated with the activity of CDK1, CDK2, C
7678792 Compositions and methods for modulating c-kit and PDGFR receptors March 16, 2010
The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiment
7642255 Compounds and compositions as protein kinase inhibitors January 5, 2010
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that invo
7638601 Transient receptor potential channel TRPM8 and its use December 29, 2009
This invention provides novel genes and polypeptides of the transient receptor potential channel family, and use of these genes and polypeptides for the treatment of pain and identification of agents useful in the treatment of pain.
7638523 Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptor December 29, 2009
Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such com
7604977 Methods and compositions for inhibiting HIV infection October 20, 2009
This invention provides novel methods for identifying agents that inhibit HIV infection. The anti-HIV agents are identified by screening test compounds for ability to modulate a biological activity of isopeptidase T (IsoT), e.g., its isopeptidase activity or its binding to another mo
7601742 Pyrrolidones with anti-HIV activity October 13, 2009
The present invention relates to inhibition of viruses, e.g., HIV using pyrrolidones and compounds related to pyrrolidones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to
7595148 Methods and compositions for modulating T lymphocytes September 29, 2009
This invention provides novel methods and compositions for modulating T cell differentiation and T cell responses. The modulators are identified by screening test compounds for ability to modulate an inositol 1,4,5-trisphosphate 3-kinase (IP3K). The IP3K modulators can be further exa
7592349 Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptor September 22, 2009
Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such com
7589101 Compounds and compositions as protein kinase inhibitors September 15, 2009
The invention provides a novel class of compounds of formula I, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disord
7579363 Bicyclic compounds and compositions as PDF inhibitors August 25, 2009
This invention is directed to novel bicyclic compounds, to the uses of these compounds in various medicinal applications, including treating disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections, and to pharmaceutical compositions
7578206 Sample deposition method and system August 25, 2009
A method and system to deposit rapidly, accurately and efficiently liquid droplets onto a sample plate. A liquid from which the droplet is formed contains sample molecules, matrix molecules or a mixture of both sample and matrix molecules. A sample plate is positioned with respect to a
7572811 Immunosuppressant compounds and compositions August 11, 2009
The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte intera
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