| Patent Number |
Title Of Patent |
Date Issued |
| 7608618 |
Urea or thiourea substituted 1,4-pyrazine compounds useful as anti-cancer agents and for inhibit |
October 27, 2009 |
| Compounds of the formula ##STR00001## wherein: Y' is O or S, W' is ##STR00002## optionally substituted, Z' is selected from the group consisting of ##STR00003## wherein Q' is OR.sup.7 and R.sup.7 is C.sub.1-3alkyleneC.sub.3-8heterocycloalkyl useful in the treatment of diseases and |
| 7560462 |
Compounds useful for inhibiting CHK1 |
July 14, 2009 |
| Substituted urea compounds useful in the treatment of diseases and C.sub.1-3alkyleneOR.sup.3 conditions related to DNA damage or lesions in DNA replication are disclosed formula (I), wherein X.sup.1 is null, --O--, --S--, --CH.sub.2--, or --N(R.sup.1)--; X.sup.2 is --O--, . -.English |
| 7179912 |
Materials and methods to potentiate cancer treatment |
February 20, 2007 |
| Compounds that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods to inhibit the DNA-PK biological activity, methods to sensitize cells the agents that cause DNA lesions, and methods to potentiate cancer treatment are disclosed. |
| 7176229 |
Cyclic AMP-specific phosphodiesterase inhibitors |
February 13, 2007 |
| Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system |
| 7087634 |
Cyclic AMP-specific phosphodiesterase inhibitors |
August 8, 2006 |
| Pyrazole compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) |
| 7067506 |
Compounds useful for inhibiting Chk1 |
June 27, 2006 |
| Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases |
| 7018627 |
Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof |
March 28, 2006 |
| The present invention provides purified and isolated polynucleotide sequences encoding a novel macrophage-derived C--C chemokine designated "Macrophage Derived Chemokine" (MDC), and polypeptide fragments and analogs thereof. Also provided are materials and methods for the recombinant |
| 6998416 |
Cyclic AMP-specific phosphodiesterase inhibitors |
February 14, 2006 |
| Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system |
| 6989260 |
Human poly(ADP-ribose) polymerase 2 materials and methods |
January 24, 2006 |
| The invention provides a novel human poly(ADP-ribose) polymerase (hPARP2) polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, and host cells transformed with the expression constructs. Also provided are methods for producing |
| 6949535 |
Inhibitors of human phosphatidyl-inositol 3-kinase delta |
September 27, 2005 |
| Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K.delta.) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K.delta. plays a role in leukocyte function are disclosed. Preferably, the methods employ active age |
| 6924284 |
PARP inhibitors |
August 2, 2005 |
| The present invention provides compounds comprising a bicyclic aryl moiety, such as 2H-phthalazin-1-one or derivatives thereof, compositions comprising the same, and methods for producing and using the same. In particular, the present invention provides compounds of the formula: ##ST |
| 6864070 |
Phosphodiesterase 10 |
March 8, 2005 |
| The present invention provides novel human PDE10 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE10 polypeptides; antisense polynucleotides; |
| 6818743 |
I-CAM related protein |
November 16, 2004 |
| DNA sequences encoding a novel human intercellular adhesion molecule polypeptide (designated "ICAM-R") and variants thereof are disclosed along with methods and materials for production of the same by recombinant procedures. Antibodies substances specific for ICAM-R and variants thereof |
| 6815532 |
ATR-2 cell cycle checkpoint |
November 9, 2004 |
| Polynucleotides encoding novel Atr-2 cell cycle checkpoint polypeptides are disclosed, along with expression constructs comprising the polynucleotides, host cells transformed with the expression constructs, methods to make the Atr-2 polypeptides using the host cells, Atr-2 polypeptid |
| 6797811 |
Antibodies to chemokine receptor 88C |
September 28, 2004 |
| The present invention provides polynucleotides that encode the chemokine receptors 88-2B or 88C and materials and methods for the recombinant production of these two chemokine receptors. Also provided are assays utilizing the polynucleotides which facilitate the identification of lig |
| 6790947 |
Polynucleotides encoding macrophage derived chemokine |
September 14, 2004 |
| The present invention provides purified and isolated polynucleotide sequences encoding a novel human macrophage-derived C--C chemokine designated MDC. Also provided are materials and methods for the recombinant production of the chemokine, and purified and isolated chemokine protein. |
| 6787542 |
Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-infla |
September 7, 2004 |
| The present invention relates to novel heterocyclyl-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a |
| 6784179 |
Tetracyclic derivatives, process of preparation and use |
August 31, 2004 |
| A compound of formula (I) ##STR1##and salts and solvates thereof, in which: R.sup.0 represents hydrogen, halogen or C.sub.1-6 alkyl; R.sup.1 represents hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, halo C.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkylC |
| 6737513 |
Macrophage derived chemokine (MDC) and chemokine analogs and assay to identify modulators of MDC |
May 18, 2004 |
| The present invention provides purified and isolated polynucleotide sequences encoding a novel human macrophage-derived C-C chemokine designated Macrophage Derived Chemokine (MDC), and polypeptide analogs thereof Also provided are materials and methods for the recombinant production |
| 6737059 |
Methods of inhibiting inflammatory processes and alleviating symptoms associated with multiple s |
May 18, 2004 |
| Disclosed are methods for the alleviation of symptoms associated with inflammatory disease states, and more particularly to the inhibition of inflammatory disease processes associated with the multiple sclerosis disease, by adminstering to a patient a phamaceutically effective amount |
| 6734003 |
Phosphodiesterase 10 |
May 11, 2004 |
| The present invention provides novel human PDE10 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE10 polypeptides; antisense polynucleotides; |
| 6716871 |
Cyclic AMP-specific phosphodie sterase inhibitors |
April 6, 2004 |
| Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system |
| 6680336 |
Cyclic AMP-specific phosphodiesterase inhibitors |
January 20, 2004 |
| Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disord |
| 6667300 |
Inhibitors of human phosphatidylinositol 3-kinase delta |
December 23, 2003 |
| Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K.delta.) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K.delta. plays a role in leukocyte function are disclosed. Preferably, the methods employ active age |
| 6620915 |
Monoclonal antibodies specific for integrin .alpha.-d subunit |
September 16, 2003 |
| The present invention relates to monoclonal antibodies immunospecific for .alpha..sub.d integrin, and antibodies that compete with said antibodies for .alpha..sub.d binding. |
| 6608065 |
Use of cGMP phosphodiesterase inhibitors in methods to treat female sexual dysfunction |
August 19, 2003 |
| The use of (6R, 12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyraz ino[2',1':6,1]pyrido[3,4-b]indole -1,4-dione, (3S, 6R, 12aR)-2,3,6,7,12,12a-hexahydro-2,3-dimethyl-6-(3,4-methylenedioxyphenyl)py razino[2', 1':6,1]pyrido[3,4-b]indole-1,4-dione, and physiologica |
| 6599727 |
Human poly (ADP-ribose) polymerase 2 materials and methods |
July 29, 2003 |
| The invention provides a novel human poly(ADP-ribose) polymerase (hPARP2) polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, and host cells transformed with the expression constructs. Also provided are methods for producing the |
| 6569890 |
Cyclic AMP-specific phosphodiesterase inhibitors |
May 27, 2003 |
| Pyrrole compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) diso |
| 6569885 |
Cyclic AMP-specific phosphodiesterase inhibitors |
May 27, 2003 |
| Pyrazole compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) |
| 6566087 |
Phosphodiesterase 8A |
May 20, 2003 |
| The present invention provides novel human PDE8 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE8 polypeptides; antisense polynucleotides; an |
| 6521619 |
Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflam |
February 18, 2003 |
| The present invention relates to novel cyclopropane-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a |
| 6518277 |
Inhibitors of human phosphatidylinositol 3-kinase delta |
February 11, 2003 |
| Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K.delta.) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K.delta. plays a role in leukocyte function are disclosed. Preferably, the methods employ active age |
| 6500856 |
Cyclic AMP-specific phosphodiesterase inhibitors |
December 31, 2002 |
| Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disord |
| 6498015 |
Methods of identifying agents that modulate the binding between MDC and an MDC receptor |
December 24, 2002 |
| The present invention provides purified and isolated polynucleotide sequences encoding a novel human macrophage-derived C-C chemokine designated Macrophage Derived Chemokine (MDC), and polypeptide analogs thereof. Also provided are materials and methods for the recombinant production |
| 6486186 |
Thiazole compounds as cyclic AMP-specific phosphodiesterase inhibitors and method of using the s |
November 26, 2002 |
| Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disord |
| 6479256 |
Lectomedin materials and methods |
November 12, 2002 |
| Disclosed are novel seven transmembrane receptor polypeptides having characteristic extracellular structure including lectin-binding, olfactomedin-like and mucin-like domains. |
| 6462047 |
Carboline derivatives as cGMP phosphodiesterase inhibitors |
October 8, 2002 |
| Compounds of general structural formula (I) wherein A represents a 5- or 6-membered heteroaryl group containing at least one heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur, and use of the compounds, and salts and solvates thereof, as therapeutic agents, are |
| 6458787 |
Cyclic AMP-specific phosphodiesterase inhibitors |
October 1, 2002 |
| Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system |
| 6455562 |
Cyclic AMP-specific phosphodiesterase inhibitors |
September 24, 2002 |
| Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disord |
| 6444671 |
Cyclic AMP-specific phosphodiesterase inhibitors |
September 3, 2002 |
| Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disord |
| 6432404 |
Methods of inhibiting locomotor damage following spinal cord injury with .alpha. D-specific anti |
August 13, 2002 |
| Methods to treat spinal cord injury using .alpha..sub.d monoclonal antibodies are disclosed. |
| 6423710 |
Cyclic AMP-specific phosphodiesterase inhibitors |
July 23, 2002 |
| Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system |
| 6399571 |
Chitinase chitin-binding fragments |
June 4, 2002 |
| The present invention provides chitin-binding fragments of human chitinase, fragment analogs, purified and isolated polynucleotide sequences encoding such fragments and analogs, and materials and methods for the recombinant production of human chitinase fragment products which are expect |
| 6376489 |
Cyclic AMP-specific phosphodiesterase inhibitors |
April 23, 2002 |
| Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory disease and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorde |
| 6372777 |
Cyclic AMP-specific phosphodiesterase inhibitors |
April 16, 2002 |
| Pyrrole compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) diso |
| 6372212 |
Chitinase materials and methods |
April 16, 2002 |
| The present invention provides purified and isolated polynucleotide sequences encoding human chitinase. Also provided are materials and methods for the recombinant production of human chitinase products which are expected to be useful as products for treating fungal infections or for |
| 6369059 |
Tetracyclic derivatives, process of preparation and use |
April 9, 2002 |
| A compound of formula (I) ##STR1##and salts and solvates thereof, in which:R.sup.0 represents hydrogen, halogen or C.sub.1-6 alkyl;R.sup.1 represents hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, haloC.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkylC.sub.1-3 |
| 6362213 |
Cyclic AMP-specific phosphodiesterase inhibitors |
March 26, 2002 |
| Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disord |
| 6350603 |
Phosphodiesterase 10 |
February 26, 2002 |
| The present invention provides novel human PDE10 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE10 polypeptides; antisense polynucleotides; |
| 6348602 |
Cyclic AMP-specific phosphodiesterase inhibitors |
February 19, 2002 |
| Novel compounds that are potent and selective inhibitors of PIDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disor |
