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Hoffmann-La Roche Inc. Patents
Assignee:
Hoffmann-La Roche Inc.
Address:
Nutley, NJ
No. of patents:
3200
Patents:












Patent Number Title Of Patent Date Issued
RE43568 Anti-P-selectin antibodies August 7, 2012
This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for
RE34851 Biosynthesis of 2 keto-L-gulonic acid February 7, 1995
A process of producing 2-keto-L-gulonic acid from sorbose via a recombinant bacteria including expression vectors and probes for producing said recombinant bacteria.
RE33887 Anti-retroviral compounds April 14, 1992
A-B-C wherein A and C are each independently 2',3'dideoxynucleosides and B is a linking group; and a method of treating or preventing a retroviral injection in a subject by administering the compounds of the invention.
RE31440 Electrochemical electrode with heating means November 15, 1983
An electrode arrangement for application to a body surface for bloodless measurement in connection with the concentration or the partial pressure of a gas in the blood comprising a sensor unit having a face member for body contact, and a heating unit coupled to the sensor unit for tr
RE30473 Benzophenone glycinamide derivatives January 6, 1981
This invention is directed toward pharmacologically active compounds of the formula ##STR1## wherein A represents a nitrogen atom which may be substituted by a methyl, cyclopropylmethyl, di(C.sub.1-4 alkyl)aminoethyl, methoxymethyl or hydroxyethyl group and B represents a carbony
RE30452 3-Phenoxymorphinans and derivatives thereof December 16, 1980
Levo-rotary 3-phenoxy N-substituted morphinans and derivatives thereof useful as analgesics and/or narcotic antagonists and their preparation form (-)-3-hydroxy-N-lower alkyl morphinan including intermediates in this preparation.
RE30260 1-(2,6,6-Trime thyl-3-hydroxy-1-cyclohexen-1-yl)-3-methyl-penta-1,4-diene[or 1-yn-4-en]-3-ols April 22, 1980
A total synthesis of canthaxanthin, a known food coloring agent from alpha or retro ionone.
RE29842 Untriakontapeptide with opiate activity November 21, 1978
An untriakontapeptide having significant opiate agonist activity has been isolated from camel pituitary glands. The structure of this peptide has been determined and this peptide was then synthesized utilizing solid phase peptide synthesis. Both natural and synthetic material show id
RE29651 Derivatives of antibiotic X-537A May 30, 1978
Compound of the formula ##STR1## where R.sub.1 is hydrogen, lower alkyl, phenyl, or phenyl substituted by halogen, nitro or lower alkyl; R.sub.2 is hydrogen; lower alkyl; lower alkanoyl; benzoyl; benzoyl substituted by halogen, nitro or lower alkyl; or R.sub.3 is hydrogen, haloge
RE29244 Coccidiostats May 31, 1977
Compositions containing the antibiotic having the designation X-537A, useful for the treatment and prevention of coccidiosis in poultry feed compositions containing the antibiotic and methods of treating coccidiosis are disclosed.
RE29163 1,2,3,4,10,19-Hexanor-9-oxo-5,9-seco-25D-spirostan-5-oic acid March 29, 1977
The spirostan derivative 1,2,3,4,10,19-hexanor-.[.5.]. .Iadd.9.Iaddend.-oxo-5,9-seco-25D-spirostan-5-oic acid is obtained by the microbiological degradation of diosgenin utilizing Proactinomyces restrictus Turfitt CBS 157.45 or enzymes derived therefrom. The aforesaid spirostan deriv
RE29003 (R)-1-(2-furoyloxy)-3-methylbutyl-penicillin October 12, 1976
Compounds represented by the following formula ##EQU1## wherein A is a substituted or unsubstituted heterocyclic radical and T is a C.sub.2 -C.sub.5 alkyl, alkenyl, cyclopropylmethyl, cyclobutylmethyl or cyclopentyl groupA process for their preparation and novel intermediates therefo
RE28700 Antibiotic X-5108 for stimulating growth January 27, 1976
A new antibiotic, designated as antibiotic X-5108, is produced by a new species of streptomyces. The new antibiotic is active against gram-positive and gram-negative bacteria and produces growth stimulation and increased feed efficiency in poultry.
D562463 Microtiter plate February 19, 2008
D540665 Pharmaceutical package April 17, 2007
D342793 Cuvette December 28, 1993
D288845 Cuvette assembly March 17, 1987
D287812 Safety bottle cap remover January 20, 1987
D266055 Bottle guard September 7, 1982
D249530 Hair microanalyzer September 19, 1978
8586747 3,3-dimethyl tetrahydroquinoline derivatives November 19, 2013
A compound of formula (I) ##STR00001## as well as pharmaceutically acceptable salt thereof, wherein R.sup.1 to R.sup.5 have the significance given in claim 1, can be used as a medicament.
8586617 Aminomethyl-4-imidazoles November 19, 2013
The present invention relates to amino-4-methyl imidazoles and pharmaceutically-acceptable salts thereof. The compound may be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychoti
8586581 Ethynyl compounds useful for treatment of CNS disorders November 19, 2013
The present invention relates to ethynyl compounds of formula ##STR00001## wherein X, Y, Z, and R.sup.4 are as defined herein or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoi
8586579 Anellated pyridine compounds November 19, 2013
The present invention is concerned with novel dual modulators of the 5-HT.sub.2A and D.sub.3 receptors of formula (I) ##STR00001## wherein X, Y, A, R.sup.1, R.sup.2, and R.sup.3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. Further the pr
8580933 Variable tangential flow filtration November 12, 2013
The current invention reports a method for concentrating an immunoglobulin solution by tangential flow filtration wherein the transmembrane pressure and the cross-flow are variable.
8580821 Serotonin transporter (SERT) inhibitors for the treatment of depression and anxiety November 12, 2013
The present invention relates to trans-derivatives of formula ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, and the dotted line are as defined herein and to pharmaceutically acceptable acid addition salts thereof. The compounds of formula I are good inhibitors of the serotonin tra
8580264 Subcutaneously administered anti-IL-6 receptor antibody November 12, 2013
The present application discloses methods for treating an IL-6-mediated disorder such as rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), systemic JIA (sJIA), polyarticular course JIA (pcJIA), systemic sclerosis, or giant cell arteritis (GCA), with subcutaneously admin
8569306 JNK modulators October 29, 2013
Compounds of formula (I) modulate JNK wherein X.sup.1 and X.sup.2 are each simultaneously N or CH; X.sup.3 is CH--R.sup.2 Or N--SO.sub.2R, where R is lower alkyl; R.sup.1 is aryl or heteroaryl, substituted with 0-3 lower alkyl radicals; R.sup.2 is (II), where R.sup.3 is H, lower acyl
8299023 Neuropeptide-2 receptor (Y-2R) agonists October 30, 2012
Provided herein are neuropeptide-2 receptor agonists of the formula (I): Y--R.sub.1--R.sub.2--X--R.sub.3--R.sub.4--R.sub.5--R.sub.6--R.sub.7--R.su- b.8--R.sub.9--R.sub.10--R.sub.11--R.sub.12--R.sub.13--R.sub.14--NH.sub.2 (I) (SEQ ID NO: 1), as well as pharmaceutically acceptable salts,
8293916 Diazole derivatives October 23, 2012
The present invention relates to diazole derivatives of the general formula ##STR00001## wherein A, E, R.sup.1, R.sup.2 and R.sup.3 are as defined in application and pharmaceutical compositions containing them. The invention also relates to use of such compounds for the treatment of
8293770 Pyrrolidine derivatives as NK-3 receptor antagonists October 23, 2012
The present invention relates to a compound of formula I ##STR00001## wherein Ar.sup.1, Ar.sup.2, R.sup.1, R.sup.2, R.sup.3, n, o, and p are as described herein or to a pharmaceutically active salt, to all stereoisomeric forms, including individual diastereoisomers and enantiomers a
8293730 Substituted imidazo[1,5-A][1,2,4]triazolo[1,5-D][1,4]benzodiazepine derivatives October 23, 2012
The present invention is concerned with a method of treating Alzheimer's disease by administering a therapeutically effective amount of a substituted imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine of formula I ##STR00001## wherein R.sup.1, R.sup.2, and R.sup.3 are as defin
8288541 Piperazine amide derivatives October 16, 2012
The invention is concerned with novel piperazine amide derivatives of formula (I) ##STR00001## wherein R.sup.1 to R.sup.11, W, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds bind to LXR alpha and LXR bet
8288431 Substituted spiroindolinones October 16, 2012
There is provided a compound of the formula ##STR00001## wherein X, Y, W, R.sub.1, R.sub.2 and R.sub.3 are as described herein. The compounds have activity as anticancer agents.
8288403 Heterocyclic gamma secretase modulators October 16, 2012
The invention relates to methods for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome which comprise administering a therapeutically
8268870 Aminotetrahydroindazoloacetic acids September 18, 2012
The invention is concerned with the compounds of formula I: ##STR00001## and pharmaceutically acceptable salts and esters thereof, wherein Q, R1-R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and u
8268820 2,3-diaryl- or heteroaryl-substituted 1,1,1-trifluoro-2-hydroxypropyl compounds September 18, 2012
The present invention relates to compounds of formula I ##STR00001## wherein R.sup.1a to R.sup.1c, R.sup.2, R.sup.3 and R.sup.5 are as defined in the description and claims and R.sup.4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically acceptable
8268784 Neuropeptide-2 receptor (Y-2R) agonists and uses thereof September 18, 2012
Provided herein are neuropeptide-2 receptor agonists of the formula (I): ##STR00001## as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. X is 4-oxo-6-(1-piperazinyl)-3(4H)-quinazoline-ace
8268314 Bispecific anti-VEGF/anti-ANG-2 antibodies September 18, 2012
The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
8263656 Substituted aminotetralines September 11, 2012
The invention is concerned with the compounds of formula I: ##STR00001## and pharmaceutically acceptable salts and esters thereof, wherein R.sup.1-R.sup.4 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and
8263584 Imidazopyridines September 11, 2012
The invention is concerned with novel imidazopyridine derivatives of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and A are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compoun
8258158 HSL inhibitors useful in the treatment of diabetes September 4, 2012
The present invention relates to compounds of formula (I) ##STR00001## as well as pharmaceutically acceptable salts thereof, wherein A.sup.1, A.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 have the significance given herein.
8258149 Isoquinoline derivatives September 4, 2012
The invention provides novel compounds of formula (I) ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 to R.sup.7 are as described herein, compositions including the compounds and methods of preparing and using the compounds.
8258134 Pyridazinone glucokinase activators September 4, 2012
Provided herein are compounds of the formula (I): ##STR00001## as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment
8252826 Cyclopentyl- and cycloheptylpyrazoles August 28, 2012
This invention relates to novel cyclopentyl- and cycloheptylpyrazole derivatives of the formula I ##STR00001## wherein A and R.sup.1 to R.sup.4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. The invention relates also to co
8242276 Methods for the preparation of N-(S)-1-azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide hydro August 14, 2012
The present invention provides novel methods for preparing N--(S)-1 -azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide HCl salt 1, a nicotinic .alpha.-7 receptor ligand, that are useful for the scaled-up preparation of compound 1. Compound 1 is useful in the treatment of disease co
8242247 Bivalent, bispecific antibodies August 14, 2012
The present invention relates to novel domain exchanged, bivalent, bispecific antibodies, their manufacture and use.
8242153 4,5-dihydro-oxazol-2YL derivatives August 14, 2012
The invention relates to compounds of formula I ##STR00001## wherein R.sup.1, R.sup.2, X, Y, and n are defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The invention also provides pharmaceutical compositions and methods of manufacture of
8232412 Diazonium-free method to make an indazole intermediate in the synthesis of bicyclic 5-(trifluorm July 31, 2012
The present invention provides novel methods for preparing 5-(trifluoromethoxy)-1H-3-indazolecarboxylic acid (3), which is a useful precursor for the preparation of bicyclic-5-trifluoromethoxy-1H-indazole-3-carboxylic acid amides of Formula (1). Compounds of Formula (1) are active as
8227613 Heteroaryl carboxamide derivatives July 24, 2012
The invention is concerned with novel heteroaryl carboxamide derivatives of formula (I), ##STR00001## wherein ##STR00002## m, X, Y, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These

 
 
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