| Patent Number |
Title Of Patent |
Date Issued |
| 5399496 |
DNA shuttle vectors for E. coli, Gluconobacter, and Acetobacter |
March 21, 1995 |
| Novel shuttle vectors which are useful as shuttle vectors among microorganisms belonging to Escherichia coli, Gluconobacter and Acetobacter comprising one or more marker genes, a replication origin functional in Escherichia coli, a replication origin functional in Gluconobacter oxyda |
| 5389653 |
Catechol derivatives |
February 14, 1995 |
| Catechol derivatives of the formula ##STR1## wherein Ra, Rb and Rc have the significance given herein, the ester and ether derivatives thereof which are hydrolyzable under physiological conditions and the pharmaceutically acceptable salts thereof are described and possess valuabl |
| 5389616 |
Amino acid derivatives |
February 14, 1995 |
| The compounds of the formula ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as set forth above, are described.The compounds of formula I have an inhibitory activity on the natural enzyme renin and can accordingly be used in the form of pharmaceutical |
| 5389512 |
Method for determining the relative amount of a viral nucleic acid segment in a sample by the po |
February 14, 1995 |
| The present invention provides a method for determining the relative amount of a nucleic acid segment in a sample by the polymerase chain reaction. The method involves the simultaneous amplification of the nucleic acid segment and a second nucleic acid segment present in the sample. The |
| 5386022 |
Primes and probes for the amplification and detection of aids associated nucleic acids |
January 31, 1995 |
| The presence or absence of a nucleic acid sequence associated with AIDS in a sample containing one or more nucleic acids and suspected of containing such sequence can be detected by amplifying the sequence using primers to form extension products as templates and detecting the amplified |
| 5376674 |
Oxetanone compounds containing proline and pharmaceutical compositions thereof |
December 27, 1994 |
| Novel compounds of the formula ##STR1## wherein Q, R.sup.1 and R.sup.2 are described herein, are disclosed along with pharmaceutical compositions, methods of use, and process for producing compounds of formula I which starts from the corresponding .beta.-hydroxycarboxylic acids. |
| 5362646 |
Expression control sequences |
November 8, 1994 |
| Expression control sequences are provided for the expression of pro- and eukaryotic proteins. These control sequences are produced by combining promoter sequences having a low signal strength and a high in vivo promoter strength and operator/repressor systems having a high association |
| 5360908 |
Isoquinoline derivatives |
November 1, 1994 |
| A process for the preparation of isoquinoline derivatives of the formulas ##STR1## wherein R.sup.1 and R.sup.2 have the significances herein after set forth in the description, is described.The compounds of formula IV are obtained by asymmetrically hydrogenating the compounds of form |
| 5346831 |
Cytorich process system |
September 13, 1994 |
| A process for producing a monolayer of cytological material on an optically-clear, cationically-charged substrate, includes the steps of separating the cytological material by centrifugation over a density gradient, producing a packed pellet of the cytological material, mixing the pe |
| 5344843 |
Cat-1 inhibitors, pharmaceutical compositions and methods of use |
September 6, 1994 |
| The invention relates to compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.2 ' X, Y, Z, A, B, Q and n are as described herein. Their pharmaceutically acceptable salts, and when appropriate, enantiomers, racemates, diastereomers or mixtures thereof or geometric iso |
| 5322770 |
Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription |
June 21, 1994 |
| Methods are provided for the replication and amplification of RNA sequences by thermostable DNA polymerases. Reverse transcription of RNA is catalyzed by, for example, 92 kDa Taq, 64 kDa Taq, and Tth DNA polymerase. Reverse transcription is coupled to PCR amplification in a one enzyme pr |
| 5314809 |
Methods for nucleic acid amplification |
May 24, 1994 |
| Methods are provided for enhanced specificity and sensitivity of nucleic acid amplification. The methods are simplified nested amplification procedures wherein both inner and outer primer pairs are present in the amplification reaction mixture. According to the methods, the thermocyc |
| 5310663 |
Affinity peptides |
May 10, 1994 |
| Fusion proteins and a process for their purification by means of metal chelate affinity chromatography on NTA resins are provided by this invention. |
| 5310652 |
Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription |
May 10, 1994 |
| Methods are provided for the replication and amplification of RNA sequences by thermoactive DNA polymerases. In a preferred embodiment, high temperature reverse transcription is coupled to nucleic acid amplification in a one tube, one enzyme procedure using a thermostable DNA polymerase. |
| 5296608 |
Intermediates for analogs of tyrosine sulfate or tyrosine phosphate containing peptides |
March 22, 1994 |
| Analogs of Tyrosine Sulfate or Tyrosine Phosphate containing peptides, the novel intermediate compounds used in the preparation of these analogs, as well as a method for suppressing appetite in subjects by administering to the subject an effective amount of CCK analog wherein one or more |
| 5292747 |
Substituted pyrroles |
March 8, 1994 |
| Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X, m, n, p, and q are as set forth in the specification, as well as pharmaceutically acceptable salts of acidic compounds of formula I with bases and of basic compounds of for |
| 5276197 |
Process for manufacture of beta-isophorone |
January 4, 1994 |
| The invention is concerned with a process for the manufacture of beta-isophorone from alpha-isophorone by converting alpha-isophorone into beta-isophorone in the presence of a heterogeneous catalyst in the gas phase. The heterogenous catalyst used is especially an oxide or mixed oxid |
| 5260294 |
Chromanes and their pharmaceutical compositions and methods |
November 9, 1993 |
| Racemic Compounds of the formula ##STR1## A is --C.tbd.C--R.sub.6, --CH.sub.2 --CH.sub.2 --R.sub.7 or ##STR2## and the remainder of the variables are as defined in the specification, and their enantiomers and salts thereof are described.The compounds of formula I exhibit activity |
| 5235193 |
Device for identifying a container carrier for an automatic analytical apparatus with faceted li |
August 10, 1993 |
| A device for identifying a container carrier for an automatic analytical apparatus is described. The carrier has an array of fields on a flange, some of the fields being transparent and the other fields being opaque. The device includes an electro-optical arrangement to detect whether ea |
| 5234622 |
Alkenyloxyphenylpyrimidine derivatives and liquid crystalline mixtures containing same |
August 10, 1993 |
| Compounds of the formula ##STR1## wherein R.sup.1 signifies a straight-chain alkyl group with 7 to 10 carbon atoms; R.sup.2 represents a straight-chain alkyl group with 1 to 8 carbon atoms; and n signifies either 1, 2 or 3, their preparation, liquid crystalline mixtures which con |
| 5214162 |
Process for manufacturing 5-cyano-4-lower alkyloxazoles |
May 25, 1993 |
| The invention is concerned with a process for the manufacture of 5-cyano-4-lower alkyl-oxazoles by dehydrating a 5-carbamoyl-4-lower alkyl-oxazole in the gas phase in the presence of a heterogeneous catalyst based on silicon dioxide and in the presence of an inert solvent. The hetero |
| 5210015 |
Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
May 11, 1993 |
| The present invention is directed to a process of detecting a target nucleic acid using labeled oligonucleotides. This process uses the 5' to 3' nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled olig |
| 5204482 |
Compounds for treating and preventing cognitive diseases and depression and methods of making sa |
April 20, 1993 |
| Ethylenediamine monoamides of the formulawherein R is one of groups ##STR1## in which R.sup.1 is phenyl, monohalophenyl, monolower-alkylphenyl, monolower-alkoxyphenyl, monotrifluoromethylphenyl, monocyanophenyl or monaryl-lower-alkoxyphenyl, dihalophenyl, furyl, thienyl or monoha |
| 5200549 |
Antipsoriatic agents |
April 6, 1993 |
| The invention relates to compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl; ##STR2## wherein R.sub.2 is lower alkyl; R.sub.3 is phenyl, or phenyl substituted by 1 to 3 substituents selected from the group consisting of halo, lower alkyl, and lower alkoxy |
| 5171472 |
Phenylcyclohexyldioxane derivatives having an ether bond for electro-optical displays |
December 15, 1992 |
| A compound represented by formula (I). ##STR1## wherein R represents a straight chain alkyl group having 1 to 7 carbon atoms; n is an integer of 1 to 5; X represents F, Cl or CN; Y represents H or F; and a dioxane ring in a trans configuration with respect to a cyyclohexane ring. |
| 5166445 |
Method for the manufacture of carotinoids and the novel intermediates |
November 24, 1992 |
| Phosphonium salts of the formula ##STR1## wherein A signifies aryl and Y.sup.- signifies C.sub.1 -C.sub.6 -alkanoate or hydroxytrifluoroborate, as well as their manufacture from 3,7,11-trimethyldodeca-1,4,6,10-tetraen-3-ol with a triarylphosphine and with a C.sub.1 -C.sub.6 -alk |
| 5153344 |
Vitamin E intermediates and a process for their manufacture and conversion into vitamin E |
October 6, 1992 |
| Novel methyl carbinol derivatives of Vitamin E and a method for their manufacture. |
| 5141854 |
Enzymatic composition for ethanol assay |
August 25, 1992 |
| An enzymatic assay composition for ethanol determination is provided. A compound of the formulawhereR is H, CH.sub.3, or OH andN is 0-4acts as a buffer and a trapping agent for a product of the enzymatic reaction. Long stability of the assay composition is achieved. |
| 5141735 |
Substituted amino-benzodiazepines having anitviral activity |
August 25, 1992 |
| Novel substituted 2-amino-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepines and compositions containing same for treatment and prophylaxis of viral infections, including HIV infections. |
| 5134123 |
Amino acid derivatives |
July 28, 1992 |
| The compounds of the formula ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as set forth above, are described.The compounds of formula I have an inhibitory activity on the natural enzyme renin and can accordingly be used in the form of pharmaceutical |
| 5128448 |
CCK analogs with appetite regulating activity |
July 7, 1992 |
| The invention is directed to novel CCK analogs wherein Tryptophan and/or Phenylalamine are substituted with a radical which provides enhanced appetite suppressant activity to the peptide. |
| 5114934 |
Tricyclic pyridone derivatives |
May 19, 1992 |
| The compounds of the formula ##STR1## wherein R.sub.a, R.sub.b, R.sub.c, R.sub.d are defined in the specification and pharmaceutically acceptable addition salts are disclosed. The compounds of formula I have valuable pharmacological properties and can be used for the control of p |
| 5100577 |
Ferroelectric liquid crystal mixtures and compounds as well as electro-optical devices employing |
March 31, 1992 |
| A ferroelectric liquid crystalline mixture containing at least one optically active compound of the general formula ##STR1## wherein X.sup.1 denotes a single covalent bond, --COO--, --OOC--, --CH.sub.2 CH.sub.2 --, --OCH.sub.2 -- or --CH.sub.2 O--; one of rings A.sup.1, A.sup.2 a |
| 5087619 |
Vitamin D.sub.3 analogs |
February 11, 1992 |
| Compounds of the formula ##STR1## wherein R is hydrogen or hydroxy, R.sub.5 is hydrogen, and A is --C.tbd.C--, ##STR2## or --CH.sub.2 --CH.sub.2 --, with the proviso that when A is --C.tbd.C--, R.sub.5 may also be deuterium, are described.The compounds of formula I are useful |
| 5081872 |
Pipetting insert |
January 21, 1992 |
| A pipetting insert for a pipetting device for taking a liquid sample from a vacuum tube closed in air-tight manner by a stopper. In order to prevent the undesirable escape of fragments of a sample from the vacuum tube before the sample is taken, the pipetting insert is made of plastic, h |
| 5073491 |
Immobilization of cells in alginate beads containing cavities for growth of cells in airlift bio |
December 17, 1991 |
| Method and apparatus are provided for immobilizing and growing cells in airlift bioreactors to obtain increased cell density. Cells are immobilized by forming alginate beads containing cells and gelatin particles, and dissolving the gelatin by heating to form cavities in the beads en |
| 5070010 |
Method for determining anti-viral transactivating activity |
December 3, 1991 |
| The anti-viral transactivating activity of a test substance is determined by (a) putting both the expression of the Secreted Alkaline Phosphatase gene and the viral transactivator gene under the control of a viral promoter responsive to the action of the transactivator, (b) transfecting |
| 5061629 |
Production of 2-hydroxy substituted arylalkanoic acids and esters by enzymatic hydrolysis |
October 29, 1991 |
| Enantiomerically pure (2R)-2-hydroxy arylalkanoic acid esters and (2S)-2-hydroxy arylalkanoic acids are prepared by the Pseudomonas lipase-catalyzed selective hydrolyxis of racemic (2RS)-2-hydroxy arylalkanoic acid esters in solution or suspension in an aqueous medium at a controlled |
| 5041563 |
Rearrangement process |
August 20, 1991 |
| A process for the manufacture of ascorbic acid from 2-ketogulonic acid esters (KGAE) utilizing amine salts of the latter is disclosed. |
| 5030739 |
Process for the catalytic oxidation of isoprenoids having allylic groups |
July 9, 1991 |
| The invention is directed to a process for the catalytic oxidation of an isoprenoid containing at least one allylic hydrogen atom, which process comprises reacting the isoprenoid with oxygen or an oxygen-containing gas in an inert solvent in the presence of a N-hydroxydicarboxylic acid i |
| 5021451 |
Method for inhibiting hyperproliferative diseases |
June 4, 1991 |
| A method of treating hyperproliferative skin diseases, such as psoriasis, using a compound of formula ##STR1## wherein R.sub.1 is hydrogen when R.sub.2 is hydroxy, and R.sub.1 is methyl when R.sub.2 is hydrogen; and A is alkyl; cycloalkyl; alkenyl; alkyl substituted with trifluor |
| 5019351 |
Agglutination reaction slide |
May 28, 1991 |
| A test element for agglutination tests, comprising a receiving and mixing region for a sample and reagents and a reaction capillary having an upstream region which produces a capillary effect causing the sample-reagents mixture to flow at a speed which is greater than along a downstr |
| 5006651 |
Phosphinic acid derivatives |
April 9, 1991 |
| The invention relates compounds of the formula ##STR1## wherein R.sup.1 -R.sup.5 and X have the significance given in the description, and their pharmaceutically acceptable salts. The compounds of formula I inhibit the enzyme collagenase and can be used in the form of medicaments |
| 4973599 |
Phenylthioheterocyclic derivatives |
November 27, 1990 |
| Compounds of the formula ##STR1## wherein n is a integer of 0 to 2; R.sub.1 ' and R.sub.2 ' are, independently, hydrogen, halogen, trifluoromethyl, lower alkoxy or lower alkyl; and X is pyrimidinyl, thiazolyl or ##STR2## wherein R is hydrogen, lower alkyl, aryl or ar-lower al |
| 4940707 |
Stilbene derivatives for treatment of skin disorders |
July 10, 1990 |
| Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 each independently are lower-alkyl; or together are alkylene with 3-5 C-atoms in a straight chain; one of the residues R.sup.3 and R.sup.4 is hydrogen and the other is hydrogen or lower-alkyl; R.sup.6 and R.sup.7 are h |
| 4929741 |
Propiolophenone derivatives |
May 29, 1990 |
| Propiolophenone derivatives of the formula ##STR1## wherein R.sup.6 is hydrogen, lower alkyl or a group of the formula ##STR2## as well as corresponding hydroxy compounds of the formula ##STR3## wherein R.sup.6' is hydrogen, lower alkyl, a group of formula (a), (b), (c), |
| 4927838 |
Pyridine compounds which are useful in treating a disease state characterized by an excess of pl |
May 22, 1990 |
| The invention relates to compounds of the formula ##STR1## wherein Y and Y' are hydrogen or taken together are O or S, *A is paraphenylene or *----(CH.sub.2).sub.n --(X).sub.s --(CH.sub.2).sub.r ----, X is O, S or --CH.dbd.CH--, n or r, independently, are integers from 0 to 3, m |
| 4927826 |
Cycloproylpropenamides useful as platelet activing factor (PAF) antagonists |
May 22, 1990 |
| The invention relates to compounds of the formula ##STR1## Y is O or S, *A is paraphenylene or *--(CH.sub.2).sub.n --(X).sub.m --(CH.sub.2).sub.r --, X is O, S or --CH.dbd.CH--, n or r, independently, are integers from 0 to 3, s is an integer from 0 to 1, m is an integer from 0 t |
| 4921699 |
Polypeptides having interferon activity |
May 1, 1990 |
| A polypeptide having interferon activity which has an amino acid sequence corresponding to an amino acid sequence of an interferon selected from rIFN-.alpha., hybrid rIFN-.alpha., rIFN-.beta. and rIFN-.gamma. interferons in which at least one cysteine residue in the amino acid sequen |
| 4912214 |
Isothiazolyl beta-lactam antibacterial agents |
March 27, 1990 |
| Compounds of the formula ##STR1## wherein A is ##STR2## in which R.sub.1 is acyl, R.sub.2 is hydrogen, lower alkyl, lower alkoxy-carbonyl or aminocarbonyl, R.sub.3 is hydrogen or lower alkyl, R.sub.4 and R.sub.4, are each hydrogen, lower alkyl, lower alkoxy, aryl, aryloxy |
