Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Health Research, Inc. Patents
Assignee:
Health Research, Inc.
Address:
Buffalo, NY
No. of patents:
197
Patents:


1 2 3 4










Patent Number Title Of Patent Date Issued
RE43274 Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy March 27, 2012
Provided herein are compounds for detection, diagnosis and treatment of target tissues or target compositions, including hyperproliferative tissues such as tumors, using photodynamic methods. In particular, photosensitizer compounds that collect in hyperproliferative tissue are provi
RE39094 Pyropheophorbides and their use in photodynamic therapy May 9, 2006
Pyropheophorbide compounds are injected into a host and accumulate in tumor tissue to a higher degree than surrounding normal tissues. When the pyropheophorbide compounds are exposed to a particular wavelength of light the compounds become cytotoxic and destroy the tumor or diseased
RE38994 Pyropheophorbides conjugates and their use in photodynamic therapy February 28, 2006
Conjugate are formed by covalently linking a target-specific compound to pyropheophorbide compound which conjugated are injected into a host and accumulate in tumor tissue to a higher degree than surrounding normal tissues. When the pyropheophorbide compound component of the conjugate is
8580269 Survivin peptides for autoimmune therapies November 12, 2013
Compositions and methods for stimulating an immune response against cells that express survivin are provided. The method is suitable for prophylaxis and/or therapy of autoimmune disorders. The method involves administering to an individual a composition that contains a survivin pepti
8569450 CD3 epsilon immunogens and antibodies October 29, 2013
The present invention relates to novel CD3 epsilon peptides, antibodies against the novel CD3 epsilon peptides. The invention also relates to methods of identifying an immunodeficiency (such as severe combined immunodeficiency (SCID) or a T cell immunodeficiency) in a patient, which
8562944 PAA nanoparticles for enhancement of tumor imaging October 22, 2013
A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and an imaging agent and methods for making and using same.
8278072 Method for synthesis of sialylated products using reversible sialylation October 2, 2012
A method for producing sialylated molecules based on reverse sialylation that catalytically transfers the sialic acid moiety of sialylated donors to nucleotide monophosphates or transfer sialic acid moieties from sialylated donors to acceptor glycoproteins or glycolipids.
8241845 Steroid 5.alpha.-reductase August 14, 2012
The invention provides an isolated, novel steroid 5.alpha.-reductase enzyme termed SRD5AIII. The protein has an estimated molecular weight of 37 kDa and is capable of converting testosterone to dihydrotestosterone at a pH of about 7.0. Also provided is a method for identifying inhibi
8236320 Compositions and methods for using CA9 protein to stimulate an immune response August 7, 2012
Provided are methods for stimulating an immune response to an antigen by administering a composition to an individual in an amount effective to stimulate an immune response to the antigen. The stimulated immune response to the antigen is greater than the immune response stimulated by
8198432 Porphyrin-based compounds for tumor imaging and photodynamic therapy June 12, 2012
This invention describes a first report on the synthesis of certain .sup.124I-labelled photosensitizers related to chlorines and bacteriochlorins with long wavelength absorption in the range of 660-800 nm. In preliminary studies, these compounds show a great potential for tumor detec
8133875 Method for inhibiting scavenger receptor-A and increasing immune response to antigens March 13, 2012
Provided is a method for enhancing an immune response to a desired antigen in an individual. The method is performed by administering to the individual an agent capable of inhibiting class A macrophage scavenger receptor (SR-A) and optionally administering the desired antigen. Also p
8133473 Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and N.sub.2S.sub.2 conjugates fo March 13, 2012
A compound comprising a chemical combination of a photodynamic tetra-pyrrolic compound with a plurality of radionuclide element atoms such that the compound may be used to enhance MR imaging and also be used as a photodynamic compound for use in photodynamic therapy to treat hyperpro
8119339 Heteroduplex tracking assay February 21, 2012
A change in viral tropism occurs in many HIV positive individuals over time and may be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the pre
8080388 Stress protein compositions and methods for prevention and treatment of cancer and infectious di December 20, 2011
Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or grp170 polypeptide complexed with an immunogenic polypeptide. The immunogenic polypeptide
8048640 Methods for evaluating and implementing prostate disease treatments November 1, 2011
Provide is a method for evaluating test agents as candidates for treating prostatic diseases, including benign prostatic hyperplasia (BPH) and androgen dependent and androgen independent prostate cancer. The method comprises providing a mouse comprising a human prostate primary xenog
8043815 Methods for analysis of PDEF and survivin as interconnected cancer biomarkers and targets for pe October 25, 2011
Provided are methods for determining whether an individual is a candidate to receive treatment with a DNA methylation inhibitor. The method can be performed a biological sample of cancerous tissue of the individual. Determining that PDEF expression is absent or low and survivin expressio
7998698 Method for predicting susceptibility to radiation pneumonitis August 16, 2011
Provided is a method for determining whether an individual is likely to be susceptible to radiation pneumonitis from radiation therapy and for developing a treatment based on the determination of susceptibility. The method involves measuring SOD and GPX activity levels. A high SOD or low
7976846 Stress protein compositions and methods for prevention and treatment of cancer and infectious di July 12, 2011
Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or grp170 polypeptide complexed with an immunogenic polypeptide. The immunogenic polypeptide
7968708 Azepans and methods for making and using same June 28, 2011
Disclosed are compounds having the formula: ##STR00001## wherein Z.sup.1 is an alkylene moiety; Q is a carboxylic acid derivative; and R.sup.1 and R.sup.2 are the same or different and are selected from the group consisting of alkyl, aryl, alkylcarbonyl, arylcarbonyl, hydroxycarbon
7947729 Adduct of fluorescent dye and tumor avid tetrapyrrole May 24, 2011
A compound having preferential localization in tumor tissue relative to normal tissue, a preferential electromagnetic absorption at a wavelength between about 660 and 900 nm, and a fluorescence at a wavelength shifted from the preferential absorption by at least +30 nm and preferably at
7943297 Analysis of HIV-1 coreceptor use in the clinical care of HIV-1-infected patients May 17, 2011
A change in viral tropism occurs in many HIV positive individuals over time and can be indicated by a change in coreceptor usage from CCR5 to CXCR4. The change in coreceptor usage to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, t
7943138 Survivin peptides as cancer vaccines May 17, 2011
Provided are compositions and methods for treating survivin expressing cancers. The compositions contain peptide survivin peptide mimics with improved MHC-I binding characteristics. The method involves administering a survivin peptide mimic with improved MHC-I binding characteristics to
7897140 Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents March 1, 2011
Novel tetrapyrollic water soluble photosensitizing and imaging compounds and the methods of treating and imaging hyperproliferative tissue, e.g. tumors and hypervacularized tissue such as found in macular degeneration. Broadly, the compounds are tetrapyrollic photosensitizer compounds wh
7887822 Peptides for stimulating an immune response against melanoma February 15, 2011
Provided in the present invention are recombinant peptides and a method for using the peptides in stimulating an immune response against human high molecular weight-melanoma associated antigen (HMW-MAA). The peptides were designed from the identification of regions of structural and amin
7820143 Water soluble tetrapyrollic photosensitizers for photodynamic therapy October 26, 2010
A tetrapyrollic photosensitizer compound having at least one pendant --CH.sub.2CH.sub.2CON(CH.sub.2CON(CH.sub.2COOH).sub.2).sub.2 or --N(CH.sub.2COOH).sub.2 group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimid
7744854 Method for optimizing cancer therapy by monitoring maturation of tumor associated vasculature by June 29, 2010
This invention provides a method for a method for optimizing the regimen for the administration of chemotherapeutic agents. The method comprises administration of a selenium compound to an individual, monitoring the modulation of tumor vessel maturation (TVM) to identify an optimal time
7718356 Heteroduplex tracking assay May 18, 2010
A change in viral tropism occurs in many HIV positive individuals over time and may be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the pre
7709191 Heteroduplex tracking assay May 4, 2010
A change in viral tropism occurs in many HIV positive individuals over time and may be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the pre
7691374 Method for increasing the efficacy of anti-tumor agents by anti-endoglin antibody April 6, 2010
The present invention provides a method for enhancing the efficacy of chemotherapeutic agents for therapy of cancer including tumors and other angiogenesis-associated diseases such as rheumatoid arthritis. The method comprises the steps of administering to an individual in need of tr
7687473 5-amino-4-imidazolecarboxamide riboside and its nucleobase as potentiators of antifolate transpo March 30, 2010
The present invention provides a method for increasing the efficacy of antifolates which act via inhibition of dihydrofolate reductase (DHFR). The method comprises the steps of administration of 5-amino-4-imidazolecarboxamide riboside (Z) or its base with the antifolate such that the
7592421 HLA class II peptide mimics September 22, 2009
The present invention provides peptide mimics for HLA class II antigens. The peptide mimics were identified by panning phage display peptide libraries with anti-HLA class II monoclonal antibodies. The peptide mimics inhibit the binding of an anti-HLA class II antigen antibody to HLA
7585945 Use of recombinant heat shock protein complexed to kidney cancer antigen September 8, 2009
A heat shock protein in combination with carbonic anhydrase IX and a method for improving immune response to carbonic anhydrase IX in a mammal by complexing it with a heat shock protein prior to administration to the mammal.
7585522 Oral immunology using plant product containing a non-enteric pathogen antigen September 8, 2009
A method for obtaining an immune response to a non-enteric pathogen antigen (NEPA) such as hepatitis B surface antigen (HBsAg) by feeding the antigen in a plant material to an animal that is immunoreceptive to the NEPA. It has now been discovered that the animal may be made immunorec
7572466 Oral immunology using plant product containing a non-enteric pathogen antigen August 11, 2009
A method for obtaining an immune response to a non-enteric pathogen antigen (NEPA) such as hepatitis B surface antigen (HBsAg) by feeding the antigen in a plant material to an animal that is immunoreceptive to the NEPA. It has now been discovered that the animal may be made immunorec
7569221 Compositions and methods for identifying agents that alter expression of survivin August 4, 2009
Provided are compositions and methods for identifying agents that can modulate expression of the human survivin gene. The compositions include eukaryotic cells that contain a human survivin promoter sequence operably linked to a reporter gene. The method comprises determining whether a
7534818 Method of reducing alopecia and bladder toxicity of cyclophosphamide May 19, 2009
The present invention discloses a method for reducing alopecia and bladder toxicity associated with the anti-cancer agent cyclophosphamide. The method comprises administering to an individual, in need of such a treatment, cyclophosphamide and a selenium compound. The selenium compoun
7527810 Oral immunology using plant product containing hepatitis surface antigen May 5, 2009
A method for obtaining an immune response to hepatitis B surface antigen (HBsAg) by feeding the antigen in a plant material to an animal that is immunoreceptive to the HBsAg. It has now been discovered that the animal may be made immunoreceptive to HBsAg either by administering the plant
7501509 Water soluble tetrapyrollic photosensitizers for photodynamic therapy March 10, 2009
A tetrapyrollic photosensitizer compound having at least one pendant --CH.sub.2CH.sub.2CON(CH.sub.2CON(CH.sub.2COOH).sub.2).sub.2 or --N(CH.sub.2COOH).sub.2 group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimid
7479370 Detection of 13q14 chromosomal alterations January 20, 2009
The present invention relates to methods for detection of chromosomal alterations which are associated with the presence of various leukemias and lymphomas. The method comprises the steps of obtaining a biological sample comprising lymphocytes from an individual and assaying the sample
7449303 Use of JAG2 expression in diagnosis of plasma cell disorders November 11, 2008
The present invention is based on the finding that plasma cell disorders such as Multiple Myeloma and Monoclonal Gammopathy of Unknown Significance are characterized by an increase in the expression of JAG2. Accordingly, the present invention provides a method for diagnosis of plasma
7427608 Protection against and treatment of hearing loss September 23, 2008
The present invention provides a method for protecting against or treating hearing loss in a subject. This method involves administering an effective amount of a protein tyrosine kinase inhibitor to the subject to protect against or to treat hearing loss.
7425414 Method of prognosis of metastasis by detection of FRA12E fragile site within the SMRT gene/locus September 16, 2008
Provided are methods for prognostic prediction of metastasis. The method comprises identifying the presence or absence of a fragile site FRA12E on chromosome 12q24 at the SMRT gene locus. The presence of FRA12E in an individual can be determined in cell samples obtained from the individu
7384785 Diagnostic test for West Nile virus June 10, 2008
The present invention provides a rapid and sensitive method for the detection of a West Nile virus (WNV), Japanese encephalitis virus (JEV), St. Louis encephalitis virus (SLEV) and Dengue virus (DENV) and antibodies directed against thereof involving contacting a biological specimen
7355033 Screening for West Nile Virus antiviral therapy April 8, 2008
The instant invention provides stable and novel lineage I WNV reverse genetics systems, and methods for making the reverse genetics systems, specifically, a fully-infectious lineage I WNV cDNA or replicon system engineered with one or more nucleotide sequences each encoding a reporter
7351547 Diagnostic test for West Nile virus April 1, 2008
The present invention provides a rapid and sensitive method for the detection of a West Nile virus (WNV), Japanese encephalitis virus (JEV), St. Louis encephalitis virus (SLEV) and Dengue virus (DENV) and antibodies directed against thereof involving contacting a biological specimen
7351530 Prognostic significance of molecular genetic aberrations on chromosome segment 11p15.5 in non-sm April 1, 2008
The present invention provides a method for detection of loss of heterozygosity (LOH) at human chromosome segment 11p15.5 in a tumor sample from a patient with non-small-cell lung cancer (NSCLC), and a method for prognosis of the patient's disease progression. The prognosis is useful
7348153 Method for identifying and designing immunogenic peptides March 25, 2008
The invention provides a method for identifying peptides for use in increasing a cytotoxic T lymphocytes (CTL) response to an antigen. The method comprises the steps of comparing the amino acid sequence of the VH and/or VL portions of an anti-idiotypic monoclonal antibody to the amino
7344830 Heteroduplex tracking assay March 18, 2008
A change in viral tropism occurs in many HIV positive individuals over time and may be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the pre
7323313 Methods for protein interaction determination January 29, 2008
The present invention provides a method for identifying a plurality of pairs of interacting proteins and plasmids for use in the method. The pair of plasmids is adapted for use in a modified two hybrid system wherein wherein each plasmid comprises a recombinase recognition site. The
7306801 Methods of therapy for cancers characterized by overexpression of the HER2 receptor protein December 11, 2007
Methods for treating a subject with a cancer that is characterized by overexpression of HER2 receptor protein using a combination of interleukin-2 (IL-2) or variant thereof and at least one anti-HER2 antibody or fragment thereof are provided. These anti-tumor agents are administered
1 2 3 4

 
 
  Recently Added Patents
Organic light emitting display apparatus
Floor standing rack
Media identification system with fingerprint database balanced according to search loads
Unified feedback frame for supporting a plurality of feedback modes and a multiple-input multiple-output (MIMO) communication system using the unified feedback frame
Event handling in an integrated execution environment
Driving system of display panel having a circuit of a voltage generator and driving method thereof
Lighting fixture
  Randomly Featured Patents
Rocker arm assembly for radial and axial loads
Low insertion force lead socket insert
LED module and LED lighting device
Apparatus, and associated method of phase-offset modulation, for space-time coded wireless communication systems
Digital video recording system
Semiconductor photoelectron emission device
Time-keeping instrument, in particular an analog-type electric wrist watch
Device for dispensing portions of grainy media, in particular pellets
Sanitary napkin package with integral release liner
Cache control unit using a plurality of request stacks