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Gist-Brocades N.V. Patents
Assignee:
Gist-Brocades N.V.
Address:
Delft, NL
No. of patents:
179
Patents:


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Patent Number Title Of Patent Date Issued
RE32597 Apparatus for the anaerobic purification of waste water February 9, 1988
In apparatus for the anaerobic purification of waste water the invention aims at improving the structure and the operation. In known apparatus of this kind there is a reactor tank with one or more aftersettling compartments in the upper part thereof, with inlet and outlet openings for
RE32423 Infectious bronchitis virus strain May 19, 1987
Infectious bronchitis (IB) vaccines for poultry derived from at least one novel virus strain of novel infectious bronchitis serotypes, selected from the group consisting of culture Nos. CNCTC A 07/80, CNCTC A 08/80, CNCTC A 09/80, CNCTC A 010/80, CNCTC A 011/80, CNCTC A 013/80, CNCTC A 0
RE32283 Vaccines November 11, 1986
Infectious bronchitis vaccines for poultry derived from at least a virus strain of a novel serotype of the infectious-bronchitis virus (IBV), identified by the internal indication Gelderland. 901 and Brabant. 802, which have been deposited at the Czechoslovak National Collection of Type
RE31830 Infectious bronchitis vaccine for poultry February 12, 1985
Infectious bronchitis (IB) vaccines for poultry derived from at least one novel virus strain of novel infectious bronchitis serotypes, selected from the group consisting of culture Nos. CNCTC A 07/80, CNCTC A 08/80, CNCTC A 09/80, CNCTC A 010/80, CNCTC A 011/80, CNCTC A 013/80, CNCTC A 0
RE30669 Microbial rennin July 7, 1981
The production of a rennin of high milk coagulating activity and low proteolytic activity from a selected strain of Mucor miehei which is useful in cheese making.
RE30602 Alkaline protease produced by a bacillus May 5, 1981
A novel enzyme having a high proteolytic activity in alkaline media and being suitable for inclusion in washing compositions and which is produced by a novel Bacillus strain designated "PB 92", or its proteolytic enzyme producing mutants or variants. A culture of the Bacillus is deposite
7033627 Production of enzymes in seeds and their use April 25, 2006
A method of catalyzing in vitro reactions using seeds containing enhanced amounts of enzymes is disclosed. The method involves adding transgenic, non-wild type seeds, preferably in a ground form, to a reaction mixture, especially a bakery process and allowing the enzymes in the seeds to
6361808 Process for the production of alcoholic beverages using maltseed March 26, 2002
The invention relates to a process for the production of alcoholic beverages such as beer or whiskey with a mixture of enzymes comprising an endo-.beta.(1,4)-xylanase, an arabinofuranosidase, an alpha-amylase, an endo-protease and a .beta.-(1,3, 1,4)-glucanase, and optionally, a sacc
6106872 Process for obtaining aroma components and aromas from their precursors of a glycosidic nature, August 22, 2000
An enzymatic hydrolysis of a glycosidic substrate containing at least one of the said precursors is performed with at least one enzyme chosen in accordance with the structure of the said precursor, to liberate the corresponding monoglycosides by cleavage at a glycoside bond, and, in a
5939110 Pectinesterase in the treatment of fruit and vegetables August 17, 1999
The present invention discusses the use of pectinesterase to demethoxylate high-methoxylated pectins. The pectinesterase makes possible the preparation of food containing fruit or vegetables in a more efficient way. Specifically, fruit and vegetable jams, jellies, compotes and soups
5935831 Mutated .beta.-lactam acylase genes August 10, 1999
New mutant .beta.-lactam acylases are provided exhibiting altered substrate specificities. These .beta.-lactam acylases are obtained by expression of a gene encoding said .beta.-lactam acylase and having an amino acid sequence which differs at least in one amino acid from the wild-type
5910425 Microbial strains producing sphingolipid bases June 8, 1999
Microbial strains capable of producing enhanced levels of sphingosine, dihydrosphingosine, phytosphingosine and/or derivatives thereof are disclosed. Additionally, there are disclosed methods based on mutagenesis, or other selection techniques, whereby such strains can be produced. As a
5882879 Method for influencing .beta.-lactam antibiotic production and for isolation of large quantities March 16, 1999
Novel methods and compositions are provided for the enhanced production of .beta.-lactam antibiotics. The process is exemplified by the production of penicillin. In addition, the P. chrysogenum and A. chrysogenum .delta.-(L-.alpha.-aminoadipyl)-L-cysteinyl-D-valine synthetase genes have
5849874 Process for the purification of serum albumin December 15, 1998
Recombinantly produced serum albumin is purified in a series of steps, optionally by incubation with an anion-exchange adsorbent, followed by affinity chromatography employing a hydrophobic solid phase and using a water-soluble lipid anion as desorbens in the aqueous phase. This immobile
5830737 Cloning and expression of the exo-polygalacturonase gene from aspergillus November 3, 1998
The exo-polygalacturonase gene from Aspergillus is identified, and the enzyme encoded thereby is expressed. Specifically, the exo-polygalacturonase gene from Aspergillus tubingensis is is cloned and expressed, and DNA sequences from other Aspergillus strains that specifically hybridi
5830735 Method for producing lipolytic enzymes using transformed Pseudomonas November 3, 1998
Novel microbial host strains are provided which are transformed by a vector molecule comprising a DNA fragment encoding a lipolytic enzyme and a marker for selection, capable of producing active lipase. Said DNA fragment is preferably derived from a Pseudomonas species.
5821233 Antifungal composition October 13, 1998
Novel compositions that comprise solvates, salts, or other modified crystalline forms of polyene-type antifungal compounds are provided. Representative of such compositions are formulations that comprise the novel cystalline substances .delta.-natamycin and .gamma.-natamycin. Additio
5792794 Retinoylamide based derivatives of sphingoid bases August 11, 1998
The present invention relates to active derivatives of sphingoid bases. Specifically, the invention relates to retinoylamide based derivatives of sphingoid bases. The present invention describes a method for obtaining these compounds. The invention also relates to the use of these compou
5719047 Gram-negative alkaliphilic microorganisms February 17, 1998
Gram-negative bacteria, which are obligate alkaliphiles, have been isolated from samples of soil, water and sediment and a number of other sources obtained from in and around soda lakes. These bacteria have been analyzed according to the principles of numerical taxonomy with respect to e
5709856 Astaxanthin-producing yeast cells, methods for their preparation and their use January 20, 1998
An isolated pure culture of a strain of Phaffia rhodozyma which produces astaxanthin in an amount of at least 600 .mu.g per g Phaffia rhodozyma dry matter, as determined by HPLC analysis.
5695978 Penicillin G acylase, a gene encoding the same and a method for the production of this enzyme December 9, 1997
The invention provides a gene encoding penicillin G acylase, the enzyme encoded by said gene and a method for the production of said enzyme by incorporating said gene in a host and bringing the same to expression. The gene is preferably obtained from a strain of the microorganism Alcalig
5674707 Production of heterologous proteins in filamentous fungi October 7, 1997
Expression of proteins in filamentous fungal hosts is achieved in the presence of glucose using promoter variants in which creA binding sites are functionally disrupted.
5648261 Strains of Phaffia rhodozyma containing high levels of astaxanthin and low levels of 3-hydroxy-3 July 15, 1997
The present invention provides Phaffia rhodozyma strains having increased levels of astaxantin and a low percentage of 3-hydroxy-3',4'-didehydro-.beta.,.psi.-caroten-4-one (HDCO). Such strains are obtained by a combination of mutagenesis and selection. The invention further provides
5643719 Intersexual heterozygous phycomyces July 1, 1997
The present invention discloses intersexual heterozygous Phycomyces strains. These strains show an improved .beta.-carotene productivity and an increased stability when compared with both the wild type and heterokaryotic Phycomyces strains. The present invention also discloses a meth
5639494 Pectinesterase in the treatment of fruit and vegetables June 17, 1997
A method to prepare a food containing a gel of a low-methoxylated pectin of at least one fruit or vegetable is disclosed. The method comprises adding pectin esterase to the fruit or vegetable or to the pulp thereof in an amount effective to demethoxylate pectin, optionally adding calcium
5610046 Cloning and expression of xylanase B March 11, 1997
Method and expression constructs are provided for the cloning of genes from fungal origin which encode polypeptides having the activity of the Aspergillus tubigensis XYL B enzyme and their overexpression in a selected microbial host cell. The present invention provides for the high level
5599711 Astaxanthin-producing yeast cells, methods for their preparation and their use February 4, 1997
An isolated pure culture of a strain of Phaffia rhodozyma which produces astaxanthin in an amount of at least 600 .mu.g per g Phaffia rhodozyma dry matter, as determined by HPLC analysis.
5571716 Gram-negative alkaliphilic microorganisms November 5, 1996
Gram-negative bacteria, which are obligate alkaliphiles, have been isolated from samples of soil, water and sediment and a number of other sources obtained from in and around soda lakes. These bacteria have been analyzed according to the principles of numerical taxonomy with respect to e
5547690 Compositions and method for improving flour dough August 20, 1996
A method for improving the rheological properties of a flour dough through the use of an enzyme preparation which contains sulfhydryl oxidase and glucose oxidase.
5538876 Stabilization of carboxyl esterase July 23, 1996
Carboxyl esterase is inactivated by several chemical compounds such as naproxen or diclofop. By substituting or modifying certain basic residues of the carboxyl esterase, this enzyme shows improved stability properties during application. In this way it is possible to perform stereospeci
5538876 Stabilization of carboxyl esterase July 23, 1996
Carboxyl esterase is inactivated by several chemical compounds such as naproxen or diclofop. By substituting or modifying certain basic residues of the carboxyl esterase, this enzyme shows improved stability properties during application. In this way it is possible to perform stereospeci
5516512 N- and C-terminal truncation and deletion mutants of human interleukin-3 May 14, 1996
Biologically active deletion and substitution mutants of hIL-3 are provided. Preferred mutants are those having one or more deletions at the N-terminus (amino acids 1-14) and/or the C-terminus (amino acids 116-133, 120-130 and/or 130-133). Preferred substitution mutants include Cys.sup.1
5514575 Gram-negative alkaliphilic microorganisms May 7, 1996
Gram-negative bacteria, which are obligate alkaliphiles, have been isolated from samples of soil, water and sediment and a number of other sources obtained from in and around soda lakes. These bacteria have been analyzed according to the principles of numerical taxonomy with respect to e
5462862 Method and compositions for enhancing production of secondary metabolites using clustered biosyn October 31, 1995
Clustered antibiotic biosynthetic genes are employed for improvement of production of the antibiotic in microorganisms and for the isolation of other genes involved in the biosynthesis of the antibiotic. The invention is exemplified with improved production of penicillin in Penicillium
5459062 Gram-negative alkaliphilic microorganisms October 17, 1995
Gram-negative bacteria, which are obligate alkaliphiles, have been isolated from samples of soil, water and sediment and a number of other sources obtained from in and around soda lakes. These bacteria have been analyzed according to the principles of numerical taxonomy with respect to e
5457032 Mutated .beta.-lactam acylase genes October 10, 1995
New mutant .beta.-lactam acylases are provided exhibiting altered substrate specificities. These .beta.-lactam acylases are obtained by expression of a gene encoding said .beta.-lactam acylase and having an amino acid sequence which differs at least in one amino acid from the wild-type
5436156 Cloning and expression of phytase from aspergillus July 25, 1995
A nucleotide sequence encoding phytase has been isolated and cloned. The coding sequence has been inserted into an expression construct which in turn has been inserted into a vector capable of transforming a microbial expression host. The transformed microbial hosts may be used to ec
5426043 Cloning and expression of acetyl xylan esterases from fungal origin June 20, 1995
Methods and DNA constructs are provided for the expression of a fungal acetyl xylan esterase gene in microbial hosts. A purified fungal acetyl xylan esterase is obtained which is suited for the use as an accessory enzyme in the degradation of acetylated xylans.
5401657 Gram-positive alkaliphilic microorganisms March 28, 1995
The present invention provides novel aerobic, Gram-positive alkaliphilic bacteria which have been isolated from in and around alkaline soda lakes. These alkaliphiles have been analyzed according to the principles of numerical taxonomy with respect to each other and also to a collection o
5384257 Glucose isomerases with an altered pH optimum January 24, 1995
A method for selecting amino acid residues is disclosed which upon replacement will give rise to an enzyme with an altered pH optimum. The method is specific for metalloenzymes which are inactivated at low pH due to the dissociation of the metal ions. The method is based on altering the
5376536 Glucose isomerase enzymes and their use December 27, 1994
New mutant glucose isomerases are provided exhibiting improved properties under application conditions. These glucose isomerases are obtained by expression of a gene encoding said enzyme, having an amino acid sequence which differs at least in one amino acid from the wildtype glucose
5364782 Mutant microbial .alpha.-amylases with increased thermal, acid and/or alkaline stability November 15, 1994
Thermostable and acid stable .alpha.-amylases are provided as expression products of genetically engineered .alpha.-amylase genes isolated from microorganisms, preferably belonging to the class of Bacilli. Both chemical and enzymatic mutagenesis methods are e.g. the bisulphite method
5358864 Cloning and expression of xylanase genes from fungal origin October 25, 1994
Methods and expression constructs are provided for the cloning and overexpression of xylanases of fungai origin in a selected microbial host cell. Xylanases of fungal origin generally have lower pH optima and remain stable over a broader pH range than do xylanases of bacterial origin. Th
5352809 9-alpha-hydroxy steroids, process for their preparation, process for the preparation of the corr October 4, 1994
New 9-alphahydroxy steroids are prepared by the introduction of substituents on the D-ring of 9-alpha-hydroxy-androst-4-ene-3,17-dione. The resulting compounds are useful intermediates in the synthesis of corticosteroids.
5340738 Modified prokaryotic glucose isomerase enzymes with altered pH activity profiles August 23, 1994
A method for selecting amino acid residues is disclosed which upon replacement will give rise to an enzyme with an altered pH optimum. The method is specific for metalloenzymes which are inactivated at low pH due to the dissociation of the metal ions. The method is based on altering the
5336611 PB92 serine protease muteins and their use in detergents August 9, 1994
New proteolytic enzymes are provided exhibiting improved properties for application in detergents, especially laundry detergents. These enzymes are obtained by expression of a gene encoding a proteolytic enzyme having an amino acid sequence which differs at least in one amino acid from t
5324653 Recombinant genetic means for the production of serine protease muteins June 28, 1994
New proteolytic enzymes are provided exhibiting improved properties for application in detergents, especially laundry detergents. These enzymes are obtained by expression of a gene encoding a proteolytic enzyme having an amino acid sequence which differs at least in one amino acid from t
5312909 Recombinant DNA encoding neutral trehalase May 17, 1994
A transformed yeast is disclosed, comprising at least one gene encoding neutral trehalase or trehalose-6-phosphate synthase which gene has been modified such that it differs from a corresponding wild-type gene encoding neutral trehalase or trehalose-6-phosphate synthase, the yeast having
5310665 Glucose isomerases having altered substrate specificity May 10, 1994
A method for selecting amino acid residues is disclosed which upon replacement will give rise to an enzyme with an altered substrate specificity. New mutant glucose isomerases with an altered substrate specificity are provided according to this method. These altered properties are us
5304637 Expression and purification of human interleukin-3 and muteins thereof April 19, 1994
Methods are provided for improved production of hIL-3 either in glycosylated form from mammalian and yeast cells or in unglycosylated form from prokaryotes. Recombinantly produced human IL-3 is purified in a series of steps, initially employing hydrophobic interaction, followed by io
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