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Genetronics, Inc. Patents
Assignee:
Genetronics, Inc.
Address:
San Diego, CA
No. of patents:
60
Patents:


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Patent Number Title Of Patent Date Issued
7960536 Synthetic cell-or tissue-specific transcriptional regulatory regions June 14, 2011
The invention concerns making and evaluating synthetic regulatory regions for controlling gene expression. The invention features a method for identifying transcription factor binding sites and a method for evaluating the regulatory functions of synthetic regulatory regions.
7922709 Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation April 12, 2011
In vivo methods are provided for using an electric field to delivery therapeutic or immunizing treatment to a subject by applying non-invasive, user-friendly electrodes to the surface of the skin. Thus, therapeutic or immunizing agents can be delivered into cells of skin for local an
7579326 Gene switch systems employing regulators with decreased dimerization August 25, 2009
Disclosed is a novel inducible expression system characterized by undetectable biological effect in the absence of an inducer, but which exhibits efficient inducibility in the presence of an inducer.
7570992 Electrical field therapy with reduced histopathological change in muscle August 4, 2009
In vivo methods are provided for using an electric field to delivery therapeutic treatment to a subject while reducing inducement of histopathological change in the target muscle tissue, such as is associated with induction or amplification of an immune response caused by the pulsed
7412284 Apparatus for electroporation mediated delivery for drugs and genes August 12, 2008
A device for in vivo electroporation therapy comprising an electrode applicator with at least two pairs of electrodes arranged relative to one another to form an array and a power supply. The device is used to generate an electric field in a biological sample and effect introduction
7395110 Electrode apparatus and method for the delivery of drugs and genes into tissue July 1, 2008
An electrode assembly for an apparatus for trans-surface molecular includes a non-conductive carrier having a proximal surface, a distal surface, and a plurality of through holes from the proximal surface to the distal surface, a plurality of first electrodes disposed on the proximal
7181271 Synergism of photodynamic and electropermeation effect on cell vitality as a novel cytotoxic age February 20, 2007
The present invention is based on the discovery that electroporation of a photosensitive agent in a cell and subsequent activation of the agent provides more effective killing of the electroporated cell than cells exposed to a photosensitive agent alone. The invention provides a method
7171264 Intradermal delivery of active agents by needle-free injection and electroporation January 30, 2007
Methods are proved for introducing a biologically active agent into cells of a subject by introducing the agent in a form suitable for electrotransport into a region of tissue of the subject using one or more needle-free injectors, and applying a pulsed electric field to the region o
7054685 Method and apparatus for reducing electroporation-mediated muscle reaction and pain response May 30, 2006
A method for delivery of an agent to a cell using electroporation is disclosed. The method includes positioning a first electrode and a second electrode such that an electrical signal passed between the first electrode and the second electrode passes through the cell. The method also
6972013 Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation December 6, 2005
In vivo methods are provided for using an electric field to delivery therapeutic or immunizing treatment to a subject by applying non-invasive, user-friendly electrodes to the surface of the skin. Thus, therapeutic or immunizing agents can be delivered into cells of skin for local and
6958060 Method for muscle delivery of drugs, nucleic acids and other compounds October 25, 2005
A method is disclosed for delivering molecules such as pharmaceutical drugs and nucleic acids into skeletal muscle in vivo. The molecule is first injected into the muscle at one or multiple sites. Immediately or shortly after injection, electrodes are placed flanking the injection site a
6947791 Method and apparatus for electrically assisted topical delivery of agents for cosmetic applicati September 20, 2005
The present invention is based on the development of a method for cosmetic delivery of L-ascorbic acid-containing compositions to the layer of the skin wherein collagen formation takes place to enhance production of collagen and thereby combat some of the effects of aging and oxy-radical
6865416 Electrically induced vessel vasodilation March 8, 2005
The invention provides methods for inducing or increasing the vasodilation of a vessel. The invention further provides methods for inducing or increasing the flow of fluid through a vessel. An electrical impulse is applied to the vessel in order to induce or increase vessel vasodilation
6800484 High efficiency transfection based on low electric field strength, long pulse length October 5, 2004
A method is provided for introducing nucleic acid into a cell, by contacting the cell with a nucleic acid and applying a low electrical field impulse for a long pulse length. A method is provided for introducing a polypeptide into a cell, by contacting the cell with the polypeptide a
6763264 Method of treatment using electroporation mediated delivery of drugs and genes July 13, 2004
A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.
6748265 Electrode apparatus and method for the delivery of drugs and genes into tissue June 8, 2004
An electrode assembly for an apparatus for trans-surface molecular includes a non-conductive carrier having a proximal surface, a distal surface, and a plurality of through holes from the proximal surface to the distal surface, a plurality of first electrodes disposed on the proximal sur
6746441 Flow-through electroporation system for ex vivo gene therapy June 8, 2004
A method and apparatus for introducing a preselected molecule into a living cell by contacting the cell with the preselected molecule and applying a multiple series of electrical pulses to the cell. The method can be utilized ex vivo. The multiple electrical pulses generate rotating
6678558 Method and apparatus for reducing electroporation-mediated muscle reaction and pain response January 13, 2004
A method for delivery of an agent to a cell using electroporation is disclosed. The method includes positioning a first electrode and a second electrode such that an electrical signal passed between the first electrode and the second electrode passes through the cell. The method also
6678556 Electrical field therapy with reduced histopathological change in muscle January 13, 2004
In vivo methods are provided for using an electric field to delivery therapeutic treatment to a subject while reducing inducement of histopathological change in the target muscle tissue, such as is associated with induction or amplification of an immune response caused by the pulsed
6654636 Skin and muscle-targeted gene therapy by pulsed electrical field November 25, 2003
The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic
6569149 Method of treatment using electroporation mediated delivery of drugs and genes May 27, 2003
A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.
6567694 Needle electrodes for mediated delivery of drugs and genes May 20, 2003
A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.
6520950 Method of electroporation-enhanced delivery of active agents February 18, 2003
Methods are provided for introducing a biologically active agent into cells of a subject by injecting the agent with a needle-free injector and applying a pulsed electric field to the region of tissue to cause electrotransport of the agent into cells of the tissue. Preferably the age
6516223 Apparatus for electroporation mediated delivery for drugs and genes February 4, 2003
A device for in vivo electroporation therapy comprising an electrode applicator with at least two pairs of electrodes arranged relative to one another to form an array and a power supply. The device is used to generate an electric field in a biological sample and effect introduction
6451002 Method of treatment using electroporation mediated delivery of drugs and genes September 17, 2002
A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.
6418341 Needle electrode assembly for electroporation mediated delivery of genes and drugs July 9, 2002
A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.
6347247 Electrically induced vessel vasodilation February 12, 2002
The invention provides methods for inducing or increasing the vasodilation of a vessel. The invention further provides methods for inducing or increasing the flow of fluid through a vessel. An electrical impulse is applied to the vessel in order to induce or increase vessel vasodilation
6302874 Method and apparatus for electrically assisted topical delivery of agents for cosmetic applicati October 16, 2001
The present invention is based on the development of a method for cosmetic delivery of L-ascorbic acid-containing compositions to the layer of the skin wherein collagen formation takes place to enhance production of collagen and thereby combat some of the effects of aging and oxy-radical
6266560 Electrically assisted transdermal method and apparatus for the treatment of erectile dysfunction July 24, 2001
A non-invasive method is provided for treating erectile dysfunction using electroporation enhanced with delivery of a vasoactive or androgenic composition applied to the penis which affords an alternative treatment for patients afflicted with erectile dysfunction (ED). Sufficient electri
6241701 Apparatus for electroporation mediated delivery of drugs and genes June 5, 2001
A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In
6233482 Method of electroporation mediated delivery of drugs and genes May 15, 2001
A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In
6216034 Method of programming an array of needle electrodes for electroporation therapy of tissue April 10, 2001
A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In
6208893 Electroporation apparatus with connective electrode template March 27, 2001
An electrode template apparatus, includes a three dimensional support member having opposite surfaces, a plurality of bores extending through the support member and through the opposite surfaces, a plurality of conductors on the member separately connected to the plurality of bores, a
6192270 Apparatus and method for the delivery of drugs and genes into tissue February 20, 2001
An electrode assembly for an apparatus for and a method of trans-surface molecular delivery, including a non-conductive carrier having a proximal surface, a distal surface, and a plurality of through holes from the proximal surface to the distal surface, a first electrode disposed on at
6181964 Minimally invasive apparatus and method to electroporate drugs and genes into tissue January 30, 2001
A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In
6150148 Electroporation apparatus for control of temperature during the process November 21, 2000
An electroporation method and apparatus generating and applying an electric field according to a user-specified pulsing and temperature profile scheme. The apparatus includes a cuvette holder with a Peltier device forming part of the electrode structures that form part of the holder.
6132419 Electroporetic gene and drug therapy October 17, 2000
A method and apparatus are provided for introducing molecules such as genes and pharmaceutical compounds into living blood cells of a patient for therapeutic purposes. A device is placed into contact with the body of the patient for generating an electric field at a preselected location
6120493 Method for the introduction of therapeutic agents utilizing an electroporation apparatus September 19, 2000
A method is provided for the introduction of an agent to a neoplastic cell for electroporating the cell, including contacting the cell with an electrode template apparatus. The electrode template apparatus is utilized to apply an electric field to the cell in order to introduce the agent
6096020 Electroporation employing user-configured pulsing scheme August 1, 2000
An electroporation method and apparatus generating and applying an electric field according to a user-specified pulsing scheme. Advantageously, one such pulse includes a low voltage pulse of a first duration, immediately followed by a high voltage of a second duration, immediately follow
6055453 Apparatus for addressing needle array electrodes for electroporation therapy April 25, 2000
A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In
6027488 Flow-through electroporation system for ex vivo gene therapy February 22, 2000
A method and apparatus for introducing a preselected molecule into a living cell by contacting the cell with the preselected molecule and applying a multiple series of electrical pulses to the cell. The method can be utilized ex vivo. The multiple electrical pulses generate rotating
6014584 Electroporation therapy apparatus January 11, 2000
A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In
6009347 Electroporation apparatus with connective electrode template December 28, 1999
An electrode template apparatus, comprises a three dimensional support member having opposite surfaces, a plurality of bores extending through the support member and through the opposite surfaces, a plurality of conductors on the member separately connected to the plurality of bores, a
6009345 Method and apparatus for a combination of electroporation and iontophoresis for the delivery of December 28, 1999
An apparatus for transdermal molecular delivery, comprises a first electrode assembly having an anode and a cathode in closely spaced relation for engaging the stratum corneum through which to apply an electric field, first power supply including a first circuit connected to the firs
5993434 Method of treatment using electroporation mediated delivery of drugs and genes November 30, 1999
A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.
5968006 Method and apparatus for a combination of electroporation and iontophoresis for the delivery of October 19, 1999
An apparatus and method for transdermal molecular delivery, comprises a first electrode assembly having an anode and a cathode in closely spaced relation for engaging the stratum corneum through which to apply an electric field, a second electrode assembly spaced from the first elect
5944710 Electroporation-mediated intravascular delivery August 31, 1999
A method for sustained intravascular delivery via electroporation is provided. The method is useful for delivery of therapeutic compositions such as antithrombotic and anticoagulant agents. The invention also provides a catheter apparatus for introducing a composition into at least o
5869326 Electroporation employing user-configured pulsing scheme February 9, 1999
An electroporation method and apparatus generating and applying an electric field according to a user-specified pulsing scheme. Advantageously, one such pulse includes a low voltage pulse of a first duration, immediately followed by a high voltage of a second duration, immediately follow
5859327 Electroporation-mediated molecular transfer in intact plants January 12, 1999
A method for producing a genetically modified plant by introducing a polynucleotide to an intact plant or plant cell(s) via electroporation, in the absence of cell wall-degrading enzymes. Genetically engineered plants produced by the method of the invention are also provided. The inventi
5810762 Electroporation system with voltage control feedback for clinical applications September 22, 1998
An electrode apparatus for the application of electroporation to a portion of the body of a patient, comprising a support member, a pair of electrodes adjustably mounted on the support member for movement toward and away from one another for positioning on opposite sides of a body po
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