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Genetic Systems Corporation Patents
Assignee:
Genetic Systems Corporation
Address:
Seattle, WA
No. of patents:
31
Patents:












Patent Number Title Of Patent Date Issued
6322964 Synthetic HIV-2 gag and env oligopeptides reactive with HIV-2 specific antibodies November 27, 2001
Peptide sequences are disclosed which immunologically mimic proteins encoded by the env and gag regions of LAV-2, a retrovirus associated with AIDS. The peptide can be used in various specific binding assays to detect the presence of antibodies to LAV-2 in individuals previously exposed
6130314 Synthetic antigen for the detection of AIDS-related disease October 10, 2000
Novel peptides are provided having substantially the same sequence as immunologically significant fragments of AIDS-related viruses. The polypeptides can be used as reagents in the determination of exposure of a human host to the virus. Of particular interest is the use of polypeptides
5716829 Diagnostic test for Pseudomonas aeruginosa infections February 10, 1998
Methods and reagents are provided for a novel immunodiagnostic test for the presence of P. aeruginosa in a biological sample. Monoclonal antibodies are employed which bind to an outer membrane protein antigen, which may be exposed by a solubilizing reagent. The antibody binds substantial
5514542 Methods for propagating retrovirus for use in antibody assays May 7, 1996
Cell lines which lack human class II histocompatibility antigens are disclosed. The cell lines may be utilized within a method for propagating microorganisms, such as viruses, for determining the presence and/or amount of antibody to a microorganism in a biological fluid, and within a
5459043 Hybridoma CT43 producing a monoclonal antibody to a novel mucin epitope which correlates with th October 17, 1995
The present invention relates to a novel monoclonal antibody reactive with human colorectal mucin antigen. More particularly, the antibody of the invention is a murine monoclonal antibody, CT43, reactive with a novel antigenic determinant on much antigen highly correlated with human
5439792 Cysteine thiol-protected peptides for use in immunoassays August 8, 1995
Peptides immunoreactive with antibodies to native proteins, and which have at least two cysteine residues that contribute to mimicking an epitope of the protein, are prepared with the cysteine thiol groups protected. When deprotected, the peptides have enhanced immunoreactivity. The pept
5369010 Monoclonal antibody to polymorphic HLA determinant -B27 November 29, 1994
Novel cell lines, receptors and monoclonal antibodies prepared therefrom that are specific for the human HLA-B27 antigen are provided. The monoclonal antibodies are useful in diagnosis and therapy, particularly with respect to certain rheumatoid disorders.
5206178 Membrane affinity concentration immunoassay April 27, 1993
Methods for determining the presence and/or concentration of an analyte in a biological fluid sample are disclosed. The methods generally include admixing in solution certain polymer/reactant and reporter/reactant conjugates along with the biological fluid sample suspected of containing
5206136 Rapid membrane affinity concentration assays April 27, 1993
Rapid assays for analytes of interest in a fluid sample utilize a first conjugate of a labelled reactant that specifically binds to the analyte, and a second conjugate that binds to the analyte coupled to a polymer that has an affinity for a selected solid phase. The reaction components
5196308 Methods for identifying the DQw3.2 allele associated with increased risk of insulin-dependent di March 23, 1993
Methods for identifying individuals at increased risk of diabetes are disclosed. The methods disclosed utilize the discovery of the DQw3.2 variant, which identifies a specific allelic polymorphism at a sinle gene locus. One preferred method utilizes a labeled probe to detect the DQw3.2
5175098 Expression and diagnostic use of gag encoded peptides which are immunologically reactive with an December 29, 1992
Immunologically reactive gag proteins of LAV are expresesed in bacterial cells. The gag proteins are encoded by a recombinant plasmid containing procaryotic transcriptional and translational signals for expression, followed downstream by a DNA sequence comprising a portion of the gag
5175097 Expression and diagnostic use of GAG-1 encoded peptides which are immunologically reactive with December 29, 1992
Immunologically reactive gag proteins of LAV/HTLV-III are expressed in bacterial cells. The gag proteins are encoded by a recombinant plasmid containing procaryotic transcriptional and translational signals for expression, followed downstream by a DNA sequence comprising pGAG-1. Pref
5104790 Monoclonal antibodies to specific antigenic regions of the human immunodeficiency virus and meth April 14, 1992
Monoclonal antibodies capable of binding antigenic determinants within regions of the core proteins of the Human Immunodeficiency Virus and immortalized cell lines producing those monoclonal antibodies are provided. The monoclonal antibodies find use in a variety of ways, including H
5087557 Human monoclonal antibody to lymphadenopathy-associated virus February 11, 1992
Human monoclonal antibodies capable of specifically reacting with an antigenic determinant of LAV/HTLV-III and cell lines producing those monoclonal antibodies are disclosed. The human monoclonal antibodies may be utilized in a method for determining the presence of LAV/HTLV-III in b
5075211 Synthetic antigen for the detection of AIDS-related disease December 24, 1991
Novel peptides are provided having substantially the same sequence as immunologically significant fragments of AIDS-related viruses. The polypeptides can be used as reagents in the determination of exposure of a human host to the virus. Of particular interest is the use of polypeptides
5068178 Method of enhancing direct immunofluorescence staining of cells November 26, 1991
A method of identifying and enumerating specific cell types in a heterogeneous population of cells by enhancing the specific staining of desired cells, comprising contacting a sample from the heterogeneous population of cells with a labeled primary antibody which recognizes and binds
5002889 Reaction well shape for a microwell tray March 26, 1991
A microwell for enzyme-linked immunosorbent assays has a concavely curved, circumferential sidewall, a flat optical bottom and a top lip, including smooth transitions between the top lip, concave sidewall and flat bottom. This shape minimizes the tendency of fluid to cling to the well fo
4970070 Protective monoclonal antibody compositions for infections due to group B streptococcus November 13, 1990
Immortalized cell lines have been produced that secrete human monoclonal antibodies capable of binding to bacterial species which are a major cause of neonatal sepsis and meningitis. These antibodies have been found to be protective against lethal challenges of these bacteria, which incl
4851333 Method and composition for the detection and diagnosis of Legionella pneumophila July 25, 1989
Method and compositions including monoclonal antibodies to a serogroup-common antigen are provided for the detection and diagnosis of Legionella pneumophila. The monoclonal antibodies recognize a proteinaceous antigen of molecular weight 28,000-29,000 Daltons which is detected in at
4843010 Polymerization-induced separation immunoassays June 27, 1989
Immunoassay methods and compositions are disclosed for the detection of analytes in fluid samples. The disclosure provides conjugates of analytes or reactants with polymerizable organic monomers. Specific binding reactions between reactants are detected by means of resporter/reactant
4834976 Monoclonal antibodies to pseudomonas aeruginosa flagella May 30, 1989
Cell lines have been produced that secrete monoclonal antibodies capable of binding to the flagellar proteins of selected Pseudomonas aeruginosa strains. Some of these antibodies have been found to be protective against lethal challenges of P. aeruginosa. Pharmaceutical compositions cont
4784941 Expression and diagnostic use of pENV-3 encoded peptides which are immunologically reactive with November 15, 1988
A method of expressing peptides which are immunologically reactive with antibodies to LAV is disclosed. The peptides are produced by bacterial host cells transformed with a recombinant plasmid which includes appropriate procaryotic transcriptional and translational signals for expres
4780409 Thermally induced phase separation immunoassay October 25, 1988
An immunoassay in which a thermally induced phase separation is used to effect the separation of specifically bound reactants from free reactants is disclosed. A first reactant is conjugated to a temperature-sensitive polymer to form a polymer/reactant conjugate, and a second reactant is
4752638 Synthesis and use of polymers containing integral binding-pair members June 21, 1988
Conjugate monomers, polymers, and methods for the de novo synthesis of the polymers are provided. Conjugate organic monomers contain binding-pair members which upon polymerization become integrally associated with the resultant polymer. Specifically, antigens, antibodies, receptors, and
4749647 Polymerization-induced separation assay using recognition pairs June 7, 1988
Methods and compounds are disclosed for determining the presence, amount of, or association between substances of interest in samples suspected of containing same. The methods are based on the polymerization-induced separation of specifically-bound, reporter-labeled recognition reactants
4711840 Polymerization-induced separation immunoassays December 8, 1987
Immunoassay methods and compositions are disclosed for the detection of one or more analytes in fluid samples. The disclosure provides conjugates of analytes or reactants with polymerizable organic monomers. Specific binding reactions between reactants are detected by means of report
4677061 T-cell lymphocyte subset monitoring of immunologic disease June 30, 1987
Methods and compositions are provided for determining a change in status of a multiple sclerosis victim. Particularly, the ratio of helper or suppressor T cell subsets having specific surface markers associated with proliferation is determined, where a particular ratio value is associate
4629783 Synthetic antigen for the detection of AIDS-related disease December 16, 1986
Novel peptides are provided having substantially the same sequence as immunologically significant fragments of AIDS-related viruses. The polypeptides can be used as reagents in the determination of exposure of a human host to the virus. Of particular interest is the use of polypeptides
4609707 Synthesis of polymers containing integral antibodies September 2, 1986
A method is disclosed for the de novo synthesis of antibody-containing polymers and the preparation of a class of polymerizable compounds used in the synthesis of such antibody-containing polymers. Antibody-containing polymers formed from monomer/antibody conjugates and nonderivatized
4511478 Polymerizable compounds and methods for preparing synthetic polymers that integrally contain pol April 16, 1985
A method is disclosed for the de novo synthesis of polypeptide-containing polymers. This disclosure also includes a description of, and a method for the preparation of, a class of polymerizable compounds used in the synthesis of polypeptide-containing polymers. These polymerizable co
4464465 Cell-driven viral transfer in eukaryotes August 7, 1984
Novel method, cells and compositions are provided involving transforming B-lymphocytes to provide immortalization for continuous production of monoclonal antibodies to a predetermined ligand. T-cell free B-lymphocytes are combined with an Epstein-Barr virus transformed cell sensitive to

 
 
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