| Patent Number |
Title Of Patent |
Date Issued |
| H2181 |
Human tPA production using vectors coding for DHFR protein |
February 6, 2007 |
| A method for producing tissue plasminogen activator (t-PA) in eukaryotic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild-type DHFR with methotrexate. |
| D315107 |
Height measuring device |
March 5, 1991 |
|
| 7619062 |
PRO214 polypeptides |
November 17, 2009 |
| The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those peptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention |
| 7618631 |
Treatment with anti-ErbB2 antibodies and EGFR-targeted drugs |
November 17, 2009 |
| The present application describes methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies, and EGFR-targeted drugs. |
| 7615529 |
Methods and compositions for modulating hyperstabilized c-met |
November 10, 2009 |
| The invention provides methods and compositions for modulating the HGF/c-met signaling pathway, in particular by inhibiting a hyperstabilized c-met protein. |
| 7615383 |
Methods for treating neuropathy by agonist anti-trk-C monoclonal antibodies |
November 10, 2009 |
| The invention concerns agonist anti-trkC monoclonal antibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such antibodies in the prevention and/or treatment of cellular degeneration, including nerve cell damage |
| 7608681 |
Methods and compositions for prolonging elimination half-times of bioactive compounds |
October 27, 2009 |
| Peptide ligands having affinity for IgG or for serum albumin are disclosed. Also disclosed are hybrid molecules comprising a peptide ligand domain and an active domain. The active domain may comprise any molecule having utility as a therapeutic or diagnostic agent. The hybrid molecul |
| 7608429 |
Methods and compositions for increasing antibody production |
October 27, 2009 |
| The invention provides methods and compositions for improved expression and production of recombinant antibodies in host cell expression systems. In particular, prokaryotic expression and production of antibodies with modified hinge cysteine residues are provided. The invention further |
| 7605229 |
PRO87299 polypeptides |
October 20, 2009 |
| The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related diseases. |
| 7601827 |
Polynucleotides encoding polypeptides that bind to the P185.sup.HER2 receptor |
October 13, 2009 |
| Novel 2 polypeptides with binding affinity for the p185.sup.HER2 receptor, designated heregulin 2-.alpha. and heregulin 2-.beta., have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-.alpha. has been isolated from human tissue and sequenced. Pr |
| 7601514 |
Nucleic acid encoding PRO10268 polypeptides |
October 13, 2009 |
| The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases. |
| 7601335 |
Pretreatment of a biological sample from an autoimmune disease subject |
October 13, 2009 |
| The present application describes a method for pretreating a biological sample from an autoimmune disease subject in order to avoid interference, especially where the sample is to be subjected to a cell-based biological activity assay, such as a neutralizing antibody assay. |
| 7596455 |
Crystallization of IGF-1 |
September 29, 2009 |
| Crystalline IGF-1 is provided along with a method for production thereof. Crystallizing IGF-1 comprises the steps of mixing an aqueous solution comprising IGF-1 with a reservoir solution comprising a precipitant to form a mixture; and crystallizing the mixture, optionally also recrys |
| 7595399 |
Tyrosine derivatives |
September 29, 2009 |
| The compounds of the invention are inhibitors of alpha4 containing integrin-mediated binding to ligands such as VCAM-1 and MAdCAM. |
| 7595046 |
Treatment of cancer using anti-Apo-2 antibodies |
September 29, 2009 |
| Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided. |
| 7592439 |
Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method |
September 22, 2009 |
| A method of making monoclonal antibodies according to a mixed antigen immunization protocol is described. In addition, antibodies obtainable by the method are disclosed which specifically cross-react with two or more different receptors to which Apo-2 ligand (Apo-2L) can bind. |
| 7589172 |
PRO256 polypeptides |
September 15, 2009 |
| The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invent |
| 7585953 |
Antibodies specific for TAT285-1 |
September 8, 2009 |
| The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. |
| 7585673 |
.gamma.-heregulin |
September 8, 2009 |
| A novel member of the heregulin superfamily has been identified which is designated ".gamma.-HRG". This molecule, secreted by human breast cancer MDA-MB-175 cells, leads to the formation of a constitutive active receptor complex and stimulates the growth of these cells in an autocrine |
| 7582445 |
Anti-interferon-.alpha. antibodies |
September 1, 2009 |
| Compositions of matter encoding or useful for expressing anti-interferon alpha antibodies are provided. Methods of using such compositions of matter for producing anti-interferon alpha antibodies are also provided. |
| 7582311 |
Injection vehicle for polymer-based formulations |
September 1, 2009 |
| The invention provides injection vehicles suitable for administering particulate suspensions, such as polymer-based formulations, as well as associated pharmaceutical formulations, articles of manufacture, and kits. Other aspects of the invention included methods for producing and ad |
| 7582293 |
Anti-PRO6308 antibodies |
September 1, 2009 |
| The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invent |
| 7579161 |
Assay methods for suppressor of fused modulation of hedgehog signaling |
August 25, 2009 |
| The present invention is directed to novel polypeptides having homology to a polypeptide suppressor of the Drosophila melanogaster fused protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid se |
| 7576187 |
Family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use |
August 18, 2009 |
| An isolated polynucleotide at least 60% homologous to SEQ ID NO: 1, 3, 5 or 18 encoding a SARP polypeptide; vectors comprising a polynucleotide sequence encoding at least 11 consecutive amino acids of .alpha.SARP polypeptide; a host cell transformed with an isolated polynucleotide or |
| 7576185 |
PRO34128 antibodies |
August 18, 2009 |
| The present invention is directed to novel polypeptides having sequence similarity to GDNFR and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising th |
| 7576182 |
Compositions and methods for the treatment of immune related diseases |
August 18, 2009 |
| The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases. |
| 7575893 |
Methods for producing humanized antibodies and improving yield of antibodies or antigen binding |
August 18, 2009 |
| The present invention provides methods for producing humanized antibodies and increasing the yield of antibodies and/or antigen binding fragments when produced in cell culture. In one aspect of the invention, at least one framework region amino acid residue of the variable domain is |
| 7575879 |
Polypeptides homologous to VEGF and BMP1 |
August 18, 2009 |
| The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation |
| 7575748 |
Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
August 18, 2009 |
| The application concerns methods of treatment using anti-ErbB receptor antibody-maytansinoid conjugates, and articles of manufacture suitable for use in such methods. In particular, the invention concerns ErbB receptor-directed cancer therapies, using anti-ErbB receptor antibody-mayt |
| 7572447 |
Methods and compositions for selective modulation of vascularization |
August 11, 2009 |
| The invention provides methods and compositions for modulating vascularization and angiogenesis, including selective modulation of stages of multi-step vascularization and angiogenesis. |
| 7566774 |
PRO4977 polypeptides |
July 28, 2009 |
| The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invent |
| 7566536 |
WNT-regulated cytokine-like polypeptide and nucleic acids encoding same |
July 28, 2009 |
| The present invention provides novel polypeptides, termed FCTRX polypeptides, as well as polynucleotides encoding FCTRX polypeptides and antibodies that immunospecifically bind to an FCTRX or a derivative, variant, mutant, or fragment of an FCTRX polypeptide, polynucleotide or antibo |
| 7563867 |
PRO4356 polypeptides |
July 21, 2009 |
| The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invent |
| 7563583 |
Heregulin variants |
July 21, 2009 |
| The present invention provides heregulin variants that are capable of binding an ErbB receptor. Included in the invention are variants of human heregulins, and, in particular, variants of human heregulin-.beta.1 having enhanced affinity for the ErbB-3 and ErbB-4 receptors. These vari |
| 7560111 |
HER2 antibody composition |
July 14, 2009 |
| A composition comprising a main species HER2 antibody that binds to domain II of HER2, and an amino acid sequence variant thereof comprising an amino-terminal leader extension is disclosed. Pharmaceutical formulations comprising the composition, and therapeutic uses for the composition a |
| 7557192 |
Anti-PRO335 antibodies |
July 7, 2009 |
| The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invent |
| 7547768 |
Anti-TAT 113 antibodies |
June 16, 2009 |
| The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. |
| 7547507 |
Methods for the diagnosis of tumors |
June 16, 2009 |
| The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. |
| 7544659 |
Promotion of axonal regeneration |
June 9, 2009 |
| The present invention concerns a method of promoting axonal regeneration. In particular, the invention concerns a method of promoting the growth or regeneration of neurons, and treating disease or conditions associated with the loss, loss of function or dysfunction of nerve cells, in |
| 7544482 |
Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof |
June 9, 2009 |
| The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invent |
| 7538086 |
PRO1303 polypeptides |
May 26, 2009 |
| The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invent |
| 7537931 |
Humanized anti-ERBB2 antibodies and treatment with anti-ERBB2 antibodies |
May 26, 2009 |
| The present application describes humanized anti-ErbB2 antibodies and methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies. |
| 7534856 |
PRO19624 antibodies |
May 19, 2009 |
| The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invent |
| 7531645 |
Protein purification |
May 12, 2009 |
| A method for purifying a polypeptide by ion exchange chromatography is described which involves changing the conductivity and/or pH of buffers in order to resolve a polypeptide of interest from one or more contaminants. |
| 7528236 |
Humanized anti-beta7 antagonists and uses therefor |
May 5, 2009 |
| The invention provides therapeutic anti-beta7 antibodies, compositions comprising, and methods of using these antibodies. |
| 7528233 |
Pantropic neurothrophic factors |
May 5, 2009 |
| Pantropic neurotrophic factors which have multiple neurotrophic specificities are provided. The pantropic neurotrophic factors of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the pantropic neurotrophins are als |
| 7527791 |
Humanized anti-TGF-beta antibodies |
May 5, 2009 |
| Humanized anti-TGF-beta antibodies are provided, as well as methods for their preparation and use, including methods for treating TGF-beta disorders, for example, cancer. Also provided are articles of manufacture designed for various uses that contain the humanized antibodies. |
| 7524937 |
WSX receptor agonist antibodies |
April 28, 2009 |
| Methods for identifying antibodies that decrease body weight, fat depot weight or food intake in an obese animal are provided, as well as antibodies. Preferred antibodies bind to a reactor having a WSX motif and the extracellular domain sequence within SEQ ID NO:2. |
| 7524497 |
Antibodies to PRO 1120 polypeptide |
April 28, 2009 |
| The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invent |
| 7521539 |
Anti-PRO4989 antibodies |
April 21, 2009 |
| The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invent |
