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Genencor International Inc Patents
Assignee:
Genencor International Inc
Address:
Wilmington, DE
No. of patents:
416
Patents:


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Patent Number Title Of Patent Date Issued
8192959 Promoter and plasmid system for genetic engineering June 5, 2012
This invention provides a series of low-copy number plasmids comprising restriction endonuclease recognition sites useful for cloning at least three different genes or operons, each flanked by a terminator sequence, the plasmids containing variants of glucose isomerase promoters for
7968318 Process for conversion of granular starch to ethanol June 28, 2011
A method is disclosed for producing glucose from a granular starch substrate including, contacting a slurry comprising granular starch obtained from plant material with an alpha-amylase at a temperature below the starch gelatinization temperature of the granular starch to produce oli
7858762 Phosphate limited inducible promoter and a Bacillus expression system December 28, 2010
An evolvable production strain of B. subtilis exhibiting continuous or high level expression during protein evolution is described. An evolved Bacillus subtilis pstS promoter facilitates screening and production of secreted proteins.
7803591 Multimeric oxidoreductases September 28, 2010
Described are multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate. The complexes having a dehydrogenase subunit and a cytochrome C subunit. Also described are polynucleotides coding for the multimeric complexes and methods of use there
7745189 Regulatable growth of filamentous fungi June 29, 2010
The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemicals from filamentous
7745184 Process for the biological production of 1,3-propanediol with high yield June 29, 2010
The present invention provides a microorganism useful for biologically producing 1,3-propanediol from a fermentable carbon source at higher yield than was previously known. The complexity of the cofactor requirements necessitates the use of a whole cell catalyst for an industrial pro
7723079 Trichoderma reesei glucoamylase and homologs thereof May 25, 2010
The present invention is related to glucoamylases having at least 80% sequence identity to a Trichoderma glucoamylase having the sequence of SEQ ID NO: 4 and biologically functional fragments thereof. The invention is also related to DNA sequences coding for the glucoamylases, vectors
7691806 Repeat sequence protein polymer active agent congjugates, methods and uses April 6, 2010
Biomolecular conjugates are provided which comprise the conjugation product of a repeat sequence protein polymer and at least one active agent. Additional aspects provide methods for their manufacture and various industrial and consumer applications.
7642077 Biocomposite comprising co-precipitate of enzyme, silicate and polyamine January 5, 2010
This invention relates to a method of immobilizing biocatalysts including protein and cells by co-precipitation with silicate or organosilicate matrices through the action of an organic template molecule. The organic template molecule is in general a polyamine such as polyethylenimine
7638613 Xylanase, microorganisms producing it, DNA molecules, methods for preparing this xylanase and us December 29, 2009
The invention relates to a xylanase originating from a Bacillus strain. This xylanase is active over a wide range of acid and basic pH.The invention also relates to new strains of microorganisms producing this xylanase and to methods for preparing this xylanase.The invention also rel
7638073 Photochromic material comprising a proteorhodopsin apoprotein and a retinal analog December 29, 2009
The present invention relates to a photochromic material comprising a proteorhodopsin apoprotein and a retinal analog. In one embodiment, the retinal analog is an azulenic retinoid compound. In another embodiment, the retinal analog is a compound that is structurally similarly to all
7629451 Acid fungal proteases December 8, 2009
The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and host cells includi
7626004 Protein purification December 1, 2009
The present invention relates to a method of purifying a protein of interest from its fusion analog, comprising obtaining a protein solution comprising a protein of interest and its fusion analog; adjusting the pH and/or ionic strength of the protein solution with an appropriate buffer
7604974 Bacillus 029cel cellulase October 20, 2009
The present invention provides a novel cellulase nucleic acid sequence, designated 029cel, and the corresponding 029cel amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding 029cel, recombinant 029cel proteins and
7592420 Expression in filamentous fungi of protease inhibitors and variants thereof September 22, 2009
Described herein are protease inhibitors, variants thereof and methods for their production.
7592157 Expression in filamentous fungi of protease inhibitors and variants thereof September 22, 2009
Described herein are protease inhibitors, variants thereof and methods for their production.
7566448 Reduced aerosol generating formulations July 28, 2009
The present invention relates to compositions comprising high molecular weight polymers, particularly polyethylene oxide polymers, wherein the high molecular weight polymer serves as an anti-misting agent to reduce the potential of aerosol generation from a composition when used in a
7563609 Mutant 2,5-diketo-L-gluconic acid reductases July 21, 2009
Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated from the environment using PCR methods are described.
7563607 Acid fungal protease in fermentation of insoluble starch substrates July 21, 2009
The invention is directed to methods of producing ethanol and decreasing residual starch production in a no cook fermentation comprising contacting granular starch containing substrates with a granular starch hydrolyzing enzyme, a protease, and a fermenting microorganism under suitab
7544490 Secretion, transcription and sporulation genes in Bacillus clausii June 9, 2009
The present invention relates to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms having exogenous nucleic acid sequences introduced therein and methods
7544489 Secretion, transcription and sporulation genes in Bacillus clausii June 9, 2009
The present invention relates to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms having exogenous nucleic acid sequences introduced therein and methods
7544488 Secretion, transcription and sporulation genes in Bacillus clausii June 9, 2009
The present invention relates to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms having exogenous nucleic acid sequences introduced therein and methods
7524816 Peptides and supported peptides for treating skin diseases April 28, 2009
The present invention provides peptides and supported peptides for treating proliferative diseases. In particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred
7510831 Trichoderma reesei phytase enzymes, nucleic acids encoding such phytase enzymes, vectors and hos March 31, 2009
A novel DNA is provided which encodes an enzyme having phytase activity isolated from Trichoderma. Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from organisms which possess such DNA, transformation of the DNA into a suitable host organism,
7501488 Proteorhodopsin mutants with improved optical characteristics March 10, 2009
The present invention is directed to a proteorhodopsin mutant having improved optical characteristics. One improved optical characteristic is having a lower pH (pK.sub.rh) at which equal concentrations of the acidic and basic spectral form of the proteorhodopsin molecules are present.
7498159 Heterologous alpha amylase expression in Aspergillus March 3, 2009
The present invention relates to the co-expression and production of a heterologous alpha amylase and an endogenous glucoamylase in an Aspergillus strain and enzyme compositions including the same.
7494685 Trichoderma reesei glucoamylase and homologs thereof February 24, 2009
The present invention is related to glucoamylases having at least 80% sequence identity to a Trichoderma glucoamylase having the sequence of SEQ ID NO: 4 and biologically functional fragments thereof. The invention is also related to DNA sequences coding for the glucoamylases, vectors
7485618 FGF-5 supported and binding peptides February 3, 2009
The present invention provides peptides and supported peptides that bind to FGF-5.
7476528 Proteins producing an altered immunogenic response and methods of making and using the same January 13, 2009
The present invention relates to novel protein variants that exhibit reduced allergenicity when compared to the parental proteins. Also included are DNA molecules that encode the novel variants, host cells comprising the DNA and methods of making proteins less allergenic.
7456298 Synthesis of acetonides from aryl silanes November 25, 2008
The present invention is related to cis-diols and biological methods of producing cis-diols. The present invention further relates to processes for subsequently converting such silane cis-diols to the more stable acetonide derivatives, as well as a process for converting silane cis-d
7456147 Controlled release of active agents utilizing repeat sequence protein polymers November 25, 2008
Systems are provided for the controlled release delivery of active agents through the use of repeat sequence protein polymers. The systems may exist as matrices, gels, hydrogels, films, emulsions or microparticles and are particularly useful for incorporating active agents into personal
7455998 Methods for forming structurally defined organic molecules November 25, 2008
Methods of forming organic molecules comprising contacting a hydrolase enzyme with an organic reactant are provided. Methods for forming an organosilicon molecule comprising contacting a hydrolase enzyme with an organosilicon reactant are also provided.
7453023 Manipulation of the phenolic acid content and digestibility of plant cell walls by targeted expr November 18, 2008
Described herein are methods to enhance the production of more highly fermentable carbohydrates in plants, especially forage grasses. The invention provides for transgenic plants transformed with expression vectors containing a DNA sequence encoding ferulic acid esterase I from Asper
7449320 Truncated forms of pullulanase November 11, 2008
The present invention relates to modified pullulanases useful in the starch industry. The present invention provides methods for producing the modified pullulanase, enzymatic compositions comprising the modified pullulanase, and methods for the saccharification of starch comprising t
7449317 Phytase enzymes, nucleic acid sequences encoding phytase enzymes and vectors and host cells inco November 11, 2008
DNA is provided which encodes an enzyme having phytase activity isolated from Penicillium, Fusarium, Humicola and Emericella. Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from organisms which possess such DNA, transformation of the DNA into a
7429476 Acid fungal proteases September 30, 2008
The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and host cells includi
7429475 Phytase enzymes, nucleic acid sequences encoding phytase enzymes and vectors and host cells inco September 30, 2008
DNA is provided which encodes an enzyme having phytase activity isolated from Penicillium, Fusarium, Humicola and Emericella. Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from organisms which possess such DNA, transformation of the DNA into a
7425450 Regulatable growth of filamentous fungi September 16, 2008
The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemicals from filamentous
7413879 Trichoderma reesei glucoamylase and homologs thereof August 19, 2008
The present invention is related to glucoamylases having at least 80% sequence identity to a Trichoderma glucoamylase having the sequence of SEQ ID NO: 4 and biologically functional fragments thereof. The invention is also related to DNA sequences coding for the glucoamylases, vectors
7413877 Bacterial expression of bowman-birk protease inhibitors and variants thereof August 19, 2008
The present invention provides compositions and methods related to the expression of Bowman-Birk protease inhibitors and variants thereof in bacterial species. The present invention further provides fusion nucleic acids, vectors, fusion polypeptides, and processes for obtaining the B
7407791 Production of secreted polypeptides August 5, 2008
Described herein are methods and compositions for the production and secretion of polypeptides. Included herein is the use of interrupting peptide transport activity for an increase in polypeptide production and/or secretion.
7407780 Process for producing glycerol in recombinant bacterial host cells August 5, 2008
The invention provides methods for producing products comprising improved host cells genetically engineered to have uncoupled productive and catabolic pathways. In particular, the present invention provides host cells having a modification in nucleic acid encoding an endogenous enzym
7402664 Nucleic acids and expression vectors comprising carotenoid binding peptides July 22, 2008
The present application relates to peptides which bind to a target stain, phenol oxidizing enzyme-binding peptide complexes wherein the binding peptide is attached to the C-terminus of the phenol oxidizing enzyme or is inserted or substituted into the phenol oxidizing enzyme. In a pr
7399623 Modified forms of pullulanase July 15, 2008
The present invention relates to modified pullulanases useful in the starch industry. The present invention provides methods for producing the modified pullulanase, enzymatic compositions comprising the modified pullulanase, and methods for the saccharification of starch comprising t
7396688 Mass spectrometric analysis of biopolymers July 8, 2008
The present invention makes use of unique tags of a specific biopolymer that can be exploited for determining the concentration the biopolymer in crude solutions. In preferred embodiments the biopolymer is either a protein or a polynucleotide. Particularly, the invention provides a m
7381830 Synthesis of cis-diols from aryl silanes June 3, 2008
The present invention is related to cis-diols and biological methods of producing cis-diols. The present invention further relates to processes for subsequently converting such silane cis-diols to the more stable acetonide derivatives, as well as a process for converting silane cis-d
7381812 Enhanced secretion of a polypeptide by a microorganism June 3, 2008
Described herein are methods for the enhanced production of secreted proteins. The secretion of a protein of interest having a substantially non-polar carboxy tail is enhanced by the placement of charged amino acid residues at the carboxy terminus either by adding to the native peptide
7381789 Synthesis of inorganic structures using templation and catalysis by self assembled repeat protei June 3, 2008
Methods for forming repeat protein polymers and utilizing the repeat protein polymers to form inorganic structures are provided. The inorganic structures may have features on the nanoscale, and the structures generally do not have the repeat protein polymer incorporated therein.
7378256 Aspergillus niger promoter for expressing genes in host cells May 27, 2008
The present invention relates to isolated promoter sequences, particularly a promoter isolated from Aspergillus niger designated herein as A4-L or A4 and DNA constructs and vectors including the same.
7378219 Optical information carrier comprising immobilized proteorhodopsin May 27, 2008
The present invention relates to materials comprising hydrophilic polymers and immobilized proteorhodopsin and the use of such materials as an optical information carrier. The material comprises one or more hydrophilic polymers that are capable to form a homogeneous phase with proteo
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