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Gen-Probe Incorporated Patents
Assignee:
Gen-Probe Incorporated
Address:
San Diego, CA
No. of patents:
360
Patents:


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Patent Number Title Of Patent Date Issued
RE39007 Isothermal strand displacement nucleic acid amplification March 7, 2006
Methods for amplifying target nucleic acid sequences using a nucleic acid polymerase lacking 5' exonuclease activity and a set of oligonucleotide primers. Preferably, a primer array is used. The primer array contains two sets of primers. One set contains at least two complementary primer
RE38960 Isothermal strand displacement nucleic acid amplification January 31, 2006
Methods for amplifying target nucleic acid sequences using a nucleic acid polymerase lacking 5' exonuclease activity and a set of oligonucleotide primers. Preferably, a primer array is used. The primer array contains two sets of primers. One set contains at least two complementary primer
D520352 Clamp May 9, 2006
D519024 Clamp April 18, 2006
D510017 Clamp for tubular structures and the like September 27, 2005
D457247 Cap May 14, 2002
D410080 Diagnostic testing instrument May 18, 1999
8586724 Oligonucleotides for amplifying Chlamydophila pneumoniae nucleic acid November 19, 2013
Amplification oligonucleotides for use in amplifying a sequence contained in nucleic acid derived from Chlamydophila pneumoniae.
8580574 Method and apparatus for stripping a contact-limiting element from a pipette probe November 12, 2013
An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a
8580510 Tagged oligonucleotides and their use in nucleic acid amplification methods November 12, 2013
The present invention provides nucleic acid amplification systems and methods that desirably reduce or eliminate false positive amplification signals resulting from contaminating biological material, e.g., nucleic acid, that may be present in one or more reagents used in an amplifica
8574847 Use of blocker oligonucleotides in selective amplification of target sequences November 5, 2013
A method for the selective amplification of a target sequence. The method includes hybridizing a tagged oligonucleotide to the target sequence and reducing the effective concentration of unhybridized tagged oligonucleotide which is capable of hybridizing to the target sequence. The t
8574841 Compositions, reaction mixtures and methods for detecting nucleic acids from type A1 and/or type November 5, 2013
Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specime
8573072 Method for removing a fluid substance from a sealed collection device November 5, 2013
A method for removing a fluid substance from a sealed collection device comprising a cap and a fluid-holding vessel, where the method aids in venting air from the collection device when the cap is penetrated by a fluid transfer device used to withdraw a fluid substance from the vessel.
8569020 Method for simultaneously performing multiple amplification reactions October 29, 2013
An automated method for performing multiple nucleic acid amplification procedures in multiple receptacles of a set of receptacles contained in an analyzer.
8569019 Method for performing an assay with a nucleic acid present in a specimen October 29, 2013
An automated process for isolating and amplifying a target nucleic acid in a self-contained analyzer.
8563707 Compositions and methods for detection of hepatitis A virus nucleic acid October 22, 2013
Nucleic acid oligomeric sequences and in vitro nucleic acid amplification and detection methods for detecting the presence of HAV RNA sequences in samples are disclosed. Kits comprising nucleic acid oligomers for amplifying and detecting HAV nucleic acid sequences are disclosed.
8293885 Assay and compositions for detection of Bacillus anthracis nucleic acid October 23, 2012
The invention includes compositions and methods of detection of Bacillus anthracis that use oligonucleotide probes specific for genetic material contained in the pXO1 and pXO2 plasmids in nucleic acid hybridization reactions. Embodiments of the method may include additional probes sp
8278052 Tagged oligonucleotides and their use in nucleic acid amplification methods October 2, 2012
The present invention provides kits containing tagged oligonucleotides for use in certain nucleic acid amplification methods to desirably reduce or eliminate false positive amplification signals resulting from contaminating biological material, e.g., nucleic acid, that may be present
8276762 Method and system for performing a magnetic separation procedure October 2, 2012
Methods, systems, and apparatus are provided for automated isolation of selected analytes, to which magnetically-responsive solid supports are bound, from other components of a sample. An apparatus for performing an automated magnetic separation procedure includes a mechanism for eff
8275556 Method of quantifying polynucleotides using a stored calibration curve September 25, 2012
Method for quantifying analyte polynucleotide in a test sample using real-time amplification and adjustment of a stored calibration curve. The method may be practiced using as few as a single adjustment calibrator to adjust the stored curve. This simplifies the quantitative analysis
8224584 Parametric system for quantifying analyte polynucleotides July 17, 2012
System for quantifying analyte polynucleotides employs computer-implemented analysis of real-time amplification data using a calibration curve defined by parametric equations.
8221705 Receptacles for storing substances in different physical states July 17, 2012
A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents.
8221682 System for incubating the contents of a reaction receptacle July 17, 2012
An automated analyzer for performing multiple diagnostic assays includes multiple modules in which aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a sample, pre-heating the sample, incubatin
8206662 Collection device including a penetrable cap having an absorbent pile fabric June 26, 2012
A cap including a penetrable material adapted to be pierced by a fluid transfer device and an absorbent material positioned above the penetrable material. The absorbent material permits passage of the fluid transfer device and absorbs fluid material present on an outer surface of the
8202978 Compositions for detecting group A streptococci June 19, 2012
Compositions, methods and kits for detecting Group A streptococci. Particularly described are oligonucleotides that are useful as amplification primers and hybridization probes for detecting very low levels of Group A streptococci nucleic acids.
8198027 Methods and compositions for nucleic acid amplification June 12, 2012
Compositions that are used in nucleic acid amplification in vitro are disclosed, which include a target specific universal (TSU) promoter primer or promoter provider oligonucleotide that includes a target specific (TS) sequence that hybridizes specifically to a target sequence that i
8192992 System and method for incubating the contents of a reaction receptacle June 5, 2012
An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a
8188258 Oligonucleotides for amplifying Chlamydophila pneumoniae nucleic acid May 29, 2012
Oligonucleotides for use in determining the presence of Chlamydophila pneumoniae in a test sample. The oligonucleotides are incorporated into detection probes, capture probes, and amplification oligonucleotides, and can be used in various combinations thereof.
8183359 Kits for amplifying DNA May 22, 2012
Kits for amplifying DNA which include a priming oligonucleotide that hybridizes to a 3'-end of a DNA target sequence, a displacer oligonucleotide that hybridizes to a target nucleic acid containing the DNA target sequence at a position upstream from the priming oligonucleotide, and a
8153772 Oligonucleotide probes and primers comprising universal bases for diagnostic purposes April 10, 2012
Aspects of the invention relate to novel oligonucleotides comprising universal and generic bases for use as primers and probes, as well as, methods of using said oligonucleotides for the diagnosis of disease.
8145435 Real-time amplification and monitoring system incorporating vector-based algorithm for analyzing March 27, 2012
System for analyzing a polynucleotide-containing sample using real-time amplification and monitoring. The system includes a computer or processing device with software for performing a vector analysis of growth curves. The vector analysis advantageously simplifies polynucleotide quan
8137620 Temperature-controlled incubator having an arcuate closure panel March 20, 2012
An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a
8124335 Compositions and assays to detect influenza virus A and B nucleic acids February 28, 2012
Methods for detecting influenza virus A and influenza virus B nucleic acids in biological samples by using in vitro amplification and detection are disclosed. Compositions that are target-specific nucleic acid sequences and kits comprising target-specific nucleic acid oligomers for a
8097409 Kits for detecting group B Streptococci January 17, 2012
Compositions, methods and kits for detecting Group B streptococci. Particularly described are oligonucleotides that are useful as amplification primers and hybridization probes for detecting very low levels of Group B streptococci nucleic acids.
8071301 Method of isolating nucleic acids from a biological sample December 6, 2011
Method of preparing a biological sample appropriate for use in a subsequent in vitro nucleic acid amplification reaction. The method involves a rapid, transient exposure to alkaline conditions which can be achieved by mixing an alkaline solution with a pH-buffered solution that inclu
8063197 Compositions and methods for detection of hepatitis A virus nucleic acid November 22, 2011
Nucleic acid oligomeric sequences and in vitro nucleic acid amplification and detection methods for detecting the presence of HAV RNA sequences in samples are disclosed. Kits comprising nucleic acid oligomers for amplifying and detecting HAV nucleic acid sequences are disclosed.
8058006 Method for obtaining and initiating amplification of a target nucleic acid sequence November 15, 2011
The present invention relates to oligonucleotides useful for determining the presence of Mycobacterium tuberculosis complex organisms in a test sample. The oligonucleotides of the present invention may be incorporated into detection probes, helper probes, capture probes and amplification
8057762 Penetrable cap November 15, 2011
A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals are constructed so that air passageways are formed between the
8052944 Penetrable cap November 8, 2011
A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so that air passageway
8052929 Gravity-assisted mixing methods November 8, 2011
A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents.
8048375 Gravity-assisted mixing methods November 1, 2011
A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents.
8047086 Method and apparatus for stripping a contact-limiting element from a pipette probe November 1, 2011
An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a
8038967 Method for accessing the contents of a closed vessel containing a specimen retrieval device October 18, 2011
Method for obtaining a fluid from a collection device assembled to isolate a specimen retrieval device from the pathway of a fluid transfer device used to penetrate a cap of the collection device and to draw and remove the fluid from the collection device for analysis.
8034570 Tagged oligonucleotides and their use in nucleic acid amplification methods October 11, 2011
Disclosed are methods for selective amplification of target nucleic acid sequence using a tagged oligonucleotide comprising a target hybridizing sequence that hybridizes to a 3'-end of the target nucleic acid and a tag sequence situated 5' to the target hybridizing sequence. The tagged
8034554 Methods and compositions to detect nucleic acids in a biological sample October 11, 2011
Methods of the invention separate a target nucleic acid from a sample by using at least one capture probe oligonucleotide that contains a target-complementary region and a member of a specific binding pair that attaches the target nucleic acid to an immobilized probe on a capture sup
8026066 Detection of nucleic acids from multiple types of human papillomaviruses September 27, 2011
Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specime
8012419 Temperature-controlled incubator having rotatable door September 6, 2011
An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a
8008066 System for performing multi-formatted assays August 30, 2011
An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating
8008017 Compositions and methods for detecting the presence of cryptosporidium organisms in a test sampl August 30, 2011
The present invention describes novel oligonucleotides targeted to nucleic acid sequences derived from Cryptosporidium organisms, and Cryptosporidium parvum organisms in particular, which are useful for determining the presence of Cryptosporidium organisms in a test sample. The oligo
7993853 Methods of nucleic acid target capture August 9, 2011
Methods for efficiently capturing a target nucleic acid from a sample by using a mixture that contains a capture probe specific for the target nucleic acid, the target nucleic acid, and a denaturant chemical, which mixture is incubated at elevated temperature for a short time, are di
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