| Patent Number |
Title Of Patent |
Date Issued |
| 7608242 |
Peptide-chelate conjugates |
October 27, 2009 |
| A peptide-chelate conjugate with affinity for the ST receptor is disclosed, wherein the chelate is tetradentate. The peptide-chelate conjugate of the invention may be labelled with a radiometal to provide a metal complex. A radiopharmaceutical composition comprising the metal complex |
| 7597875 |
Chelator conjugates |
October 6, 2009 |
| The present invention relates to improved chelator conjugates with biological targeting molecules, suitable for forming metal complexes with radiometals. The radiometal complexes, especially with the radiometal.sup.99mTc, are useful as radiopharmaceuticals. |
| 7592605 |
Radioisotope generator and method of construction thereof |
September 22, 2009 |
| A device for producing a fluid containing a radioactive constituent, comprising a shielded chamber (5) with an opening for receiving an isotope container (6) housing a radioactive isotope (7); a chamber closure (18) adapted for cooperating with and closing the chamber opening; a firs |
| 7553942 |
Method for the use of [.sup.11C] carbon monoxide in labeling synthesis of .sup.11C-labelled amid |
June 30, 2009 |
| Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using weakly nucleophilic amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharmaceuticals, especially for use in Positron Emission |
| 7521544 |
Method and apparatus for the use of [.sup.11C] carbon monoxide in labeling synthesis by photo-in |
April 21, 2009 |
| Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET |
| 7501236 |
NMR spectroscopic in vitro assay using hyperpolarization |
March 10, 2009 |
| An in vitro assay method which comprises the use of an assay reagent containing at least one NMR active nucleus, and hyperpolarising at least one NMR active nucleus of the assay reagent; and analysing the assay reagent and/or the assay by NMR spectroscopy and/or NMR imaging. The assa |
| 7470813 |
Method for the production of pyruvic acid |
December 30, 2008 |
| The invention relates to a method for the production of pyruvic acid, in particular pyruvic acid that is .sup.13C-enriched at the C1-atom, i.e. .sup.13C.sub.1-pyruvic acid. |
| 7368474 |
Radiofluorination methods |
May 6, 2008 |
| The present invention relates to methods and reagents for [.sup.18F]-fluorination, particularly of peptides. The resultant .sup.18F-labelled compounds are useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET). Thus, a compound of formula .sup.18F- |
| 7332352 |
Separation particles |
February 19, 2008 |
| A composition comprising colloidal Fe.sub.3O.sub.4 particles coated with streptavidin is disclosed. These particles can be used in a method for separating biotinylated compounds from a solution in which the biotinylated compounds bind to the streptavidin-coated particles which are at |
| 7264792 |
Solid phase preparation of .sup.18F-labelled amino acids |
September 4, 2007 |
| A process for the production of an .sup.18F-labelled tracer which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO.sub.2--O-TRACER (I) with .sup.18F-- to produce the labelled tracer of formula (II) ##STR00001## |
| 7214539 |
Scintillation proximity test |
May 8, 2007 |
| The invention concerns scintillation proximity assays performed in multiwell plates where a charge coupled device is used to image the wells. Conventional phosphors emit blue light (350 450 nm) which is absorbed by yellow or brown assay components. This problem is addressed by the us |
| 7173061 |
Compounds for imaging alzheimer's disease |
February 6, 2007 |
| The invention provides compounds of formula (I) or a salt thereof, radiolabelled versions thereof, and their use in the diagnosis or in vivo imaging of Amyloid-associated diseases such as Alzheimer's disease ##STR00001## |
| 7101719 |
Support and method for cell based assays |
September 5, 2006 |
| Disclosed is a method for the measurement of a cellular process, or for the measurement of the effect of a test compound on a cellular process, in one or more different populations of cells. The method comprises providing separate samples of one or more different populations of cells |
| 7091317 |
Fluorescent proteins |
August 15, 2006 |
| The present invention provides novel engineered derivatives of green fluorescent protein (GFP) which have an amino acid sequence which is modified by amino acid substitution compared with the amino acid sequence of wild type Green Fluorescent Protein. The modified GFPs exhibit enhanc |
| 7083566 |
Grooved brachytherapy sources |
August 1, 2006 |
| Radioactive sources, preferably radioactive seeds, for use in brachytherapy comprising a radioisotope within a sealed biocompatible container, wherein at least one part of the outer surface of the container is grooved, preferably with a curved groove. The grooved outer surface is pre |
| 7081365 |
Scintillation proximity test |
July 25, 2006 |
| The invention concerns scintillation proximity assays performed in multiwell plates where a charge coupled device is used to image the wells. Conventional phosphors emit blue light (350 450 nm) which is absorbed by yellow or brown assay components. This problem is addressed by the us |
| 7060998 |
Component support and radioisotope generator including one or more component supports |
June 13, 2006 |
| The invention relates to a component support (29) for use in a radioisotope generator, the component support comprising a latching member (5) movable between an engaging position and an open position characterised by further including a bracing member (13) mechanically associated wit |
| 7052672 |
Stabilized radiopharmaceutical compositions |
May 30, 2006 |
| The present invention relates to stabilized .sup.99mTc radiopharmaceutical compositions, which include both a radioprotectant and one or more antimicrobial preservative(s), and hence have an extended lifetime of use. The radioprotectant is ascorbic acid, para-aminobenzoic acid, genti |
| 7011619 |
Apparatus and methods for radiotherapy |
March 14, 2006 |
| The invention provides the use of a radiation source which is a low energy X-ray emitter, e.g. with an energy of emission of the principal photon in the range of 20 to 100 keV, preferably 20 to 40 keV and with a half life of 10 to 100 days, preferably 15 to 70 days, for the treatment of |
| 6897209 |
Labelled factor XIIIa substrates |
May 24, 2005 |
| A complex of a radiometal or paramagnetic metal ion with a metal chelating agent such as a diaminedioxime has attached thereto a substituent of formula (Y).sub.m -A-NHR).sub.k can function as a substrate for the fibrin-stabilizing Factor XIIIa. The complex is useful for the diagnosis |
