| Patent Number |
Title Of Patent |
Date Issued |
| RE35218 |
Azatetracycle compounds |
April 23, 1996 |
| An azatetracycle compound useful as 5HT.sub.3 antagonists of the general formula ##STR1## wherein D is a tetracycle of the structure ##STR2## wherein Ar is an aromatic moiety and B is either NH or O. |
| RE29556 |
1,1-Diaryl-1-oxadiazol-alkylamines |
February 28, 1978 |
| The present invention relates to compounds of the following formula ##STR1## wherein Y is straight or branched chain alkylene containing 1-4 carbon atoms; R.sub.1 is lower alkyl containing 1-7 carbon atoms; X is hydrogen, halo such as fluoro, chloro, bromo or iodo, or lower alkyl con |
| RE29324 |
N-Substituted aspartyl peptide amides |
July 26, 1977 |
| Peptides containing the residues of methionine and aspartic acid are prepared by standard coupling techniques and display valuable pharmacological, e.g. gastrin-inhibitory, properties. |
| RE28738 |
Quench correction in liquid scintillation counting |
March 16, 1976 |
| A means for determining counting efficiency in a liquid scintillation system. Pulse amplitudes are accumulated as are the number of pulses contributing thereto. The accumulated pulse amplitude sum is divided by the accumulated number of pulses to produce an average pulse amplitude for |
| D376201 |
Urine collection funnel |
December 3, 1996 |
|
| 7232817 |
.alpha.- and .beta.-amino acid hydroxyethlamino sulfonyl urea derivatives useful as retroviral p |
June 19, 2007 |
| .alpha.- and .beta.-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. |
| 7202258 |
.alpha.- and .beta.-amino acid hydroxyethylamino sulfamic acid derivatives useful as retroviral |
April 10, 2007 |
| Certain Alpha- and Beta-amino acid hydroxyethylamino sulfamic acid derivatives represented by the following formula are useful as retroviral protease inhibitors: ##STR00001## |
| 7199158 |
Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibit |
April 3, 2007 |
| Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: ##STR00001## wherein R.sup.1 R.sup.6, R.sup.7, R.sup.7', R.sup.8, R.sup.30 R.sup.34, X', Y, Y', t, x, and n are as defined herein, are effective as retroviral protease inhibitors, and in particular as inhibit |
| 7192983 |
N-protected/N-substituted-beta-amino hydroxy sulfonates |
March 20, 2007 |
| N-protected/N-substituted alpha-amino aldehydes, which are useful as pharmaceuticals and pharmaceutical intermediates, can be stored and shipped in a more stable form as N-protected/N-substituted-beta-amino hydroxy sulfonates which can be readily converted back into the aldehyde unde |
| 7189864 |
Method of preparing intermediates useful in synthesis of retroviral protease inhibitors |
March 13, 2007 |
| A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde. |
| 7161033 |
Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
January 9, 2007 |
| Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel com |
| 7141609 |
.alpha.- and .beta.-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhi |
November 28, 2006 |
| .alpha.- and .beta.-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. |
| 7141594 |
Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
November 28, 2006 |
| Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to se |
| 7138411 |
Substituted benzopyran derivatives for the treatment of inflammation |
November 21, 2006 |
| A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR00001## wherein X, A.sup.1, A.sup.2, A.sup.3, A |
| 7135489 |
Crystalline form of 4-[5-methyl-3-phenylisoxazol-4-yl] benzenesulfonamide |
November 14, 2006 |
| A stable crystalline form of 4-[5-methyl-3-phenylisoxazol-4-yl]benzenesulfonamide is described. This crystal structure, designated Form B, is more stable, has favorable handling properties and is characterized by its melting point, x-ray and other physical characterizations. |
| 7132441 |
Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase |
November 7, 2006 |
| This invention is in the field of a combination comprising a therapeutically-effective amount of a cyclooxygenase-2 inhibitor, a 5-lipoxygenase inhibitor and an immunosuppressive drug selected from antiproliferative agents, antiinflammatory-acting compounds and inhibitors of leukocyt |
| 7115632 |
Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
October 3, 2006 |
| A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound in a MMP |
| 7115618 |
.alpha.- and .beta.-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhi |
October 3, 2006 |
| .alpha.- and .beta.-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. |
| 7112683 |
Cyclic sulfone containing retroviral protease inhibitors |
September 26, 2006 |
| The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease. |
| 7098202 |
Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
August 29, 2006 |
| Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, |
| 7091219 |
Bis-sulfonamide hydroxyethyl-amino retroviral protease inhibitors |
August 15, 2006 |
| Bis-sulfonamido hydroxyethylamino compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease inhibiting compounds of the formula: ##STR00001## or a pharmaceutically acceptable salt, pro |
| 7060851 |
Method of preparing retroviral protease inhibitor intermediates |
June 13, 2006 |
| Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chir |
| 7045518 |
Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
May 16, 2006 |
| Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected no |
| 7038084 |
Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
May 2, 2006 |
| Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. |
| 7038040 |
Process for preparation of 9, 11-epoxy steroids and intermediates useful therein |
May 2, 2006 |
| Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula I ##STR00001## wherein: -A-A- represents the group --CHR.sup.4--CHR.sup.5-- or CR.sup.4.dbd.CR.sup.5-- R.sup.3, R.sup.4 and |
| 7037941 |
Alpha-and Beta-amino acid hydroxyethylamino sulfamic acid derivatives useful as retroviral prote |
May 2, 2006 |
| Certain Alpha- and Beta-amino acid hydroxyethylamino sulfamic acid derivatives represented by the following formula are useful as retroviral protease inhibitors: ##STR00001## |
| 7030161 |
.alpha.-and .beta.-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral p |
April 18, 2006 |
| .alpha.- and .beta.-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. |
| 7030153 |
3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents |
April 18, 2006 |
| A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: # |
| 7026485 |
Retroviral protease inhibitors |
April 11, 2006 |
| N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. |
| 7026333 |
Retroviral protease inhibitors |
April 11, 2006 |
| HIV protease inhibitors are disclosed which are characterized as having both hydroxyethylamine and N-heterocyclic moieties. |
| 7019005 |
3 (5)-heteroaryl substituted pyrazoles as p38 kinase inhibitors |
March 28, 2006 |
| A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula I ##STR00001## wherein R.sup.1, R.sup.2, Ar.sup.1 and HetAr.sup.2 are as described in the specification. |
| 6984633 |
Method to treat cardiofibrosis with a combination therapy of an angiotensin II antagonist and ep |
January 10, 2006 |
| A therapeutic method is described for treating cardiofibrosis or cardiac hypertrophy using a combination therapy comprising a therapeutically-effective amount of an angiotensin II receptor antagonist and a therapeutically-effective amount of expoxymexrenone. |
| 6974876 |
Method for preparing intermediates useful in synthesis of retroviral protease inhibitors |
December 13, 2005 |
| A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde. |
| 6951886 |
Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibit |
October 4, 2005 |
| Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: ##STR1##wherein the substituents are as defined in the specification, are effective as retroviral protease inhibitors and in particular as inhibitors of HIV protease. |
| 6943189 |
Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG CO-A r |
September 13, 2005 |
| Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with |
| 6924286 |
.alpha.- and .beta.-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhi |
August 2, 2005 |
| .alpha.- and .beta.-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. |
| 6924099 |
Biomarkers and assays for carcinogenesis |
August 2, 2005 |
| The present invention relates to carcinogenesis biomarkers produced by phenobarbital-treated rat hepatocytes, nucleic acid molecules that encode carcinogenesis biomarkers or a fragment thereof and nucleic acid molecules that are useful as probes or primers for detecting or inducing c |
| 6875790 |
Cyclic sulfone containing retroviral protease inhibitors |
April 5, 2005 |
| The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease. |
| 6863902 |
Immediate release eplerenone compositions |
March 8, 2005 |
| The invention relates to oral pharmaceutical compositions useful as aldosterone receptor blockers comprising the active agent micronized eplerenone in an amount of about 10 mg to about 1000 mg and one or more carrier materials. |
| 6861561 |
Substituted aromatic policyclic tertiary-heteroalkylamines useful for inhibiting cholesteryl est |
March 1, 2005 |
| The invention relates to substituted aromatic polycyclic tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary arte |
| 6861539 |
Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
March 1, 2005 |
| Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel com |
| 6858636 |
1-phenyl imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders |
February 22, 2005 |
| A class of 1-phenyl imidazol-2-one biphenylmethyl compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula ##STR1##wherein each of R.sup.1, R.sup.2 and R.sup.3 is independently selected from h |
| 6858598 |
Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a |
February 22, 2005 |
| A method of using an MMP inhibitor and optionally radiation therapy, and one or more antineoplastic agents of the topoisomerase class selected from the group consisting of irinotecan and topotecan, as a combination therapy for the treatment of neoplasia is disclosed. |
| 6852740 |
Pyrazole derivatives as p38 kinase inhibitors |
February 8, 2005 |
| A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula I ##STR1##wherein Q, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as described in the specification. |
| 6849760 |
Method of preparing retroviral protease inhibitor intermediates |
February 1, 2005 |
| Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chir |
| 6846954 |
.alpha.- and .beta.-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhi |
January 25, 2005 |
| .alpha.- and .beta.-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. |
| 6833373 |
Method of using an integrin antagonist and one or more antineoplastic agents as a combination th |
December 21, 2004 |
| The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of an integrin antagonist and an antineoplastic agent. |
| 6831199 |
Pyrimidine compounds and derivatives thereof |
December 14, 2004 |
| The present invention relates to a class of compounds represented by the Formula I ##STR1##or a pharmaceutically acceptable salt thereof, wherein A is ##STR2##pharmaceutical compositions thereof and methods of using such compounds and compositions as .alpha..sub.v.beta..sub.3 anta |
| 6806360 |
Nucleic acids encoding human tissue factor inhibitor |
October 19, 2004 |
| A cDNA clone having a base sequence for human tissue factor inhibitor (TFI) has been developed and characterized and the amino acid sequence of the TFI has been determined. |
| 6806288 |
Substituted benzopyran derivatives for the treatment |
October 19, 2004 |
| A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1##wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R", R.sup.1 and R.sup.2 are as described in the specification. |
