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Fred Hutchinson Cancer Research Center Patents
Assignee:
Fred Hutchinson Cancer Research Center
Address:
Seattle, WA
No. of patents:
111
Patents:


1 2 3










Patent Number Title Of Patent Date Issued
8232314 Compounds that protect against sensory hair cell death July 31, 2012
The present invention provides methods of identifying compounds that protect against ototoxicity induced by one or more noxious stimuli, and methods of treating an individual with compounds identified using the present screening methods. Also provided are compounds demonstrated to ha
8101155 Sequence of STRO-1 antibody variable region January 24, 2012
The amino acid sequence of the heavy chain polypeptide and the light chain polypeptide of the STRO-1 antibody is disclosed. Also disclosed are methods for detecting and isolating cells expressing the STRO-1 cell surface protein.
8071377 Methods for immortalizing cells December 6, 2011
The present invention provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, said methods comprising culturing the precursor cells in the presence of a Notch agonist and one or more growth factors that support the prolifera
8014957 Genes associated with progression and response in chronic myeloid leukemia and uses thereof September 6, 2011
The invention provides molecular markers that are associated with the progression of chronic myeloid leukemia (CML), and methods and computer systems for monitoring the progression of CML in a patient based on measurements of these molecular markers. The present invention also provid
7993681 Methods, compositions and devices for inducing stasis in tissues and organs August 9, 2011
The present invention concerns the use of oxygen antagonists for inducing stasis in tissue, including all or part of organs. It includes methods and apparatuses for achieving stasis in tissue, so as to preserve and/or protect them. In specific embodiments, preservation methods and ap
7972791 Methods for haplotyping genomic DNA July 5, 2011
The present invention provides a novel method for specifically isolating and separating large segments of genomic DNA that can subsequently be used to determine a genomic haplotype. The invention relies on using a solid phase having a flat surface arrayed with oligonucleotides designed
7959916 Negative immunomodulation of immune responses by ERp5 June 14, 2011
The present invention relates to methods of treating immune disorders and cancers. In particular the invention provides methods of inhibiting the negative immunomodulatory effects of ERp-5 on T cells and dendritic cells, in conjunction with other surface receptors.
7892770 Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and February 22, 2011
In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are (a) a monoclonal antibody named Met4, which antibody is specific for Met, and (b) a hybrid
7795411 Vectors for expressing in vivo biotinylated recombinant proteins September 14, 2010
The present invention provides compositions and methods for generating in vivo biotinylated, secreted recombinant polypeptides comprising recombinantly co-expressing in a yeast cell (a) a secreted recombinant polypeptide comprising a biotin accepting site; and (b) a biotin ligase fus
7771718 Soluble MIC polypeptides as markers for diagnosis, prognosis and treatment of cancer and autoimm August 10, 2010
The present invention provides prognostic and diagnostic methods for cancer, as well as methods for monitoring or staging cancer. Methods involve assaying for tumor-derived soluble MIC polypeptide--either MICA or MICB or both--in a sample from a subject. Assays can be implemented wit
7729863 Methods and materials for canine breed identification June 1, 2010
In one aspect, the invention provides methods for determining the contributions of canid populations to a canid genome. The methods comprise the steps of: (a) obtaining the identity of one or both alleles in a test canid genome for each of a set of markers; and (b) determining the co
7666417 Methods and compositions for treating autoimmune diseases or conditions February 23, 2010
The present invention relates to methods of treating immune disorders, particularly autoimmune and inflammatory disorders such as rheumatoid arthritis, and methods of producing antibodies for use in therapeutic strategies for treating such disorders. Generally, the present methods in
7625704 Methods and compositions for identifying bacteria associated with bacteria vaginosis December 1, 2009
The present invention provides methods and compositions for identifying bacteria associated with bacterial vaginosis and diagnosing bacterial vaginosis in a subject.
7615350 Methods for haplotyping genomic DNA November 10, 2009
The present invention provides a novel method for specifically isolating and separating large segments of genomic DNA that can subsequently be used to determine a genomic haplotype. The invention relies on using a solid phase having a flat surface arrayed with oligonucleotides designed
7560610 p27-deficient mouse exhibiting tissue hypertrophy July 14, 2009
Hypercellular nonhuman organisms have functionally inactivated expression of a cyclin inhibitor gene, especially p27. The growth rate of nonhuman organisms are increased such that a desired size is attained more quickly than as compared to nonvariant organisms. Inhibitors of the p27 cycl
7560117 Foamy virus mutant reverse transcriptase July 14, 2009
The present invention relates to a highly processive reverse transcriptase having DNA polymerase activity and substantially reduced protease activity. More specifically, the invention relates to an isolated reverse transcriptase from foamy virus comprising a substantially inactivated
7514406 Methods for inhibiting deacetylase activity April 7, 2009
A method for identifying a compound that inhibits the NAD.sup.+-dependent deacetylase activity of a SIR2 protein is disclosed. These compounds are useful for the treatment of cancers and other diseases, through the activation of silenced genes, through the promotion of apoptosis in c
7491865 Mouse models of prostate cancer development and metastasis through expression of a hepsin transg February 17, 2009
Transgenic, non-human animal model of cancer, methods of making such animals and methods of using such animals to screen test compounds are provided.
7449186 Methods of blocking the interaction between stromal cells and hemopoietic cells with anti-VCAM-1 November 11, 2008
A therapeutic method of modulating the immune response, by administering to a patient an amount of IL-4 effective to promote peripheral blood lymphocyte adhesion to microvascular endothelial cells in lymphoid organs. The IL-4 is preferably coadministered with IL-1.beta..An improved m
7435591 Compositions and methods for increasing animal size growth rate October 14, 2008
The present invention relates to germ line and somatic cells comprising a mutant p27.sub.kip1 protein lacking a Cdk2 phosphorylation site. Also provided are transgenic animals and methods of making such transgenic animals which have increased size and/or growth rate.
7399633 Methods for immortalizing cells July 15, 2008
The present invention provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, said methods comprising culturing the precursor cells in the presence of a Notch agonist and one or more growth factors that support the prolifera
7300755 Methods for haplotyping genomic DNA November 27, 2007
The present invention provides a novel method for specifically isolating and separating large segments of genomic DNA that can subsequently be used to determine a genomic haplotype. The invention relies on using a solid phase having a flat surface arrayed with oligonucleotides designed
7250505 Isolation and expression of a disabled protein gene mDab1 and methods July 31, 2007
A mammalian homology of Drosophila Disabled protein has been identified and cloned. In particular, the murine homolog designated mDab1 has been cloned and expressed. mDab1, when tyrosine phosphorylated, binds to the SH2 domain of Src, Abl and Fyn. Antibodies specific for mDab1 are pr
7241804 Compositions and methods for modulating apoptosis in cells over-expressing Bcl-2 family member p July 10, 2007
The present invention provides agents and compositions for modulating the apoptotic state of a cell. The agents comprise derivatives of antimycins which bind to an anti-apoptotic Bcl-2 family member protein. Further, the agents preferentially induce apoptosis in cells that over-express
7238668 Inhibition of lymphocyte adherence with CS-1-peptides and fragments thereof July 3, 2007
The present invention relates to a method for inhibiting the adhesion of one cell to another comprising interfering with the interaction between the extracellular matrix receptor and its ligand.The invention is based upon the discovery that the .alpha.4.beta.1 extracellular matrix recept
7230089 Methods for increasing plant cell proliferation by functionally inhibiting a plant cyclin inhibi June 12, 2007
The present invention provides methods for modulating the growth and/or yield of plants. In particular the methods comprise the use of agents which functionally inhibit the expression of plant D-like cyclin inhibitors including isolated polynucleotide sequences which interact with DN
7208315 Compositions and methods for efficient AAV vector production April 24, 2007
The present invention provides packaging cell lines for the efficient production of an Adeno-associated virus (AAV) vector which does not require "helper" virus function for the replication and encapsidation of the AAV vector particles. Packaging cells, methods for their production a
7173063 Topoisomerase poisons for the treatment of proliferative disorders February 6, 2007
Methods for the treatment of a proliferative disorder are provided in which a subject in need of such treatment is administered an effective amount of a compound selected from: compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein X.sup.1 and X.sup.2 are ind
7129086 Human marrow stromal cell lines which sustain hematopoiesis October 31, 2006
Immortalized human stromal cell lines sustain and expand human hematopoietic precursor cells. The precursor cells are obtained from a blood product and inoculated into a culture medium conditioned by exposure to a human stromal cell line. Preferred human stromal cell lines secrete SC
7122312 Methods for drug target screening October 17, 2006
The present invention provides methods for identifying targets of a drug in a cell by comparing (i) the effects of the drug on a wild-type cell, (ii) the effects on a wild-type cell of modifications to a putative target of the drug, and (iii) the effects of the drug on a wild-type cell
7037509 Immunologically significant herpes simplex virus antigens and methods for using same May 2, 2006
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic
6946266 Gene transfer in chicken bursal stem cells September 20, 2005
The invention relates to a method of expressing proteins in higher eukaryotes in vitro. In general, the invention sets forth a method of expressing exogenous proteins as fusion partners with the immunoglobulin molecules of avian species specifically chickens. The technology involves,
6825034 Human RRN3 and compositions and methods relating thereto November 30, 2004
Polynucleotide sequences encoding eukaryotic Rrn3 polypeptides are provided. Rrn3 is a eukaryotic RNA polymerase I transcription factor. The Rrn3 polypeptides, and antibodies thereto, can be used as diagnostic tools, as therapeutic agents and to identify agonist and antagonists of Rr
6596501 Method of diagnosing autoimmune disease July 22, 2003
The present invention relates to diagnostic applications. For autoimmune diseases more particularly, it is demonstrated herein that individuals with SLE, APLA, MCDS and PSS have antibodies that are specific for SR proteins. Thus, in particular aspects the present invention provides m
6461864 Methods and vector constructs for making non-human animals which ubiquitously express a heterolo October 8, 2002
Transgenic non-human animals one having a general deletor construct and a second having a general reporter construct are described. The general deletor animals express a heterologous recombinase under the control of an ubiquitously expressed endogenous promoter. Specifically, the Cre
6461807 Methods for drug target screening October 8, 2002
The present invention provides methods for identifying targets of a drug in a cell by comparing (i) the effects of the drug on a wild-type cell, (ii) the effects on a wild-type cell of modifications to a putative target of the drug, and (iii) the effects of the drug on a wild-type cell w
6444463 Neurogenic differentiation gene neurod3 and methods for inducing differentiation of cells September 3, 2002
Provided are methods of classifying and prognosticating human neuroectodermal tumors by analyzing a sample of the tumor to determine whether various bHLH proteins are detectably expressed in the sample. In the methods disclosed herein, expression of the bHLH genes is assessed by meas
6420374 Use of xanthines as immunosuppressants and to inhibit allograft reactions July 16, 2002
A family of compounds effective in suppressing lymphocyte activation is comprised of 7-(oxoalkyl)1,3-dialkyl xanthines, other than denbufylline, of the formula ##STR1##in which R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of straight-chain
6413518 Immunologically significant herpes simplex virus antigens and methods for identifying and using July 2, 2002
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic
6368862 Polymerase I promoter plasmid and vector constructs April 9, 2002
rDNA promoter constructs useful in plasmids and vectors directing transcription of RNAs in a Pol I-specific manner constructed of four elements in a serial array: a first nucleotide sequence, capable of hybridizing under stringent conditions to an rDNA promoter element; a second nucl
6355774 Isolated p27 protein March 12, 2002
An isolated protein designated p27 is disclosed. The p27 protein has an apparent molecular weight of about 27 kD, and is capable of binding to and inhibiting the activation of a cyclin E-Cdk2 complex. A nucleic acid sequence encoding p27 protein is disclosed, as well as a method for
6171824 Hybrid cytokines January 9, 2001
Therapeutic hybrid cytokines, having a size ranging from about 10 to about 30 kDa, comprise portions of cytokines: leukemia inhibitory factor (LIF), granulocyte-colony stimulating factor (G-CSF), interleukin-6 (IL-6), interleukin-11 (IL-11), oncostatin-M (OSM), and ciliaryneurotrophic fa
6165709 Methods for drug target screening December 26, 2000
The present invention provides methods for identifying targets of a drug in a cell by comparing (i) the effects of the drug on a wild-type cell, (ii) the effects on a wild-type cell of modifications to a putative target of the drug, and (iii) the effects of the drug on a wild-type cell w
6136598 Mus dunni endogenous retroviral packaging cell lines October 24, 2000
Retroviral packaging cells produce replication-defective retroviral particles capable of binding to Mus dunni endogenous virus retroviral receptors on target cells and are useful in gene transfer and gene therapy. The packaging cell employs a vector encoding a M. dunni retroviral Env
6123915 Methods for using agents that bind to VCAM-1 September 26, 2000
A therapeutic method of modulating the immune response, by administering to a patient an amount of IL-4 effective to promote peripheral blood lymphocyte adhesion to microvascular endothelial cells in lymphoid organs. The IL-4 is preferably coadministered with IL-1.beta..An improved metho
6120991 Epiligrin, an epithelial ligand for integrins September 19, 2000
Nucleic acid sequences are disclosed encoding an E170 epithelial ligand and capable of hybridizing under stringent conditions to the nucleotide sequences derived from cDNA clones shown in the figure. Also disclosed are vectors containing the nucleic acid sequences, and cells transformed
6103522 Human marrow stromal cell lines which sustain hematopoiesis August 15, 2000
Immortalized human stromal cell lines sustain and expand human hematopoietic precursor cells. The precursor cells are obtained from a blood product and inoculated into a culture medium conditioned by exposure to a human stromal cell line. Preferred human stromal cell lines secrete SC
6040177 High efficiency transduction of T lymphocytes using rapid expansion methods ("REM") March 21, 2000
The present invention provides a rapid expansion method (termed "REM"), for quickly generating large numbers of T lymphocytes, including cytolytic and helper T lymphocytes. REM involves culturing the T cells in association with a disproportionately large concentration of nondividing feed
6007816 Methods of using CD44-specific antibodies December 28, 1999
Therapeutic methods using antibodies to an adhesion receptor for high endothelial venules (HEV).
5972643 Isolated polynucleotide molecules encoding CTCF, a CCCTC-binding factor October 26, 1999
Polynucleotide molecules encoding CTCF are isolated and purified and sequenced. The CTCF proteins and antibodies thereto can be used to identify mutant CTCFs in methods of diagnosis.
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