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Focal, Inc Patents
Assignee:
Focal, Inc
Address:
Lexington, MA
No. of patents:
41
Patents:












Patent Number Title Of Patent Date Issued
6960340 Apparatus and method for local application of polymeric material to tissue November 1, 2005
An apparatus is provided for applying to a surface of mammalian tissue including soft, living tissue an initially fluent material and then activating the material by exposure to an energy source. The material may be a liquid capable of polymerization to a non-fluent state by exposure to
6936005 Biodegradable tissue retractor August 30, 2005
This invention describes novel methods and devices for stabilizing and retracting tissue during surgery, in particular internal tissue. Patches of material, preferably biodegradable, are adhered to tissue surfaces. By manipulation of the patches, for example directly with forceps, or via
6860870 Self-cleaning fluid delivery device for medical applications March 1, 2005
A gas powered spraying device that can be used for single or multi-part reactive medical polymer compositions is provided. A fluid or one or more reactive solutions are sprayed independently at a tissue surface, and the spraying of each solution of multi-component embodiments is controll
6639014 Multiblock biodegradable hydrogels for drug delivery and tissue treatment October 28, 2003
Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gel
6586751 Light source power tester July 1, 2003
A device for testing the light power output of an optical system comprises a thermochromic element, a body element optionally providing collimation or other means of reproducible positioning, and optionally filters and attenuation. A preferred device fits onto the end of an optical power
6531147 Compliant tissue sealants March 11, 2003
An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure
6468520 Apparatus and method for local application of polymeric material to tissue October 22, 2002
An apparatus is provided for applying to a surface of mammalian tissue including soft, living tissue an initially fluent material and then activating the material by exposure to an energy source. The material may be a liquid capable of polymerization to a non-fluent state by exposure to
6410645 Multiblock biodegradable hydrogels for drug delivery and tissue treatment June 25, 2002
Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gel
6387977 Redox and photoinitiator systems for priming for improved adherence of gels to substrates May 14, 2002
An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a
6352710 Compliant tissue sealants March 5, 2002
An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure
6352682 Polymeric delivery of radionuclides and radiopharmaceuticals March 5, 2002
Locally deposited polymer depots are used as a vehicle for the immobilization and local delivery of a radionuclide or radiopharmaceutical. Radionuclides are incorporated in their elemental forms, as inorganic compounds, or are attached to a larger molecule or incorporated into the po
6261544 Poly(hydroxy acid)/polymer conjugates for skin applications July 17, 2001
A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cos
6217894 Compliant tissue sealants April 17, 2001
An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure
6201065 Multiblock biodegradable hydrogels for drug delivery and tissue treatment March 13, 2001
Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gel
6177095 Polymerizable biodegradable polymers including carbonate or dioxanone linkages January 23, 2001
Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymeri
6176871 Apparatus and methods for intraluminal photothermoforming January 23, 2001
A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wav
6162241 Hemostatic tissue sealants December 19, 2000
A method of controlling hemostasis by applying a hemostatic agent in a tissue sealant composition. The tissue sealant is a biodegradable, biocompatible synthetic polymer that may not intrinsically possess strong hemostatic properties. Inclusion of a hemostatic material in the tissue
6123667 Retracting tissue using photoadhering adhesive September 26, 2000
This invention describes methods and devices for stabilizing and retracting tissue during surgery, in particular internal tissue. Patches of material, preferably biodegradable, are adhered to tissue surfaces. By manipulation of the patches, for example directly with forceps, or via sutur
6121341 Redox and photoinitiator systems for priming and improved adherence of gels to substrates September 19, 2000
An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a
6083524 Polymerizable biodegradable polymers including carbonate or dioxanone linkages July 4, 2000
Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymeri
6051248 Compliant tissue sealants April 18, 2000
An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure
6004547 Apparatus and method for local application of polymeric material to tissue December 21, 1999
An apparatus is provided for applying to a surface of mammalian tissue including soft, living tissue an initially fluent material and then activating the material by exposure to an energy source. The material may be a liquid capable of polymerization to a non-fluent state by exposure to
6004315 Optical fiber diffuser and method of making December 21, 1999
An optical fiber device includes a polymeric optical fiber having a proximal end for coupling to a source of light, and a diffusing region. The polymeric optical fiber includes a core and a cladding around the core. The diffusing region includes a length of the polymeric optical fibe
5942209 Method of local radiotherapy by polymerizing a material in vivo to form a hydrogel August 24, 1999
Locally deposited polymer depots are used as a vehicle for the immobilization and local delivery of a radionuclide or radiopharmaceutical. Radionuclides are incorporated in their elemental forms, as inorganic compounds, or are attached to a larger molecule or incorporated into the po
5900245 Compliant tissue sealants May 4, 1999
An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure
5879713 Targeted delivery via biodegradable polymers March 9, 1999
Delivery of bioactive molecules such as nucleic acid molecules encoding a protein can be significantly enhanced by immobilization of the bioactive molecule in a polymeric material adjacent to the cells where delivery is desired, where the bioactive molecule is encapsulated in a vehicle s
5879688 Hydroxy-acid cosmetics March 9, 1999
A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cos
5849035 Methods for intraluminal photothermoforming December 15, 1998
A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wav
5844016 Redox and photoinitiator priming for improved adherence of gels to substrates December 1, 1998
An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. The barrier can be prepared by staining tissue with a photoinitiator, applying a solution containing a polymerizable barrier
5800373 Initiator priming for improved adherence of gels to substrates September 1, 1998
An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having add
5785993 Reduction of adhesions using controlled delivery of active oxygen inhibitors July 28, 1998
SOD and other active oxygen inhibitors are directly applied in combination with a barrier material at local sites of tissue injury to prevent or decrease formation of adhesions and undesirable proliferation of cells. Preferred barrier materials are polymeric hydrogels providing controlle
5779673 Devices and methods for application of intraluminal photopolymerized gels July 14, 1998
Devices for providing polymeric layers on the interior surface of body lumens and spaces are disclosed. The devices can include proximal and distal occlusion elements to define the treatment space and an optical emitter to provide light for a photopolymerization procedure. The devices
5749968 Device for priming for improved adherence of gels to substrates May 12, 1998
An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto
5749915 Polymeric endoluminal paving process May 12, 1998
A method for applying a paving material to a tissue surface is described. The method involves positioning a non-fluent polymeric material at the surface to be paved, rendering the material fluent, contacting the fluent polymer with the tissue surface, and allowing the polymer to return t
5741323 Polymeric article for intraluminal photothermoforming April 21, 1998
A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wav
5698189 Method for local application of polymeric material to tissue December 16, 1997
This invention relates to devices and techniques for applying therapeutic polymeric material to living tissue.
5665063 Methods for application of intraluminal photopolymerized gels September 9, 1997
Devices for providing polymeric layers on the interior surface of body lumens and spaces are disclosed. The devices can include proximal and distal occlusion elements to define the treatment space and an optical emitter to provide light for a photopolymerization procedure. The devices
5662712 Apparatus for intraluminal photothermoforming September 2, 1997
A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wav
5634946 Polymeric endoluminal paving process June 3, 1997
A method for applying a paving material to a tissue surface is described. The method involves positioning a non-fluent polymeric material at the surface to be paved, rendering the material fluent, contacting the fluent polymer with the tissue surface, and allowing the polymer to return t
5618850 Hydroxy-acid cosmetics April 8, 1997
A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cos
5612050 Apparatus and method for local application of polymeric material to tissue March 18, 1997
An apparatus is provided for applying to a surface of mammalian tissue including soft, living tissue an initially fluent material and then activating the material by exposure to an energy source. The material may be a liquid capable of polymerization to a non-fluent state by exposure to

 
 
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