| Patent Number |
Title Of Patent |
Date Issued |
| 5391735 |
Process for the preparation of 3-substituted derivatives of 1-amino-2-hydroxy-propane |
February 21, 1995 |
| The present invention relates to a new process for the preparation of 3-substituted derivatives of 1-amino-2-hydroxy-propane in the form of single diastereoisomers, to certain of these diastereoisomers, and to compounds which are intermediates in the new process of the invention. |
| 5310752 |
Site specific alkylating agents |
May 10, 1994 |
| The invention relates to distamycin A analogs of the following formula ##STR1## wherein n is 2, 3 or 4; A is an optionally substituted divalent radical chosen from ##STR2## and --Het-- wherein Het is a pentatomic or hexatomic heteromonocyclic ring, except pyrrole; and wherein |
| 5138042 |
6-deoxyanthracyclines |
August 11, 1992 |
| Anthracycline glycosides useful as antitumor agents of formula XV: ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydroxy group, one of R.sub.2 and R.sub.3 represents a hydrogen atom, the other of R.sub.2 and R.sub.3 represents a hydrogen atom or a hydroxy group and X is a |
| 5124317 |
Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
June 23, 1992 |
| According to the invention there is provided a sterile, pyrogen-free, ready-to-use solution of an anthracycline glycoside, especially doxorubicin, which consists essentially of a physiologically acceptable salt of an anthracycline glycoside dissolved in a physiologically acceptable s |
| 5051416 |
Oral antibacterial method |
September 24, 1991 |
| A method is provided for treating a warm-blooded animal having a susceptible bacterial infection which comprises administering orally to said animal a non-toxic, antibacterially effective amount of acetoxymethyl ester of (5R,6S)-2(5R,6S)-2-carbamoyloxymethyl-6-[1(R)-hydroxyethyl]-2-p |
| 5043440 |
Oxidation process for preparing 4-acyloxy azetidinones in a two-phase system |
August 27, 1991 |
| Process for preparing compounds according to formula (I) ##STR1## wherein R.sub.1 and R.sub.2 represent a hydrogen atom or a protective group and R.sub.3 represents a C.sub.1 -C.sub.10 alkyl or an aryl group, by oxidation of compounds according to formula (II) ##STR2## wherei |
| 5037970 |
6-deoxyanthracyclines |
August 6, 1991 |
| A compound of the formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydroxy group, one of R.sub.2 and R.sub.3 represents a hydrogen atom, the other of R.sub.2 and R.sub.3 represents a hydrogen atom or a hydroxy group and X is a hydrogen atom or a trifluoro acetyl g |
| 5017599 |
Site specific alkylating agents |
May 21, 1991 |
| The invention relates to distamycin A analogs of the following formula ##STR1## wherein n is 2, 3 or 4; A is an optionally substituted divalent radical chosen from ##STR2## and -Het- wherein Het is a pentatomic or hexatomic heteromonocyclic ring, except pyrrole; and wherein e |
| 4946831 |
Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
August 7, 1990 |
| According to the invention there is provided a sterile, pyrogen-free, ready-to-use solution of an anthracycline glycoside, especially doxorubicin, which consists essentially of a physiologically acceptable salt of an anthracycline glycoside dissolved in a physiologically acceptable s |
| 4942155 |
Biosynthetic anthracyclines related to daunorubicin |
July 17, 1990 |
| The novel compounds are provided with good antibacterial and antitumour activity. |
| 4939282 |
The process for preparing 6-deoxynthracyclines |
July 3, 1990 |
| A new process for the preparation of 6-deoxyanthracyclinones of general formula I: ##STR1## wherein R represents a hydrogen atom, a hydroxy group or a lower alkoxy group is described. The process provides a total synthesis of the 6-deoxyanthracyclinones of formula I using 1,2,3,6 |
| 4904650 |
Substituted androsta-1,4-diene-3,17-diones |
February 27, 1990 |
| The invention relates to 6-alkylidenadrosta-1,4-diene-3,17-dione derivatives, having the following general formula ##STR1## wherein each of R and R.sub.2, independently, is hydrogen or C.sub.1 -C.sub.6 alkyl and R.sub.1 is hydrogen, halogen or C.sub.1 -C.sub.6 alkyl, which are us |
| 4895933 |
New antitumor agent obtained by microbial stereoselective reduction of 4'-deoxy-4'-iododoxorubic |
January 23, 1990 |
| 4'-Deoxy-13(S)-dihydro-4'-iododoxorubicin having the formula (II): ##STR1## and pharmaceutically acceptable salts thereof are anti-tumor agents. |
| 4895836 |
Nor-cholanic acid derivatives, a process for their preparation, their use and pharmaceutical com |
January 23, 1990 |
|
| 4882315 |
Aminoglycoside steroids, a process for their preparation, their use and pharmaceutical compositi |
November 21, 1989 |
|
| 4873233 |
17-Substituted androsta-1,4-dien-3-one derivatives |
October 10, 1989 |
| The invention relates to new 17-hydroxy androsta-1,4-diene-3-one derivatives of the following formula ##STR1## wherein each of R and R.sub.3, independently, is hydrogen or C.sub.1 -C.sub.6 alkyl;R.sub.1 is hydrogen, halogen or C.sub.1 -C.sub.6 alkyl;R.sub.2 is hydrogen or C.sub.1 -C. |
| 4861793 |
D-nor-7-ergoline derivatives having anti-Parkinson and antipsychosis activity and pharmaceutical |
August 29, 1989 |
| Pharmaceutical compounds of the formula ##STR1## wherein R is H or CH.sub.3, R.sub.1 is H or OCH.sub.3, R.sub.2 is a C.sub.1 -C.sub.4 hydrocarbon group and X is an organic group. Also disclosed is a process for the preparation of these compounds. The compounds have dopamine agoni |
| 4843073 |
1-t-butyl ergolines useful in the treatment of cerebral insufficiency and senile dementia |
June 27, 1989 |
| t-Alkyl ergoline derivatives of formula I are produced ##STR1## wherein (R.sub.1 =H, OCH.sub.3 and R.sub.2 =H) or (R.sub.1 +R.sub.2 =a ring bond and R.sub.3 =H, optionally substituted nicotinoyl or 1-oxo-2-cyclopenten-3-yl); and their pharmaceutically acceptable salts.A process for t |
| 4839346 |
Antitumor anthracycline glycosides, intermediates thereof, and composition and use thereof |
June 13, 1989 |
| New anthracycline glycosides having formula: ##STR1## wherein R.sup.1 is hydrogen or hydroxy and either R.sup.2 or R.sup.3 is hydrogen with the other amino-methyl are described. The new compounds and their pharmaceutically acceptable addition salts are useful as antitumour agents |
| 4801588 |
Tetracyclic indole derivatives for treating hypertension |
January 31, 1989 |
| Compounds of the formula I: ##STR1## wherein R.sub.1 =H, CH.sub.3 ; m=0,1; R.sub.2 =R.sub.3 =H or R.sub.2, R.sub.3 =bond, R.sub.4 =C.sub.1 -C.sub.4 hydrocarbon, n=1 or 2 and their pharmaceutically acceptable salts are antihypertensive agents. Their preparation and pharmaceutical |
| 4797411 |
Cycloalkyl-substituted 4-pyridyl derivatives and use as aromatase inhibitors |
January 10, 1989 |
| The invention relates to cycloalkyl-substituted 4-pyridyl derivatives of formula (I) ##STR1## wherein R is C.sub.1 -C.sub.4 alkyl;each of R.sub.1 and R.sub.2 is, independently, hydrogen or C.sub.1 -C.sub.4 alkyl;n is an integer of 1 to 5; and either(a) A is >C.dbd.O and B is --O-- |
| 4795595 |
Taurine derivatives |
January 3, 1989 |
| A process of preparing taurine-containing peptides of formula (I): ##STR1## comprises reacting a protected aminoacid with cysteamine or cystamine in the presence of a condensing agent, oxidizing the resulting compound and deprotection. |
| 4787429 |
Device for coupling a small tube to an apparatus adapted for fitting a syringe to a drug holding |
November 29, 1988 |
| Device for easily and simply coupling to the free end of a small tube (7) mounted on a transfusion needle an apparatus of the type used for coupling a syringe to a drug holding bottle. The device comprises a hollow shaped body (1) that can be coupled to the small tube (7). An axial passa |
| 4786281 |
Device for connecting one end of a liquid medicament delivery cannula to an apparatus for connec |
November 22, 1988 |
| In order to withdraw pharmaceutical products from sterile vials by means of a syringe, apparatus is used on one end of which a syringe possibly containing a liquid solvent is mounted and at the other end of which a seat is provided for housing the mouth of a vial. The syringe needle can |
| 4785858 |
Device for firmly locking a syringe on a body which may be coupled thereto |
November 22, 1988 |
| A body is provided with members for coupling it to one end of a bottle or the like. The body has a seat for housing the free end of a syringe, with a hole for allowing for the syringe needle to pass through. The free end of a syringe may be housed and threaded in the seat. On the side op |
| 4785001 |
Ergoline esters |
November 15, 1988 |
| Ergoline Esters having the formula (I) ##STR1## in which R.sub.1 =H or CH.sub.3 ; R.sub.2 =C.sub.1 -C.sub.4 hydrocarbon; R.sub.3 =H or OCH.sub.3 ; R.sub.4 =H or halogen; R.sub.5 =C.sub.1 -C.sub.4 alkyl and their pharmaceutically acceptable salts are active at the central nervous |
| 4784803 |
Chemiluminescent composition, and a reactive component suitable for such a composition |
November 15, 1988 |
| The invention relates to a chemiluminescent composition, i.e. one which emits light when its various constituent components are mixed together.The composition consists of at least two separate solutions of at least one oxalate, at least one fluorescent substance, hydrogen peroxide and at |
| 4771134 |
Ring-opening process for preparing azetidinone intermediates |
September 13, 1988 |
| Compounds of formula I ##STR1## wherein R.sub.1 and R.sub.2 is each H, halo or an organic group, R.sub.3 is H or organic group, n=1 or 2, M is a heavy mono- or divalent metal, or M.sub.2 A wherein M.sub.2 is a heavy divalent metal and A is an organic or inorganic group, are prepa |
| 4771043 |
Steroidic aromatase inhibitors |
September 13, 1988 |
| The invention relates to 6-substituted androsta-1,4-diene-3,17-dione derivatives wherein the 6 substituent is an azido, amino or substituted amino group.The invention provides also a process for preparing the said compounds and pharmaceutical compositions containing same.The compounds of |
| 4769483 |
Cycloalkyl-substituted 4-aminophenyl derivatives and process for their preparation |
September 6, 1988 |
| The invention relates to cycloalkyl substituted 4-aminophenyl derivatives of formula (I) ##STR1## wherein R is C.sub.1 -C.sub.4 alkyl:n is an integer of 1 to 5; and either(a) A is ##STR2## and B is --O--, --NH-- or --CH.sub.2 --; or (b) A is --CH.sub.2 -- and B is --O--, --N |
| 4766214 |
Ethers of substituted hydroxymethylpyrazines |
August 23, 1988 |
| The compounds of the invention have the following general formula (I) ##STR1## wherein each of the groups R, R.sub.1 and R.sub.2, which may be the same or different, represents a hydrogen atom, a C.sub.1 -C.sub.6 alkoxy or C.sub.1 -C.sub.6 alkyl group, and R.sub.3 represents a straig |
| 4760058 |
Penam derivatives |
July 26, 1988 |
| Described is a novel process for the preparation of penams and penems useful as antibacterial agents, which comprises the reaction of an appropriate f-substituted-azetidin-2-one with a base, followed by reaction of the thereby formed penam compound with an oxidating agent and an orga |
| 4757061 |
4-amino androstendione derivatives and process for their preparation |
July 12, 1988 |
| The invention discloses 4-substituted androstendione derivatives of the following formula (I) ##STR1## wherein R is amino or substituted amino or azido,one of R.sub.1 and R.sub.2 is hydrogen and the other is hydrogen, alkyl, alkenyl or alkynyl, and(x) and (y) are each, independently, |
| 4749693 |
Nitro anthracyclines, process for their preparation and use thereof |
June 7, 1988 |
| Anthracycline glycosides of the general formula (A'): ##STR1## wherein R.sub.1 represents a hydrogen atom, a hydroxy group or a methoxy group; one of R.sub.2 and R.sub.3 represents a hydroxy group and the other of R.sub.2 and R.sub.3 represents a nitro group; and R.sub.4 represents a |
| 4746666 |
Ergoline compounds useful as antiparkinson agents |
May 24, 1988 |
| Ergoline derivatives of the formula I ##STR1## wherein R.sub.1 =H,CH.sub.3 ; R.sub.2 =H, halogen, CH.sub.3, CN, C.sub.1 -C.sub.4 alkylthio or phenylthio; R.sub.3 =C.sub.1 -C.sub.4 hydrocarbon; R.sub.4 =H, OCH.sub.3 ; R.sub.5 =H and R.sub.6 =--CH.dbd.CH--CONHR.sub.7 or R.sub.5 and |
| 4746516 |
Pharmaceutical compositions consisting or consisting essentially of freeze-dried drug-carrying l |
May 24, 1988 |
| A method is disclosed for purifying non-homogeneous systems, known as liposomic suspensions, from non-entrapped drugs wherein said suspensions are treated with liquid or solid polymers of synthetic and organic nature having chemical functionality, which are used as ion-exchangers. The |
| 4738980 |
Distamycin derivatives and process for their preparation |
April 19, 1988 |
| Distamycin A derivatives of formula ##STR1## wherein R is (a)--NHR.sub.3, wherein R.sub.3 is(a')--CON(NO)R.sub.4, in which R.sub.4 is C.sub.1 -C.sub.4 alkyl either unsubstituted or substituted by halogen; or(b') --CO(CH.sub.2).sub.m --R.sub.5, in which R.sub.5 is halogen, oxiranyl, m |
| 4732897 |
Steroidic 5.alpha.-reductase inhibitors |
March 22, 1988 |
| The present invention relates to new 4-aza-17.beta.-substituted 5.alpha.-androstan-3-ones, to a process for their preparation, to pharmacological compostions containing them, and to the use of said compounds as inhibitors of androgen action by means of testosterone 5-reductase inhibi |
| 4729990 |
Substituted penem derivatives |
March 8, 1988 |
| Antibacterial compounds of formula (I) ##STR1## wherein, R.sub.1 ' is alkyl or hydroxyalkyl;R.sub.2 is hydrogen or a carboxy protecting group; andY' is a group-S-heterocyclic or pyridyl, which group may be substituted, and pharmaceutically or veterinarily acceptable salts thereof and |
| 4716228 |
Condensed 2-substituted thiazole derivatives |
December 29, 1987 |
| A process for preparing compounds of the formula I ##STR1## wherein either (i) each of R.sub.1 and R.sub.2 independently represents H or an organic group, or (ii) NR.sub.1 R.sub.2 is a heterocyclic ring or (iii) R.sub.2 is H and R.sub.1 is ##STR2## wherein each of R.sub.6 and |
| 4713450 |
2-thiacephems and (5R) penems derivatives |
December 15, 1987 |
| A new process is described for the preparation of (5R)-penem derivatives of the general formula I: ##STR1## wherein R.sub.1 represents a hydrogen atom or an organic group; R.sub.2 represents a hydrogen atom or a carboxy protecting group and Y represents a hydrogen or halogen atom |
| 4713378 |
Penem derivatives |
December 15, 1987 |
| There are provided compounds of formula ##STR1## wherein R is hydrogen atom or C.sub.1 -C.sub.3 alkyl group optionally substituted from halogen atom or hydroxy group optionally protected, and Q.sup.(+) represents a group ##STR2## wherein R.sub.1, R.sub.2 and R.sub.3 are each |
| 4684629 |
3'-deamino-3'-hydroxy-4'-deoxy-4'-amino doxorubicin and related daunorubicin |
August 4, 1987 |
| Anthracycline glycosides of general formula (I) ##STR1## wherein R is hydrogen or hydroxy, and pharmaceutically acceptable salts thereof, are anti-tumor agents. |
| 4675311 |
Pharmaceutical compositions containing anthracycline glycosides |
June 23, 1987 |
| Stable, rapidly soluble, lyophilized injectable preparations comprising an anthracycline glycoside, or a pharmaceutically acceptable salt thereof, as the active drug substance, and use of said preparations in the treatment of tumors. |
| 4672057 |
Morpholino derivatives of daunorubicin and doxorubicin |
June 9, 1987 |
| Anthracycline glycosides of the general formula (A): ##STR1## wherein X is hydrogen or hydroxy and R is hydrogen or a methyl or a hydroxymethyl group; and their pharmaceutically acceptable salts; are useful as antitumor agents. |
| 4670457 |
2H-benzofuran-3-one-derivatives and process for their preparation |
June 2, 1987 |
| 2H-Benzofuran-3-one derivatives, process for their preparation and pharmaceutical compositions containing them. The compounds and compositions are useful in the treatment of allergies. |
| 4670262 |
Novel pharmacological compositions based on Cisplatinum and method for obtaining same |
June 2, 1987 |
| The present invention relates to the preparation of sterile and stable freeze-dried forms of Cisplatinum containing from 10 to 50 mg of active ingredient, which can be obtained on an industrial scale and which have particular characteristics of facility and rapidity of dissolution which |
| 4668821 |
Method for extracting phenylalanine from broths of bioconversion |
May 26, 1987 |
| The invention discloses a method for extracting phenylalanine from the broths obtained by enzymatic processes; this method consists in flocculating and filtering the broth, concentrating the filtrate followed by filtering off the resulting cinnamic acid, decolorating and concentratin |
| 4665084 |
Condensed benzopyrone derivatives |
May 12, 1987 |
| The present invention relates to new condensed benzopyrone derivatives having a 5-tetrazolyl substituent thereon, and to pharmaceutical compositions containing them. The compounds are useful in the treatment of allergic conditions. |
| 4663451 |
Process for the synthesis of penems and penams |
May 5, 1987 |
| Described is a novel process for the preparation of penams and penems useful as antibacterial agents, which comprises the reaction of an appropriate 4-substituted-azetidin-2-one with a base, followed by reaction of the thereby formed penam compound with an oxidating agent and a organic |
