| Patent Number |
Title Of Patent |
Date Issued |
| 5418223 |
Method for lyophilization of cyclophosphamide and product |
May 23, 1995 |
| A process for preparing a pharmaceutical preparation consisting essentially of a lyophilized cake of cyclophosphamide monohydrate and a bulking agent which comprises freezing cyclophosphamide, a bulking agent, and water, lyophilizing part of the water, obtaining and melting a supersatura |
| 5336669 |
Cyclophosphamide monohydrate and lactose |
August 9, 1994 |
| A parmaceutical preparation consisting essentially of a lyophilized cake of cyclophosphamide monohydrate and lactose prepared by the process of freezing cyclophosphamide, lactose and water, lyophilizing part of the water, obtaining and melting a supersaturated cyclophosphamide-lactose |
| 5268368 |
Cyclophosphamide--amino acid lyophilizates |
December 7, 1993 |
| A stable rapidly dissolving lyophilized composition of cyclophosphamide and an amino acid selected from the group consisting of glycine, valine and serine is provided which contains an amount of water which is equimolar to the amount of amino acid and the amount of cyclophosphamide in sa |
| 5130305 |
Cyclophosphamide - sodium bicarbonate lyophilizates |
July 14, 1992 |
| A stable rapidly dissoloving lyophilized and hydrated composition of cyclophosphamide and sodium bicarbonate is provided which contains an amount of water which is at least equimolar to the combined amount of cyclophosphamide and sodium bicarbonate in the composition and the weight r |
| 5126364 |
4-amino-5-chloro-n-(2-pyrrolidinylmethyl)-2,3-dihydrobenzo[b]fura n-7-carboxamide and pharmaceuti |
June 30, 1992 |
| The compound (R) (-)-4-amino-5-chloro-N-(2-pyrrolidinylmethyl)-2,3-dihydrobenzo[b]furan-7-c arboxamide; the S isomer thereof, and pharmaceutical compositions containing the same. |
| 5122528 |
Analgesic use of benzobicyclic carboxamides |
June 16, 1992 |
| Pyrrolidinyl derivatives of Benzofuran-7-carboximides with analgesic activity". |
| 5114947 |
Method for alleviating anxiety using benzobicyclic carboxamides |
May 19, 1992 |
| Benzofuran--7--carboxamides with anxiolytic activity. |
| 5066647 |
Cyclophosphamide - alanine lyophilizates |
November 19, 1991 |
| A stable rapidly dissolving lyophilized composition of cyclophosphamide and alanine is provided. |
| 5013547 |
Anticancer drug - antibody conjugates and method for preparing same |
May 7, 1991 |
| A drug-protein conjugate of the general formula (I): ##STR1## where the moiety A--NH-- is the condensation product of an anticancer antibiotic having a free amino group, n is 0, 1 or 2, m is 0, 1, 2 or 3, the moiety --NHAB is the condensation product of a protein having a free am |
| 5002774 |
Sustained release pharmaceutical tablet |
March 26, 1991 |
| A sustained release solid composition for delivering an amount of a pharmaceutical material, prticularly magnesium lactate, to the gastro-intestinal tract comprising:an active pharmaceutical powder material;a compressibility aid material for improving the compressibility of said pharmace |
| 4963679 |
Process for preparing bis (3,5-dioxopiperazinyl) alkanes or alkenes |
October 16, 1990 |
| A process for preparing a compound of the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and methyl or R.sub.1 and R.sub.2 together represent an ethylene bridge group comprising:reacting a diamine of the formula (II) w |
| 4963551 |
Stable lyophilized form of (S)-(+)-bis-4,4'-(1-methyl-1,2-ethanediyl)2,6-piperazinedione and |
October 16, 1990 |
| The present invention is directed to a stable, rapidly soluble lyophilized injectable composition containing up to about 6% moisture and capable of being stored at room temperature comprising the hydrochloric or sulfate salt of a compound selected from the group consisting of (S)-(+) |
| 4950766 |
Preparation of benzamides useful as antiemetic agents |
August 21, 1990 |
| A method for preparing a benzamide by reacting an aromatic acid with an amine having a primary amino group and a secondary amino group wherein the reaction is directed to the primary amino group by first reacting the acid with N,N'-carbonyldiimidazole. |
| 4775533 |
Reconstitution of dry fill cyclophosphamide |
October 4, 1988 |
| In a method for reconstituting dry fill cyclophosphamide, the vial volume is at least 50 ml and the headspace is at least 15 ml. |
| 4775376 |
Method and apparatus for catching fluids purged from a syringe |
October 4, 1988 |
| A syringe purging device comprises a closed chamber into which air and/or any excessive amount of a hazardous liquid, such as a chemotherapy drug, is ejected from a syringe to overcome the health hazard created by openly purging syringes into the air or into a pad of gauze material. A sh |
| 4772459 |
Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful the |
September 20, 1988 |
| A method for alleviating emesis caused by chemotherapy which comprises administering an antiemetic agent or a pharmaceutically acceptable salt thereof to a patient in conjunction with the administration of a chemotherapeutic agent, said antiemetic agent being represented by the formu |
| 4769026 |
Method and apparatus for purging a syringe |
September 6, 1988 |
| A syringe purging device comprises a liquid-tight chamber into which air and/or any excessive amount of a hazardous liquid, such as a chemotherapy drug, is ejected from a syringe to overcome the health hazard created by openly purging syringes into the air or into a pad of gauze material |
