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Emory University Patents
Assignee:
Emory University
Address:
Atlanta, GA
No. of patents:
406
Patents:


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Patent Number Title Of Patent Date Issued
8569305 Treatment of tuberous sclerosis associated neoplasms October 29, 2013
The present invention relates to the use of PDGF receptor tyrosine kinase or bcr-abl tyrosine kinase inhibitors, especially of N-phenyl-2-pyrimidine-amine derivatives of formula I, ##STR00001## in which the symbols and substituents have the meaning as defined herein in free form or
8568311 Display enhanced testing for concussions and mild traumatic brain injury October 29, 2013
Cognitive assessment systems and methods that provide an integrated solution for evaluating the presence or absence of cognitive impairment. The present invention is used to test cognitive functions of an individual including information processing speed, working memory, work list le
8563305 Rapid generation of antibodies October 22, 2013
High efficient methods for producing an antibody molecule that binds an antigen are described. The methods include obtaining a population of PBMC enriched for CD19.sup.highCD3.sup.negCD20.sup.low to negCD38.sup.highCD27.sup.high cells from a mammal exposed to an antigen from sample o
8268809 Kinase inhibitors for preventing or treating pathogen infection and method of use thereof September 18, 2012
The present invention provides compositions and methods of use thereof to prevent and/or treat pathogenic infection. In particular, the present invention provides the use of kinase inhibitors to inhibit kinases that involve in pathogen-host cell interactions that are associated with or
8252846 Strategies for delivery of active agents using micelles and particles August 28, 2012
The present invention provides biodegradable particles (e.g., three-dimensional particles) and micelles which can be used to encapsulate active agents for delivering to a subject. The present invention further provides methods for producing and delivering such particles and micelles.
8203009 Neurotrophic activity of deoxygedunin June 19, 2012
Novel compounds and methods for activating the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing four six-membered rings and a substituted or unsubstituted C.sub.5 or C.sub.6 heteroaryl or het
8197435 Methods and devices for drug delivery to ocular tissue using microneedle June 12, 2012
Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and
8193249 Triptolide analogs for the treatment of autoimmune and inflammatory disorders June 5, 2012
The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of triptolide alone or in combination or alternation with other anti-autoimmune or anti-inflammat
8193200 Antagonists of A2B adenosine receptors for treatment of inflammatory bowel disease June 5, 2012
The present invention relates to method for treating inflammatory bowel disease that includes administration of an effective amount of an antagonist of A.sub.2B adenosine receptors (ARs).
8168583 2-fluoronucleosides May 1, 2012
2'-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: ##STR00001## wherein Base is a purine or
8147512 Dual closing guide for a surgical instrument April 3, 2012
A hand-operated surgical instrument with sequentially engaged tip closing guides. The instrument includes first and second arms having tips that close during a closure operation. A slotted tip closure guide on the arms engages first during the closure operation. A pin closure guide on th
8114994 2' and 3'-substituted cyclobutyl nucleoside analogs for the treatment viral infections and abnor February 14, 2012
Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and HCV) infection, or conditions related to abnormal cellular proliferation, in a host, in
8114884 CXCR4 antagonists for the treatment of medical disorders February 14, 2012
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative conditions mediated by CXCR4 receptors. The compounds provided interfere with the binding of SDF1
8101718 Methods of administering porcine B-domainless fVIII January 24, 2012
The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against bleeding episodes, compared to formerly available methods, or to provide more effective
8080659 CXCR4 antagonists including diazine and triazine structures for the treatment of medical disorde December 20, 2011
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative conditions mediated by CXCR4 receptors or for the treatment of viral infections. The compounds
8071795 HIF inhibitors December 6, 2011
HIF-1 inhibitors and methods of use thereof are provided.
8067537 Composition and method for treatment of stomatitis November 29, 2011
A composition and a method effective in preventing or treating stomatitis are presented. The composition contains glutathione or a pharmaceutically acceptable salt thereof and/or orotic acid or a derivative thereof or a pharmaceutically acceptable salt thereof is provided.
8067424 Selective inhibitors for cyclin-dependent kinases November 29, 2011
This invention provides a class of compounds which are useful for specifically inhibiting cyclin-dependent kinases. This class of compounds finds use in treating diseases resulting from inappropriate activity of cyclin-dependent kinases, including cancer, viral infections (e.g., HIV)
8034579 Proteins with enhanced functionality and methods of making novel proteins using circular permuta October 11, 2011
The present disclosure is relates to novel proteins and peptides having novel and/or enhanced functions and/or behaviors with respect to a native protein or peptide, and methods of making the novel proteins and peptides using techniques of circular permutation and protein engineering.
8032335 Evaluating magnetic resonance spectra October 4, 2011
Provided are methods, systems and computer program products evaluating magnetic resonance (MR) signals from a sample. The methods and systems can be used to evaluate MR signals from various constituents (e.g., metabolites, macromolecules) of the sample.
8008312 CXCR4 antagonists for the treatment of HIV infection August 30, 2011
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor, and in particular to inhibit viral entry of certain viruses. Certain compounds in particular can reduce entry of immunodeficiency
8003324 Modulation of sodium channels by nicotinamide adenine dinucleotide August 23, 2011
The present invention relates to the use of oxidized nicotinamide adenine dinucleotide (NAD.sup.+) or of its reduced form, NADH, as sodium channel modulators. The present invention also relates to the use of compositions containing NAD.sup.+ or NADH to treat conditions associated with so
7989649 Tumor imaging compounds August 2, 2011
The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of .alpha.-aminoisobutyric acid (AIB) analogs namely, their rapid uptake and prolonged retention in tumors with the properti
7972311 Cardioplegia catheter system July 5, 2011
A cardioplegia catheter system for delivery of a cardioplegia solution, comprising a cardioplegia catheter comprising an elongate tubular catheter body that defines a continuous central lumen and a flange that is connected to and extends therefrom an exterior surface of the catheter
7960589 Synthesis of sphingosines and their derivatives June 14, 2011
Embodiments of the present disclosure provide for methods of making sphingosines and derivatives thereof, and the like.
7918814 Method for drug delivery to ocular tissue using microneedle April 5, 2011
Methods and devices are provided for administering a drug to a patient's eye. The methods include (a) inserting a hollow microneedle into the sclera or corneal stroma without penetrating across the sclera or corneal stroma; and (b) infusing a fluid drug formulation through the microneedl
7915244 Methods for the treatment of a traumatic central nervous injury March 29, 2011
Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is admi
7867982 MVA expressing modified HIV envelope, gag, and pol genes January 11, 2011
The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
7846412 Bioconjugated nanostructures, methods of fabrication thereof, and methods of use thereof December 7, 2010
Nanostructures, methods of preparing nanostructures, methods of detecting targets in subjects, and methods of treating diseases in subjects, are disclosed. An embodiment, among others, of the nanostructure includes a quantum dot and a hydrophobic protection structure. The hydrophobic
7846123 Conduit device and system for implanting a conduit device in a tissue wall December 7, 2010
Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in cooperation for securing the device within an aperture defined in the tissue wall. Some embodi
7842705 Curcumin analogs with anti-tumor and anti-angiogenic properties November 30, 2010
The present invention is directed to curcumin analogs exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.
7837982 Imaging agents November 23, 2010
The present invention provides novel amino acid compounds useful in detecting and evaluating brain and body tumors. These compounds have the advantageous properties of rapid uptake and prolonged retention in tumors and can be labeled with halogen isotopes such as fluorine-18, iodine-123,
7833978 Thrombomodulin derivatives and conjugates November 16, 2010
The transmembrane human protein thrombomodulin (TM), as a critical regulator of the protein C pathway, represents the major anticoagulant mechanism that is operative in both normal and injured blood vessels under physiologic conditions in vivo. Compositions and methods are disclosed
7824672 Method for coating living cells November 2, 2010
The invention comprises anti-inflammatory conformal barriers with controllable permeability properties that can be applied to living cells prior to transplant, and methods for coating living cells with conformal barriers. The coatings comprise polymer layers deposited on a cell surfa
7807181 Neisseria mutants, lipooligosaccharides and immunogenic compositions October 5, 2010
Provided herein are mutant strains of Neisseria meningitidis which produce Kdo-free lipid A as well as the Kdo-free lipid A molecules and immunogenic compositions containing such Kdo-free lipid A molecules from a Neisseria strain containing a genetically stable mutation which inactiv
7795017 DNA expression vectors and methods of use September 14, 2010
The present invention relates to novel plasmid constructs useful for the delivery of DNA vaccines. The present invention provides novel plasmids having a transcription cassette capable of directing the expression of a vaccine nucleic acid insert encoding immunogens derived from any p
7785839 Methods to manufacture 1,3-dioxolane nucleosides August 31, 2010
This application provides a process for preparing enantiomerically pure .beta.-D-dioxolane nucleosides. In particular, a new synthesis of (-)-DAPD, suitable for large scale development, is described. In one embodiment the invention provides a process for preparing a substantially pur
7772208 2',3'-dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections August 10, 2010
A method for the treatment or prevention of Flaviviridae infections, in particular, hepatitis C virus infection, in a host, and in particular, a human, is provided that includes administering an effective amount of a .beta.-L- or .beta.-D-2',3'-dideoxynucleoside or a pharmaceutically
7772185 Method for promoting axonal outgrowth in damaged nerves August 10, 2010
The subject invention pertains to the therapeutic use of certain GAG-degrading enzymes, and enzyme combinations, to promote nerve repair and regeneration.
7744523 Drive circuit for magnetic stimulation June 29, 2010
The inventive technique includes devices and methods for generating a magnetic field. One such device may include an inductor for generating a magnetic field and a power source for providing power. Such a device may also include a semiconductor switching device that operatively couples
7713708 Immunological assay system and method May 11, 2010
An immunological or immunohematological assay system is disclosed that includes a filter vessel capable of containing an assay sample, an incubator, a sample separation system, an image acquisition system, and a robotic pipettor. The immunological assay system may also include a wash
7713544 Biological component comprising artificial membrane May 11, 2010
A biocompatible biological component is provided comprising a membrane-mimetic surface film covering a substrate. Suitable substrates include hydrated substrates, e.g. hydrogels which may contain drugs for delivery to a patient through the membrane-mimetic film, or may be made up of
7691289 Compositions, materials incorporating the compositions, and methods of using the compositions, a April 6, 2010
Compositions, materials incorporating the compositions, and methods of use thereof, are disclosed. In one embodiment, the composition includes a metal nitrate selected from d-block metal nitrates and f-block metal nitrates and a metal salt having weakly bound counter anions. The metal
7686781 Catheter for modified perfusion March 30, 2010
A catheter adapted for use in passing fluids and medicines therethrough for use in the perfusion or reperfusion of blood or blood-fluid mixtures into the arteries, veins, tissues, conduits, or organs of a patient is disclosed. The catheter has an elongate tubular body with an elongate
7662938 2'-fluoronucleosides February 16, 2010
A class of 2'-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formula: ##STR00001## wherein Base is a p
7655594 Materials for degrading contaminants February 2, 2010
Briefly described, compositions, materials including the compositions, methods of using the compositions, and methods of degrading contaminants, are described herein. The composition can include a polyoxometalate/ cationic silica material. In addition, the compositions can be made of a
7652033 HIF-1 inhibitors January 26, 2010
HIF-1 inhibitors and methods of their use are provided. In particular, 2,2-dimethylbenzopyran based compounds and methods of their use, for example in the treatment or prevention of hypoxia-related pathologies are provided.
7648993 Methods of treating disorders with Group I mGluR antagonists January 19, 2010
mGluR5 antagonists are used for the treatment and prevention of disorders, including Fragile X, autism, mental retardation, schizophrenia and Down's Syndrome. The methods of the invention can be used to treat epilepsy and anxiety in a human having Fragile X syndrome, autism, mental retar
7648845 Porous materials embedded with nanospecies, methods of fabrication thereof, and methods of use t January 19, 2010
Briefly described, embodiments of this disclosure include structures, methods of forming the structures, and methods of using the structures. One exemplary structure, among others, includes a nanospecies and a porous material. The nanospecies has a first characteristic and a second d
7638502 Treatment of EBV and KHSV infection and associated abnormal cellular proliferation December 29, 2009
A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an effective amount of a 5-substituted uracil nucleoside or its pharmaceutically acceptable sal
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